BIODEGRADATION
·
2022
·Vol. 34
·期 1
·73-81
·
IF 3.731
Gu Chen,Liang Jinxuan,Liu Ming,Rui Jianliang,Shi Jiyan,Yu Yanming,Zhang Xuwang
Bisphenol A (BPA) has been widely used in the manufacture of polymeric materials. BPA is regarded as an endocrine disrupting chemical, posing a great threat to the public health. In this study, a bacterial strain LM-1, capable of utilizing BPA as the sole carbon and energy source under aerobic conditions, was originally isolated from an activated sludge sample. The isolate was identified as Pseudomonas sp. based on 16S rRNA gene sequence analysis. Strain LM-1 was able to completely degrade 25–100 mg/L BPA within 14–24 h, and it also exhibited high capacity for BPA degradation at a range of pH (6.0–8.0). (NH 4 ) 2 SO 4 and NH 4 NO 3 were the suitable nitrogen sources for its growth and BPA biodegradation, and the BPA degradation could be accelerated when exogenous carbon sources were introduced as the co-substrates. Metal ions such as Zn 2+ , Cu 2+ , and Ni 2+ could considerably suppress the growth of strain LM-1 and BPA degradation. According to the analysis of liquid chromatography coupled to Q-Exactive high resolution mass spectrometry, hydroquinone, p -hydroxybenzaldehyde, and p -hydroxybenzoate were the predominate metabolites in the BPA biodegradation and the degradation pathways were proposed. This study is important for assessment of the fate of BPA in engineered and natural systems and possibly for designing bioremediation strategies.
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APPLIED CATALYSIS A-GENERAL
·
2022
·
IF 5.723
Yue Li,Huan Ren,Daolai Sun,Xinqiang Zhao,Satoshi Sato
Liquid-phase catalytic hydrodeoxygenation of 1,2-decanediol (1,2-DDO) to form 1-decanol was performed over various non-noble metal-loaded acidic catalysts, and Cu loaded on amorphous SiO 2 -Al 2 O 3 exhibited a high catalytic activity for the formation of 1-decanol. A high 1-decanol selectivity of 84.7% with a complete 1,2-DDO conversion was obtained within only 15 min over the Cu/SiO 2 -Al 2 O 3 at 250 °C under 10 MPa H 2 pressure. The temperature at 250 °C and the H 2 pressure higher than 3 MPa were conducive to the efficient production of 1-decanol from 1,2-DDO. In contrast to the previously reported noble metal catalysts, Cu/SiO 2 -Al 2 O 3 required a relatively high reaction temperature, while an extremely high 1-decanol productivity of 78 mmol g cat −1 h −1 could be achieved. Meanwhile, the hydrodeoxygenation of 1,2-decanediol over Cu/SiO 2 -Al 2 O 3 proceeded via a reaction mechanism in which decanal was formed as the intermediate. In addition, the Cu/SiO 2 -Al 2 O 3 catalyst was reusable at least five times without serious deactivation.
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Biomedical Optics Express
·
2023
·Vol. 14
·期 11
·5921-5931
·
IF 3.4
Hang Qu,Linyao Tan,Fang-Cai Wu,Weiyuan Huang,Kaiwei Li,Xiaoyong Chen,Xiaoyong Chen,Yi-Wei Xu,Yi-Wei Xu,Xuehao Hu
Autoantibodies against New York esophageal squamous cell cancer 1 (NY-ESO-1) play a crucial role in the diagnosis of esophageal cancer. In this work, a surface plasmonic tilted fiber Bragg grating (TFBG) biosensor is proposed for the detection of NY-ESO-1 antibody, as well as the investigation of the hook effect (which refers to the false negative result in some immunoassays when the concentration of antibodies in the sample is very high) during biomolecular binding between NY-ESO-1 antigen and antibody. The biosensor is made by an 18° TFBG coated with a 50-nm-thick gold film over the fiber surface together with NY-ESO-1 antigens attached to the metallic surface serving as bio-receptors. This biosensor can provide a limit of detection at a concentration of 2 × 10−7 µg/ml with a good linearity in the range from 2 × 10−7 to 2 × 10−5 µg/ml. For a concentration higher than 2 × 10−3 µg/ml, the performance of the sensor probe is reduced owing to the hook effect. Furthermore, experimental results have also demonstrated the repeatability of the proposed biosensor. This proposed biosensor features label-free, compactness, and fast response, which could be potentially applied in the diagnosis of esophageal cancer.
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JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
·
2023
·
IF 1.7
Jin-Bu Xu,Shi-Xing Miao,Feng Gao,Lin-Xi Wan
A series of arylated huperzine A (HPA) derivatives (1–24) were efficiently synthesized in good yields (45–88% yields) through the late-stage modification of structurally complex natural anti-Alzheimer’s disease (AD) drug huperzine A (HPA), using the palladium-catalyzed Suzuki-Miyaura cross-coupling reaction. The acetylcholinesterase (AChE) inhibitory activity of all synthesized compounds was evaluated to screen the potential anti-AD bioactive molecules. The results showed that introducing the aryl groups to C-1 position of HPA resulted in the unsatisfactory AChE inhibitory activity. The present study demonstrably verifies pyridone carbonyl group could be the necessary and unchangeable pharmacophore for maintaining HPA's anti-AChE potency, and provides the helpful information on the further research for developing anti-AD HPA analogues.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 12
·1-8
·
IF 5.479
Meng Xiangying,Chen Xiao,Wu Weihua,Zheng Wei,Deng Haohua,Xu Luyao,Chen Wei,Li Zhulai,Peng Huaping
Molybdenum oxide quantum dots (MoO x QDs) were synthesized by a one-pot method and used as a versatile probe in an electrochemiluminescent (ECL) immunoassay of the non-small cell lung cancer biomarker cytokeratin 19 fragment 21–1 (CYFRA21-1) as a model analyte. The MoO x QDs exhibited stable and strong cathodic green ECL, with an emission peak at 535 nm, in the presence of K 2 S 2 O 8 within the potential range of −2.0 to 0 V. On exposure to CYFRA21-1, the ECL decreases because of the immunoreaction between CYFRA21-1 and its antibody which generates a barrier for electron transfer. The determination of CYFRA21-1 with favorable analytical performances was successfully realized under the optimal conditions. ECL decreases linearly in the 1 pg mL −1 to 350 ng mL −1 CYFRA21-1 concentration range, and the detection is as low as 0.3 pg mL −1 . Excellent recoveries from CYFRA21-1-spiked human serum indicate that the assay can be operated under physiological conditions.
Schematic representation of the fabrication of molybdenum oxide quantum dots (MoO x QDs) and the electrochemiluminescent (ECL) immunoassay based on the use of the MoO x QDs ECL probe for cytokeratin 19 fragment 21–1 (CYFRA21-1).
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Cell Discovery
·
2023
·Vol. 9
·期 1
·1-18
·
IF 33.5
Gao Xiu Kui,Sheng Zu Kang,Lu Ye Hong,Sun Yu Ting,Rao Xi Sheng,Shi Lin Jing,Cong Xiao Xia,Chen Xiao,Wu Hao Bo,Huang Man,Zheng Qiang,Guo Jian-sheng,Jiang Liang Jun,Zheng Li Ling,Zhou Yi Ting
The scaffold protein IRS-1 is an essential node in insulin/IGF signaling. It has long been recognized that the stability of IRS-1 is dependent on its endomembrane targeting. However, how IRS-1 targets the intracellular membrane, and what type of intracellular membrane is actually targeted, remains poorly understood. Here, we found that the phase separation-mediated IRS-1 puncta attached to endoplasmic reticulum (ER). VAPB, an ER-anchored protein that mediates tethers between ER and membranes of other organelles, was identified as a direct interacting partner of IRS-1. VAPB mainly binds active IRS-1 because IGF-1 enhanced the VAPB-IRS-1 association and replacing of the nine tyrosine residues of YXXM motifs disrupted the VAPB-IRS-1 association. We further delineated that the Y745 and Y746 residues in the FFAT-like motif of IRS-1 mediated the association with VAPB. Notably, VAPB targeted IRS-1 to the ER and subsequently maintained its stability. Consistently, ablation of VAPB in mice led to downregulation of IRS-1, suppression of insulin signaling, and glucose intolerance. The amyotrophic lateral sclerosis (ALS)-derived VAPB P56S mutant also impaired IRS-1 stability by interfering with the ER-tethering of IRS-1. Our findings thus revealed a previously unappreciated condensate-membrane contact (CMC), by which VAPB stabilizes the membraneless IRS-1 signalosome through targeting it to ER membrane.
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Advanced Healthcare Materials
·
2023
·
IF 10
Jian Tang,Yang Liu,Mingxi Li,Xiao Wang,Anning Du,Ning Gu,Fang Yang
Vascular inflammation is an early manifestation and common pathophysiological basis of numerous cardiovascular and cerebrovascular diseases. However, effective surveillance methods are lacking. In this study, sulfur hexafluoride (SF 6 )-loaded polylactic acid- co -glycolic acid (PLGA) nanobubbles (NBs) with a surface assembly of cyclodextrin (CD) and sphingosine-1-phosphate (S1P) (S1P@CD-PLGA NBs) are designed. The characterization results show that S1P@CD-PLGA NBs with diameters of ≈200 nm have good stability, biosafety, and ultrasound imaging-enhancement effects. When interacting with inflammatory vascular endothelial cells, S1P molecules encapsulated in cyclodextrin cavities exhibit a rapid, excellent, and stable targeting effect owing to their specific interaction with the highly expressed S1P receptor 1 (S1PR1) on the inflammatory vascular endothelial cells. Particularly, the S1P–S1PR1 interaction further activates the downstream signaling pathway of S1PR1 to reduce the expression of tumor necrosis factor-α (TNF-α) to protect endothelial cells. Furthermore, mouse models of carotid endothelial injuries and mesenteric thrombosis demonstrate that S1P@CD-PLGA NBs have excellent capabilities for in vivo targeting imaging. In summary, this study proposes a new strategy of using S1P to target inflammatory vascular endothelial cells while reducing the expression of TNF-α, which has the potential to be utilized in the targeted surveillance and treatment of vascular inflammatory diseases.
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Journal of Flow Chemistry
·
2023
·Vol. 13
·期 4
·375-383
·
IF 2.7
Lai Liangchuan,Gao Liang,Liu Minjie,Guo Yongxing,Cheng Dang,Jiang Meifen,Chen Fener
Continuous flow technology has been widely adopted in manufacturing active pharmaceutical ingredients (APIs). Herein, we report an expeditious multi-step continuous-flow strategy for an efficient and highly productive flow synthesis of 7-methoxy-1-tetralone, which is an essential intermediate for the opioid analgesic drug (-)-dezocine. Compared with the traditional batch operation, this work presents significant advantages of continuous-flow chemistry with dramatically reduced reaction time, highly improved reaction efficiency, good controls over reaction optimizing conditions, etc. The flow protocol in this work provided the desired product in an overall yield of up to 76.6% with 99% purity, much higher than those from batch process (i.e., 50% yield, 92% purity). Moreover, reaction efficiency is highly improved with a throughput of 0.49 g/h, the total reaction time is markedly reduced from hours in batch to minutes in flow process. Graphical abstract
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ECS Journal of Solid State Science and Technology
·
2023
·Vol. 12
·期 12
·123003
·
IF 2.2
Lirui Shi,Qingyu Wang,Xin Zhou,Zhaoliang Xing,Chuncheng Hao
Nano-composite dielectric materials are considered as the most promising insulating materials for HVDC cables. The effects of different concentration of nano-filler and structure of nanoparticle on the electrical properties of crosslinked polyethylene (XLPE) composites were studied by using three different chemical treated titanium-silicon molecular sieves TS-1 as nano-filler. The experimental results show that the dielectric properties of the composites increased by 17.76%, 19.16% and 16.36%, respectively, after TS-1 and alkali treatment for 12 h and 24 h. After the addition of the first two fillers, the resistivity was nearly doubled to 46.71% and 47.41%, respectively, and the breakdown field strength was increased by 3.40% and 9.28%, respectively. After 24 h alkali treatment, the volume resistivity and breakdown field strength of TS-1 were lower than that of pure XLPE.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2023
·
IF 22.1
Wanying Liang,Guangyue Xu,Yao Fu
A series of metal-TS-1 zeolite catalysts were designed to selectively catalyze the photo oxidation of furfural to C 4 carboxylic acid derivatives at ambient temperature and pressure. The photocatalytic preparation of malic acid from furfural was realized for the first time. The selective distribution of products could be controlled by adjusting the physical and chemical characteristics of the catalyst. Smaller pore size prevented the further conversion of maleic acid to malic acid; moderate acidity was beneficial for the preparation of malic acid; lower valence band was in favor of maleic acid production while higher valence band tended to form malic acid. The synergistic effect of pore structure, acidity and energy band structure of catalysts affected the product distribution. The yield of maleic acid reached as high as 40% over Fe-TS-1, meanwhile, the yield of malic acid reached as high as 63% over Ni-TS-1. The doping of metal was believed to be an effective procedure to adjust the structure and physicochemical properties of zeolite. Matel-TS-1 zeolite was also expected to be widely used in photocatalytic system to achieve more selective reactions.
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RSC Advances
·
2023
·Vol. 13
·期 22
·14980-14990
·
IF 3.9
Xiaoyu Hu,Jinchuan Wang,Shangkun Li,Xuanhao Hu,Rongxing Ye,Linsen Zhou,Peilong Li,Changlun Chen
Extensive research has been devoted to developing metal nanoparticle (NP) doped porous materials with large hydrogen storage capacity and high hydrogen release pressure at ambient temperature. The ultra-sound assisted double-solvent approach (DSA) was applied for sample synthesis. In this study, tiny Pd NPs are confined into the pore space of HKUST-1, affording Pd@HKUST-1-DS with minimizing the aggregation of Pd NPs and subsequently the formation of Pd NPs on the external surface of HKUST-1. The experimental data reveal that the obtained Pd NP doped Pd@HKUST-1-DS possessed an outstanding hydrogen storage capacity of 3.68 wt% (and 1.63 wt%) at 77 K and 0.2 MPa H2 (and 298 K and 18 MPa H2), in comparison with pristine HKUST-1 and impregnated Pd/HKUST-1-IM. It is found that the storage capacity variation is not only ascribed to the different textural properties of materials but is also illustrated by the hydrogen spillover induced by different electron transport from Pd to the pores of MOFs (Pd@HKUST-1-DS > Pd/HKUST-1-IM), based on X-ray photoelectron spectroscopy and temperature desorption spectra. Pd@HKUST-1-DS, featuring high specific surface area, uniform Pd NP dispersion and strong interaction of Pd with hydrogen in the confined pore spaces of the support, displays the high hydrogen storage capacity. This work highlights the influence of spillover caused by Pd electron transport on the hydrogen storage capacity of metal NPs/MOFs, which is governed by both physical and chemical adsorption.
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Arabian Journal of Chemistry
·
2023
·
IF 6
Ruifeng Liao,Liangliang Shi.,Yi Zhou,Chenyue Jia,Jiangtao Feng,Weinong Zhang,Junbo He
Four novel nonionic 1-alkylaminoglycerol Gemini surfactants, represented by m-s-m ( m = C 8 and C 12 , s = 3 and 4), were synthesized through a two-step reaction in high yields, and confirmed by 1 H NMR, 13 C NMR, and HRMS. The synthesized Gemini surfactants exhibited low CMC (1.41–5.25 mmol/L), excellent surface-tension-reducing ability (25.45–26.83 mN/m), and wetting ability on hydrophobic interface. Gemini surfactants in aqueous solutions were in stable nanoscale dispersion, and exhibited strong and long-lasting foaming ability and emulsifying abilities for benzene/water and triacylglyceride/water systems. Especially, 12 – 4-12 solution displayed excellent tolerance to wide pH range and high salinity. Biological evaluation demonstrated that these Gemini surfactants, except for 8 – 4-8 , showed significant antibacterial activities against Staphylococcus aureus and Escherichia coli at 25 and 50 µg/mL. Hence, these Gemini surfactants have the potential to be used in a varieties of fields as highly efficient agents.
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