CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Po-Hsiang Chang,Yating Yang,Yaqi Wen,M.M.M. Ahmed,Jou-Chieh Chang,Ting-Yu Chang,Yu-Min Tzou,Zhaohui Li,Ahmed I. Osman
This study explores the efficacy of sodium alginate/graphene oxide (SA/GO) composite beads for ethidium bromide (EtBr) removal from aqueous solutions. GO was synthesized and crosslinked with SA to design composite beads, which were evaluated under various physicochemical conditions. Characterization techniques, including FESEM, TGA, XRD, and FTIR, were employed to analyze the beads before and after EtBr adsorption. Results demonstrated rapid EtBr adsorption onto SA/GO, following the Freundlich isotherm model with a maximum adsorption capacity of 2.97 mmol g −1 (1171.05 mg g −1 ). The influence of solution pH and the negligible role of Br − ions suggested that electrostatic interaction was the primary mechanism for EtBr adsorption on SA/GO. XRD and FTIR analyses revealed that EtBr adsorption also occurred in the interlayer space of SA/GO beads, with the ethidium cations (Et + ) entering this space in a horizontal or oblique (≥45°) orientation. The accumulation of Et + within the interlayer space was estimated to form 1–6 basic inclined layers. SA/GO beads demonstrated promising characteristics for EtBr pollutant treatment, including low environmental impact, cost-effectiveness, rapid adsorption kinetics, and high removal efficiency. This study provides valuable insights into the adsorption mechanisms and performance of SA/GO beads, highlighting their potential for future field applications in the environmental remediation of EtBr contamination.
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FOOD HYDROCOLLOIDS
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2024
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IF 11
Xin-Yu Jiang,Lin Li,Jia-Nan Yan,Li-Chao Zhang,Ce Wang,Bin Lai,Hai-Tao Wu
The purpose of this study was to construct calcium cross-linked gelatinized lotus rhizome starch (LRS)/sodium alginate (SA) hydrogel beads of adjustable quality and to reduce the digestibility of gelatinized starch. LRS was mixed with SA, gelatinized by heating and subsequently cross-linked with Ca 2+ to form hydrogel beads. The digestibility of the gelatinized LRS could be adjusted by changing the dose of SA in the hydrogel beads. When the LRS/SA ratio was 4/6, the rapidly digested starch (RDS) content in the beads was reduced by 26.9% compared with gelatinized LRS alone, whereas the slowly digested starch (SDS) and resistant starch (RS) contents increased by 12.3-fold and 2.3-fold, respectively. In addition, the water distribution in the Ca 2+ -crosslinked LRS/SA hydrogel bead samples also showed an SA dose dependence. With increasing SA concentration, the ability of the hydrogel beads to immobilize water increased. The diffusion of Ca 2+ into the interpenetrating polymer network that was prepared with gelatinized LRS and SA gradually resulted in gelation dominated by ion bonds, leading to the heterogeneous microstructure of the hydrogel beads, which also involved intermolecular hydrogen bond interactions. Overall, the present study suggested a strategy for developing novel LRS hydrogel bead systems for quality control and gelatinized starch digestibility downregulation by adjusting the SA dose, which provided insights for the innovation of personalized and convenient starchy products in the food industry.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Dong Shu,Lingling Fan,Wei Gong,Dezhan Ye,Zikui Bai,Jie Xu
Utilizing inexhaustible solar energy for water purification represents a green and sustainable solution to water scarcity. However, the developments of efficient, inexpensive, convenient and reliable photothermal materials remain a major challenge. Herein, a facile and versatile preparation strategy of sodium alginate (SA)-CuS composite coating with superior adhesion and stability has been proposed toward high-efficiency solar-driven interfacial evaporation. The fabrication process can be quickly completed in aqueous solution with cheap reagents. The SA-CuS coating can be firmly adhered on different substrates, which can withstand rinsing treatment, iterative freeze-thaw cycles as well as high and low pH environments. The SA-CuS coating can convert various substrates into photothermal materials with broad light absorption for desirable solar evaporation because of high CuS loading and rough surface. As a proof of concept, a wood evaporator covered with the SA-CuS coating can achieve a water evaporation rate of ∼2.2 kg m −2 h - 1 under one sun illumination, which is superior to most reported wood-based solar evaporators.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Jun Liao,Congcong Ding,Junping Shi,Liang Jiang,Qiuyi Wang,Lielin Wang,Rong Wang
In this work, the modified‑sodium alginate gel beads were prepared by sol-gel method. Due to the presence of water channels in the sodium alginate gel bead, amidoxime groups and PO 4 3− were exposed to the surface of the adsorbent to the maximum extent, resulting in the excellent adsorption capacity of modified‑sodium alginate gel beads. The introduction of amidoxime-modified hydroxyapatite significantly improved the adsorption capacity and the adsorption rate of the gel beads. The adsorption capacity increased from 308.7 to 466.0 mg/g and the adsorption equilibrium time was shortened from 300 min to 120 min. The modified‑sodium alginate gel bead possessed the advantages of short adsorption time, high adsorption efficiency and large adsorption capacity, which could be regarded as a potential adsorbent for uranium. Moreover, the uranium removal ability on the modified gel beads was mainly attributed to the Coulomb force between PO 4 3− and uranium and the complexation between uranium and amidoxime groups. In summary, this work would provide a new idea for the modification and application of sodium alginate-based materials.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Xinyue Liu,Yan Shu,Jingjing Zhu,Huan Fang,Ya Su,Hailin Ma,Bing Li,Jie Xu,Yuen Yee Cheng,Bo Pan,Kedong Song
Colorectal cancer (CRC) is now the third most common cancer worldwide. However, the development cycle for anticancer drugs is lengthy and the failure rate is high, highlighting the urgent need for new tumor models for CRC-related research. The decellular matrix (dECM) offers numerous cell adhesion sites, proteoglycan and cytokines. Notably, porcine small intestine is rich in capillaries and lymphatic capillaries, which facilitates nutrient absorption. This study, we utilized dECM, along with methylacryloyl gelatin (GelMA), sodium alginate (SA) and nanoclay (NC) to create a hydrogel scaffold through 3D extrusion bioprinting. Human CRC cells (HCT8) were seeded onto the scaffold and their drug resistance was tested using 5-fluorouracil (5-FU). Our findings indicate that dECM enhances the hydrophilic properties, mechanical strength and biocompatibility of the scaffold. Furthermore, compared to traditional two-dimensional (2D) models, the three-dimensional (3D) scaffold supports the long-term growth of tumor spheres. After 2 days of 5-FU treatment, the cell survival rate reaches 88.06 ± 0.51 %. This suggests that our scaffold provides a promising alternative platform for in vitro research on cancer mechanisms, anti-cancer drug screening and new drug development.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Yijiang Li,Chen Chen,Wencheng Xia,Hongxin Qiu,Yaoli Peng
In this study, the responsiveness of Na + , Mg 2+ , Ca 2+ and Al 3+ to sodium alginate (SA) and their influence on kaolinite dispersion/flocculation behavior were investigated through rheology and turbidity tests. The effects of metal ions on the interaction between SA and kaolinite were analyzed by zeta potential, fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and density functional theory (DFT). The results showed that Na + and Mg 2+ resulted in a decreasing of the viscosity and modulus of SA solution for they have the electrostatic shielding effect on SA. Ca 2+ and Al 3+ significantly increased the viscosity and modulus of SA solution because Ca 2+ and Al 3+ not only have the electrostatic shielding effect on SA but also could form the different network structure complexes. The order of the responsiveness of metal ions and SA sorted by intensity level was: Al 3+ > Ca 2+ >Mg 2+ > Na + . SA has a dispersion effect on kaolinite particles under the background of Na + and Mg 2+ , and SA has a flocculation effect on kaolinite particles in the presence of Ca 2+ and Al 3+ . The flocculation efficiency of SA on kaolinite suspension containing Al 3+ was much higher than that of SA on kaolinite suspension in the presence of Ca 2+ . Zeta potential and FTIR results showed that SA could be adsorbed on the kaolinite surface through electrostatic force and hydrogen bond in the presence of Na + and Mg 2+ . Microscope observation , XPS and DFT results showed SA could not only form chemical adsorption with Ca 2+ /Al 3+ on the kaolinite surface but also be cross-linked with Ca 2+ /Al 3+ to form a network structure, which could sweep and trap kaolinite particles in suspension. This work has strategic significance for the responsiveness of natural polysaccharide to metal ions and their application in environmental protection of mine wastewater, as well as the clean and circular utilization of water.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Pan Wu,Rong-Huan He,Yaru Fang,Kezhou Chen,Mi Wu,Wenchang Zhang,Jianhua Lv,Yan Zhao
Developing an injectable hemostatic dressing with shape recovery and high blood absorption ratio for rapid hemostasis in noncompressible hemorrhage maintains a critical clinical challenge. Here, double-network cryogels based on carboxymethyl chitosan, sodium alginate, and methacrylated sodium alginate were prepared by covalent crosslinking and physical crosslinking, and named carboxymethyl chitosan/methacrylated sodium alginate (CM) cryogels. Covalent crosslinking was achieved by methacrylated sodium alginate in the freeze casting process, while physical crosslinking was realized by electrostatic interaction between the amino group of carboxymethyl chitosan and the carboxyl group of sodium alginate. CM cryogels exhibited large water swelling ratios (8167 ± 1062 %), fast blood absorption speed (2974 ± 669 % in 15 s), excellent compressive strength (over 160 kPa for CM100) and shape recovery performance. Compared with gauze and commercial gelatin sponge, better hemostatic capacities were demonstrated for CM cryogel with the minimum blood loss of 40.0 ± 8.9 mg and the lowest hemostasis time of 5.0 ± 2.0 s at hemostasis of rat liver. Made of natural polysaccharides with biocompatibility, hemocompatibility, and cytocompatibility, the CM cryogels exhibit shape recovery and high blood absorption rate, making them promising to be used as an injectable hemostatic dressing for rapid hemostasis in noncompressible hemorrhage.
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Food Bioscience
·
2025
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IF 5.9
Jiaying Ren,Jiarui Jin,Yuze Wang,Yu Liu,Hang Qi
Fucoxanthin (FX), a natural carotenoid sourced from algae, is renowned for its strong antioxidant, anti-inflammatory, and anticancer effects, positioning it as a promising candidate for applications in functional foods and pharmaceuticals. Despite its potential, FX suffers from low oral bioavailability and is prone to degradation during digestion, hindering its effective absorption in the colon. In this study, κ-carrageenan-sodium alginate (Car-SAA) hydrogel beads were employed as an encapsulation system to investigate their pH-responsive drug release behavior and their influence on FX's oral bioavailability. The results showed that the hydrogel beads exhibited excellent mechanical properties in simulated colonic fluid (SCF), intestinal fluid (SIF), and gastric fluid (SGF). FX was gradually released in SGF and SIF, while a rapid release was observed in SCF, with a cumulative release of 74.38 ± 2.00% after 72 h for Car-SAA2.0-FX. This behavior was likely due to the swelling properties of the hydrogel, and the release kinetics were consistent with the Korsmeyer-Peppas model. Moreover, in vitro cytotoxicity assays showed that FX-loaded Car-SAA2.0 hydrogel beads had no significant impact on HaCaT cells but exhibited significant inhibitory effects on cancer cells. These findings indicated that the formulation holds promise as a colon-targeted delivery system, paving the way for future innovations in functional foods and pharmaceutical formulations.
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ACS Omega
·
2024
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IF 3.7
Zijian Liu,Shangbo Li,Zexian Xu,Li Li,Yanshan Liu,Xiaohan Gao,Yaru Diao,Liqiang Chen,Jian Sun
Herein, we introduce a novel composite hydrogel scaffold designed for addressing infectious jaw defects, a significant challenge in clinical settings caused by the inherent limited self-regenerative capacity of bone tissues. The scaffold was engineered from a blend of carboxymethyl chitosan (CMCS)/sodium alginate (SA) hydrogel (CSH), β-cyclodextrin/chlorhexidine clathrate (β-CD-CHX), and strontium-nanohydroxyapatite nanoparticles (Sr-nHA). The β-CD-CHX and Sr-nHA components were synthesized using a saturated aqueous solution and a coprecipitation method, respectively. Subsequently, these elements were encapsulated within the CSH matrix. Comprehensive characterization of the CMCS/SA/β-CD-CHX/Sr-nHA composite hydrogel scaffold via scanning electron microscopy, X-ray photoelectron spectroscopy, and Fourier-transform infrared spectroscopy validated the successful synthesis. The swelling and in vitro degradation behaviors proved that the composite hydrogel had good physical properties, while in vitro evaluations demonstrated favorable biocompatibility and osteoinductive properties. Additionally, antibacterial assessments revealed its effectiveness against common pathogens, Staphylococcus aureus and Escherichia coli. Overall, our results indicate that the CMCS/SA/β-CD-CHX/Sr-nHA composite hydrogel scaffolds exhibit significant potential for effectively treating infection-prone jaw defects.
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Scientific Reports
·
2024
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IF 3.8
Liqing Zhu,Fenfen Ouyang,Xue Fu,Yimei Wang,Ting Li,Min Wen,Guodong Zha,Xue Yang
Natural polymer-based hydrogels have demonstrated great potential as wound-healing dressings. They help to maintain a moist wound environment as well as promote faster healing. In this work, a multifunctional hydrogel was prepared using keratin, sodium alginate, and carboxymethyl chitosan with tannic acid modification. Micro-morphology of hydrogels has been performed by scanning electron microscopy. Fourier Transform Infrared Spectroscopy reveals the presence of hydrogen bonding. The mechanical properties of the hydrogels were examined using a universal testing machine. Furthermore, we investigated several properties of the modified hydrogel. These properties include swelling rate, water retention, anti-freezing properties, antimicrobial and antioxidant properties, hemocompatibility evaluation and cell viability test in vitro. The modified hydrogel has a three-dimensional microporous structure, the swelling rate was 1541.7%, the elastic modulus was 589.74 kPa, the toughness was 211.74 kJ/m 3 , and the elongation at break was 75.39%, which was similar to the human skin modulus. The modified hydrogel also showed inhibition of S. aureus and E. coli , as well as a DPPH scavenging rate of 95%. In addition, the modified hydrogels have good biological characteristics. Based on these findings, the K/SA/CCS hydrogel holds promise for applications in biomedical engineering.
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CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2024
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IF 3.7
Xi Quan,Jun Zhang,Linlin Yin,Wei Zuo,Yu Tian
In this work, a novel composite material based on β-cyclodextrin-immobilized sodium alginate aerogel (β-CD/NaAlg) was developed utilizing cross-linker of epichlorohydrin and applied as an adsorbent to remove tetracycline antibiotics from reclaimed wastewater. A series of characterizations were utilized to confirm the successful synthesis of the adsorbent and this β-CD/NaAlg presented a three-dimensional network at the nano or micro scale. Under optimal conditions (pH=4, t =8 h, β-CD: NaAlg=9, adsorbent dosage=1.5 g·L –1 ), the maximum removal rate of β-CD/NaAlg to tetracycline was 70%. The adsorption behavior of tetracycline on β-CD/NaAlg conformed to the Freundlich isotherm model ( R 2 =0.9977) and the pseudo-second-order kinetic model ( R 2 =0.9993). Moreover, the adsorbent still removed 55.3% of tetracycline after 5 cycles. Specially, the adsorbent was integrated with ultrafiltration to adsorb tetracycline antibiotics from simulated reclaimed wastewater, and the removal rate of tetracycline reached 78.9% within 2 hours. The existence of Cr (VI) had a negligible impact on tetracycline removal, while the presence of humic acid exhibited a promoting effect. The possible adsorption mechanisms were also elucidated through X-ray photoelectron spectroscopy and density functional theory analysis. In summary, β-CD/NaAlg represents an environmentally friendly, efficient, and sustainable adsorbent for removing tetracycline antibiotics from reclaimed water.
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Food Bioscience
·
2024
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IF 4.8
Yilun Huang,Yuwei Liu,Wenting Liu,Huiyu Hu,Daoxue Zhou,Xiaoxiang Peng,Chang Li,Yi Chen,Qiang Yu,Yuting Wang
5 Hydroxymethylfurfural (5-HMF) is a heat-induced hazard that common in baked goods. Although bioactive compounds such as catechins and polysaccharides could inhibit 5-HMF, their inhibition efficiency was limited when used alone. Therefore, this study aimed to explore the synergistic inhibitory impact of catechins and polysaccharides on 5-HMF in biscuits. Epigallocatechin gallate (EGCG), chitosan, and sodium alginate were screened out due to their high maximum inhibition rates (55.90, 67.20 and 66.62%, respectively), and their synergistic inhibitory effects on 5-HMF were investigated by isobologram analysis. The interaction index (γ) varies inversely with the synergism. When γ < 1 or >1, it represented synergism or antagonism, respectively. The results showed the EGCG/chitosan ratios of 1:1 (γ = 0.221) had better synergism than that of 1:2 (γ = 0.671) and 1:3 (γ = 0.523). Moreover, EGCG and sodium alginate only showed a synergistic effect at ratio of 1:1 (γ = 0.358), while an antagonistic effect was observed at ratios of 1:2 and 1:3 (γ = 1.12 and 1.25, respectively). The optimal inhibitory effect (54.57%) was achieved when EGCG-sodium alginate (1:1) at 0.2 g/kg. Compared with those used alone, the co-addition of EGCG and chitosan could decrease the dosage of EGCG to 1/5 and that of chitosan to 1/7, indicating a significant improvement of inhibit efficiency. Finally, Inhibitors’ concentration correlated negatively with 5-HMF content and browning index, suggesting they might inhibit 5-HMF by hindering Maillard or caramelization reactions. This study provided an efficient and cost-effective solution for 5-HMF control in baking products.
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