JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
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2018
·Vol. 56
·期 14
·1520-1527
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IF 2.588
Chunying Wang,Yunhui Li,Yuqin Ma,Ying Gao,Dewen Dong,Jianyong Fang,Ning Zhang
Hydrogen bonding is widely present and plays a significant role in material science and supramolecular chemistry. This work reports a straightforward strategy for the preparation of polymeric nanoparticles from neutral poly(2-oxazoline)s (POx) and tannic acid (TA) driven by their intermolecular hydrogen bonding. Dynamic light scattering (DLS) and scanning electron microscope (SEM) measurements showed that POx bearing different substituents, that is, methyl, ethyl and n -propyl in the 2-position all could assemble with TA into stable nanoparticles in water or ethanol. The diameter of the assembled nanoparticles could be manipulated by varying parameters such as molecular weight of POx, concentration and ratio of POx, and TA. Interestingly, POx/TA nanoparticles exhibited upper critical solution temperature (UCST)-type thermoresponsive properties in ethanol or water depending on the molecular weight and substituent in the 2-position of POx. Increasing or decreasing the temperature at the transition point resulted in the reversible transformation between assembled nanoparticles and disassembled poly(2- n -propyl-2-oxazoline) (PnPrOx) and TA. In view of the tailored size of the stable nanoparticles and the biocompatibilities of POx and TA, the prepared thermoresponsive nanoparticles are promising candidates as carriers for medicine toward related biomedical applications. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018 , 56 , 1520–1527
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Polymer Chemistry
·
2018
·Vol. 9
·期 42
·5215-5223
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IF 4.927
Wei Yuan,Weiwen Chi,Ting Han,Jun Du,Hongkun Li,Yongfang Li,Ben Zhong Tang
Cu(I)-mediated and metal-free click polymerizations of azides and terminal alkynes have been developed into powerful techniques for constructing linear and hyperbranched polytriazoles. However, the 1,3-dipolar cycloaddition of azides with internal alkynes is rarely employed as a synthetic tool to prepare functional polymers. In this work, metal-free phenylpropiolate-azide polycycloaddition was developed for efficient synthesis of poly(phenyltriazolylcarboxylate)s (PPTCs), a kind of polyester. The aromatic and aliphatic diphenylpropiolates could readily react with diazides under heating, affording soluble PPTCs with high molecular weights (Mw up to 28 500) in excellent yields (up to 98%). The polymerization is insensitive towards oxygen and moisture, and can proceed smoothly in an open atmosphere. The obtained PPTCs are thermally stable with 5% weight loss temperatures higher than 318 °C. As the polymers contained ester groups, they exhibited fast degradation under basic conditions. The PPTC containing tetraphenylethene moieties shows a unique phenomenon of aggregation-induced emission, and can be employed as a fluorescent chemosensor to sensitively detect explosives. Its thin film can generate two-dimensional fluorescent photopatterns by UV irradiation.
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BIOMEDICAL MICRODEVICES
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2019
·Vol. 21
·期 4
·1-11
·
IF 2.327
Qiu Renna,Li Jian,Sun Denghua,Li Hongjun,Qian Feng,Wang Lizhe
Postoperative peritoneal adhesions are one of the most common surgical complications. In this study, we developed a 20(S)-ginsenoside Rg3-loaded methoxy poly (ethylene glycol)-block-poly(L-lactide-co-glycolide) (mPEG- b -PLGA) electrospun membrane (PEM/Rg3) that could not only serve as a physical barrier, but also as a drug delivery system that releases 20(S)-ginsenoside Rg3 constantly to prevent postoperative peritoneal adhesions. The characteristics of PEM/Rg3, including scanning electron microscopy, water contact angle, and mechanical analyses, were assessed. Degradation and drug release assays of PEM/Rg3 were performed. The anti-adhesion efficacy of PEM/Rg3 was evaluated in an abdomen-cecum mouse model. The adhesion scores, adhesion areas, hematoxylin and eosin (H&E) staining, immunofluorescence, and western blotting were assessed. The 20(S)-ginsenoside Rg3 loaded mPEG- b -PLGA electrospun fibers were successfully fabricated. The fibers were smooth, with no obvious drug crystals. PEM/Rg3 membranes were biodegradable and could be degraded gradually to release 20(S)-Ginsenoside Rg3 constantly from the membranes. The animal study showed that PEM/Rg3 exhibited an excellent adhesion prevention ability when compared with the control group, the PEM group, and polylactic acid (PLA) commercial membrane (Surgiwrap™) group. Immunofluorescence and western blotting studies showed that PEM/Rg3 inhibited the expressions of interleukin 1 (IL-1), interleukin 6 (IL-6), and reactive oxygen species modulator-1 (ROMO1). The 20(S)-ginsenoside Rg3-loaded mPEG- b -PLGA electrospun membranes exhibited satisfactory anti-adhesion efficacy by inhibiting inflammatory responses and oxidative stress. This composite represents a promising strategy to prevent postoperative peritoneal adhesions.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
·
IF 8.1
Huiling Tang,Hengchao E,Chunxia Yao,Xuesheng Wang,Jiaxin Zhou,Wei Song,Zhijie Zhang
Exploring efficient photocatalysts holds significant importance for the prevention and treatment of antibiotic pollution. This research reports a 2D/2D CeO 2 /BiOCl S-scheme photocatalyst constructed by mesoporous CeO 2 and BiOCl nanosheets (NSs). Efficient charge separation and transfer was achieved by the synergistic effect of large-area contact and S-scheme charge transfer mechanism, which significantly enhanced the photocatalytic performance of CeO 2 /BiOCl. Experimental results demonstrated that the CeO 2 /BiOCl photocatalyst displayed superior photocatalytic activity to the individual components, which could efficiently eliminate four types of antibiotics, namely tetracycline (TC), chlortetracycline (CTC), doxycycline (DOC), and oxytetracycline (OTC) under UV light irradiation. Particularly, the sample of 0.4CeO 2 /BiOCl exhibited the highest catalytic efficiency, with a TC degradation rate constant of 0.01524 min −1 , which was 1.85 and 22.74 times higher than that of single CeO 2 and BiOCl, respectively. Moreover, liquid chromatograph-mass spectrometer (LC-MS) analysis is employed to reveal the degradation pathways of TC. This work offers an insightful idea for the fabrication of novel S-scheme photocatalysts applied in environmental purification.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Xin Bai,Jian Nie,Siyao Cheng,Daohu Sheng,Jijun Xiao,Wei Dong
The development of non-viral gene delivery systems often requires balancing transfection efficiency and cytotoxicity, particularly when using cationic polymers. Poly(2-hydroxypropenimine) (PHP), with its hydroxyl groups, presents a more biocompatible alternative to traditional polymers such as polyethyleneimine (PEI). In this study, we explored the potential to enhance PHP’s transfection capabilities and reduce its cytotoxicity through a targeted fluorination strategy. Specifically, fluorinated alkyl groups were grafted onto PHP via an ethylene oxide ring-opening reaction, with the reaction conditions optimized for temperature, solvent, and time to ensure efficiency. Transfection experiments using HEK 293 cells demonstrated that fluorinated PHP variants, especially PHP-FH8 16 , significantly improved transfection efficiency, achieving a 75.1 % gene expression rate at an N/P ratio of 2, compared to 44.0 % for unmodified PHP. The transfection experiments in Hela cells also showed substantial transfection efficiency. The gene expression rate was 53.2 % at an N/P ratio of 2 compared to 31.6 % for unmodified PHP. Notably, the fluorinated polymers exhibited lower cytotoxicity and increased serum stability, which suggests their potential as safer gene delivery systems. This study carefully evaluates the feasibility of using fluorinated cationic polymers as next-generation gene delivery vectors, balancing efficacy and safety. It underscores the strategic application of fluorination technology in developing modified polymer vectors that could lead to more efficient and safer non-viral gene therapy solutions.
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RSC Advances
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2016
·Vol. 6
·期 62
·57346-57356
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IF 3.289
Xue-ling Wu,Jun Zong,Han Xu,Wei Wang,Xing-jiang Liu
In this work, the solid electrolyte of Li1.5Al0.5Ge1.5(PO4)3 (LAGP) is used to suppress polysulfides shuttling in Li–S cells. Firstly, the H-type visible cell is assembled by using a LAGP glass ceramic plate and normal poly-propylene (PP) separator. It is demonstrated that the LAGP glass ceramic plate is quite effective in shutting-down the migration of polysulfide ions and improving the utilization ratio of the sulfur cathode. However, in the commercial production of Li–S batteries it is not possible to use the LAGP glass ceramic plate as a membrane due to its brittle characteristics. Herein, the LAGP modified separator has been prepared by a simple casting procedure and applied in Li–S cells. The Li-ion conductivity of the LAGP modified separator is 6.280 × 10−4 S cm−1 at room temperature. The Li-ion transference number and the Gurley value of the modified separator show that the diffusion of the polysulfide anions can be suppressed effectively. The discharge capacity of the Li–S cell with the modified separator at the 50th cycle can reach 770.1 mA h g−1, while that of the Li–S cell with the routine PP separator is only 658.4 mA h g−1 at the 50th cycle. The superior utilization of sulfur in the Li–S cells indicates that using the LAGP modified separator is a viable way to overcome the shuttling problem for practical Li–S batteries.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2016
·Vol. 134
·期 11
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IF 1.866
Lei Huang,Yufen Jin,Li Sun,Feng Chen,Ping Fan,Mingqiang Zhong,Jintao Yang
Poly(ionic liquid)s have been demonstrated as high efficient CO 2 absorbents. In the current study, a kind of poly(ionic liquid)s, Poly[2-(methacryloyloxy)-ethyl] trimethylammonium tetrafluoroborate (P[MATMA][BF 4 ]) was used to functionalize graphene oxide (GO). The hybrid in which P[MATMA][BF 4 ] was covalently bonded on GO platelets was prepared by a simple method, that is, traditional radical polymerization. The characterizations based on transmission electron microscopy, scanning electron microscope, Fourier transform infrared spectroscopy, Raman spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy demonstrated the graft of P[MATMA][BF 4 ] on GO. N 2 adsorption measurements indicated that P[MATMA][BF 4 ] also greatly increased the specific surface area of GO. Due to the higher specific surface area and the CO 2 affinity of P[MATMA][BF 4 ], the GO-P[MATMA][BF 4 ] hybrid exhibited a much higher CO 2 adsorption capacity compared with GO, GO-NH 2 , and P[MATMA][BF 4 ]. Their study showed that the combinations of poly(ionic liquid)s and GO could be promising CO 2 absorbents. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44592.
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Science China-Chemistry
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2017
·Vol. 60
·期 9
·1191-1196
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IF 4.132
Ji Shaobo,El Mard Hicham,Smet Mario,Dehaen Wim,Xu Huaping
Macrocycles possess potential applications in supramolecular chemistry and biosystems. Thus development of new kinds of macrocycles is of significance. Herein, novel macrocycles containing Se–Se/Se–S bonds were synthesized via transformation between selenium related dynamic covalent bonds. A monomer containing two ebselen moieties was synthesized ( M1 ). The Se–N bonds in M1 were reduced by dithiothreitol, forming Se–S linked dimer ( D1 ). To realize the transformation from Se–S bonds to Se–Se bonds, guest molecules were added as template, triggering the formation of Se–Se linked dimer ( D2 ). The formation of these two new kinds of macrocycles was determined by 1 H NMR and 77 Se NMR, and the necessity of guest molecules was also confirmed. The introduction of ebselen moieties and Se–S bonds or Se–Se bonds into macrocycles may endow it with new responsiveness and bioactivities, as well as new types of host-guest chemistry.
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JOURNAL OF HAZARDOUS MATERIALS
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2016
·
IF 4.836
Penghui Shao,Xiaoguang Duan,Jun Xu,Jiayu Tian,Wenxin Shi,Shanshan Gao,Mingjun Xu,Fuyi Cui,Shaobin Wang
Recently, tremendous efforts have been devoted to developing carbon-based metal-free catalysts as an alternative to metal-based catalysts for remediation of emerging contaminants. However, further investigations have demonstrated that the durability of carbocatalysts is poor. Therefore, it is extremely desirable to seek a novel metal-free catalyst with high efficiency and superb stability. Herein, we first discovered that amorphous boron (A-boron) can be used as a metal-free catalyst for peroxymonosulfate (PMS) activation to produce free radicals for effective degradation of bisphenol S (BPS), which is a newly-occurring estrogenic endocrine-disrupting chemical. It exhibited outstanding catalytic activity and superior stability as comparing to metal-based and metal-free carbon-based catalysts. Moreover, many other typical organic pollutants in water such as bisphenol F, sulfamethoxazole, rhodamine B and methyl orange can also be effectively decomposed in A-boron/PMS oxidative system. The effects of reaction parameters on BPS degradation were systematically investigated. The catalytic oxidation mechanism was proposed. The intriguing catalytic feature of A-boron discovered in this study will provide new opportunities for the future development of A-boron based materials with promising applications in water remediation.
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2015
·
IF 1.648
Zhenqian Gu,Fangjie Wang,Haoxiang Lu,Xinling Wang,Zhen Zheng
A new kind of biodegradable poly(urethane-urea)s based on poly-lysine oligomer used as the soft segment was synthesized and characterized. In vitro degradation behavior of poly (urethane-urea)s was investigated, and was assessed by 1H NMR and mass loss. The results indicated that the peptide bonds in poly(urethane-urea)s were effectively cleaved in simulated pancreatic juice containing trypsin, while those in buffer solution without trypsin remained unaffected. The degradability was obviously improved by introducing poly-lysine oligomer into the main chain of poly(urethane-urea)s. The results of cells viability test indicated that the poly (urethane-urea)s showed a good biocompatibility on endothelial cells. The thermostability and hydrophilicity of poly(urethane-urea)s increased with increase in poly-lysine oligomer content.
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HIGH PERFORMANCE POLYMERS
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2014
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IF 1.09
Yewei Xu,Yi Sun,Yonglin Lei,Jichuan Huo,Lin Zhang
Poly(N-arylenebenzimidazole ketone ketone pyridine)s have been prepared via N–C coupling reaction that removed the N–H sites from the novel bis(benzimidazoyl) derivatives with activated aromatic difluorides in sulfolane. The reaction was carried out at 210°C in the presence of anhydrous potassium carbonate. The structures of the polymers were characterized by means of Fourier transform infrared and proton nuclear magnetic resonance spectroscopies and elemental analysis. All resulting polymers showed essentially amorphous patterns. Differential scanning calorimetry and thermogravimetric measurements showed that the polymers had high glass transition temperatures (>179°C), good thermostability, and high decomposition temperatures (>401°C). These novel polymers also showed easy solubility.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2013
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IF 2.39
Weidong Xiang,Cuiping Xie,Jing Wang,Jiasong Zhong,Xiaojuan Liang,Hailong Yang,Le Luo,Zhaoping Chen
Silver indium sulfide (AIS) quantum dots (QDs) with different Ag/In molar ratios were synthesized via a hot-injection method. Intense photoluminescence (PL) originating from the donor–acceptor pair recombination were observed for all the samples and the emission peak blue-shifted from 739 to 632 nm, being similar to the behavior of the absorption onset as the Ag/In ratios decreased. The highest PL quantum yield (QY) of the obtained ternary AIS QDs was ca. 62% with an optimum ratio of Ag/In = 1/4. Compared with AIS QDs, when Zn ions were introduced, the absorption spectra of the obtained quaternary Ag–Zn–In–S QDs were blue-shifted, and their emission peaks moved to higher energies accordingly, showing a tunable emission from red to green by altering the band gap energy. In order to further study the electroluminescence (EL) as well as looking forward to the applications in the optoelectronic devices of the obtained highly luminescent nanoparticles, the colloidal AIS QDs were deposited as thin films to the sandwich-like structured QD-LED. The experimental results showed that the obtained EL device exhibited EL emission originated from QDs thin films by adjusting the turn on voltage, which is for the first time to realize EL of AIS QDs in such QD-LED.
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