International Journal of Nanomedicine
·
2026
·
IF 8.7
Wen Chao Xu,Xiao Qu Duan,Li Zhong,Yuan Chao Li,Lei Ran,Hai Huan Xu,Qian Wu,Ke Huang,Na Nan Miao,Tao Jiang,Qiu Han Chen,Yang Zhang,Hong Zhuang Zhang,Ru Peng Wang,Mingfu Gong
Background Atopic dermatitis (AD) severely impairs the lives of patients and existing therapies are limited by side effects or insufficient efficacy. In this study, we developed a multifunctional nanocomposite hydrogel that integrates immunoregulation, antioxidant, antibacterial, and skin repair for the integrative treatment of AD.Methods Fe3O4-Aushell (FA) nanoparticles (NPs) were synthesized, melittin (MLT) was anchored onto FA NPs, and MLT-Fe3O4-Aushell (MFA) was loaded into Pluronic F-127 (PF127), to prepare the MFA@PF127 hydrogel. After a comprehensive evaluation of the physicochemical properties, MFA@PF127 was incubated with HaCaT cells and administered to AD lesions to demonstrate its therapeutic efficiency for AD in vitro and in vivo.Results The Fe3O4‑Aushell (FA) NPs with a heterodimer morphology and uniform size were successfully prepared, and the MLT was then loaded onto FA NPs with a high loading efficiency of 64.5%. By loading MLT-FA (MFA) NPs into PF127, the MFA@PF127 nanocomposite hydrogel with thermosensitivity, a porous structure, and good biocompatibility was successfully constructed. After incubation with MFA@PF127 and irradiated with near-infrared (NIR) laser, HaCaT cells showed significantly lower thymic stromal lymphopoietin (TSLP) expression and reactive oxygen species (ROS) levels than the control. The growth of S. aureus and biofilm formation were suppressed by MFA@PF127 under NIR irradiation. When administered to AD lesions, MFA@PF127+NIR significantly alleviated the dermatitis severity score; downregulated TSLP, IL‑4, and IL‑13 expression, suppressed S. aureus colonization; reduced ROS levels; and alleviated epidermal thickening and mast cell infiltration.Conclusion MFA@PF127 exhibited multifunctionality of immunoregulation, and antioxidant and antibacterial activities, which significantly alleviated AD symptoms in a mouse model and provided a potential strategy for AD treatment after further preclinical validation.
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高影响因子
BIOCHEMICAL ENGINEERING JOURNAL
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2026
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IF 3.6
Chen Li,Yue Yu,Xin Liu,Xiaodong Cui,Yuru Guo,Jiao Li,Fang Li
● Recombinant BTI was immobilized on PDA-coated Fe₃O₄ nanoparticles. ● Fe₃O₄@PDA@BTI enabled one-step trypsin purification from porcine pancreatic homogenate. ● The maximum trypsin adsorption capacity was 13.78 ± 0.34 mg/g. A magnetic affinity adsorbent, Fe₃O₄@PDA@BTI, was prepared by immobilizing recombinant buckwheat trypsin inhibitor (BTI) on polydopamine (PDA)-coated Fe₃O₄ nanoparticles. TEM, FTIR, XRD, VSM, BTI-loading analysis, and retained inhibitory activity collectively supported the successful construction of the material. The adsorbent recovered trypsin from porcine pancreatic extract in a single batch purification step, with a maximum adsorption capacity of 13.78 ± 0.34 mg/g. Fe₃O₄@PDA@BTI retained more than 90% of its inhibitory activity at pH 4–10, more than 85% of its inhibitory activity after 3 h at 30–80 ℃, and approximately 94% after 30 d at 4 ℃. It also exhibited good stability against ethanol, dimethyl sulfoxide (DMSO), urea, and sodium dodecyl sulfate (SDS). However, the relative adsorption capacity decreased to 45.35 ± 0.19% after 10 reuse cycles, indicating that ligand coupling and regeneration require further optimization. These results demonstrate the feasibility of combining recombinant inhibitor recognition with magnetic recovery for trypsin purification.
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高影响因子
Coatings
·
2025
·Vol. 15
·期 6
·728
·
IF 2.8
Xingpu Yin,Bo Zhao,Lu Chen,Xuan Di,Baoe Li,Hongshui Wang,Donghui Wang,Chunyong Liang
Dental implant papilla (DIP) is susceptible to bacterial adhesion and biofilm formation, and oral pathogenic biofilms can cause persistent oral infections. Enrichment of bacterial biofilms on implants can lead to soft tissue irritation and adjacent bone resorption, severely compromising dental health and potentially leading to periodontitis, implant loss and costly follow-up care. Nanozymes (NZs) are recently used in biofilm removal as they can induce the production of reactive oxygen species (ROS), which can kill bacteria. However, the short lifespan of ROS limits their diffusion distance, and affects their therapeutic efficacy. In this study, we prepared Fe3O4nanoparticles (NZs) with different morphologies: flower-like (F-Fe3O4), hollow spherical (M-Fe3O4), octahedral (O-Fe3O4), and conventional nanoparticles (N-Fe3O4). The ferromagnetic properties of Fe3O4NZs allow them to move and penetrate the biofilm under the action of a magnetic field. The saturation magnetic intensities of the four samples were as follows: F-Fe3O4(23.1 emu g−1), M-Fe3O4(73.34 emu g−1), O-Fe3O4(96.06 emu g−1), and N-Fe3O4(52.15 emu g−1). The synergistic combination of photothermal action and catalytic sterilization can effectively remove the biofilm. In addition, the prepared Fe3O4nanozymes were able to maintain high biological activity on the implant surface with some osteogenic effect.
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高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Xinyu Mu,Deng Lingli,Yang Guo,Rui Zhou,Xiaoying Guo,Xian Jian,Xiangyu Zhao
Construction of homogeneous composite structures based on covalent bond mediation represents an effective approach to achieve excellent microwave absorption performance (MAP). In this study, Ti 3 C 2 T x @Fe 3 O 4 @SiO 2 nanocomposites with uniform architecture were successfully fabricated using 3-aminopropyltrimethoxysilane (APTMS) as a coupling agent. By functionalizing Fe 3 O 4 @SiO 2 nanoparticles with surface amino groups via APTMS, covalent bonding was established between Ti 3 C 2 T x nanosheets through amide linkages, enabling homogeneous anchoring of Fe 3 O 4 @SiO 2 within Ti 3 C 2 T x . This fabrication method based on covalent bond mediation enhances interfacial polarization of the composite while simultaneously optimizing its conductive networks and impedance matching characteristics. Together with intrinsic magnetic resonance and eddy current loss mechanisms of Fe 3 O 4 , these enhancements endow the Ti 3 C 2 T x @Fe 3 O 4 @SiO 2 composites with exceptional MAP. At a thickness of 1.26 mm, the material exhibits an effective absorption bandwidth of 4.11 GHz, spanning the frequency range of the Ku band. At a slightly higher thickness (1.5 mm), a minimum reflection loss of −48.98 dB is attained. Notably, the composites also demonstrate superior thermal conductivity, enabling efficient electromagnetic energy dissipation through the conversion into thermal energy. The proposed covalent bonding-based scheme provides a theoretical framework for microstructure design and performance optimization of novel MXene-based microwave absorbers.
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高影响因子
JOURNAL OF POLYMER SCIENCE
·
2020
·Vol. 58
·期 24
·3411-3418
·
IF 0
Yang Chen,Wenhao Xiao,Jie Zhang,Minglu Bu,Xiaoqing Zhang,Anfu Chen,Jinbao Xu,Caihong Lei
An iminotris(dimethylamino)phosphorane (HMP 1 ) phosphazene superbase has been anchored onto poly(hexachlorocyclotriphosphazene- co -4,4′-sulfonyldiphenol) (PZS)-coated Fe 3 O 4 magnetic nanoparticles (MNPs) through efficient phosphorous-chloride (from PZS surface) and imino (from HMP 1 ) reaction. Subsequently, these novel heterogeneous Fe 3 O 4 @PZS@HMP 1 catalysts have been successfully utilized in the ring-opening polymerization of ε -caprolactone ( ε -CL) and δ -valerolactone ( δ -VL). Notably, such catalysts can be easily removed from the reaction mixture and reused 3 times without obvious activity loss. Graphical Phosphazene superbase was anchored onto poly(hexachlorocyclotriphosphazene- co -4,4′-sulfonyldiphenol) (PZS)-coated Fe 3 O 4 nanoparticles as immobilized catalyst for ring-opening polymerization and its catalytic activity, recoverability and recyclability was investigated.
研究领域:
材料科学
·
催化化学
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Arabian Journal of Chemistry
·
2022
·Vol. 15
·期 9
·104071
·
IF 6.212
Ruoshui Liu,Di'an Wu,Xiang Yu,Ningfang Zhou,Dan Liu,Lichen Wang,Zhiyi Xu,Huayang Gong,Tongyun Zhao,Jirong Sun,Fengxia Hu,Baogen Shen
Sintered polycrystalline strontium hexaferrite, which is one of the most widely used permanent magnetic materials, has been applied in many areas such as electrical and mechanical transductor devices. Improving the coercivity ( H cJ ) of M-type strontium hexaferrite with a nominal composition SrFe 12 O 19 (SrM) plays an essential role to adapt to many modern applications, but is limited by the process and purity of raw materials. In this work, we prepared SrM powders with different iron resources, sintering temperatures, and Fe/Sr atom ratios. It was found that using Fe 3 O 4 nanoparticles with a Fe/Sr atom ratio of 12 at 1100 °C performed the self-composites with 70% nano-size and 30% micro-size, which had the best performance. The coercivity reaches 348.9 kA/m, which is improved compared to pure SrM obtained by other iron resources in the solid-state method. This process shows a unique formation mechanism and the resulting self-composite microstructure eventually causes enhancement in the properties, which provides a new way for high-performance hexaferrites.
研究领域:
材料科学
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磁学与磁性材料
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陶瓷
·
纳米材料
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高影响因子
ACS Sustainable Chemistry & Engineering
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2017
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IF 5.951
Ling-Feng Shen,Yi-Zhou Zhu,Peng-Fei Zhang,He-Fang Wang
Selectively capturing nanosized titanium dioxide (nano-TiO2) from complex mixtures is a very significant but very formidable task both for enriching the analytical methodology and removing/recycling of nano-TiO2. We presented a novel sustainable strategy for such a task by using the bisphosphonate-functionalized Fe3O4 (BP-Fe3O4) nanoparticles as the highly selective adsorbents toward nano-TiO2. The BP-Fe3O4 exhibited high equilibrium adsorption capacity (Qe) toward nano-TiO2 (2.45 g g–1 for 60 nm anatase TiO2) but negligible Qe toward nano-SiO2 (0.01 g g–1 for 15 nm SiO2). The BP-Fe3O4 also had good adsorption capability toward nano-TiO2 in complex liquid media, or in the solid mixtures containing 10−500 times of coexisting nano-SiO2. This capturing strategy enables the green pretreatment for quantitative analysis of nano-TiO2 in complex real samples with the spike recoveries of 69.9–99.0% and low detection limit of 0.02 ppm. Furthermore, this strategy offers great convenience for identification of the crystal forms and even the morphology of nano-TiO2 existing in complex real samples. Besides, this capturing strategy holds great potential for separating or removing nano-TiO2 from the environment and the sustainable recycling of nano-TiO2.
研究领域:
环境科学
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纳米技术
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分析化学
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材料科学
·
可持续化学
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高影响因子
FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES
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2023
·
IF 2.3
Dong-Dong Mai,Jun-Feng She,Dong-Liang Shi,Fu-An He,Bo Lin,Kwok-Ho Lam
In this work, the Fe3O4-carbon black filler was obtained from an in-situ coprecipitation method followed by the modification of the heptadecafluorodecyltrimethoxysilane and the Fe3O4-carbon black/poly(vinylidene fluoride) (PVDF) composites with enhanced properties were prepared by a simple solution blending-water precipitating method. The Fe3O4-carbon black distributed well in the PVDF matrix, which was confirmed by the SEM. According to the results of FTIR and WAXD, a lot of useful polar crystalline phases of PVDF formed in the Fe3O4-carbon black/PVDF composites. The electrically conductive ability, the dielectric permittivity, the dielectric loss factor, and the magnetic saturation value of the Fe3O4-carbon black/PVDF composite increased with the increasing loading amount of Fe3O4-carbon black filler. Especially, when the Fe3O4-carbon black was 5 wt.%, the dielectric permittivity of Fe3O4-carbon black/PVDF composite reached as high as 23.5 at 1000 Hz with a relatively low dielectric loss factor value of 0.38 and a magnetic saturation value of 0.64 emu/g.
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高影响因子
INTEGRATED FERROELECTRICS
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2016
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IF 0.375
Yaohui Xu,Tonghui Wang,Dongfeng Sun,Ruixing Li
Fe3O4 nanoparticles were synthesized by a facile one-pot hydrothermal process just using ferric citrate and water without any additional reagent and post-treatment. The temperature of hydrothermal reaction had important influence on the crystallinity and magnetic property of Fe3O4 samples. Fe3O4 sample synthesized at 200 °C for 24 h showed a narrow size distribution (4 to 8 nm in diameter), and exhibited apparent superparamagnetism with saturated magnetization of 55.1 emu/g. The narrow size distribution and superparamagnetism were the interesting features of these Fe3O4 nanoparticles.
研究领域:
材料科学
·
纳米技术
·
磁性材料
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高影响因子
ACS Omega
·
2025
·
IF 4.3
Tai Zhou,Xue Liu,Zhimin Wu,Riley Lyu,Caizhi Peng,Hongyi Zhang,Yajing Xia
Background: Skin wound healing is a common clinical challenge, facing multiple obstacles including delayed healing, local hypoxia, and bacterial infection, which may lead to prolonged nonhealing or wound infection. Traditional therapeutic strategies mostly intervene in single factors, making it difficult to achieve synergistic effects. Therefore, developing an innovative approach to simultaneously address multiple issues is of great significance. Objective: This study aims to develop a multifunctional hydrogel patch (Cu–Fe3O4-loaded HAMA, CFH) by integrating three core functions of promoting healing, supplying oxygen, and antibacterial activity, achieving a “one-for-three” therapeutic effect to provide a more comprehensive solution for wound repair. Methods: Cu–Fe3O4 nanoclusters (NCs) were synthesized via a hot solvent method, and CFH hydrogel patches were constructed using molds. In vitro experiments were performed to verify their biosafety, antibacterial properties, and nanozyme activity. A mouse full-thickness skin defect model was established to validate the wound-healing effect of CFH hydrogel patches in vivo. Results: Cu–Fe3O4 NCs were successfully synthesized, exhibiting good biocompatibility and significantly promoting the proliferation and migration of human skin fibroblasts (HSFs). Meanwhile, the material showed excellent nanozyme activity, effectively catalyzing the decomposition of hydrogen peroxide and glutathione to remarkably improve local oxygen supply in wounds. Antibacterial experiments confirmed significant inhibitory effects against MRSA and Escherichia coli. In vivo experiments further demonstrated that CFH hydrogel patches adhered well to wounds, enabling rapid, efficient, and aseptic wound healing within 14 days. Conclusions: This study successfully developed a multifunctional CFH hydrogel patch based on Cu–Fe3O4 NCs, integrating three functions of promoting cell proliferation, improving oxygen supply, and broad-spectrum antibacterial activity. It provides a safe and efficient novel therapeutic strategy for clinical wound repair, holding important clinical application value.
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PubMed
高影响因子
OZONE-SCIENCE & ENGINEERING
·
2018
·
IF 1.232
Shengtao Jiang,Jianzhong Zhu,Zibo Wang,Min Ge,Huayue Zhu,Ru Jiang,Enmin Zong,Yujiang Guan
The nanosized Fe3O4 catalyst was synthesized via a modified reverse coprecipitation method and characterized by means of a scanning electron microscope (SEM) and an X-ray diffraction (XRD) analysis instrument. The degradation efficiency and reaction rate of Fe3O4 in activating sodium persulfate used to degrade ciprofloxacin were determined from the catalyst dosage, oxidant concentration, and initial pH. The results showed that under the optimum conditions of a catalyst dosage of 2.0 g·L−1, a sodium persulfate concentration of 1.0 g·L−1, and an initial pH of 7, the degradation rate of ciprofloxacin was 93.73%, the removal rate of total organic carbon was 78%, and the first-order reaction constant was 0.06907 min−1 within 40 min. It was also demonstrated that the reactive oxygen species in the Fe3O4/sodium persulfate catalytic system were mainly composed of SO4– and supplemented by OH· and HO2· using probe compounds such as ethanol, tertiary butanol, and benzoquinone.
研究领域:
环境科学
·
化学工程
·
高级氧化技术
·
纳米催化
·
水处理技术
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高影响因子
Journal of Water Process Engineering
·
2026
·
IF 6.6
Xinyu Tang,Liangquan Lu,Hua Zhang,Xiaojie Sun,Bin Dong,Mingxin Bin,Jianhong Bi,Pengfei Yang
A magnetic Fe 3 O 4 -EDTA@Zr-MOF composite was successfully synthesized and characterized. • The maximum adsorption capacity for chlortetracycline reached 268.10 mg/g. • The adsorbent retained around 80% removal efficiency after six regeneration cycles. The long-term accumulation and serious pollution of chlortetracycline in the environment have emerged as a global pollution concern, posing a serious threat to ecosystems and public health. To overcome the limitations of traditional adsorbents, including low adsorption capacity, poor selectivity and limited regenerative properties, this study synthesized a composite material Fe 3 O 4 -EDTA@Zr-MOF that combines magnetic separation and ligand functionality by the hydrothermal method for CTC adsorption. Successful synthesis was verified by structural characterization, including FTIR and XRD. The adsorption kinetics were well described by the PSO model, suggesting that active-site-controlled surface interactions played an important role in CTC uptake. Thermodynamic analysis showed ΔG 0 < 0 and ΔH 0 > 0, indicating a spontaneous and endothermic process. The adsorption isotherms fitted the Langmuir model well, with a maximum theoretical capacity (q max ) of 268.10 mg/g. Circulation experiments show that the adsorption capacity of the material was still around 80% after 6 cycles. Fe 3 O 4 -EDTA@Zr-MOF combines high adsorption efficiency with easy magnetic recovery and good reusability, providing a potential solution for the treatment of tetracycline antibiotics in aquatic environments. Download: Download high-res image (122KB) Download: Download full-size image
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