JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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2025
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IF 3.1
Yingxia Guo,Jiaxin Zhang,Runran Mei,Zihan Tang,Meichen Liu,Xixian Weng,Meiyun Shi,Lei Yin
Addressing critical gaps in understanding the in vivo behavior of polyethylene glycol (PEG)-based excipients, this study systematically elucidates the biological fate of methoxy-PEG₆-hydroxyl (M-PEG₆-OH) through comprehensive pharmacokinetic and metabolic investigations in rats. Employing a validated ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) methodology, we reveal distinctive biodistribution characteristics including rapid systemic clearance (Half-life (t 1/2 ) = 1.92 ± 1.16 h) and extensive tissue penetration (Apparent volume of distribution (V d ) = 0.84 ± 0.45 L/kg), suggesting efficient extravascular dissemination. Excretion pathways analysis demonstrated predominant renal elimination, with 59.03 % of the administered dose recovered in urine within 48 h post-IV injection, contrasting with minimal fecal excretion (0.99 %). Quantitative metabolite profiling identified M-PEG₅-CH₂COOH as the oxidative transformation product through terminal hydroxyl modification. The significantly higher relative abundance of metabolites (M-PEG 5 -CH 2 COOH) in urine compared to feces within the same time period provides critical insights into the biotransformation processes and metabolic pathways of the PEG polymer. These findings establish the first systematic evidence of metabolic trajectory and elimination mechanisms for M-PEG-OH, offering vital references for optimizing PEGylated drug delivery systems with enhanced biocompatibility and predictable safety profiles.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Yanpei Xu,Silong Li,Shuxian Gao,Fudong Jia,Liang Guo,Jiangrong Hou,Shaowei Ma,Heya Zheng,Chuxiao Sun,Qi Wang
Prostate-specific antigen (PSA) detection is vital for early prostate cancer diagnosis, yet conventional methods suffer from sensitivity and label-dependent limitations. This study presents a surface plasmon resonance (SPR) biosensor enhanced by Ni(OH) 2 /Ti 3 C 2 T x MXene nanocomposites (NTC) for sensitive detection of total PSA (tPSA) in serum. The NTC architecture synergizes carboxyl-functionalized MXene, amplifying localized electric fields and antibody-binding sites, with Ni(OH) 2 nanoflowers that prevent MXene stacking and enhance refractive index (RI) sensitivity. Optimized via finite element modeling (50-nm Au film, 72.4 ° incident angle), the Au-NTC architecture achieved a 39.34% improvement in RI sensitivity (3064.86 nm/RIU) compared to pristine Au. Through the dual signal amplification mechanism of synergistic enhancement by nanomaterials and sandwich method with gold nanoparticles, enabled detection of tPSA in 20% serum across a wide dynamic range (0.2–160 ng/mL), fully covering the clinical risk threshold (4–10 ng/mL). The platform demonstrated an ultralow limit of detection (LOD) of 0.0361 ng/mL (0.5157 pM) and high specificity against interferons. Kinetic analysis revealed strong antigen-antibody affinity (equilibrium dissociation constant K D = 4 . 26 × 1 0 − 10 M), while batch-producible sensor chips and integrated microfluidics underscored practical applicability. This work advances label-free SPR biosensing for precision prostate cancer diagnostics, offering significant potential in point-of-care testing and early intervention strategies.
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ACS Applied Energy Materials
·
2025
·
IF 5.5
Liru Yan,Shishuai Sun,Shuangting Ruan,Xiaocheng Liu,Huanqi Cao,Shougen Yin
Design of the photosensitive electrode material provides an effective strategy to improve the capacity and stability of supercapacitors. In this study, the photothermal-driven cobalt–zinc-doped Ni(OH)2/g-C3N4@NF nanoflower electrode materials were prepared base on the in situ chemical etching strategy. The electrochemical performance indicated that the optimized CZNC2.18 (cobalt–zinc codoped β-Ni(OH)2@g-C3N4) electrode material with exceptional stability (103.74% capacitance retention after 5000 cycles at 20 mA/cm2) exhibited an ultrahigh capacitance of 19.10 F/cm2 at a current density of 10 mA/cm2 under illumination, compared to 12.8 F/cm2 under dark conditions, achieving a light gain of 149%. The assembled asymmetric photothermal-assisted supercapacitor device delivers energy densities of 3.55 mWh/cm2 (1.23 mWh/cm2) at corresponding power densities of 8.39 mW/cm2 (37.03 mW/cm2) under illumination, surpassing performance metrics observed under dark conditions. The synergistic effects of photogenerated carriers (holes oxidizing Ni(OH)2 to NiOOH and electrons enhancing conductivity), Zn/Co codoping-induced conductivity improvement, and photothermal-assisted ion transport collectively enable CZNC2.18 exceptional photoelectrochemical performance, establishing a paradigm for light-responsive energy storage material design.
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JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
·
2025
·
IF 4.9
Dadaso D. Mohite,Sachin S. Chavan,P.E. Lokhande,Syed Khasim,Taymour A. Hamdalla,Vishal Kadam,Chaitali Jagtap,Udayabhaskar Rednam
Supercapacitors (SCs) are essential components in next-generation energy storage systems due to their excellent power density and fast charge-discharge capability. However, their limited energy density continues to impede broader adoption. This study explores the electrochemical properties of electrospun polyacrylonitrile (PAN) nanofiber composites doped with nickel and cobalt hydroxide (NiCo(OH) 2 ) nanoparticles to address this challenge. The fabrication process involves electrospinning PAN solutions with NiCo(OH) 2 precursors, followed by heat treatment to enhance the structural and electrochemical properties. The crystallographic structure and morphology of the composite fibers were examined using standard characterization techniques. XPS analysis confirmed the presence of Ni 2+ , Ni 3+ , Co 2+ , and Co 3+ states, while BET analysis revealed a high surface area of 99 m 2 g -1 and mesoporous structure; TEM images confirmed uniform nanofiber morphology with embedded nanoparticles. Electrochemical testing showed that the synergistic effect of NiCo 2 O 4 /PAN carbon nanofibers improved specific capacitance, rate performance, and cycling stability, signifying progress toward advanced SCs. The highest specific capacitance achieved was 440 F g -1 at a current density of 1 A g -1 . A supercapacitor device, composed of NiCo 2 O 4 /PAN-carbon NFs//AC electrodes and a PVA/KOH gel electrolyte, demonstrated an energy density of 6 Wh kg -1 at a power density of 2000 Wk g -1 . Furthermore, it exhibited exceptional cycling stability, retaining 98% of its capacitance after 5000 cycles, highlighting its solid electrochemical reversibility, which is crucial for practical SC applications.
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Advanced Science
·
2024
·
IF 14.3
Jin Li,Qiuling Jiang,Xiujing Xing,Cuilian Sun,Ying Wang,Zhijian Wu,Wei Xiong,Hao Li
Electrochemical conversion of nitrate (NO 3 − ) to ammonia (NH 3 ) is a potential way to produce green NH 3 and remediate the nitrogen cycle. In this paper, an efficient catalyst of spherical CuO made by stacking small particles with oxygen-rich vacancies is reported. The NH 3 yield and Faraday efficiency are 15.53 mg h −1 mg cat −1 and 90.69%, respectively, in a neutral electrolyte at a voltage of -0.80 V (vs. reversible hydrogen electrode). The high activity of the electrodes results from changes in the phase and structure during electrochemical reduction. Structurally, there is a shift from a spherical structure with dense accumulation of small particles to a layered network structure with uniform distribution of small particles stacked on top of each other, thus exposing more active sites. Furthermore, in terms of phase, the electrode transitions from CuO to Cu/Cu(OH) 2 . Density functional theory calculations showed that Cu(OH) 2 formation enhances NO 3 - adsorption. Meanwhile, the Cu(OH) 2 can inhibit the competing hydrogen evolution reaction, while the formation of Cu (111) crystal surfaces facilitates the hydrogenation reaction. The synergistic effect between the two promotes the NO 3 - to NH 3 . Therefore, this study provides a new idea and direction for Cu-based oxides in electrocatalytic NH 3 production.
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ChemCatChem
·
2025
·
IF 3.9
Xiaoqi Tian,Dongxu Chen,Houde She,Jingwei Huang,Lei Wang,Qizhao Wang
Volatile organic compounds (VOCs) pose significant environmental and health risks, necessitating effective remediation strategies. This study addresses these challenges by synthesizing ZnSn(OH) 6 /TiO 2 heterojunction composites using a coprecipitation-hydrothermal coupling technique. Experiments showed that the synergistic effect of ZnSn(OH) 6 and TiO 2 significantly reduced the band gap (3.10 eV) of the composites and enhanced the visible light absorption ability, whereas the photogenerated electron–hole pair complexation was effectively suppressed through the interfacial charge transfer mechanism. Under simulated sunlight, 15% ZnSn(OH) 6 /TiO 2 degraded toluene at an initial concentration of 2,500 ppm by up to 90.51% in 90 min, with a mineralization rate of more than 84.51%, which is about three times higher than the performance of pure ZnSn(OH) 6 . Cycling experiments showed that the degradation rate remained at 90.32% after five times of reuse, demonstrating excellent stability. A combination of density functional theory (DFT) calculations and radical trapping experiments revealed that ·OH and ·O 2 − were the main active species in the composites, and the hydroxyl structure of ZnSn(OH) 6 promoted the adsorption and activation of toluene. This work presents a novel interfacial engineering and crystallographic regulation strategy for deep mineralization of VOCs, providing insights for designing cost-effective, durable environmental photocatalysts. Graphical This study describes the synthesis, structural, and surface characterization of TiO 2 nanoparticle-decorated layered ZnSn(OH) 6 composite catalysts, systematically evaluates their photocatalytic activity, degradation kinetics, and long-term stability for gaseous toluene under simulated solar light, and investigates photogenerated electron-hole migration pathways, separation efficiency, and reactive oxygen species formation mechanisms.
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IONICS
·
2025
·
IF 2.6
Wang Zhaomin,Zhao Chaoyue,Niu Xiaodong,Cheng Yong,Wang Limin,Huang Pai
With high theoretical discharge specific capacity, excellent reversibility of electrochemical reaction, and suitable oxygen evolution overpotential, α -Ni(OH) 2 is an auspicious cathode material for alkaline batteries, which supports the development of high-capacity nickel-based batteries. Nevertheless, α -Ni(OH) 2 exhibits substandard structural stability and is susceptible to crystalline transformation, leading to capacity degradation, affecting the battery charge/discharge performance and cycle life. In this study, the TiO 2 -nickel hydroxide (TiO 2 - α -Ni(OH) 2 ) is prepared by high-energy ball milling. Among them, TiO 2 can be uniformly dispersed on the surface of α -Ni(OH) 2 , which can effectively prevent the collapse of the α -phase structure. Benefiting from the unique elemental doping technology, the TiO 2 - α -Ni(OH) 2 composites as a nickel-metal hydride (Ni-MH) battery cathode can release a reversible specific capacity of 390 mAh g −1 at a 2 C rate for 200 cycles. A reversible specific capacity of 210 mAh g −1 is still released after 200 cycles at a 5 C rate. Consequently, TiO 2 - α -Ni(OH) 2 is a promising candidate for high-power Ni-MH batteries.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Lanlan Yu,Jincheng Mu,Huiling Liu,Gang Liao,Boyi Li,Yufen Xia,Zhimin Wang,Jili Yuan,Jiachao Shen,Chengbin Liu
Electrocatalytic nitrate reduction into ammonia (NitRR) over Co-based catalysts is attractive but still constrained by the competition with H* coupling to produce H 2 . Additionally, the fundamental mechanism underlying the interfacial engineering associated with electronic state transformation for strengthening oriented NitRR remains elusive. Herein, a Co(OH) 2 /Bi 12 O 17 Br 2 heterostructure is fabricated using a one-step wet chemistry method, performing remarkable reactivity for NH 3 production own to the formation of electron-deficiency Co sites induced by Bi 12 O 17 Br 2 . Unexpectedly, the NitRR activity of Co(OH) 2 /Bi 12 O 17 Br 2 increases gradually in the initial stage and then keeps at a high level, which is uncovered as the reconstruction of Bi 12 O 17 Br 2 into Bi 0 . Theoretical calculations suggest that the in situ reconstruction guides the electron-deficiency of Co and the shift of d -band center of Co toward the Fermi level, thus promoting the adsorption and conversion of intermediates. The synergistic effect of the hydrolysis dissociation over Co(OH) 2 and the inhibition of H* coupling over Bi 0 contributes to high selectivity and activity for NitRR. The reconstructed catalyst shows a high ammonia yield rate of 7343.3 µg h −1 mg −1 at −0.6 V versus RHE and nearly 100% Faradaic efficiency at −0.4 V versus RHE. This study provides insight into the strengthening mechanism of Co-based catalysts for NitRR.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Peng Zu,Haoning Li,Guangming Yan,Gang Zhang
In this study, Ti 3 C 2 T x layers with an average lateral size of approximately 8.3 μm were prepared. The LLM composite membranes synthesized from these layers not only possessed long and narrow mass transfer channels but also further prevented the generation of internal non-selective defects. Additionally, a strategy of compositing these Ti 3 C 2 T x layers and Al(OH) 3 was adopted. The strategy contributed to expanding the interlayer distances of the composite membranes and adjusting the in-plane stacking order, thereby facilitating the construction of mass transfer channels characterized by high permeance within the membranes. This resulted in the preparation of LLMA membranes. Among these LLMA membranes, the LLMA-1:7 composite membranes displayed outstanding performance in the sieving process. Their permeances were more than 10 times higher than those of the LLM membranes (with a thickness of 1 μm). Also, the rejection ratio for CV dye could even exceed 99 %, and the operational stability was also significantly improved. These advantages enabled them to avoid some of the shortcomings commonly found in two-dimensional (2D) separation membranes to a certain extent. In summary, the LLMA-1:7 composite membranes designed in this study demonstrated superior overall performance, compared to the majority of the previously reported 2D membranes. This research is expected to establish a solid foundation for the application of 2D MXene membranes in the field of water treatment.
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ACS Applied Nano Materials
·
2022
·
IF 6.14
Le Zhang,Xin Zhou,Shaohua Chai,Jian Guan,Guijun Fan,Wuxinchen Yang,Guojun Ma,Ning Han,Yunfa Chen
There is a high demand to synthesize ozone decomposition catalysts especially in high-space-velocity and high-relative-humidity (RH) environments. Herein, two polymorphs of cobalt hydroxide, α- and β-Co(OH)2, are synthesized and applied for ozone elimination. β-Co(OH)2 shows ∼90% ozone decomposition efficiency under high space velocity (weight hourly space velocity (WHSV) = 1,200,000 mL g–1 h–1, 25 °C, 40 ppm), which is far higher than that of α-Co(OH)2 (∼5%). β-Co(OH)2 has high spin Co(II) in distorted octahedral coordination caused by the Jahn-Teller effect, leading to a higher crystal field splitting energy level and thus contributing to the easier electron transfer between the ozone and catalyst. Moreover, β-Co(OH)2 still shows high performance (∼87%) even in humid conditions (RH ∼50%, 25 °C, 40 ppm, WHSV = 600,000 mL g–1 h–1), which is attributable to its abundant surface non-hydrogen-bonded hydroxyls weakening water molecule adsorption, providing an idea to develop highly efficient catalysts for ozone decomposition in humid environments.
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CHEMICAL PAPERS
·
2019
·Vol. 73
·期 7
·1761-1766
·
IF 1.246
Zhang Li-hui,Zhou Yan-biao,Li Wei-li,Zhao Xu-yao,Wang Ya-bo
Lu(OH)CO 3 :Ln 3+ /LuBO 3 :Ln 3+ (Ln = Eu, Tb) nanospheres have been synthesized by the soft chemistry route. This synthesis process does not require the addition of any organic solvents and surfactant. The whole process consists of homogeneous precipitation and hydrothermal process. First, uniform spherical Lu(OH)CO 3 :Ln 3+ (Ln = Eu, Tb) nanoparticles with the sizes of 70 nm were obtained by the classic urea-based homogeneous precipitation. Then, with the above Lu(OH)CO 3 :Ln 3+ (Ln = Eu, Tb) nanosphere as the precursor, the composites of Lu(OH)CO 3 :Ln 3+ /LuBO 3 :Ln 3+ (Ln = Eu, Tb) nanospheres formed by the simple hydrothermal process. The phases, morphologies, as well as the luminescence properties of as-prepared samples were characterized by means of X-ray diffraction, field-emission scanning electron microscopy, transmission electron microscopy, and photoluminescence. Under a short wavelength excitation, the down-conversion Eu 3+ and Tb 3+ -doped LuBO 3 samples were investigated and explained.
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JOURNAL OF CHEMICAL PHYSICS
·
2022
·Vol. 156
·期 1
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IF 4.304
Lei Xueyan,Fu Zhengping,Xiang Bin,Lu Yalin
The low stability and poor activities of transition metal selenides (TMSs) in alkaline electrolyte limit their application in supercapacitors. Metal doping and hybridization of various electroactive materials with different properties are utilized to enhance the electrochemical performance of TMSs by optimizing their electronic structure and providing rich electrochemical active sites. Herein, we report a simple two-step hydrothermal method for the growth of Zn-doped NiSe 2 and Ni(OH) 2 nanocomposites on Ni foam [Zn–NiSe 2 /Ni(OH) 2 ]. The resulting material delivers high specific capacity (1525.8 C g −1 /564.7 mA h g −1 at 6 A g −1 and 1220 C g −1 at 10 A g −1 ) in a three-electrode system. A Zn–NiSe 2 /Ni(OH) 2 //porous carbon (PC) aqueous asymmetric supercapacitor (ASC) was built by utilizing Zn–NiSe 2 /Ni(OH) 2 as the positive electrode and PC as the negative electrode. This Zn–NiSe 2 /Ni(OH) 2 //PC ASC shows an energy density of 75.8 W h kg −1 at a power density of 916.1 W kg −1 and achieves a specific capacity retention of 100% after 25 000 cycles at 10 A g −1 . These results reveal that the Zn doping and the hybridization of NiSe 2 with Ni(OH) 2 can obtain impressive electrochemical properties in ASCs.
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