Advanced Healthcare Materials
·
2023
·Vol. 12
·期 15
·2202280
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IF 10
Wenya Li,Rongtian Li,Qiang Ye,Yiming Zou,Xing Lu,Wenhua Zhang,Jinxiang Chen,Yinghua Zhao
Nanomedicine exhibits emerging potentials to deliver advanced therapeutic strategies in the fight against triple-negative breast cancer (TNBC). Nevertheless, it is still difficult to develop a precise codelivery system that integrates highly effective photosensitizers, low toxicity, and hydrophobicity. In this study, PCN-224 is selected as the carrier to enable effective cancer therapy through light-activated reactive oxygen species (ROS) formation, and the PCN-224@Mn 3 O 4 @HA is created in a simple one-step process by coating Mn 3 O 4 nanoshells on the PCN-224 template, which can then be used as an “ROS activator” to exert catalase- and glutathione peroxidase-like activities to alleviate tumor hypoxia while reducing tumor reducibility, leading to improved photodynamic therapeutic (PDT) effect of PCN-224. Meanwhile, Mn 2+ produced cytotoxic hydroxyl radicals (∙OH) via the Fenton-like reaction, thus producing a promising spontaneous chemodynamic therapeutic (CDT) effect. Importantly, by remodeling the tumor microenvironment (TME), Mn 3 O 4 nanoshells downregulated hypoxia-inducible factor 1 α expression, inhibiting tumor growth and preventing tumor revival. Thus, the developed nanoshells, via light-controlled ROS formation and multimodality imaging abilities, can effectively inhibit tumor proliferation through synergistic PDT/CDT, and prevent tumor resurgence by remodeling TME.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Junjie Wu,Peng Shen,Xian Qin,Yulu Yang,Chuanchuan Lin,Xuan Li,Wenbo Geng,Pengfei Gao,Lixue Chen,Li Miao,Yang Jiao,Bailong Tao
Bacterial wound infection is a major challenge to human health worldwide. In this study, a composite nanogenerator, CaO 2 @ZIF-67-PLL, was fabricated via a bottom-up approach with chemodynamic therapy (CDT)/hypoxia improvement for rapid therapy of biofilm-infected wounds. Under a pathologically acidic microenvironment, the out layer ZIF-67 can be decomposed to rapidly release Co 2+ and CaO 2 ; Subsequently, the unprotected CaO 2 reacts with H 2 O to produce O 2 and H 2 O 2 . The self-supply of O 2 relieves hypoxia and inflammatory response induced by infections, while the generated H 2 O 2 and poly- l -lysine (PLL) exhibited synergistic strong anti-biofilm capability against Escherichia coli ( E. coli) and Staphylococcus aureus (S. aureus) as assessed by reactive oxygen species (ROS) generation, membrane permeability change, ATP reduction, o -nitrophenyl-β-d-galactopyranoside (ONPG) hydrolysis and intracellular component leakage. Meanwhile, CaO 2 @ZIF-67-PLL exhibited good cytocompatibility and promoted the adhesion, proliferation, and migration of NIH-3T3 cells by enhancing the expression of wound healing-related genes (TGF-β1, VEGF, α-SMA, Col I, Col III, and Wnt-5a). Notably, CaO 2 @ZIF-67-PLL could significantly improve the healing process of S. aureus -infected wounds via suppressed inflammatory responses, enhanced collagen disposition and angiogenesis, and stimulated HIF-1α, CD31, and Wnt-5a/β-Catenin signaling pathways. These results indicated the potential of CaO 2 @ZIF-67-PLL nanogenerator for clinical application in infected wound treatment.
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JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Xiaohong Zou,Qian Lu,Cuie Wang,Sixuan She,Kaiming Liao,Ran Ran,Wei Zhou,Liang An,Zongping Shao
Before the practical application of the Li–O 2 battery (LOB), a critical issue regarding large overpotential upon charging (which causes irreversible side reactions and low energy efficiency) should be resolved. The utilization of redox mediators (RMs) which oxidatively decompose insulating discharge product, Li 2 O 2 , is one promising solution to address this issue. However, the soluble RMs can easily diffuse to and react with the Li metal anode (encountering Li dendrites is even worse). Here, a chemical self-assembly strategy is introduced into the fabrication of the iodide-redox-phobic and Li-ion-philic membrane for LOBs, in which the electronegative δ-MnO 2 layer is in-situ grown on commercial polyethylene (PE) membrane (MnO 2 @PE). The electronegative MnO 2 layer can simultaneously repel the shuttle of iodide species and regulate the uniform Li + deposition. Controlling cut-off capacity of 1000 mAh g −1 , iodide-redox-based LOB with MnO 2 @PE demonstrates low overpotentials (∼0.7 V vs. Li + /Li), dendrite-suppressing capability, as well as impressive long-term reversibility over 500 cycles (2000 h), which urges the LOB technology competitive among the next-generation rechargeable power systems.
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Theranostics
·
2022
·
IF 11.6
Qiqi Xu,Yuetong Zhang,Zulu Yang,Guohui Jiang,Mingzhu Lv,Huan Wang,Chenghui Liu,Jiani Xie,Chengyan Wang,Kun Guo,Zhanjun Gu,Yuan Yong
Nanozyme-based tumor collaborative catalytic therapy has attracted a great deal of attention in recent years. However, their cooperative outcome remains a great challenge due to the unique characteristics of tumor microenvironment (TME), such as insufficient endogenous hydrogen peroxide (H 2 O 2 ) level, hypoxia, and overexpressed intracellular glutathione (GSH). Methods: Herein, a TME-activated atomic-level engineered PtN 4 C single-atom nanozyme (PtN 4 C-SAzyme) is fabricated to induce the “butterfly effect” of reactive oxygen species (ROS) through facilitating intracellular H 2 O 2 cycle accumulation and GSH deprivation as well as X-ray deposition for ROS-involving CDT and O 2 -dependent chemoradiotherapy. Results: In the paradigm, the SAzyme could boost substantial ∙OH generation by their admirable peroxidase-like activity as well as X-ray deposition capacity. Simultaneously, O 2 self-sufficiency, GSH elimination and elevated Pt 2+ release can be achieved through the self-cyclic valence alteration of Pt (IV) and Pt (II) for alleviating tumor hypoxia, overwhelming the anti-oxidation defense effect and overcoming drug-resistance. More importantly, the PtN 4 C-SAzyme could also convert O 2 ·- into H 2 O 2 by their superior superoxide dismutase-like activity and achieve the sustainable replenishment of endogenous H 2 O 2 , and H 2 O 2 can further react with the PtN 4 C-SAzyme for realizing the cyclic accumulation of ∙OH and O 2 at tumor site, thereby generating a “key” to unlock the multi enzymes-like properties of SAzymes for tumor-specific self-reinforcing CDT and chemoradiotherapy. Conclusions: This work not only provides a promising TME-activated SAzyme-based paradigm with H 2 O 2 self-supplement and O 2 -evolving capacity for intensive CDT and chemoradiotherapy but also opens new horizons for the construction and tumor catalytic therapy of other SAzymes.
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ELECTROCHIMICA ACTA
·
2022
·
IF 7.336
Jie Li,Youcai Lu,Shiyu Ma,Zhongjun Li,Qingchao Liu
Li–O 2 battery has attracted wide attention because it can satisfy the need for a new energy storage system with high energy density. However, poor oxygen reduction (ORR)/oxygen evolution (OER) kinetics involving Li 2 O 2 formation/decomposition is a major obstacle to its development. By designing suitable cathode with desired structure and surface electronic states, the formation/morphology of Li 2 O 2 and the reaction kinetics of charge process can be efficiently optimized simultaneously. In this work, a novel sulfur (S) and chlorine (Cl) co-doped porous carbon (CSC) were synthesized by one-step pyrolysis strategy, and the amount of heterogeneous atoms could be flexibly controlled by different calcination temperatures . Experimental combined with theoretical calculations show that the content of C Cl bond plays an important role in the adsorption of intermediate LiO 2 , thus regulating the morphology of Li 2 O 2 and ultimately affecting the release of battery energy. The C S bond mainly acts on the dynamics of the ORR and OER processes, which has an important influence on improving the round-trip efficiency of the battery. Benefiting from the synergistic effect of heteroatoms , the electrochemical performances of the Li–O 2 battery, including round-trip efficiency, discharge capacity and cycling stability are greatly improved.
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BIOCONJUGATE CHEMISTRY
·
2021
·
IF 4.774
Chunxiao Sui,Rui Tan,Yiwen Chen,Guotao Yin,Ziyang Wang,Wengui Xu,Xiaofeng Li
Metal–organic frameworks (MOFs) derivatives had been widely explored in electronic and environmental fields, but rarely evaluated in the biomedical applications. Herein, Fe–N codoped carbon (FeNC) nanoparticles were synthesized and characterized via facile pyrolysis of precursor ZIF-8 (Fe/Zn) nanoparticles, and their potential applications in tumor therapy were assessed in this investigation both in vitro and in vivo. After PAA (sodium polyacrylate) modification, the FeNC@PAA nanoparticles were able to initiate a Fe-based Fenton-like reaction to generate ·OH and O2 for chemodynamic therapy (CDT) and O2 evolution. Meanwhile, the porphyrin-like metal center in the FeNC@PAA nanoparticles could be used as a photosensitizer for photodynamic therapy (PDT) of tumors, which could be enhanced by O2 generated in CDT. Furthermore, the FeNC@PAA nanoparticles were also found to be effective in photothermal therapy (PTT) with a photothermal conversion efficiency of 29.15%, owing to a high absorbance in the near-infrared region (NIR). In conclusion, the synthesized FeNC@PAA nanoparticles exhibited promising applications in O2 evolution and CDT/PDT/PTT synergistic treatment of tumors.
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CORROSION SCIENCE
·
2020
·
IF 6.479
Junying Hu,Qi Xiong,Longjun Chen,Chenfeng Zhang,Ziqi Zheng,Shuai Geng,Zhi Yang,Xiankang Zhong
The corrosion inhibition of carbon steel in CO 2 -O 2 -containing environment is one of the biggest challenges in flue gas injection for enhanced oil recovery. Herein we report the possibility to use Bis(2-ehylhexyl) phosphate (BEP) to inhibit the corrosion in CO 2 -O 2 -containing solution and simultaneously the inhibition mechanisms are unmasked. The results show that the corrosion is greatly inhibited with 500 ppm BEP in 1 wt% NaCl solution with 0.02 MPa CO 2 and 3 mg/L O 2 . BEP could interact with Fe and corrosion products via the formation of P-O-Fe bond and P-Fe bond to generate a barrier layer, thus, offering a protective performance.
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JOURNAL OF POWER SOURCES
·
2020
·
IF 8.247
Ying Wang,Dan Li,Siqi Zhang,Ziye Kang,Haiming Xie,Jia Liu
Although dual redox mediators (RMs) largely promote the discharge capacity and decreases the charge overpotential in Li-O 2 batteries , the shuttle effect leads to a RM degradation and a serious deterioration of Li metal, which results in a poor sustainability. Here, a poly (3,4-ethylenedioxythiophene):poly (styrenesulfonate) (PEDOT:PSS) -decorated separator has been firstly introduced into a dual mixture RMs-involved Li-O 2 system, which restrains the shuttle effect via coulombic interactions. Benefiting from the advantages of as-prepared separator, a cell exhibits an enhanced cycling stability and a good reversibility associated with the Li 2 O 2 formation and decomposition during cell cycling. These results represent a promising progress in the development of an easy-to-operate modified separator for a highly efficient Li-O 2 battery.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2018
·
IF 4.61
Sharafat Ali,Izaz Ali Shah,Aziz Ahmad,Javed Nawab,Haiou Huang
In this study, pristine multi-walled carbon nanotubes (MWCNTs) were functionalized by using Ar/O 2 plasma treatment technique, which enhanced adsorptive membrane filtration of zinc ions from water and wastewater. The XPS analysis showed that plasma treatment largely increased the surface oxygen groups content of MWCNTs from 2.78% to 6.79%. This change increased the surface negative charged, dispersion and adsorption properties of MWCNTs without causing any damages to the integrity of the nanotube pattern. Pressure-driven filtration of plasma-treated MWCNT (P-CNT) dispersion formed a stable layer inside the lumen of a hollow fiber membrane. The contact angle analysis demonstrated that after incorporation of P-CNT into the HF membrane increased membrane hydrophilicity. The P-CNT membrane effectively removed almost 100% of zinc from synthetic waters and approximately 80% of zinc from a wastewater effluent by surface complexation reaction. A follow-up regeneration study demonstrated that the adsorptive removal of zinc by the CNT membrane was reversible under selected conditions, thus making it possible to repeatedly use the membrane for long-term zinc filtration. This study suggests that HF membranes modified with P-CNTs possess superb adsorption properties for metal ions , allowing the operation of CNT membranes for water treatment .
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CHEMICAL ENGINEERING JOURNAL
·
2013
·
IF 3.473
Xiaofeng Xu,Peng Liao,Songhu Yuan,Man Tong,Mingsen Luo,Wenjing Xie
A novel Pd-based electro-Fenton process has recently been developed to degrade organic contaminants in wastewaters and groundwater. However, the high cost of Pd catalyst limits the application of this process. In this study, Cu supported on bamboo charcoal (Cu/C) was synthesized to evaluate the feasibility of substituting Pd catalysts. Using phenol as a probe organic contaminant, the performance of Cu/C catalyst was evaluated for the electro-Fenton degradation of phenol in a typical undivided electrolytic system. The electrochemical degradation of phenol in the presence of Cu/C was significant, following a pseudo-first-order kinetics with rate constant ( k 1 ) of 0.008 min −1 . The addition of Fe 2+ remarkably enhanced the degradation ( k 1 = 0.012 min −1 ). H 2 O 2 and OH were validated as the reactive oxidizing species (ROSs), and OH was the main ROS contributing to phenol degradation. The as-synthesized Cu/C consisting of Cu, CuO and Cu 2 O could catalyze the production of H 2 O 2 from chemisorbed H 2 and O 2 as well as the decomposition of H 2 O 2 to OH. Particularly, the addition of Fe 2+ facilitated the transformation of H 2 O 2 to OH. Phenol degradation increased with increasing the current from 5 to 50 mA and decreased with the further increase to 100 mA. The degradation improved with the increase in Cu loadings and the decrease in solution pH. The presence of NaNO 3 , Na 2 SO 3 or Na 2 S inhibited the degradation, while the presence of NaCl increased the degradation. Although the activity of Cu/C is much lower than that of Pd/C for phenol degradation, the cost of Cu/C is much lower.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Yunxiang Bai,Xinxue Qiu,Deqiang Chen,Junwei Zheng,Liangliang Dong,Chunfang Zhang
Magnetic mixed matrix membranes (MMMs) show great potential for enhancing O 2 /N 2 separation efficiency by leveraging the inherent magnetic property differences between O 2 (paramagnetic) and N 2 (diamagnetic). However, one of the major challenges is the establishment and precise control of magnetic channels between magnetic fillers and polymer matrix. To address this issue, herein, ZIF-8 wrapped Fe 3 O 4 nanoparticles (Fe 3 O 4 @ZIF-8) were synthesized using a step-by-step assembly method, and then integrated into polymer of intrinsic microporosity (PIM-1) matrix to develop MMMs with well-defined magnetic channels for O 2 /N 2 separation. In comparison with Fe 3 O 4 , Fe 3 O 4 @ZIF-8 nanoparticles exhibited significantly enhanced compatibility with the polymer matrix, thereby facilitating uniform dispersion and improving interfacial adhesion. Gas permeation experiments revealed that the magnetic PIM-1/Fe 3 O 4 @ZIF-8 MMMs demonstrated enhanced O 2 /N 2 separation performance due to the combined effects of magnetic responsiveness and the presence of ZIF-8 magnetic channels. Under a magnetic field strength of 56mT, the magnetic MMM with a 4 wt% loading of Fe 3 O 4 @ZIF-8 exhibited optimal O 2 /N 2 separation performance with O 2 permeability of 710 Barrer and O 2 /N 2 selectivity of 3.64. These values represented a significant improvement of 42% and 24%, respectively, compared to pure PIM-1 membrane. Moreover, the simultaneous improvement of permeability and selectivity enabled the achievement of Robeson’s 2008 upper bound for O 2 /N 2 separation, underscoring the great potential of Fe 3 O 4 @ZIF-8 nanoparticles for designing magnetic MMMs with favorable structural attributes and exceptional separation efficiency.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Shengqi Ding,Liang Wu,Xianxia Yuan
Electrocatalysts with appropriate electron coupling toward LiO 2 intermediates can exhibit superior oxygen reduction/evolution reaction kinetics in Li-O 2 batteries (LOBs). In this work, a charge redistribution strategy has been developed by constructing NiS/MoS 2 heterostructure nanosheet self-assembled hollow microspheres with an internal electric field to regulate the interaction with LiO 2 and then improve the electrochemical performance of LOBs. Density functional theory calculations and physicochemical characterizations reveal that the difference of work functions between NiS and MoS 2 promotes the electron redistribution in heterointerface via built-in electrical field, leading to increased electron density of interfacial Ni atom, thereby enhancing its electron coupling toward LiO 2 intermediates and promoting one-electron oxygen reduction/oxidation reaction kinetics. As a result, the NiS/MoS 2 -based LOBs exhibit evidently higher discharge capacity and much better cycling performance than the batteries using NiS and MoS 2 . This work provides a reliable charge redistribution strategy induced by build-in electric field to design efficient catalysts for LOBs.
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