JOURNAL OF CONTROLLED RELEASE
·
2019
·
IF 7.901
Yanjuan Huang,Zhanghong Xiao,Zilin Guan,Yifeng Shen,Yali Jiang,Xiaoyu Xu,Zeqian Huang,Chunshun Zhao
Current therapeutic strategies for the treatment of bone metastases are often limited by the lack of selectivity, severe systemic toxicity and suboptimal efficacy. Nanomedicine meditated chemo-photodynamic therapy provides a promising therapeutic opportunity for enhanced cancer therapy. Herein, we constructed an alendronate (ALN)-functionalized bone-seeking nanoagent ( [email protected] ) to co-deliver the proteasome inhibitor bortezomib (BTZ) and the photosensitizer Zinc phthalocyanine (ZnPc) for synergistic chemo-photodynamic therapy of bone metastases. Results showed that [email protected] possessed favorable bone affinity both in vitro and in vivo and could release drug in a pH-responsive manner. Under irradiation, [email protected] could generate reactive oxygen species (ROS) to cause mitochondrial damage, and increase the cytosolic Ca 2+ levels and the expression of GRP78 protein to induce excessive endoplasmic reticulum (ER) stress, thereby synergistically inhibiting cell proliferation . More importantly, [email protected] could prolong blood circulation time and preferentially navigate to the bone affected site. As a result, tumor growth was significantly inhibited by bone targeted chemo-photodynamic therapy, with tumor volume cut down by 85% compared with PBS group and bone remained undamaged. Besides, the systemic toxicity of BTZ was significantly reduced. Therefore, the versatile nanoagent is expected to be a promising nanoplatform to concern multiple intracellular stress for remarkable synergistic chemo-photodynamic therapy of bone metastases.
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SURFACE & COATINGS TECHNOLOGY
·
2026
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IF 6.9
Hui Guo,Yinzhong Liu,Yun Guo,Lingchao Wang,Xiaofan Li,Xiaotao Zhu,Yiyu Qiao,Yuqing Tian,Xuechun Yang
Eu/Er co-doped MOF-ZnO sensor enables room-temperature n-butanol detection. • 13.88-fold enhancement over ZnO (555/40) and LOD 862.6 ppb • Response/recovery: 33/27 s; good selectivity & stability • DFT: oxygen vacancies, surface area, band structure, adsorption energy The rapid advancement of industrialization has led to the emission of a growing number of volatile organic compounds (VOCs) into the atmosphere, posing significant threats to human health and the environment. Among these, n-butanol is recognized as a particularly harmful VOC. Herein, we propose a MOF-ZnO-based gas sensor for n-butanol doped with rare earth elements (Eu, Er), synthesized via a homogeneous co-precipitation method. The as-prepared samples were comprehensively characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Brunauer-Emmett-Teller (BET) analysis, and ultraviolet-visible (UV–vis) spectroscopy to evaluate their morphological, structural, and physicochemical properties. Compared with the pure MOF-ZnO and the doped MOF-ZnO individually with 0.08 wt% Eu and 0.06 wt% Er, respectively, the co-doped MOF-ZnO with 0.04 wt% Eu 0.03 wt% Er presented the highest oxygen vacancy concentration and the largest specific surface area, as well as the optimal response, selectivity, and long-term stability toward n-butanol. Notably, at room temperature, the co-doped ZnO sensor achieved the highest response value of 555 toward 100 ppm n-butanol, representing a 13.88-fold enhancement over pure MOF-ZnO (40), with a limit of detection (LOD) as low as 862.6 ppb. The sensor also displayed fast response and recovery times of 33 s and 27 s, respectively, for n-butanol detection. Furthermore, the modified energy band structure and surface adsorption energy (E ads ) of the doped product were investigated via Density Functional Theory (DFT) mechanistic calculations. These findings offer a versatile and highly promising strategy for constructing high-performance VOC sensors.
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RSC Advances
·
2018
·Vol. 8
·期 18
·9611-9617
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IF 2.936
Ji-Wei Shen,Zhiqing Wang,Xiaoxuan Wei,Jiawei Liu,Yinmao Wei
Herein, user-friendly control of the synthesis of sub-10 nm hexagonal (β-) NaYbF4:Er nanocrystals (NCs) with extremely low-level Gd3+ doping (0%, 10 mol%) was achieved. We reveal for the first time that the effective sodium/fluoride levels during the formation of cubic (α-) nuclei are not only controlled by the sodium/fluoride to rare-earth precursor ratios used, but also sensitively restricted by the in situ NaF generation reaction in a sodium oleate-based solvothermal system. Excessive in situ NaF generation will lead to a respective sodium- and fluoride-deficient environment, delayed α-to-β transition and larger β-NCs. Based on these effects, sub-10 nm monodisperse low-level Gd3+-doped β-NaYbF4:Er was obtained with a user-friendly low fluoride dosage by finely balancing this NaF generation reaction and achieving an intrinsic optimized sodium-fluoride level for NC nucleation. Notably, our work represents the first example where the focus is on the competing in situ NaF generation reaction and its use for nucleation regulation, as well as for the user-friendly control of the solvothermal synthesis of sub-10 nm β-NaYbF4:Er.
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Journal of Materials Chemistry C
·
2017
·Vol. 5
·期 37
·9579-9587
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IF 5.256
Ji-Wei Shen,Zhiqing Wang,Jiawei Liu,Hua Li
In an effort to address the solvothermal control synthesis issues of hexagonal upconversion nanocrystals (UCNCs) without additional co-doping, especially for NaYbF4:Er, we find for the first time that the mostly used sodium sources of NaOH and sodium oleate function through a totally unexpected NaF–HF pathway rather than the commonly accepted pathway of each of them. Specifically, NaOH reacts with NH4F and converts to nano-sized NaF completely in methanol, leading to reduced NH4F decomposition/HF generation in NaOH based synthesis. By contrast, sodium oleate-oleic acid hybrid suppresses NaF generation, leading to enhanced NH4F decomposition/HF generation in sodium oleate based synthesis. HF-flask SiO2 reaction, HF-to-NaF etching and HF tail gas were also detected for the first time. Results show the nano-sized NaF and in situ generated HF play key roles in the formation of cubic monomers and the cubic-to-hexagonal transition of UCNCs, respectively. Inspired by these results, a facile binary sodium strategy was proposed to achieve control synthesis of high-quality and small-sized hexagonal UCNCs via simultaneous regulation of nano-sized NaF and HF levels. HF was also verified as an origin of Ostwald ripening for UCNCs. The impacts of Ostwald ripening on the evolution of UCNCs were thus investigated. Our findings not only offer an advanced growth mechanism, but also present an effective control synthesis tool for UCNCs.
研究领域:
材料科学
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纳米技术
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无机化学
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发光材料
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稀土纳米材料
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ELECTROCHIMICA ACTA
·
2022
·
IF 7.336
Siqi Zhang,Shuopan Dun,Xugeng Guo,Jinglai Zhang
Introducing upconversion nanoparticles (UCNPs) or fabricating TiO 2 hollow spheres (TiO 2 -HSs) are considered two feasible strategies to enhance the photovoltaic performance of dye-sensitized solar cells (DSSCs). However, studies investigating a combination of UCNPs and TiO 2 -HSs for the application in DSSCs are still scarce. In this contribution, NaYF 4 :Yb,Er@NaGdF 4 :Nd@SiO 2 UCNPs and TiO 2 -HSs were synthesized and respectively applied as upconversion layers and scattering layers on the TiO 2 photoanode of DSSCs. The influence of different doping ratios of UCNPs on cell performance was explored. The present results reveal that the DSSCs device based on conventional P25 photoanode films incorporating the UCNPs with 10% can achieve a photovoltaic efficiency of 6.65%, showing 29.63% enhancement in comparison to the device without UCNPs. When the TiO 2 -HSs are used as scattering layers above the P25 film, the DSSCs device obtains a higher photovoltaic efficiency of 6.97%. More importantly, combining the UCNPs and TiO 2 -HSs can further enhance the photoelectrical property of DSSCs, realizing an optimal efficiency of 8.17%. Such an improvement can be attributed to a synergistic mechanism arising from the upconversion effect of UCNPs and the light scattering effect of TiO 2 -HSs. This work opens a new way of preparing composite photoanode films to improve the photovoltaic performances of DSSCs.
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CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Luo Feng,Liqing Li,Meiqi Zhang,Yijie Yang,Xiaoqi Sun
This paper reports the syntheses of a series of polychromatic pigments with the general formula LiAl 1- x M x (MoO 4 ) 2 (M = Fe, Pr, Ho, Nd, Er, Ce; x = 0–0.4) and the characterization of near-infrared reflectance properties. The synthesized pigments exhibited green (Pr), lavender (Nd), pink (Er) and different yellows (Fe, Ho, Ce). The XRD patterns of typical LiAl 1- x Fe x (MoO 4+δ ) 2 samples show that the prepared samples are triclinic lithium aluminum molybdate structures with space group P -1.The iron in the sample mainly existed in the form of Fe 3+ , which led to the directional growth of grains with different morphologies. The near-infrared solar reflectance (R*%) of LiAl 1- x Fe x (MoO 4 ) 2 pigments reached 94.19%. As the doping concentration of rare earth was increased, the color of the pigments gradually deepens. By introducing rare earth elements Pr, Ho, Nd, Er, and Ce into the LiAl(MoO 4 ) 2 matrix, the color of the pigment was successfully changed from white to green, lavender, pink, and yellow, indicating that doping can control the color of the pigment. Moreover, the prepared pigments had high R*% (>87%), indicating that the pigment samples have excellent thermal insulation properties and can be used as a new type of reflective thermal insulation coatings.
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Frontiers in Pharmacology
·
2021
·
IF 5.811
Cao Qiongqiong,Xu Dongmei,Chen Yong,Long Yueming,Dai Fang,Gui Li,Lu Yunxia
Macrovascular disease is tightly associated with obesity-induced metabolic syndrome. Sitagliptin (SIT), an orally stable selective inhibitor of Dipeptidyl peptidase-4 (DPP-4), has protective effects on endothelium. However, the mechanisms enabling SIT to exhibit resistance to diet-induced obesity (DIO) related with reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress in the aorta and endothelial cells have not been reported yet. Therefore, the present study was conducted to determine if SIT exerts protective role in the thoracic aortas isolated from the high-fat diet (HFD)-treated rats and palmitate (PA)-treated endothelial cells by alleviating ROS and ER stress. Male Sprague Dawley rats were randomly divided into standard chow diet (SCD), HFD and HFD plus sitagliptin administration (HFD + SIT) groups. The rats of latter two groups were given HFD fodder for 12 weeks, then the HFD + SIT rats were treated with SIT (10 mg/kg/d) by intragastric administration for another 8 weeks. The body mass, vascular tension, serum oxidative stress indices and inflammatory parameters, pathological changes, protein expression of endothelial nitric oxide synthase (eNOS), the genes associated with ER stress and apoptosis in the thoracic aorta were measured. Furthermore, cell proliferation, ROS and the protein expression associated with ER stress (especially CHOP) and apoptosis were assessed in human umbilical vein endothelial cells (HUVECs) incubated with SIT and PA. Compared to the SCD rats, the HFD rats had higher serum lipid levels, decreased vascular tension, increased inflammation, oxidative and ER stress, and apoptosis of endothelial cells. PA promoted ROS generation, ER stress and apoptosis, inhibited cell proliferation in HUVECs. SIT treatment obviously ameliorated apoptosis via alleviating ROS and ER stress in the thoracic aortas isolated from HFD-fed rats and PA-treated HUVECs. The results suggest that SIT improved endothelial function via promoting cell proliferation and alleviating ROS-ER stress-CHOP pathway both in vivo and in vitro.
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ENVIRONMENTAL POLLUTION
·
2023
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IF 8.9
Xiaojing Li,Qian Wu,Dan Chen,Yichen Bai,Yuhong Yang,Shiwen Xu
Cadmium (Cd) is a major contaminant in natural environments and exerts adverse effects on aquatic biota at low concentrations. Gill is as vital respiratory organ and may cause pollutants to enter fish during gas exchange. Baicalein (BAI), as a kind of flavonoids, possess antioxidant properties through inactivating free radicals. To confirm the potential effects and approaches of BAI addition in maintaining the gill stability, 90 common carps ( Cyprinus carpio L.) were selected and randomly divided into water environment exposure group (0.22 mg/L Cd) and/or feed added with 0.10 g/kg BAI for 30 days. The analysis of ion content in serum showed that Cd exposure disturbed ion homeostasis , and BAI could reduce serum Cd concentration. The histopathological results of gills showed that Cd exposure caused gill tissue lesions and structural damage, and BAI feeding effectively alleviated this damage. In addition, BAI could enhance antioxidant activity and activate Nrf2/HO-1 axis, thereby reducing oxidative stress and endoplasmic reticulum (ER) stress. Moreover, BAI lightened cytokine imbalance, inflammatory response, and necroptosis. Overall, the results indicated that BAI feeding could maintain gill homeostasis against Cd poisoning via the ROS/ER stress signaling. This trial revealed the properties of BAI resistance to metal Cd in aquaculture and partially elucidated its mechanism.
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PHYTOMEDICINE
·
2023
·
IF 7.9
Yuhong Li,Shuying Hu,Yueqi Chen,Xing Zhang,Hanchi Gao,Jing Tian,Jian Chen
Background Triple-negative breast cancer (TNBC) is a heterogeneous carcinoma characterized by the most aggressive phenotype among all breast cancer subtypes. However, therapeutic options for TNBC patients have limited clinical efficacy due to lack of specific target and efficient targeted therapeutics. Aim To investigate the biological characteristics of a novel estrogen receptor (ER)-α splice variant ER-α30 in breast cancer cells , and its possible role in the anticancer effects of calycosin , a typical phytoestrogen derived from the herbal plant Astragalus membranaceus , against TNBC. This may also provide a better understanding of the inhibitory activity of calycosin on TNBC progression. Methods Breast cancer tissues and para-cancer tissues were collected and analyzed for the expression levels of ER-α30 using immunohistochemistry (IHC), and its expression in two TNBC cell lines (MDA-MB-231 and BT-549) was detected by western blot and qRT-PCR assays. Then the alteration of cell viability , apoptosis , migration, invasion and epithelial-mesenchymal transition (EMT) in response to overexpression or knockdown of ER-α30 was separately determined by CCK-8, Hoechst 33258 , wound healing, transwell and western blot assays in two TNBC cell lines. Next, the anticancer effects of calycosin on MDA-MB-231 cells were evaluated through CCK-8, colony formation, flow cytometry, Hoechst 33258 and western blot assays, along with the role of ER-α30 in these effects and the possible downstream targets of ER-α30. In addition, the in vivo experiments were carried out using MDA-MB-231 xenograft model intraperitoneally treated with calycosin. The volume and weight of xenograft tumor were measured to evaluate the in vivo anticancer activities of calycosin, while the corresponding changes of ER-α30 expression in tumor tissues were detected by IHC. Results It was demonstrated that the novel ER-α splice variant ER-α30 was primarily distributed in the nucleus of TNBC cells. Compared with normal breast tissues, ER-α30 expression was found in significantly higher levels in breast cancer tissues of ER- and progesterone receptor (PR)-negative subtype, so did in TNBC cell lines (MDA-MB-231 and BT-549) when compared to normal breast cell line MCF10A. Moreover, ER-α30 overexpression strikingly enhanced cell viability, migration, invasion and EMT progression and reduced apoptosis in TNBC cells, whereas shRNA-mediated knockdown of ER-α30 revealed the opposite results. Notably, calycosin suppressed the expression of ER-α30 in a dose-dependent manner, accompanied with the inhibition of TNBC growth and metastasis . A similar finding was observed for the xenografts generated from MDA-MB-231 cells. The treatment with calycosin suppressed the tumor growth and decreased ER-α30 expression in tumor tissues. Furthermore, this inhibition by calycosin was more pronounced in ER-α30 knockdown cells. Meanwhile, we found a positive relationship between ER-α30 and the activity of PI3K and AKT, which could also be inactivated by calycosin treatment. Conclusion For the first time, it is demonstrated that the novel estrogen receptor-α splice variant ER-α30 could function as pro-tumorigenic factor in the context of TNBC by participating in cell proliferation , apoptosis, invasion and metastasis, thus it may serve as a potential therapeutic target for TNBC therapy. Calycosin could reduce the activation of ER-α30-mediated PI3K/AKT pathway, thereby inhibited TNBC development and progression, suggesting that calycosin may be a potential therapeutic option for TNBC.
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APPLIED SURFACE SCIENCE
·
2016
·
IF 3.15
Zhenli Qin,Sinan Du,Yang Luo,Zhijian Liao,Fang Zuo,Jianbin Luo,Dong Liu
We report the use of an efficient hydrothermal method to synthesize superparamagnetic and red luminescent bifunctional Fe 3 O 4 @Mn 2+ -doped NaYF 4 :Yb/Er nanoparticles (NPs) with core@shell structures via a seed-growth procedure. Oleic acid coated Fe 3 O 4 (OA-Fe 3 O 4 ) NPs were initially synthesized using a coprecipitation method. The as-synthesized OA-Fe 3 O 4 NPs were then used as seeds, on which the red upconversion luminescent shell (Mn 2+ -doped NaYF 4 :Yb/Er) was formed. Furthermore, hydrophobic to hydrophilic surface modification of the Fe 3 O 4 @Mn 2+ -doped NaYF 4 :Yb/Er NPs was achieved via a ligand exchange method where oleic acid was displaced by a PEG phosphate ligand [PEG = poly(ethylene glycol)]. These materials were characterized by means of transmission electron microscopy (TEM), X-ray diffraction (XRD), photoluminescence (PL) spectroscopy, and vibrating sample magnetometry (VSM). The Fe 3 O 4 cores were uniformly coated with a Mn 2+ -doped NaYF 4 :Yb/Er shell, and the bifunctional Fe 3 O 4 @Mn 2+ -doped NaYF 4 :Yb/Er NPs were monodispersed. Furthermore, the Fe 3 O 4 @Mn 2+ -doped NaYF 4 :Yb/Er NPs exhibited a saturated magnetization value of 6.2 emu/g and emitted red luminescence under a 980 nm laser. The obtained bifunctional Fe 3 O 4 @Mn 2+ -doped NaYF 4 :Yb/Er NPs may find potential applications in drug targeting, bioseparation, and diagnostic analysis. The synthetic method may be employed for the preparation of other bifunctional nanomaterials.
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TALANTA
·
2017
·
IF 4.162
Ling-Feng Jiang,Bo-Cheng Chen,Ben Chen,Xue-Jian Li,Hai-Lin Liao,Hong-Miao Huang,Zhan-Jing Guo,Wen-Yan Zhang,Lin Wu
A sensitive and stable bioassay for the detection of Aβ oligomer (Aβo), a potentially promising candidate biomarker for Alzheimer's disease (AD) diagnosis, was developed using Fe 3 O 4 magnetic nanoparticles (MNPs) as the recognition and concentration elements and BaYF 5 :Yb,Er upconversion nanoparticles (UCNPs) as highly sensitive labels, conjugated with the Aβo aptamer (DNA1) and the complementary oligonucleotide of the Aβo aptamer (DNA2), respectively. The DNA1 hybridized with DNA2 to form the duplex structure on the surface of the MNPs/UCNPs nanocomposites probe. When the target Aβo was introduced, the aptamer DNA1 preferentially bound with Aβo and caused the dissociation of some complementary DNA2, liberating some UCNP-labeled complementary DNA2 and leading to a decreased upconversion fluorescent intensity on the surface of MNPs. The decreased fluorescence intensity of UCNPs was related to the concentration of Aβo in the range of 0.2–15 nM with a detection limit of 36 pM. The developed method then was successfully applied to measure Aβo in artificial cerebrospinal fluid. Benefiting from the magnetic separation and concentration effect of MNPs, the high sensitivity of UCNPs, as well as the selectivity and stability of the aptamer, the present strategy offered valuable information related to early diagnosis of AD process.
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MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 9
·3469-3475
·
IF 4.58
Tang Yiwei,Li Min,Gao Xue,Liu Xiuying,Gao Jinwen,Ma Tao,Li Jianrong
The paper describes the preparation of a fluorescent probe based on the use of up-conversion particles (UCPs) of the type NaYF 4 : Er, Yb and shelled with a molecularly imprinted polymer (MIP) that is specific for the antibiotic enrofloxacin. The upconverted green luminescence emitted by the UCPs upon photoexcitation at 980 nm was used to locally generate a thin MIP shell around the UCPs via photopolymerization. Enrofloxacin is used as the template, and ethylene glycol dimethacrylate (EGDMA) as the cross-linking agent. It is found that enrofloxacin is well captured by the MIP and then quenches the fluorescence of the UCPs. Fluorescence decreases linearly in the 63 ng·L −1 to 60 μg·L −1 enrofloxacin concentration range, with a 8 ng·L −1 limit of detection. The method was applied to the determination of enrofloxacin in spiked fish samples. Recoveries ranged from 83.7 to 87.7%, with relative standard deviations between 2.0 and 5.5% (for n = 3).
Schematic of an NIR-responsive up-conversion nanoparticle probe of the NaYF 4 :Er,Yb type and coated with a MIP for fluorometric determination of enrofloxacin. The upconverted luminescence emitted by the UCPs was used to locally generate a thin MIP shell around the UCPs via photopolymerization.
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