JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·
IF 12.6
Xuejun Chen,Shaoyue Li,Qing Lu,Yitong Li,Mingrui Zhu,Shen Zhang,Yan Fang,Congjian Wen,Daohui Yang,Peili Fan,Huixiong Xu,Haohao Yin
Immunogenic cell death (ICD) significantly boosts anti-tumor immunotherapy effectiveness; however, the recruitment of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), driven by factors such as adenosine accumulation and oxygen depletion during ICD, impairs the overall therapeutic outcome as well as facilitates tumor development and metastasis. Recent studies identify CD300ld as a key regulator of PMN-MDSCs recruitment, making it a promising immunotherapeutic target. Here, an innovative strategy is developed to eminently amplify ICD while alleviating PMN-MDSC infiltration upon ultrasound (US) stimulation. A modified generation 5 (G5) poly(amidoamine) dendrimer (G5PBA) was employed to encapsulate hematoporphyrin (GH)-a widely used organic sonosensitizer-and modified the complex with pardaxin peptides (Par) to achieve precise endoplasmic reticulum (ER) targeting, and adsorbed the negatively charged siCD300ld (PGH@siRNA). Under US irradiation, PGH@siRNA precisely accumulates at ER to induce localized reactive oxygen species (ROS) bursts, and effectively silence CD300ld, thereby amplifying endoplasmic reticulum stress (ERS)-mediated ICD and reducing PMN-MDSCs infiltration to reshape the tumor microenvironment. This systematic preclinical evaluations demonstrated enhanced immune activation, suppressed metastasis, and improved therapeutic outcomes. This study introduces a sono-responsive synergistic strategy integrating ER-targeted sonodynamic therapy with gene silencing, offering a novel paradigm for targeting PMN-MDSCs and enhancing triple-negative breast cancer (TNBC) immunotherapy.
研究领域:
癌症免疫治疗
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纳米医学
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分子生物学
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生物医学工程
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活性氧信号传导
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产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 12
·855
·
IF 5.3
Li Jianlong,Zhang Jinmi,Hu Maoyuan,Jin Yao,Li Sheng,Xiong Xiaoli
As the most active antioxidant in the flavonol family, quercetin (QR) exhibits favorable biochemical and pharmacological properties. Therefore, rapid and accurate determination of QR is of great importance. In this study, a π-conjugated molecule, 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP) was employed to in-situ grow a conductive metal-organic framework (MOF) on CuCo-zeolitic imidazolate framework (CuCo-ZIF) by a simple one-step solvothermal coating method. This design enhances electron transfer, ultimately yielding a bimetallic MOF-on-MOF hybrid material (CuCo-ZIF@HHTP). The introduction of Cu improves the conductivity of the ZIF framework, while the π-π conjugation characteristic of HHTP further boosts the electrocatalytic performance of CuCo-ZIF. As an electroctalytic eletrode, an electrochemical sensor for sensitive detection of QR was developed, which exhibited excellent linear responses in two concentration ranges (0.25–35 µM and 35–155 µM) with an extremely low limit of detection (LOD) of 7.5 nM (S/ N = 3). The sensor also demonstrated high selectivity and reproducibility, with successful application in the quantification of QR in food samples. Graphical A π-conjugated HHTP was coated on CuCo-ZIF via one-step solvothermal method to form CuCo-ZIF@HHTP with Cu enhancing conductivity and HHTP's π-π conjugation boosting electrocatalysis for sensitive QR detection in food samples.
研究领域:
电化学
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食品科学与技术
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分析化学
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纳米材料
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传感器与生物传感器
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2025
·Vol. 60
·期 48
·25762-25778
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IF 3.9
Shehu Mustapha Sani,Saeed Alaaddin M. M.,Cao Gui-Ping,Al-Fatesh Ahmed S.,Alreshaidan Salwa B.,BaQais Amal,Zhang Qi-Jia,Wang Chun-Xue,He Xin-Yi
In this study, a novel rhodium nanocatalyst was developed through the immobilisation of rhodium nanoparticles onto multi-walled carbon nanotube substrates (Rh/MWCNTs), demonstrating high catalytic efficiency in the hydrogenation of styrene–butadiene rubber (SBR). The catalytic process led to the formation of a novel cyclic block rubber (CBR). The Rh/MWCNTs catalyst demonstrated exceptional activity, enabling the complete hydrogenation of both the aromatic benzene units and the aliphatic C = C bonds present in the SBR backbone. High-resolution transmission electron microscopy (HRTEM) confirmed the uniform dispersion and stable immobilisation of Rh nanoparticles across the MWCNTs surface. The catalyst’s excellent activity, coupled with its high stability and reusability, indicates its effectiveness in mitigating diffusion constraints and enhancing the interaction between catalytic sites and the polymer matrix. The successful conversion of SBR to fully hydrogenated CBR was corroborated by nuclear magnetic resonance (1H-NMR and 13C-NMR) and Fourier-transform infrared (FTIR) spectroscopy. Thermogravimetric analysis (TGA) revealed enhanced thermal stability of the synthesised CBR relative to the parent SBR. While a significant thermal degradation for SBR occurred at 360.5 °C, CBR remained stable up to 409.2 °C. Furthermore, differential scanning calorimetry (DSC) analysis showed that SBR had lower Tg values (− 45.1 °C heating, – 54.9 °C cooling), reflecting greater chain flexibility, whereas hydrogenated CBR exhibited higher Tg (− 33.4 °C, − 34.4 °C), confirming the enhanced thermal characteristics introduced by the hydrogenation process.
研究领域:
材料科学
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催化化学
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高分子化学
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纳米技术
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化学工程
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2025
·Vol. 60
·期 48
·25741-25761
·
IF 3.9
Gao Ningning,Pan Yucheng,Huang Wei,Xin Qingping,Zhang Min,Wu Jiaxin,Wu Dengdi,Wang Mengke,Ding Xiaoli,Lin Ligang,Zhang Yuzhong
Due to its benefits of low energy consumption, minimal environmental pollution, and simple operation, membrane technology is considered a carbon capture technology with extensive application possibilities. In this study, the ultraviolet cross-linking method is used to inhibit crystallization of polymers with a molecular weight of less than 1500 and enable polyethylene oxide (PEO) to form a rubbery polymer matrix. This approach avoids membrane separation defects and low CO 2 solubility caused by high crystallinity. The hydroxyl-rich surface of layered double hydroxide (LDH) is used to provide the CO 2 -philic site in the form of “docking station-like” by introducing amino groups with a strong affinity for CO 2 , and forming a dual facilitated transport channel through the nanosheet interlayer channel and the presence of bound water to strengthen the reaction mechanism of the membrane. Based on the coupling of solubility-diffusion and facilitated transport mechanisms, the optimal separation performance is achieved when the NH 2 -PDA-LDH doping is 0.4 wt%, with a CO 2 permeability of 572.4 Barrer and a selectivity of up to 60.5. The interlayer fast transport channels result in a maximum permeability of 3982 Barrer in the wet state. Graphical
研究领域:
材料科学
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膜技术
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碳捕集与封存
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高分子化学
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环境工程
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DOI
高影响因子
Nature Communications
·
2025
·
IF 15.7
Xu Bing,Wu Wenting,Zhang Yingxin,Qiu Chenglong,Zhu Yue,Wu Jingyi,Tian Weiqian,Huang Minghua,Wang Huanlei,Lee Pooi See,Chen Jingwei
Reversible metal electrodeposition-based electrochromic devices (RMEDs) with broadband regulation manifest great promises as smart windows to increase building energy efficiency. However, manufacturing durable and scalable RMEDs at an agreeable cost is still challenged by the limited reversibility of interfacial plating (tinting)/stripping (bleaching). Here, we report a quasi-solid-state hydrogel electrolyte with well-tuned Cu:Zn ratio and pH values to achieve highly reversible CuZn-RMEDs. The dual-metal CuZn electrolyte ensures staged nucleation and homogeneous CuZn growth, and the appropriate pH guarantees effective stripping of CuZn metal layers, thus attaining reduced metal deposition activation energy (6.7 kJ mol -1 ), increased coloration efficiency, large transmittance modulation (ΔT = 78% @550 nm), and excellent reversibility (ΔT retention over 90% after 3000 cycles). In addition, the quasi-solid-state hydrogel matrix with abundant molecular chains can inhibit strong hydrogen bonds in aqueous electrolyte, achieving anti-freezing (−20°C) and leakage-free CuZn-RMEDs with fast switching kinetics (coloration time t c = 15.0 s, bleaching time t b = 24.0 s), extended memory effect, efficient thermal insulation, and effective reusability (2000 cycles) of both the transparent conductor and hydrogel electrolyte. The as-assembled CuZn-RMEDs manifest 18% to 33% energy saving across different climatic regions. This quasi-solid-state CuZn-RMED is a successful embodiment of cost-effective and durable electrochromic smart windows towards increasing buildings’ energy efficiency.
研究领域:
材料科学
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电化学
·
智能建筑技术
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能源效率
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可持续材料
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2025
·Vol. 40
·期 6
·1563-1571
·
IF 1.1
Cao Wenjing,Liu Yiming,Zhao Dongmei,Wan Xiaobo,Liu Yang,Huang Kun,Shi Minxian
A Ti 3 SiC 2 -modified high-silica oxygen/phenolic aerogel composite with excellent oxidation resistance and high-temperature performance was prepared. The experimental results show that the obtained composite has significantly improved oxidation resistance. When the addition amount of Ti 3 SiC 2 is 75%, the carbonization volume shrinkage rate of the composite after aerobic static combustion is only 5.95%. At the same time, the LAR and MAR after 30 seconds of oxyacetylene ablation under a heat flux density of 1.5 MW/m 2 are 0.0307 mm/s and 0.0149 g/s, respectively. The compressive strength after aerobic static combustion at 1 000 °C is up to 20.43% of that before aerobic static combustion, which is 1.99 times that of the unfilled material, significantly improving the high-temperature mechanical properties of the composite.
研究领域:
材料科学
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航空航天工程
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陶瓷基复合材料
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热防护系统
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产品关联
DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2025
·
IF 3.1
Guan Chuheng,Jia Yumeng,Shi Zhongxiang,Wang Jing,Dong Yingnan,Wang Zhihui
The present paper details the preparation of CaAl 12- x O 19 : x Mn 4+ (CAO: Mn 4+ ) red phosphors based on CaAl 12 O 19 using a high-temperature solid-state method through Mn ion doping. A range of analytical techniques, including X-ray diffraction (XRD), scanning electron microscopy (SEM) and fluorescence spectroscopy, to comprehensively investigate the crystal structure, microstructure and photoluminescence characteristics of the samples. The results demonstrate that the doped Mn 4+ ions enter the octahedral sites of Al 3+ , and the lattice constants of the matrix does not change significantly because the ionic radius of the doped Mn 4+ ions is equivalent to the size of the Al 3+ ions. On this basis, the lattice size and lattice strain were calculated using the W-H equation. The results show that as the doping concentration gradually increases, both the lattice size and strain exhibit a slowly increasing trend. The prepared phosphor exhibited a polyhedral morphology, characterised by two hexagonal prisms with irregular hexagonal end faces, a substantial particle size, and optimal dispersion. When exposed to near ultraviolet light at a wavelength of 349 nm, the photoluminescence spectrum displays narrow-band emission characteristics, with the central wavelength of the emission peak at 654 nm and the full width at half maximum (FWHM) of 40.706 nm. The emission peak is attributed to the transition from 2 E g to 4 A 2g of Mn 4+ in a strong crystal field. With the increase of Mn 4+ doping concentration, the fluorescence intensity first increases and then decreases, and the fluorescence intensity is the highest when the doping concentration is 1.2 mol%. The analysis yielded three emission peaks, which were separated by the peak separation method. These peaks correspond to the emission of Mn 4+ at three different octahedral points of Al 3+ . The integrated area ratio of the three peaks indicates that Mn 4+ is predominantly present on the symmetrical sites. Thermal stability analysis demonstrates that the emission intensity of the phosphor decreases rapidly due to three factors. Firstly, the size of the Mn 4+ ions is smaller than the octahedral gap size. Secondly, the energy is higher. Thirdly, no radiation transition intensifies with the increase of temperature. The colour purity calculation indicates that the red phosphor prepared has a colour purity of over 99%. At the same time, the color temperature is below 6000k, which renders it suitable for indoor plant cultivation.
研究领域:
材料科学
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发光材料
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固态化学
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光学材料
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荧光粉技术
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产品关联
DOI
PubMed
高影响因子
HEREDITAS
·
2025
·Vol. 162
·期 1
·232
·
IF 2.5
Xiaohui Yu,Jie Li,Jiangqiao Zhou
Background Coptisine (COP) is a natural compound extracted from Rhizoma Coptidis , and it represses the malignant biological behaviors of bladder cancer cells. However, the underlying molecular mechanism has not been fully elucidated. The aim of this study was to clarify the downstream mechanism by which COP treats bladder cancer. Materials and methods SwissTargetPrediction, STITCH, SymMap, ETCM, TCMSP, CTD databases were used to collect the related targets of COP. GeneCards, DisGeNET, TTD and OMIM databases were used to obtain the related targets of bladder cancer. A Venn diagram was used to identify the potential targets of COP in bladder cancer treatment. The protein-protein interaction network was constructed using STRING database, and Cytoscape 3.9.0 software was used to screen the hub targets. The binding relationship between COP and the hub targets was verified by molecular docking and molecular dynamics simulation. After the bladder cell lines T24 and BIU-87 were treated with different doses of COP, the regulatory effects of COP on PI3K/AKT pathway were investigated with western blotting. Additionally, the tumor-suppressive properties of COP on bladder cancer cells were validated with tumorigenesis model and metastasis model in nude mice. Results RAC-alpha serine/threonine-protein kinase 1 (AKT1), glycogen synthase kinase 3 beta (GSK3B), caspase-3 (CASP3), tumor necrosis factor (TNF) and cyclin D1 (CCND1) were identified as the main hub targets of COP in bladder cancer treatment. PI3K/AKT pathway was predicted to be a crucial pathway regulated by COP. The binding affinities between COP and AKT1, GSK3B, CASP3, TNF and CCND1 were high. COP treatment markedly repressed the phosphorylation level of ERK1/2, AKT1, PI3K p85 and mTOR in T24 and BIU-87 cells, and repressed the tumorigenesis and lung/liver metastasis of T24 cells in vivo. Conclusion COP may be a natural inhibitor for AKT1, GSK3B, CASP3, TNF and CCND1. COP represses PI3K/AKT pathway to suppress the progression of bladder cancer.
研究领域:
药理学
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肿瘤学
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计算生物学
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分子生物学
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天然产物研究
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DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 12
·863
·
IF 5.3
Wen Hao-Xiang,Li Yan-Jun,Xiao Fu-Lan,Deng Yu-Yu,Zhou Lian-Di D.,Mu Yang,Zhang Qi-Hui H.,Yuan Chun-Su
Azithromycin (AZM) is regarded as a potential risk to human immunity and ecosystems, which requires an effective method for rapid on-site detection. Herein, a bifunctional monomer molecularly imprinted polymer and boronic acid-functionalized carbon dots (B-CDs) have been applied to develop an innovative sensor for the determination of AZM. The synergistic effects of boronic esters formation by boronic acid groups and non-covalent interaction of imprinted cavities by pyrrole enhance the binding affinity for improved recognition. In addition, the electrode modification strategy of B-CDs and multiwalled carbon nanotube (MWCNTs) enhance the electron transportation. The constructed sensor exhibited a broad linear detection range (0.2–300 µM), low detection limit (0.12 µM) and significant specificity for AZM (IF = 3.01). Furthermore, it showed satisfactory stability, repeatability and resistance to interference, enabling accurate detection of AZM in milk, serum and urine. This work provides a new avenue for the development of tailored sensitive electrochemical sensors to achieve specific detection. Graphical
研究领域:
分析化学
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环境监测
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电化学传感
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纳米材料
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食品安全与药物检测
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2025
·Vol. 32
·期 12
·458
·
IF 2.8
Shehu Mustapha Sani,Saeed Alaaddin M. M.,Cao Gui-Ping,Yan Jun-Yang
A novel gradient copolymer, poly(norbornadiene-grad-cyclohexadiene), was synthesized via ring-opening metathesis polymerization (ROMP) of norbornadiene (NBD) and vinyl-addition of cyclohexadiene (CHD) mechanism using Grubbs’ third-generation catalyst (G3). To overcome the intrinsic brittleness and limited thermal performance of cyclic olefin copolymers, the material was further modified through catalytic hydrogenation using a palladium supported on porous nickel decorated with carbon nanotubes (Pd@PN-CNT). The post-polymerization (catalytic hydrogenation) significantly enhanced the thermomechanical properties: the glass transition temperature increased from 127 ℃ to 139 ℃, and the degradation temperature rose from 438 ℃ to 519 ℃. Mechanical testing revealed improvements in tensile strength (from 14.58 MPa to 28.93 MPa), elongation at break (from 16.44% to 32.34%), and elastic modulus (from 28.61 MPa to 39.87 MPa). These improvements are attributed to the saturation of unsaturated bonds, reduction in chain defects, and enhanced phase separation. The high hydrogenation efficiency of the Pd@PN-CNT catalyst also demonstrated excellent reusability. This work presents a viable route for tailoring the thermal and mechanical performance of gradient copolymers, positioning hydrogenated poly(NBD-grad-CHD) as a promising candidate for advanced applications in elastomers and high-performance engineering materials.
研究领域:
高分子化学
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材料科学
·
催化化学
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高分子工程
·
热分析
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产品关联
DOI
高影响因子
Nature Communications
·
2025
·
IF 15.7
Peng Xudong,Zhang Yang,Wang Qiyu,Chen Lu,Chen Nanshan,Jiang Yanxin,Yang Zhiqiang,Pan Hongji,Li Hongxu,Zhao Tianshou,Li Yiju
Emerging applications, such as electric aircraft and ships, demand rechargeable batteries with high specific energy. However, current lithium (Li) ion batteries fall significantly short in this regard. Even with Li metal batteries, achieving a high cell-level specific energy (e.g. ≥600 Wh kg −1 ) remains a significant challenge. In this study, a synergistic strategy integrating a precisely engineered carbonate-based gel-solid-state electrolyte with a surface-modified Li is proposed. Our in-situ gelation technique confines unstable free carbonate solvent molecules, thereby suppressing the electrolyte-induced parasitic reactions. Furthermore, a bicontinuous gradient polymer layer that regulates Li deposition and improves moisture/oxygen resistance is introduced, enabling damage-free Li processing and avoiding harsh production requirements. As a result, our 11 Ah-level Li metal battery achieves a high specific energy of 604.2 Wh kg −1 (626.4 Wh kg −1 excluding the packaging materials) and operates for over 100 cycles with an energy retention of 92.83% under lean electrolyte conditions (0.85 g Ah −1 ). This work offers a practical strategy for the scalable production of long-cycle Li metal batteries with high specific energy for broad future applications.
研究领域:
储能
·
材料科学
·
电化学
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电池技术
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可持续能源
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产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·10578
·
IF 15.7
Li Shiyun,Liu Guangsheng,Liu Chuhao,Fu Yifan,Fu Yixuan,Xu Yifei,Li Chengyu,Zhang Xueqiang,Xu Bingjun,Li Wan-Lu,Li Mufan
Electrocatalysis provides a sustainable alternative route to produce nitrogen-containing molecules. However, poor carbon-nitrogen (C-N) coupling selectivity and limited current density pose challenges to its widespread adoption. Herein, we introduce a carbon-defect enhanced 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO) mediated tandem process to tackle both problems. Our hetero-homogeneous system achieves a Faraday efficiency of ~99% with industrial-level current density of ~0.6 A·cm −2 for urotropine electrosynthesis. In situ near ambient pressure X-ray photoelectron spectroscopy and quasi in situ electron paramagnetic resonance reveal that the boosted activity originated from the oxidation of TEMPOH on the carbon defective sites, which accelerates the redox cycling of the molecular mediator for urotropine formation. This work highlights the catalytic effect of carbon defects on the redox cycling of TEMPO, improves both the selectivity and the rate of the electrocatalytic C-N coupling reaction, and offers insights for designing efficient electrochemical mediated oxidation processes and C-N coupling reactions.
研究领域:
电化学
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催化
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材料科学
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有机合成
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可持续化学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）