International Journal of Nanomedicine
·
2017
·
IF 4.3
Lei Yang,Zhenghai Zhang,Jian Hou,Xin Jin,Zhongcheng Ke,Dan Liu,Mei Du,Xiaobing Jia,Huixia Lv
Ginsenoside compound K (CK) is one of the effective ingredients in antitumor composition of ginsenoside. However, the poor water solubility and significant efflux have limited the widespread clinical use of CK. In this study, preparation of novel CK-loaded d -alpha-tocopheryl polyethylene glycol 1,000 succinate/poly(ethylene glycol)-poly(ε-caprolactone) mixed micelles (CK-M) is discussed to solve the above problems. Particle size, zeta potential, and morphology were characterized using dynamic light scattering and transmission electron microscopy. CK-M are spherical shaped with an average particle size of 53.07±1.31 nm with high drug loading of 11.19%±0.87% and entrapment efficiency of 94.60%±1.45%. Water solubility of CK was improved to 3.78±0.09 mg/mL, which was ~107.35 times higher than free CK. A549 and PC-9 cells were used to evaluate in vitro cytotoxicity and cellular uptake. IC 50 values of CK-M in A549 and PC-9 cells (24 h) were 25.43±2.18 and 18.35±1.90 μg/mL, respectively. Enhanced cellular uptake of CK-M was observed in both cells. Moreover, CK-M promoted tumor cell apoptosis, inhibited tumor cell invasion, metastasis, and efflux through regulation of Bax, Bcl-2, matrix metalloproteinase-2, Caspase-3, and P-glycoprotein. In vivo imaging indicated that CK-M has excellent tumor targeting effect within 24 h, and the relative tumor inhibition rate of CK-M was 52.04%±4.62% compared with control group ( P <0.01). Thus, CK-M could be an appropriate delivery agent for enhanced solubility and antitumor effect of CK.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Yanping Yang,Shengchen Li,Shunli Shi,Jie Hu,Zexi Xuchen,Shunmin Ding,Dan zhao,Shengjun Deng,Weiming Xiao,Shuhua Wang,Chao Chen
Manganese oxide (MnO x ) catalysts are promising for low-temperature NH 3 -Selective Catalytic Reduction (NH 3 -SCR) with their superior catalytic performance. However, the presence of alkali metals in flue gases, particularly potassium (K), leads to catalyst deactivation and limits their industrial application. This study investigates the synergistic effects of Ce and Nb doping on the K resistance and low-temperature NH 3 -SCR activity of MnO x . The surface acidity and redox properties of MnO x were modulated by Ce and Nb modification. In addition, the phase structure, surface state and active sites of the catalysts were characterized before and after K poisoning. The results indicated that Nb 0.05 Ce 0.05 MnO x exhibited exceptional low-temperature performance, achieving over 90 % NO conversion at 125-250°C, along with significant resistance to K poisoning·NH 3 -TPD and in-situ experiments revealed that the loss of acid sites is the primary cause of K poisoning. The mechanism follows the L-H mechanism with L-acid sites as the main active sites on the catalyst surface and bridging nitrate as the key intermediate state. This research provides valuable insights into enhancing the industrial applicability of MnO x- based catalysts for low-temperature denitrification.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Deng Zhao,Yu Wang,Guanwei Wang,Wenming Han,Hua Liu,Huashan Wang,Hui Liu,Shuai Guo
Although alkali metal potassium (K)-catalyzed char gasification has been widely studied, the detailed mechanism of this process is still not fully understood. To study this catalytic mechanism in more detail, high-temperature in-situ DRIFTS experiments were carried out for the gasification of cellulose char with K and cellulose char without K under H 2 O and O 2 atmospheres, transient gasification experiment of char with K under H 2 O atmosphere, and char with K gasification under isotope water atmospheres. Peaks at 1945 cm −1 and 2020 cm −1 were observed. Combined with the theoretical spectra obtained by quantum chemical simulations and the prediction of catalytic gasification intermediates by molecular dynamics simulations, these two peaks were confirmed to represent char-polyynes species. Based on this result, a new mechanism is proposed: K interacts with carboxyl groups and aromatic ketones to promote desorption, thereby exposing active sites. Then, K reacts with the edge of the activated char to form numerous highly active char-polyynes species. The polyynes edge of this char-polyynes phase provides ideal adsorption–desorption sites, enabling further reaction with the gasifier. Thus, gas desorption is promoted. The adsorption and desorption peaks of catalytic gasification under the H 2 O atmosphere were located at 1400 cm −1 and 1300 cm −1 , and these peaks represented stable adsorption states and unstable desorption precursors, respectively. Based on this, adsorption–desorption theory was analyzed more comprehensively, and the adsorption–desorption process was divided into three stages: initial adsorption, intermediate conversion, and desorption. The comprehensive new mechanism proposed in this paper provides a better understanding of the nature of char catalytic gasification at a deeper level.
✓ 已验证
产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2024
·
IF 3.5
Hang Liu,Haozhou Tian,Chunhui Sun,Qiang Wang,Hongqun Zhu,Xuezhong Yang,Haoran Wang,Yuhong Zhang
A series of Nd3+/Yb3+ co-doped Ca2LaTaO6 (CLTO) phosphors are synthesized by a high temperature solid phase method. Structural characterization confirms the successful incorporation of Nd3+ and Yb3+ ions into the CLTO host lattice. The photoluminescence excitation (PLE) spectra and photoluminescence (PL) spectra of CLTO:Nd3+ and CLTO:Nd3+/Yb3+ are investigated in detail. Under the excitation of ultraviolet (UV) and visible (VIS) light, the CLTO:Nd3+/Yb3+ phosphor emits broadband near infrared (NIR) luminescence. In particular, the luminescence intensity of the Yb3+ ion is increased through an energy transfer (ET) process from Nd3+ to Yb3+. The luminescence mechanism of the CLTO:Nd3+/Yb3+ sample is analyzed based on the decay lifetime and PL spectra. In addition, the NIR emission intensity of Yb3+ ions is also enhanced by doping K+ ions. The broadband luminescence (850–1050 nm) of the CLTO:Nd3+/Yb3+/K+ phosphor has good application in solar cells and anti-counterfeiting.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2018
·
IF 2.196
Shuyu Ning,Weifeng Chen,Teng Pan,Youwei Cheng,Lijun Wang,Xi Li
Solubilities of isophthalic acid in ternary mixtures of acetic acid + water + benzoic acid were determined by the static analytical method. The temperature range was from 292.55 to 372.10 K, the mass ratios of water to acetic acid were 0, 1:9, and 1:4, and the mass fractions of benzoic acid in initial solvent ranged from 0 to 20.1%. The experimental results indicated that the solubility of isophthalic acid increased with the introduction of benzoic acid to the binary solvents of acetic acid and water, and that could be explained by Hansen’s three-dimensional parameters and like-dissolves-like rule. Then the experimental solubilities were correlated by the nonrandom two liquids (NRTL) model, and the model parameters were regressed. The values calculated by the NRTL model showed good agreement with the experiment data.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2018
·
IF 2.196
Lijiang Guo,Lanying Tu,Yaxiao Wang,Jianqiang Li
Water activities in the ternary system CsCl–MgCl2–H2O and its sub-binary systems at 323.15 K were elaborately measured by an isopiestic method. Moreover, the solubility of the CsCl–MgCl2–H2O system at 323.15 K was also measured by the flow-cloud-point method. A Pitzer model was used to predict the measured water activity and solubility data. The binary parameters for the CsCl–H2O system at 323.15 K were obtained by fitting the measured water activities for this binary system. The calculated water activity and solubility isotherms for the CsCl–MgCl2–H2O system at 323.15 K, with binary parameters only, deviated from the experimental values. This means that it is insufficient with binary parameters only to predict the water activity and calculate the solubility isotherms of the CsCl–MgCl2–H2O system at 323.15 K. The calculated solubility isotherms with both binary and mixing parameters, obtained by fitting the measured water activity, also deviated from experimental values. A new set of reasonable ternary parameters for the CsCl–MgCl2–H2O system was obtained by fitting the measured water activity and solubility data of this work. The calculated solubility isotherms with these parameters agreed with experimental results.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2012
·Vol. 95
·期 5
·1544-1548
·
IF 2.272
Qiang Xiao,Xiaodan Tang,Yijun Zhong,Weidong Zhu
A facile starch-assisted sol–gel method combined with freeze-drying technique has been developed to synthesize K-doped Li 2 ZrO 3 sorbents. SEM, TEM, and XRD techniques have been applied to characterize the morphology and structure of the synthesized K-doped Li 2 ZrO 3 samples. The CO 2 capture-regeneration properties of the prepared K-doped Li 2 ZrO 3 sample were investigated using thermogravimetric analysis at different CO 2 partial pressures. The K-doped Li 2 ZrO 3 synthesized using the starch-assisted sol–gel method combined with the freeze-drying technique shows excellent CO 2 capture properties. At 823 K and a CO 2 partial pressure of 0.25 bar, the uptake of CO 2 reaches 22 wt% within 20 min, which is approximately 87% of the stoichiometric sorption capacity (25.3 wt%) of CO 2 in the K-doped Li 2 ZrO 3 with a K:Li:Zr composition of 0.2:1.6:1 in molar ratio. Furthermore, the sorbent shows a good stability, confirmed using capture-regeneration cycles.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2017
·
IF 3.648
Midong Shi,Liping Wang,Gaoyin He,Fan Gan,Xuemin Yu,Qingsong Li
In order to remove methyl ethyl ketone from the lower fractions of C 6 in the high temperature Fischer-Tropsch synthetic oil, the liquid-liquid equilibrium (LLE) experiments for methyl ethyl ketone + n-hexane + ethylene glycol were carried out and the LLE data were measured at 298.15, 303.15, 308.15 and 313.15 K under atmospheric pressure. The analysis results demonstrated the feasibility of separating methyl ethyl ketone from n-hexane using ethylene glycol with the extraction method . Moreover, the NRTL and UNIQUAC models were successfully applied to correlate the LLE data with RMSD′ values of 0.0197 and 0.0313, respectively, which indicated that NRTL model showed a higher accuracy.
✓ 已验证
产品关联
DOI
高影响因子
CHEMISTRY & BIODIVERSITY
·
2025
·
IF 2.5
Sheng-qi Jiang,Yu-yang Chai,Shu fang Ma,Junlong Wang,Wen-pan Shi,Peng peng He,Juan xia Pang,Yong gang Lin
In this study, we optimal the ultrasound-assisted ionic liquid extraction (UAILE) process of polysaccharides from Crataegus songarica K. Koch fruits. The optimal conditions determined were: ultrasonic power of 400 W, temperature of 79 ℃, extraction time of 78 min, Ethylammonium dodecyl sulfate (EADS) concentration of 1.52 mg/mL, and liquid-solid ratio of 51:1 mL/g. Under these conditions, the polysaccharides yield was 34.37%, which was significantly higher than that obtained by the conventional ultrasound-assisted extraction (UAE) and hot water extraction (HWE) methods. After purification, we studied the chemical composition, physicochemical properties and structural characteristics of polysaccharides (CSP). The results showed that CSP is a heteropolysaccharide containing α-linkage glucopyranose, which is mainly composed of mannose, arabinose, galactose and glucose, with a molecular weight (Mw) of 27.82×104 Da. In addition, CSP demonstrated significant free radical scavenging ability, and was able to efficiently reduce the H2O2-induced HepG2 cellular malondialdehyde (MDA) content, while enhancing superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, showing its superior antioxidant activity. Based on these properties, CSP is expected to be used as a novel efficacy factor in the food and pharmaceutical industries.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Bioanalysis
·
2024
·
IF 1.9
Xiemin Qi,Ning Chen,Qinxin Song,Yanan Chu,Haiping Wu,Jingwen Shan,Huijie Yue,Guohua Zhou
Aim: Differences are existed in the bioactivity among various vitamin K (VK) forms. To investigate the correlation between clinical parameters of initial anticoagulation and plasma levels of VK1 and VK2 (MK-4 and MK-7), it was necessary to establish a quantitative method for simultaneous determination.Materials & methods: Plasma samples in cardiovascular patients were extracted by cyclohexane and analyzed using a C18 column. Baseline concentrations of VK1, MK-4 and MK-7 were 0.98 ± 0.52 ng/ml, 0.45 ± 0.13 ng/ml and 0.65 ± 0.31 ng/ml, respectively. The concentrations of MK-7 and total VKs were significantly relevant to INR0, respectively (p = 0.010 and p = 0.048, respectively).Conclusion: Thus, when adjusting anticoagulation dosage, concentrations of various VK homologues might be considered.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Lanxuan Yang,Lianjiang Tan,Ruili Xu,Zeyuan Tian,Tian Tian,Zhifu Liu,Lili Liu,Yaoqing Chu
The local crystal-field symmetry within a host material plays a critical role in modulating the luminescence behavior of Sm 3+ ions. In this study, we propose a novel Si 4+ doping strategy to enhance the photoluminescence properties of Sm 3+ in a Sr 3 Ga 2 Ge 4 O 14 host, with the effects proposed to be associated with alterations in the symmetry of the local coordination environment. A series of Si 4+ /Sm 3+ co-doped phosphors was synthesized via solid-state reaction. At an optimal Si 4+ doping level of 50 mol%, the emission intensity of Sm 3+ increased by approximately 40%. Further introduction of K + as a charge compensator considerably improved the internal quantum efficiency from 25.12% to 47.28% and color purity from 96.8% to 99.9%. A prototype WLED using the optimized phosphor exhibited a low CCT (5769 K) and a high CRI ( R a = 87.6), satisfying the requirements for indoor lighting. The phosphor was also incorporated into a PVA-based anti-counterfeiting ink, showing bright, stable, and substrate-independent UV-excited fluorescence. This work provides a feasible doping strategy for developing high-performance orange-red phosphors and demonstrates their potential in high-quality WLED and advanced anti-counterfeiting applications.
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS LETTERS
·
2016
·
IF 2.437
Hongfeng Tang,Guang-Xin Chen,Qifang Li
Polymer composites with a high dielectric constant (high-k) and low dielectric loss represent an important research topic for the rapid development of electronic industries. This paper reports on a type of high-k composite with low dielectric loss (dielectric constant is approximately 152, and dielectric loss is only 0.06 at 10 kHz) through a compounded epoxy resin with homemade core-shell-structured carbon nanotube (CNT) hybrids. The composite is prepared by in situ controlled free-radical copolymerization of divinylbenzene and glycidyl methacrylate on the surface of CNTs. The reactive shell contained epoxy groups that play a dual role in keeping the low dielectric loss of the composites and high dispersibility of the coated CNTs. The coated CNTs with proper thickness (about 30 nm) and epoxy value (0.011 mol/g) were selected to prepare the composites.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）