JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2022
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IF 5.062
Hui Yun Zhou,Jia Nan Tong,Li Jun Ren,Pei Yan Hao,Hui Jie Zheng,Xu Ming Guo,Ya Wei Chen,Jun Bo Li,Hyun Jin Park
Chitosan hydrogel had been widely used in cell culture and tissue engineering, but its long gel time, weak mechanical strength, and weak antibacterial performance limited its application. In this study, the cyclodextrin grafted glutamic acid , a water-soluble cyclodextrin derivatives , was prepared by glutamic acid (Glu) and mono-(6-OTs)-β-CD under alkaline conditions and confirmed by FTIR and 1 H NMR. Then chitosan (CS) and cyclodextrin grafted glutamic acid (CD-g-Glu) were used to prepare chitosan/cyclodextrin derivatives thermosensitive hydrogel (CS/CD-g-Glu) to improve the properties of chitosan-based thermosensitive hydrogels. The CS/CD-g-Glu hydrogel had temperature sensitivity and stable three-dimensional network structure. In addition, the hydrogel loaded with berberine hydrochloride (BBH) showed optimal sustained-release effect, and the cumulative release rate was 57% in 24 h. More importantly, the CS/CD-g-Glu hydrogel loaded with BBH showed prefect antibacterial activity against E. coli and S. aureus . Therefore, the CS/CD-g-Glu hydrogel has great promising applications in drug delivery, tissue engineering, biotechnological, and biomedical fields.
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JOURNAL OF FLUORESCENCE
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2022
·Vol. 32
·期 5
·1755-1759
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IF 2.525
Nie Jia,Xu Tong,Liu Qian,Yang Chun,Sun Xuping
Hg 2+ is one of the most toxic heavy metal ions that exist in the environment and it forms large numbers of toxic binary compounds. Accurate and rapid detection of the concentration of heavy metal ions is a prerequisite technology to achieve pollution control and prevention. Fluorescent probes have attracted extensive attention because of their high sensitivity, prominent precision, convenient and fast visualization of heavy metals. Herein, we report multi-layered graphitic carbon nitride via a simple thermopolymerization treatment as a very effectual fluorescent probe for sensitive and selective detection of Hg 2+ with a limit of detection as low as 1.14 nM.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
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IF 9.136
Liangliang Gui,Yuqi Cui,Yuzhang Zhu,Xiaoqiang An,Huachun Lan,Jian Jin
Enhancing the water permeability of reverse osmosis and nanofiltration (NF) membranes without sacrificing the quality of water production can potentially lead to substantial savings in cost and has considerable practical impact on broad application. Herein, we report a facile fabrication of thin film composite (TFC) NF membrane with crumple polyamide (PA) active layer based on a graphitic carbon nitride (g-C 3 N 4 ) nanofibers network interlayer via interfacial polymerization, where the g-C 3 N 4 nanofibers network film is formed simultaneously with the formation of PA active layer by a self-deposition process. The special g-C 3 N 4 nanofibers network film possesses ultra-high hydrophilicity, high porosity and relative smooth surface, which is favorable to form a defect-free and crumple PA active layer. The g-C 3 N 4 nanofibers network interlayer assisted TFC NF membrane exhibits a high water flux up to 152 L m -2 h −1 (4 bar) while maintains a high salt rejection with Na 2 SO 4 rejection of 98.9%.
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JOURNAL OF FLUORESCENCE
·
2023
·
IF 2.7
Yuan Xinyu,Zhang Xiufeng,Hu Jinshan,Zhang Buyue,Ma Xiaoying,He Jinxing,Shi Lei
In this report, we developed a sensing strategy based on ThT-E (a ThT derivative) and DNA G-quadruplex for the label-free detection of Zn 2+ . In the absence of Zn 2+ , there was a fluorescence enhancement of ThT-E by interaction with human telomere sequence. On the addition of Zn 2+ , Zn 2+ induced a more compact antiparallel G-quadruplex to release ThT-E, resulting in fluorescence quenching. The detection limit was 0.6996 μM, and the fluorescence intensity showed a good linear relationship with the concentration of Zn 2+ in the range of 0-10 μM. This sensing strategy which only needs to mix two kinds of materials has the characteristics of label-feel, simple operation, short response time, economical and efficient.
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NATURE
·
2023
·
IF 64.8
Xu Zheng,Guo Lulu,Yu Jingjing,Shen Siyuan,Wu Chao,Zhang Weifeng,Zhao Chang,Deng Yue,Tian Xiaowen,Feng Yuying,Hou Hanlin,Su Lantian,Wang Hongshuang,Guo Shuo,Wang Heli,Wang Kexin,Chen Peipei,Zhao Jie,Zhang Xiaoyu,Yong Xihao,Cheng Lin,Liu Lunxu,Yang Shengyong,Yang Fan,Wang Xiaohui,Yu Xiao,Xu Yunfei,Sun Jin-Peng,Yan Wei,Shao Zhenhua
Trace-amine-associated receptors (TAARs), a group of biogenic amine receptors, have essential roles in neurological and metabolic homeostasis 1 . They recognize diverse endogenous trace amines and subsequently activate a range of G-protein-subtype signalling pathways 2 , 3 . Notably, TAAR1 has emerged as a promising therapeutic target for treating psychiatric disorders 4 , 5 . However, the molecular mechanisms underlying its ability to recognize different ligands remain largely unclear. Here we present nine cryo-electron microscopy structures, with eight showing human and mouse TAAR1 in a complex with an array of ligands, including the endogenous 3-iodothyronamine, two antipsychotic agents, the psychoactive drug amphetamine and two identified catecholamine agonists, and one showing 5-HT 1A R in a complex with an antipsychotic agent. These structures reveal a rigid consensus binding motif in TAAR1 that binds to endogenous trace amine stimuli and two extended binding pockets that accommodate diverse chemotypes. Combined with mutational analysis, functional assays and molecular dynamic simulations, we elucidate the structural basis of drug polypharmacology and identify the species-specific differences between human and mouse TAAR1. Our study provides insights into the mechanism of ligand recognition and G-protein selectivity by TAAR1, which may help in the discovery of ligands or therapeutic strategies for neurological and metabolic disorders.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Ruizheng Xu,Guiyu Wei,Zhemin Xie,Sijie Diao,Jianfeng Wen,Tao Tang,Li Jiang,Ming Li,Guanghui Hu
Increasing the efficiency of charge transfer and separation efficiency of photogenerated carriers are still the main challenges in the field of semiconductor-based photocatalysts. Herein, we synthesized g-C 3 N 4 @V 2 C MXene photocatalyst by modifying g-C 3 N 4 using V 2 C MXene. The prepared photocatalyst exhibited outstanding photocatalytic performance under visible light. The degradation efficiency of methyl orange by g-C 3 N 4 @V 2 C MXene photocatalyst was as high as 94.5%, which is 1.56 times higher than that by g-C 3 N 4 . This was attributed to the V 2 C MXene inhibiting the rapid recombination of photogenerated carriers and facilitating rapid transfer of photogenerated electrons (e − ) from g-C 3 N 4 to MXene. Moreover, g-C 3 N 4 @V 2 C MXene photocatalyst showed good cycling stability. The photocatalytic performance was higher than 85% after three cycles. Experiments to capture free radicals revealed that superoxide radicals (·O 2 − ) are the main contributors to the photocatalytic activity. Thus, the proposed g-C 3 N 4 @V 2 C MXene photocatalyst is a promising visible-light catalyst.
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高影响因子
Materials
·
2023
·Vol. 16
·期 20
·6665
·
IF 3.4
Manying Sun,Chuanwei Zhu,Su Wei,Liuyun Chen,Hongbing Ji,Tongming Su,Zuzeng Qin
Photocatalytic CO2reduction is a tactic for solving the environmental pollution caused by greenhouse gases. Herein, NH4H2PO4was added as a phosphorus source in the process of the hydrothermal treatment of melamine for the first time, and phosphorus-doped hollow tubular g-C3N4(x-P-HCN) was fabricated and used for photocatalytic CO2reduction. Here, 1.0-P-HCN exhibited the largest CO production rate of 9.00 μmol·g−1·h−1, which was 10.22 times higher than that of bulk g-C3N4. After doping with phosphorus, the light absorption range, the CO2adsorption capacity, and the specific surface area of the 1.0-P-HCN sample were greatly improved. In addition, the separation of photogenerated electron–hole pairs was enhanced. Furthermore, the phosphorus-doped g-C3N4effectively activated the CO2adsorbed on the surface of phosphorus-doped g-C3N4photocatalysts, which greatly enhanced the CO production rate of photocatalytic CO2reduction over that of g-C3N4.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2021
·Vol. 32
·期 5
·6465-6474
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IF 2.478
Li Leicheng,Huang Zhiquan,Li Zhiping,Li Huan,Wang Anming
In this study, an efficient porous g-C 3 N 4 nanosheet with N defect was successfully fabricated via a facile co-thermolysis method. The porous g-C 3 N 4 nanosheet showed 96% degradation efficiency towards Eosin-Y within 100 min, which was about 1.48-fold higher than that of pure bulk g-C 3 N 4 . In addition, the modified porous g-C 3 N 4 nanosheet exhibited the hydrogen evolution performance with the activity of 450 μmol with 3 h, which was 5.29-fold higher than that of pure bulk g-C 3 N 4 . The elevated photocatalytic activity was attributed to the synergism of porous nanosheet and N defect, which improved light harvesting and accelerated separation of photo-induced e – and h + , greatly assisting in organic pollutants removal and hydrogen evolution. Furthermore, trapping experiments demonstrated that the holes and superoxide radicals were the main active species in the photocatalytic degradation of Eosin-Y solution.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
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IF 13.273
Yisa Zhou,Ya Zhang,Jian Xue,Rui Wang,Zongjie Yin,Li Ding,Haihui Wang
Highly permeable and selective membranes are desirable for energy-efficient gas separation. Two-dimensional graphitic carbon nitride (g-C 3 N 4 ) has attracted significant attention owing to its suitable pore size, high pore density, and thus minimal mass-transfer barrier. Nevertheless, it is difficult to retain the structural integrity of its two-dimensional plane during the delamination of bulky g-C 3 N 4 into nanosheets, which has greatly hindered the preparation of high-quality g-C 3 N 4 gas separation membranes. In this study, flexible graphene oxide (GO) nanosheets containing abundant functional groups were used to cover and remedy some defects in g-C 3 N 4 nanosheets. Consequently, a continuous g-C 3 N 4 -GO membrane was obtained that exhibited excellent H 2 permeation performance (H 2 permeance: 2.16 × 10 −7 mol m −2 s −1 Pa −1 , H 2 /CO 2 selectivity: 39.2) and good stability, which is promising for practical hydrogen separation processes.
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Materials
·
2021
·Vol. 14
·期 20
·5959
·
IF 3.623
Jing Zhang,Weijie Zhao,Jiaqi Pan,Ruimin Tang
The Polyacrylonitrile (PAN)/g-C3N4/CdS nanofiber sono-photocatalysts were successfully synthesized by an ordinary electrospining-chemical deposition method. The PAN/g-C3N4/CdS heterojunction nanofibers constructed with the CdS nanoparticles deposited on the PAN/g-C3N4nanofibers. The g-C3N4/CdS heterojunction increase of light absorption and the construction of heterojunction can depress recombination of charge carrier and PAN nanofibers improve the recyclability successfully. Finally, a highly effective photocatalytic activity was performed by degradation of Rhodamine B (RhB) in visible light irradiation. Furthermore, an ultrasonic method is introduced into the sono-photocatalytic system to enhance the degradation efficiency of RhB ascribed to the synergistic effect of ultrasound.Keywords:PAN/g-C3N4/CdS heterojunction;low power ultrasound;sono-photocatalytic activity;nanofibers
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高影响因子
Journal of Environmental Chemical Engineering
·
2021
·
IF 5.909
Mengyang Xu,Xiaoxue Zhao,Haopeng Jiang,Songtao Chen,Pengwei Huo
Converting carbon dioxide into valuable chemicals is seen as a promising strategy for slowing global warming while enriching energy supplies. Photocatalysts derived from Metal-Organic Frameworks (MOFs) can not only overcome the problem of poor stability of MOFs, but also inherit the advantages of MOFs to some extent. Herein, carbon doped In 2 O 3 (C-In 2 O 3 ) hollow tubular is synthesized by calcination of MIL-68(In) as sacrificial template. Then C-In 2 O 3 and g-C 3 N 4 are hydrothermal to obtain C-In 2 O 3 /g-C 3 N 4 heterojunction . The unique hollow tubular structure, carbon doping and type-II heterojunction of C-In 2 O 3 /g-C 3 N 4 expand the light absorption capacity and promote the separation of photogenerated electron-hole pairs, thus significantly improve the activity of photocatalytic reduction of CO 2 . Among them, C-In 2 O 3 /g-C 3 N 4 -5 shows the highest CO 2 reduction activity towards CO (153.42 μmol/g/h) and CH 4 (110.31 μmol/g/h).
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Frontiers in Microbiology
·
2020
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IF 4.236
Cui Haoran,Zhang Leiliang
The global coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is one of seven human coronaviruses. G-quadruplexes are intrinsic obstacles to genome replication. Whether G-quadruplexes are present in human coronaviruses is unknown. In the current study, we have predicted that all seven human coronaviruses harbor G-quadruplex sequences. Conserved G-quadruplex sequences in SARS-CoV and SARS-CoV-2 were analyzed and verified by circular dichroism (CD) spectroscopy and Thioflavin T fluorescence assay. Similar to SARS-CoV, SARS-CoV-2 encodes an nsP3 protein, which is predicted to associate with G-quadruplexes. Targeting G-quadruplex sequences in the SARS-CoV-2 genome by G-quadruplex ligands could be a new way to conquer COVID-19.
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