JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2025
·
IF 2.1
Dong-qin Bi,Shu-han Li,Xue-jia Zhang,Zi-xiao Zhao,Qi-chao Yang,Zhan-ping Qiao
Two-phase equilibrium of ternary systems of CdBr2–l-proline/(4-OH-l-proline)–H2O at T = 298.15 K is studied. Their isothermal solution equilibrium phase diagrams have been drawn based on the solubility data. Two double salts (Cd(C5H9NO2)Br2·H2O and Cd(C5H9NO3)Br2) have been found by the Schrienemakers method in phase diagrams, and they are all congruently soluble in water. Both of them have been synthesized and characterized by powder XRD and TG-DTG. For the first time, enthalpies of solution of Cd(C5H9NO2)Br2·H2O and Cd(C5H9NO3)Br2 are measured in water, and their standard molar enthalpies of formation at 298.15 K are calculated by designing thermochemical cycles according to the Hess law. By comparison, it is found that the region of infinite dissolution appears in the ternary system of CdBr2–l-proline–H2O at 298.15 K. If the composition of the solution is in this region, there is no crystal when the water evaporates and only a viscous mixture can be obtained.
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高影响因子
CHROMATOGRAPHIA
·
2024
·Vol. 87
·期 3
·147-157
·
IF 1.2
Zeng Hanlin,Peng Jingdong,Peng Huanjun,Wang Xiang,Zhang Zilong,Yang Hanqi,Yu Jiayu,Wu Jiajia
Polymer microspheres have received attention because of their excellent properties. In this work, a polymer matrix zwitterionic amino acid stationary phase was prepared. Polyglycidyl methacrylate divinylbenzene (PGMA-DVB) microspheres was used as the matrix and successful modification with L-phenylalanine by ring-opening reaction of epoxy groups on the surface of PGMA-DVB microsphere matrix. The stationary phase was characterized by scanning electron microscopy, Fourier-transform infrared spectra, and elemental analysis. The phenylalanine-modified stationary phase was used in RPLC/HILIC mixed-mode chromatography for the separation of alkylbenzenes, polycyclic aromatic hydrocarbons, phenols, nucleosides and nucleic acids and etc. as probes, respectively. The good spatial selectivity of the stationary phase was demonstrated by the separation of biphenyl isomers. The prepared stationary phase showed good stability in alkaline condition (pH = 10) and low swelling in organic solvent mobile phase. Meanwhile, the stationary phase also showed good performance in the separation of different vitamins (Rs > 5.3), and the separation and detection of PAHs in river water.
研究领域:
分析化学
·
材料科学
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高影响因子
Journal of Sensors
·
2020
·Vol. 2020
·期 1
·8828456
·
IF 1.595
Hui Gao,Yuqian Pang,Lei Li,Chun Zhu,Chaoqun Ma,Jiao Gu,Yamin Wu,Guoqing Chen
Herein, by using the green and cheap L-cysteine as the precursor, nitrogen and sulfur codoped carbon dots (NS-CDs) were synthesized via a facile one-step hydrothermal method. The obtained NS-CDs showed the relatively narrow size distributions (2.1~3.9 nm) with the lattice spacing of 0.29 nm, as well as the excitation-dependent photoluminescence (PL) emission activity with the quantum yield (QY) of 18%. More interestingly, the PL intensity of NS-CDs was quenched by the addition of copper or lead ions (Cu 2+ or Pb 2+ ), which was shown in the tradition detection method by PL spectra. The NS-CDs exhibited ultrasensitive colorimetric sensing capability for both Cu 2+ and Pb 2+ by the color variance using naked eyes without any further treating. Two different coupling ways for detecting Pb 2+ and Cu 2+ were induced by the analysis of the Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS). And the as-prepared NS-CDs showed their potential application in the heavy metal ions detection for the wastewater determination.
研究领域:
材料科学
·
环境科学
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高影响因子
Food Chemistry-X
·
2025
·
IF 8.2
Zhifeng Zhang,Zehao Li,Gang Fan,Lulu Zhang,JingNan Ren,Kangning Wu,Youli Ma
Identifying the key aroma-active compounds in wolfberry pulp is essential for ensuring product quality. In this study, the key odorants in fresh wolfberry pulp (FWP), dried wolfberry pulp (DWP) and mixed wolfberry pulp (MWP) were systematically characterized using sensory evaluation, comprehensive two-dimensional gas chromatography and time-of-flight mass spectrometry (GC × GC-TOFMS), gas chromatography-mass spectrometer-olfactometry (GC–MS-O), and headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS). A total of 58 odorants were detected across the three samples, exhibiting flavor dilution (FD) factors ranging from 1 to 243, while 33 odorants showed odor activity values (OAVs) greater than 1. Data analysis identified hexanal, ( E )-2-hexenal, geranylacetone, 2-undecanone, 6-methyl-5-hepten-2-one, 1-hexanol, 4-hexen-1-ol, 2-hexen-1-ol, 2-pentylfuran, eremophilene, and β-selinene as the key aroma-active compounds in FWP. Furthermore, HS-GC-IMS provided distinctive fingerprint profiles that allowed clear differentiation of 84 odorants among FWP, DWP, and MWP. These findings establish a theoretical basis for the quality control and improvement of wolfberry pulp products.
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PubMed
高影响因子
POWDER TECHNOLOGY
·
2025
·
IF 4.6
Zheng Ren,Pengpeng Yang,Jinqiu Fu,Mengdan Zhu,Keke Zhang
Glycyl-L-valine (GLV) is a potentially biologically active dipeptide composed of glycine and L-valine, which exhibits diverse antioxidant, anti-inflammatory, and cytoprotective properties. GLV crystals typically form needles and flakes, morphologies that may negatively impact dissolution rate, flowability, filtration, and formulation processes. For the first time, this study reports the successful preparation of spherical crystal of GLV. Spherical crystals with superior filtration efficiency, powder flowability, and bulk density were obtained in tetrahydrofuran (THF) and dioxane. The formation mechanism of GLV spherical crystals in THF was revealed: solvent-induced crystalline defects trigger non-crystallographic branching, enabling further growth into spherulites. The results demonstrate that solvent-induced non-crystallographic branching produces GLV spherical crystals with improved bulk density, flowability, compactibility, and humidity stability. The formation of GLV spherulites is governed by the synergistic interplay of intermolecular hydrogen bonding and hydrophobic interactions, establishing this system as an ideal model for elucidating non-classical crystallization pathways in short peptides. These findings provide a robust theoretical framework for the rational design of novel biomaterials.
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高影响因子
Forests
·
2022
·Vol. 13
·期 2
·253
·
IF 3.282
Xuan Li,Huijuan Bo,Jialei Zhu,Jiwei Zhang,Jun Hu,Fuyong Mu,Lishui Nie
This study aimed to explore the effects of different additives on tending shreds ofPlatycladus orientalis(L.) Franco. Two different additives (priming 0.2% and common compost 0.2%) combined with C, N, and P adjustment of raw material treatments were tested on the temperature, moisture, EC, pH, lignocellulose degradation rate, nutrient content, and toxicity of compost. Priming made the compost temperature rise rapidly, and the peak temperature of the composting group with priming reached 51 °C. At the end of composting, the moisture in each treatment from high to low was in the order: common compost > priming > C/N, C/P adjustment only > control group. The increase of EC in the treatments with additives was great, and the peak value of EC in the treatment of priming was 1.30 ms·cm−1, which was 3.9 times higher than that of the control group. At the end of composting, the decomposition rate of cellulose in priming compost was 1.7 times higher than that in the control group, and the hemicellulose decomposition rate in the common compost group was 3.2 times higher than that in the control group. By the end of composting, the pH value of the composts in additive treatments was above 7.0, and the pH value of the priming treatment was the highest (7.5). The highest content of organic matter was found in the priming treatment, which was 52%, 1.7 times higher than that in the control group. The total nutrient content (TN + K2O + P2O5) of additive treatments was higher than 5.0%, and the priming treatment was 2.7% higher than that of the control group. By the end of composting, the germination rate and germination index ranged from 88% to 91% and 60% to 81%. Except for the control group, the C/N ratio of other treatments decreased to below 25. Additives can accelerate the decomposition of raw materials, shorten the composting cycle, and improve the quality of composts, and the effect of adding priming is the most significant.Keywords:Platycladus orientalis(L.) Franco;compost;forest stand;Huairou District;nutrient cycling
研究领域:
林业学
·
生态学
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高影响因子
MOLECULES
·
2022
·Vol. 27
·期 16
·5336
·
IF 4.927
Pan Xu,Haitong Zhang,Huangting Li,Bo Liu,Rongrong Li,Jinjin Zhang,Xiaodong Song,Changjun Lv,Hongbo Li,Mingwei Chen
Pulmonary fibrosis is characterized by the destruction of alveolar architecture and the irreversible scarring of lung parenchyma, with few therapeutic options and effective therapeutic drugs. Here, we demonstrate the anti-pulmonary fibrosis of 3-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-7-yl(αS)-α,3,4-trihydroxybenzenepropanoate (MOBT) in mice and a cell model induced by bleomycin and transforming growth factor-β1. The anti-pulmonary fibrosis of MOBT was evaluated using a MicroCT imaging system for small animals, lung function analysis and H&E and Masson staining. The results of RNA fluorescence in situ hybridization, chromatin immunoprecipitation (ChIP)-PCR, RNA immunoprecipitation, ChIP-seq, RNA-seq, and half-life experiments demonstrated the anti-pulmonary fibrotic mechanism. Mechanistic dissection showed that MOBT inhibited lncITPF transcription by preventing p-Smad2/3 translocation from the cytoplasm to the nucleus, resulting in a reduction in the amount of the lncITPF–hnRNP L complex. The decreased lncITPF–hnRNP L complex reduced MEF2c expression by blocking its alternative splicing, which in turn inhibited the expression of MEF2c target genes, such as TAGLN2 and FMN1. Briefly, MOBT alleviated pulmonary fibrosis through the lncITPF–hnRNP-l-complex-targeted MEF2c signaling pathway. We hope that this study will provide not only a new drug candidate but also a novel therapeutic drug target, which will bring new treatment strategies for pulmonary fibrosis.Keywords:pulmonary fibrosis;lncITPF;hnRNP L;MEF2c
研究领域:
药理学
·
分子生物学
·
细胞生物学
·
病理学
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PubMed
高影响因子
GREEN CHEMISTRY
·
2017
·Vol. 20
·期 3
·713-723
·
IF 9.125
Yongqiang Zhang,Phongphat Prawang,Chunshan Li,Xiangzhan Meng,Yu Zhao,Hui Wang,Suojiang Zhang
Artemisinin is a kind of natural antimalarial drug exhibiting low toxicity and a very fast action against malaria. Solvent extraction is the most widely used method to separate artemisinin from the Chinese medicinal herb Artemisia annua L. In this study, a series of monoether-based solvents were investigated to extract artemisinin, and propylene glycol methyl ether (PGME) was found to be the most appropriate one for this extraction. Ultrasonic irradiation was demonstrated to be able to assist artemisinin extraction. Influence of extraction conditions, including liquid/solid ratio, extraction temperature, ultrasonic time, and ultrasonic power, on the extraction efficiency were discussed by single-factor experiments, and the main influencing factors were optimized by response surface methods. The extraction mechanism was explored using spectroscopic characterizations, and kinetics of this process was also studied. Results indicated that ultrasonic assisted extraction using PGME had faster extraction rate than conventional solvents, and ultrasonic could significantly enhance mass transfer. Compared with conventional extraction, the process developed here exhibited a higher efficiency (13.79 mg g−1vs. 13.29 mg g−1) and shorter extraction time (decreased from 8 h to 0.5 h) at a relatively low temperature. In addition, PGME had low toxicity and volatility, making the extraction process more safe and reliable. Therefore, this proposed method demonstrated that PGME-based ultrasonic assisted extraction is a rapid, efficient, simple and safe technique for natural product extraction.
研究领域:
药用植物学
·
天然产物化学
·
中药学
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高影响因子
ENVIRONMENTAL POLLUTION
·
2019
·
IF 5.714
Rong Zou,Li Wang,Yuncong C. Li,Zhaohui Tong,Wenmin Huo,Keyu Chi,Hongli Fan
Amaranth ( Amaranthus mangostanus L.) has superior capability for accumulating cadmium (Cd) and has the potential to be used for phytoremediation of Cd contaminated soils. Iron (Fe) is chemically similar to Cd and may mediate Cd-induced physiological or metabolic impacts in plants. The purpose was to investigate the model of time-dependent and concentration-dependent kinetics of Cd absorption under Fe deficiency, understanding the physiological mechanism of Cd absorption in amaranth roots. The kinetic characteristics of Cd uptake by amaranth grown in Cd enriched nutritional solution with or without Fe addition and with methanol-chloroform, carbonyl cyanide 3-chlorophenylhydrazone (CCCP), and lanthanum chloride (LaCl 3 ) were compared using 109 Cd 2+ isotope labeling technique. The results showed that Cd uptake was time-dependent and about 90–93% of uptake occurred during the first 150 min. The kinetics of Cd uptake showed that two stages were involved. The saturation stage fitted the Michaelis-Menten model when concentrations of Cd were lower than 12.71 μmol/L and then the absorption of Cd by roots was increased linearly during the second stage. Only linear absorption was observed with methanol-chloroform treatment while the metabolic inhibitor CCCP inhibited only the saturation absorption process, and the Ca channel inhibitor LaCl 3 partially inhibited the two stages of absorption. These results indicated that the root absorption of 109 Cd 2+ was enhanced under Fe deficiency which induced more Fe transporters in the root cell membrane, and the Ca channel, apoplastic and symplastic pathways enhanced the Cd absorption in roots.
研究领域:
植物学
·
环境科学
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PubMed
高影响因子
Plants-Basel
·
2023
·Vol. 13
·期 1
·10
·
IF 4.5
Yangyang Ma,Yiyu Pan,Bizeng Mao
Saffron (Crocus sativusL.), being one of the distinguished commercial spice crops in the world, is in demand for its culinary, colorant, and pharmaceutical benefits. In this study, a novel indirect somatic embryogenesis (SE) system was, thus, established for the study of this plant. To this end, firstly, the lateral buds were cultured. Then, the cultures were transformed using Murashige and Skoog (MS) medium supplemented with either 6-benzyladenine (BA: 5 and 10 mg/L), naphthalene acetic acid (NAA: 0, 1, and 2 mg/L), or trans-zeatin (tZ: 0, 0.5, and 1.0 mg/L), before being classified into four structures: white globular (WG), yellow compact nodular (YCN), yellow-brown fragile (YBF), and dark-brown porous (DBP). As soon as BA (10 mg/L) and NAA (2 mg/L) were added, elevated percentages of white globular calli (56.8%) and white globular calli (31.5%) structures were induced. Additionally, 6-benzyladenine (5 mg/L) and naphthalene acetic acid (1 mg/L) allowed the formation of yellow-brown fragile structures, and the combination of 6-benzyladenine (10 mg/L) with trans-zeatin (1 mg/L) formed the DBP structures. After three months, the white globular calli were incubated using the MS basal medium, before being augmented with thidiazuron (TDZ: 1 mg/L) and picloram (PIC: 2 mg/L), from which 60% of the cases matured into shoots and, ultimately, cormlets. Morphoanatomical analyses also showed that the white globular calli cells were closely arranged, as they had a dense cytoplasm, a significant vascular differentiation, and embryoids. Furthermore, the yellow compact nodular structures were characterized by a strong differentiation capacity and contained many meristematic cells with high caryomitosis centers. We observed that the yellow-brown fragile calli had looser cell arrangements, with a vascular structure located on the protoderm edge, while there was no obvious cellular arrangement in the dark-brown porous structures. The induction of the adventitious buds in vivo on the MS medium that was supplemented with thidiazuron and picloram accordingly demonstrated the highest rates (60%) of white globular calli.Keywords:Crocus sativus;differentiation;morpho-histological;somatic embryogenesis
研究领域:
植物生物技术
·
植物组织培养
·
植物激素
·
形态学与组织学
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PubMed
高影响因子
Food & Function
·
2026
·
IF 6.3
Yun Wang,Simin Zheng,Hao Zheng,Yangru Huang,Bowen Liang,Yingfei Gong,Jinhai Shen,Wenrui Liu,Xiaona Xu,Yuliang Ma,Zhen Liu
L-arabinose is a plant-specific pentaose with variety functional properties. Here, the effects of L-arabinose on long-term constipation were investigated. According to the results, L-arabinose significantly attenuated loperamide induced-constipation by enhancing gastrointestinal motility and relieving the intestinal injury. Besides, L-arabinose reduced neutrophils proportion and inflammatory cytokines concentrations in constipated mice, exhibiting the immunomodulatory activity. Moreover, the 16S rRNA analysis showed that L-arabinose ameliorated the gut microbiota dysbiosis induced by loperamide and Lactobacillus was the most significant dominant strain at the genus level in L-arabinose group. The in vitro cultivation experiment confirmed that L-arabinose could be used directly by Lactobacillus for its proliferation. More importantly, L-arabinose failed to relieve constipation in mice with gut microbiota depletion, confirming the necessity of gut microbiota in L-arabinose initiated constipation treatment. In summary, L-arabinose can ameliorate the loperamide-induced constipation in mice through regulation of gut microbiota.
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PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2026
·
IF 4.7
Meiling Nie,Ting Jiao,Lin Wang,Chiyi Wang,Jiahan Jin,Jialu Hu,Yang Li,Hailu Zhang
The study of pharmaceutical cocrystal polymorphism is attracting increasing interest, as variations in intermolecular interactions and packing arrangements between an active pharmaceutical ingredient (API) and the same cocrystal former (CCF) directly impact the extent to which cocrystals can tailor the API’s properties. However, the number of reported cases of cocrystal polymorphism remains relatively limited. Herein, we propose that orientational variability of hydrogen bond donors or acceptors on either the API or the CCF may drive the formation of cocrystal polymorphs. To substantiate this hypothesis, 5-fluorocytosine (5-FC) and L -malic acid ( L -MAL) were selected as the model cocrystallization system, and two distinct 2:1 polymorphs (form Ⅰ and form Ⅱ) were ultimately identified. Crystal structural analysis revealed that the two cocrystals share consistent supramolecular interactions; however, the divergent orientations of carbonyl and hydroxyl groups in L -MAL induce distinguishable hydrogen bonding configurations and molecular stacking patterns, which strongly validates the proposed origin of cocrystal polymorphism. Lattice energy calculations, polymorphic transformation studies, and melting point data collectively confirmed that these two polymorphs exhibit a monotropic thermodynamic relationship, with the high- Z ’ form Ⅱ ( Z ’ = 2) being the thermodynamically stable crystalline phase. Under higher relative humidity condition (90 % RH), an obvious phase transformation of form Ⅰ was observed within one week, whereas form Ⅱ maintains its phase stability for at least four weeks. Such performance difference between these two cocrystals further underscores the practical significance of cocrystal polymorph screening.
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