CHEMICAL ENGINEERING JOURNAL
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2023
·
IF 15.1
Jian-Li Chen,Xiao-Hui Jia,Xinyue Xia,Xuan Wu,Yan-Neng Xu,Gang Yuan,Ze-Yun Gu,Kathy Qian Luo,Ming-Heng Yuan,Ruibin Jiang,Jianfang Wang,Xiao-Ming Zhu
Autophagy induction is responsible for the chemoresistance of histone deacetylase (HDAC) inhibitors. The combination of HDAC inhibitors with autophagy inhibitors has been considered a new strategy for treating solid tumors. However, codelivery systems capable of transporting these two kinds of drugs with different physicochemical properties and the simultaneous release of drugs remain elusive. In this study, hollow zirconium dioxide (ZrO 2 ) nanoshells were synthesized to encapsulate both the autophagy inhibitor chloroquine (CQ) and the HDAC inhibitor vorinostat (Vor) for effective combinational cancer therapy. The ZrO 2 nanoshells showed high loading capacities for both CQ and Vor due to the high affinity of ZrO 2 for the phosphate and hydroxamic acid groups of the drugs, and the drug-loaded ZrO 2 nanoshells exhibited a controlled release profile. The intrinsic autophagy inhibitory effect of the ZrO 2 nanoshells enhanced the effect of either the single drug (CQ or Vor) or the combination of these two drugs. The codelivery system enhanced the autophagy inhibition and hyperacetylation level in the cells compared with free drugs, resulting in a superior antitumor effect in 4T1 tumor-bearing mice. Taken together, the multifunctional ZrO 2 nanoshells hold great potential for the codelivery of HDAC and autophagy inhibitors for solid tumors therapy.
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高影响因子
CHEMOSPHERE
·
2023
·
IF 8.8
Xiandong Wang,Yu Liu,Xinghui Zhang,Wenqing Tu,Qiyu Wang,Shuai Liu,Miao Zhang,Yongming Wu,Bixian Mai
As emerging alternatives to perfluorooctane sulfonate (PFOS), 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) and sodium p -perfluorous nonenox-benzenesulfonate (OBS) were frequently detected in the four freshwater fish species collected from Poyang Lake. Median concentrations of 6:2 Cl-PFESA and OBS in fish tissues were 0.046–6.0 and 0.46–5.1 ng/g wet weight, respectively. The highest concentrations of 6:2 Cl-PFESA was found in fish livers, whereas OBS was found in the pancreas, brain, gonads, and skin. The tissue distribution pattern of 6:2 Cl-PFESA is similar to that of PFOS. The tissue/liver ratios of OBS were higher than those of PFOS, suggesting that OBS has a greater tendency to transfer from the liver to other tissues. The logarithmic bioaccumulation factors (log BAFs) of 6:2 Cl-PFESA in three carnivorous fish species were greater than 3.7, whereas those of OBS were less than 3.7, indicating that 6:2 Cl-PFESA had a strong bioaccumulation potential. Notably, sex- and tissue-specific bioaccumulation of OBS has also been observed in catfish. Most tissues (except the gonads) exhibited higher OBS concentrations in males than in females. However, no differences were found for 6:2 Cl-PFESA and PFOS. Maternal transfer efficiency of OBS was higher than that of 6:2 Cl-PFESA and PFOS in catfish ( p < 0.05), indicating that OBS presents a higher risk of exposure to males and offspring through maternal offloading.
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高影响因子
Bio-Design and Manufacturing
·
2023
·
IF 7.9
Lu Jingyi,Sun Miao,Zhang Jingyu,Yang Xiaofu,Dong Minyi,He Huihui,Liu An,Yu Mengfei,Wang Baixiang,Wang Huiming
Regeneration and reconstruction of bone tissue is always a challenge for clinicians due to the uncertainty of bone repair materials in terms of long-term and efficient effects on osteoblasts. Here, we propose a novel strategy combining benidipine, an antihypertensive drug and nanoparticles to synergistically promote the healing of bone defects. Loose and porous benidipine-loaded magnesium silicate nanoparticles were prepared and validated for their biosafety. The nanoparticles were efficiently taken up by preosteoblasts and uniformly distributed around the nucleus. After internalization into cells, the nanosystem is degraded by lysosomes, and the effect of promoting osteogenic differentiation is reflected by the continuous release of benidipine, silicon and magnesium ions. Our results clearly evaluated that the nanoflower-like magnesium silicate delivering benidipine tends to be more appropriate for the bone regeneration in preosteoblasts, indicating that it might be a potential approach in guiding bone repair in clinical applications. Graphic abstract
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2023
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IF 4.4
Yansheng Liu,Zhenle Qin,Xiaobo Jia,Jin Zhou,Hongli Li,Xiaohong Wang,Yating Chen,Junpeng Deng,Zhicheng Jin,Guofu Wang
The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a great disaster to the economy and human society. Nowadays, SARS-CoV-2 is fading away from people’s memory but it still exists around us. PCR plays an important role in detecting SARS-CoV-2 but it requires a long detecting time, equipped laboratory, and professional operators. In comparison with polymerase chain reaction (PCR), surface-enhanced Raman scattering (SERS) is a promising method for detecting SARS-CoV-2 due to its fast, easily operated, and high-sensitivity properties. In this study, the monolayer Ag nanoparticles (MAgNPs) covered with single-layer graphene (SLG) are applied as a SERS substrate. The angiotensin converting enzyme 2 (ACE2) is selected as a bio-probes that can specifically bind to the SARS-CoV-2 S protein. The SERS-based biosensor is formed by ACE2 functionalized SLG/MAgNPs and the LODs of detecting SARS-CoV-2 S protein in phosphate-buffered saline (PBS) and in pharyngeal swabs solution (PSS) are 0.1 fg mL −1 and 10 fg mL −1 , respectively. This biosensor provides a way of directly detecting SARS-CoV-2 S protein with high sensitivity and specificity. It illustrates a practical potential in the rapid detection of the SARS-CoV-2 virus.
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高影响因子
ENERGY
·
2023
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IF 9
Hongming Fu,Yubin Shen,Zhaohao Li,Heng Zhang,Haiping Chen,Dan Gao
The application of membrane absorption for CO 2 capture has been limited by membrane wetting. In this paper, tubular Al 2 O 3 ceramic membranes (marked as M1 and M2) are hydrophobically modified by sol-gel and dip-coating method and then used for CO 2 capture. The surface morphology , surface composition, wettability and flux are characterized in detail. The mass transfer performance of M1 and M2 is studied at different gas and liquid Reynolds numbers . After modification, the surface contact angle can reach as high as 170.7°. The carbon capture performance of the modified M1 and M2 is significantly improved. Under laminar flow condition , CO 2 mass transfer coefficient increased from the initial 1.03 × 10 −4 m/s to 14.59 × 10 −4 m/s, and the CO 2 capture efficiency increased from the initial 28.55%–98.55%. The mass transfer resistance of ceramic membrane contactor is also analyzed. The resistance of liquid phase plays a leading role in the mass transfer performance in laminar flow state . For non-wetting membrane, membrane thickness has little effect on the mass transfer performance. In addition, it is shown that the superhydrophobic M1 and M2 exhibit excellent corrosion resistance . The research in this paper shows that superhydrophobic ceramic membrane is more suitable for CO 2 capture in industrial production.
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高影响因子
Materials
·
2023
·Vol. 16
·期 17
·5785
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IF 3.4
Weiran Zhang,Ziyu Li,Guohua Wu,Wei Wu,Hailan Zeng,Haiyun Jiang,Weili Zhang,Ruomei Wu,Qiong Xue
The utilization of Co-Cr-Fe-based black pigments bears considerable significance within the realm of commercial ceramic pigments, owing to their distinctive spinel structure, remarkable high-temperature stability, and exceptional chromatic attributes. This study delves into the synthesis of diverse black pigment configurations by employing the co-precipitation method, leveraging the interplay of these three metallic oxides. This investigation encompasses a comprehensive scrutiny of ion valences, crystal structures and parameters, colorimetric properties, and their interrelationships. The methodology integrates the response surface methodology (RSM) framework, using theoretical formulations to navigate the material ratios and elucidating the associations between the resultant compositions and color coordinate values, aligned with the CIE-Lab* colorimetric methodology. The derived predictive models yielded an optimized black pigment composition, characterized by heightened black intensity and a refined formulation.Keywords:black ceramic pigment;response surface methodology;co-precipitation method;chromatic properties;spinel
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高影响因子
Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 34
·8228-8240
·
IF 7
Weiwei Fei,Xiuli Wang,Jia Guo,Changchun Wang
The design of targeting agent-conjugated systems is attracting much attention in cell targeted delivery and cancer therapy. However, quantitative study of the ligand density and binding efficiency is still limited due to the technical matters and tedious work involved. In this article, benzoboroxole-modified core–shell magnetic nanoparticles (MSP-AOPB NPs) as a drug carrier model were fabricated and transferrin (Tf) was immobilized on the nanoparticle surface in a site-oriented manner (Tf-MSP-AOPB NPs). The preparation conditions were investigated in detail to optimize the Tf binding efficiency. A suitable reaction temperature, time or initial feeding amount could significantly increase the Tf binding amount. The maximum Tf binding amount on the MSP-AOPB NPs was 184 mg g−1, and the targeting ligand density on the surface could be well controlled by simply adjusting the reaction conditions. In vitro studies demonstrated the excellent Tf-mediated targeting ability and enhanced cellular uptake efficacy by varying the ligand density. The optimal ligand binding amount for achieving the highest cellular uptake efficiency was 94 mg Tf/g, which corresponds to a ligand binding density of about 0.05 Tf/nm2, and the binding efficiency of conjugation was higher than 90%. Moreover, Tf-MSP-AOPB NPs prepared by a site-oriented conjugation strategy showed the best cell targeting ability, and their cellular uptake amount was 25 and 127 times higher than that of physical adsorption and EDC/NHS coupling reaction in HepG2 cells, respectively. This study provides a facile site-oriented bioconjugation technique for different kinds of antibodies, and a suitable ligand density can be easily attained to enhance the cellular uptake efficacy, which shows great significance for targeted delivery and cancer therapy.
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高影响因子
MINERALS ENGINEERING
·
2023
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IF 4.8
Lei Hou,Alejandro López Valdivieso,Peng Chen,Guowei Zhang,Qi Zhang,Yu Chen,Shaoxian Song,Feifei Jia
Ammonia-free thiosulfate systems are known for their non-toxicity, low reagent consumption, and excellent leaching efficiency in gold extraction studies. This study proposes a novel and environmentally friendly glycine-thiosulfate system and comprehensively investigates the dissolution behavior of gold through the application of electrochemical methods. Electrochemical quartz crystal microbalance (EQCM) has demonstrated that the anodic dissolution of gold is predominantly influenced by the forms of copper(II)-glycine complexes as catalysts, and the presence of Cu(C 2 H 4 NO 2 ) 3 − complex in strong alkaline has enhanced dissolution rate of gold, in contrast to Cu(C 2 H 4 NO 2 ) 2 0 complex in near-nurture condition. Such excellent catalytic capability of the Cu(C 2 H 4 NO 2 ) 3 − complex for gold dissolution can be attributed to the lowest corrosion potential, slighter passivation behavior, and rapid electron transfer from the analysis of corrosion electrochemistry (OCP, PDP, and EIS) and advanced spectrum technologies (LA-ICP-MS and XPS). The dissolution of gold in the novel glycine-thiosulfate system undergoes a typical ligand exchange process (Au + →Au(C 2 H 4 NO 2 ) 2 − →Au(S 2 O 3 ) 2 3− ), and the formation of passivation species on the gold surface is predominantly formed by Au(I)-glycine coordination, rather than the sulfur-containing products from thiosulfate decomposition. Based on these results, the proposed two electrochemical reaction mechanisms will contribute to the optimization of leaching conditions in the novel glycine-thiosulfate system.
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Journal of Energy Storage
·
2023
·
IF 9.4
Lan Jiang,Xiaowu Hu,Guangbin Yi,Shikun Xiao,YuQiong Xie,Bin Chen,Jue Wang,Zezong Zhang,Wenjing Chen,Qinglin Li,Xiongxin Jiang
As a solution to the conflict between energy supply and demand, phase change materials (PCMs) could preserve and release energy. However, traditional PCMs suffer from low thermal conductivity and photo-thermal conversion efficiency. This paper reported a method to prepare carbonized polydopamine (PDA)-modified silica aerogel-based (CPS) shape-stable composite phase change materials (ss-PCMs) via carbonizing PDA coating at different temperatures in order to increase the thermal conductivity and photo-thermal conversion efficiency of composite PCMs. The ss-PCMs made from the carrier materials prepared by carbonization at 400, 600, and 800 °C compounded with polyethylene glycol (PEG) were named PEG/400CPS, PEG/600CPS, and PEG/800CPS respectively. It was found that the carbon layer-modified silica aerogel carriers with excellent three-dimensional (3D) porous structure could more effectively absorb the molten PEG (reach 75 %). Particularly, the carbonization temperature was found to determine the degree of carbonization of PDA. When the carrier carbonization temperature reached 600 °C, PEG/600CPS demonstrated a relative thermal efficiency of 97.7 %, with the greatest thermal cycling performance and photo-thermal conversion performance among the series of ss-PCMs created. In this work, our study provided valuable insight into the design of high-performance CPS-based ss-PCMs and demonstrated the manner in which they could be utilized for solar energy storage.
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高影响因子
MOLECULES
·
2023
·Vol. 28
·期 14
·5573
·
IF 4.6
Ling-Xiao Chen,Shi-Jun Yin,Tong-Qing Chai,Jia-Li Wang,Guo-Ying Chen,Xi Zhou,Feng-Qing Yang
A core–shell-derived structural magnetic zeolite imidazolate framework-67 (Fe3O4[email protected]) nanocomposite was fabricated through a single-step coating of zeolite imidazolate framework-67 on glutaric anhydride-functionalized Fe3O4nanosphere for the magnetic solid-phase extraction (MSPE) of theophylline (TP). The Fe3O4[email protected]nanocomposite was characterized through scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray spectrometry, Fourier transform infrared spectroscopy, Zeta potential analysis, X-ray diffraction, Brunauer–Emmett–Teller, and vibrating sample magnetometer. The material has a high specific surface area and good magnetism, which maintains the regular dodecahedron structure of ZIF-67 without being destroyed by the addition of Fe3O4-COOH nanospheres. The Fe3O4[email protected]can rapidly adsorb TP mainly through the strong coordination interaction between undercoordinated Co2+on ZIF-67 and –NH from imidazole of TP. The adsorption and desorption conditions, such as the amount of adsorbent, adsorption time, pH value, and elution solvent, were optimized. The kinetics of TP adsorption on Fe3O4[email protected]was found to follow pseudo-second-order kinetics. The Langmuir model fits the adsorption data well and the maximum adsorption capacity is 1764 mg/g. Finally, the developed MSPE-HPLC method was applied in the enrichment and analysis of TP in four tea samples and rabbit plasma. TP was not detected in oolong tea and rabbit plasma, and its contents in jasmine tea, black tea, and green tea are 5.80, 4.31, and 1.53 μg/g, respectively. The recoveries of spiked samples are between 74.41% and 86.07% with RSD in the range of 0.81–3.83%. The adsorption performance of Fe3O4[email protected]nanocomposite was nearly unchanged after being stored at room temperature for at least 80 days and two consecutive adsorption–desorption cycles. The results demonstrate that Fe3O4[email protected]nanocomposite is a promising magnetic adsorbent for the preconcentration of TP in complex samples.Keywords:magnetic zeolite imidazolate framework;core–shell-derived structure;theophylline;magnetic solid-phase extraction;tea
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Yuanyuan Yang,Xiaohui Liu,Shuang Meng,Shun Mao,Wenquan Tao,Zhuo Li
A molecularly imprinted polymers (MIPs)-isolated AuNP-enhanced fluorescence sensor, AuNP@MIPs-CdTe QDs, was developed for highly sensitive and selective detection of oxytetracycline (OTC) in aqueous medium. The developed sensor combined the advantages of strong fluorescence signal of metal-enhanced fluorescence (MEF), high selectivity of MIPs, and stability of CdTe QDs. The MIPs shell with specific recognition served as an isolation layer to adjust the distance between AuNP and CdTe QDs to optimize the MEF system. The sensor demonstrated the detection limit as low as 5.22 nM (2.40 μg/L) for a concentration range of 0.1–3.0 μM OTC and good recovery rates of 96.0–103.0% in real water samples. In addition, high specificity recognition for OTC over its analogs was achieved with an imprinting factor of 6.10. Molecular dynamics (MD) simulation was utilized to simulate the polymerization process of MIPs and revealed H-bond formation as the mainly binding sites of APTES and OTC, and finite-difference time-domain (FDTD) analysis was employed to obtain the distribution of electromagnetic field (EM) for AuNP@MIPs-CdTe QDs. The experimental results combined with theoretical analyses not only provided a novel MIP-isolated MEF sensor with excellent detection performance for OTC but also established a theoretical basis for the development of a new generation of sensors.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Jing Zhang,Yi Shen,Chenge Liang,Huiyu Yi,Jining Liu,Yungui Li,Qingqing Li,Qile Fang
In response to phosphorus pollution, developing functional materials for phosphate adsorption is an ideal method to reach an ultralow phosphate concentration in effluent. Herein, a hexagon flower-shaped architecture constructed of Fe-composited lanthanum (La)-based hydroxide nanosheets was fabricated from LaFe cyano-bridged metal frameworks (CMs) via a self-templating strategy using NH 3 ‧H 2 O as the conversion reagent. The ion exchange process using weak alkaline reagent enables the formation of secondary nanosheets on the architecture, thus leading to a high surface area and a large number of mesopores that provide abundant active sites and mass transfer channels for phosphate adsorption. A superior adsorption capacity of 127.5 mg P/g can be obtained on the La/Fe-based architecture, which also shows satisfactory applicability over a wide pH range. A ligand exchange between -OH and phosphate ions is verified as the main adsorption mechanism, which properly accounts for its excellent selectivity for phosphate adsorption when coexisting with other anions/cations and natural organic matters . Overall, the present study provides a new method for constructing porous La-based hydroxide materials for phosphorus control in water.
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