Food & Function
·
2021
·Vol. 12
·期 5
·2148-2160
·
IF 5.396
Yaojie Liu,Ying Liu,Yatu Guo,Lin Xu,Hao Wang
Phlorizin is the main active ingredient of apple peel and has potential utilization value. Some recent studies have suggested that phlorizin may have antioxidant capacity and protect the liver. The injection of a low dose of D-galactose can cause some changes that resemble accelerated aging in mice. This study explored the protective effects of phlorizin on D-galactose-induced mice and PC12 cells. In this study, ICR mice were divided into a normal group (NOR), a D-galactose model group (D-gal) and phlorizin treatment groups (100 mg kg−1, 200 mg kg−1 and 400 mg kg−1). In addition to the NOR group, four other groups were injected with D-galactose (120 mg kg−1) for 12 weeks. The results showed that phlorizin reduced the decline of strength, coordination and spatial memory caused by aging, increased the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), increased total antioxidant capacity (T-AOC), and reduced the content of malondialdehyde (MDA). On the other hand, phlorizin increased the levels of interleukin-2 (IL-2) and acetylcholine (ACh), reduced the release of interleukin-6 (IL-6), aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and decreased the activity of acetylcholinesterase (AChE) in the brain, improved the expression of antioxidant genes related to the nuclear factor E2-related factor 2 (Nrf2) pathway, and reduced the occurrence of morphological lesions in the hippocampus and liver. In addition, phlorizin improved cell viability and reduced the cytotoxicity of D-galactose-induced oxidative stress in PC12 cells. Meanwhile, the protective effect of phlorizin was abolished in Nrf2 gene knockdown PC12 cells. Furthermore, molecular docking showed that phlorizin could bind Keap1 protein, which can interact with Nrf2 protein. Therefore, these results suggest that phlorizin may delay senescence and enhance antioxidant capacity through the Nrf2 pathway.
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高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Danni Ran,Jiani Mao,Changyou Zhan,Cao Xie,Huitong Ruan,Man Ying,Jianfen Zhou,Wan-Liang Lu,Weiyue Lu
Compared to that of other tumors, various barriers, such as the blood–brain barrier (BBB), enzymatic barriers, and the blood–brain tumor barrier, severely impede the successful treatment of gliomas. Peptide ligands were frequently used as targeting moieties to mediate brain tumor-targeted drug delivery. LWSW (SYPGWSW) is a recently reported quorum-sensing (QS) peptide that is able to efficiently cross the BBB. Even though linear LWSW traverses the BBB in vitro, its in vivo targeting ability has been greatly impaired due to proteolysis. Here, we developed a stable peptide, DWSW (DWDSDWDGDPDYDS), using the retro-inverso isomerization technique to achieve an enhanced antiglioma effect. In vitro studies have demonstrated that both the LWSW and DWSW peptides possessed excellent tumor-homing properties and barrier-penetration abilities, whereas DWSW exhibited exceptional stability in serum and maintained its targeting ability after serum preincubation. In vivo, DWSW-modified probes and micelles accumulated more efficiently in the glioma region in comparison with LWSW-modified probes and micelles because of full resistance to proteolysis in blood circulation. As expected, DWSW-modified paclitaxel (PTX)-loaded micelles (DWSW Micelle/PTX) exhibited the longest median survival time among glioma-bearing nude mice. Our results suggested that the QS peptide appears to be a promising targeting moiety, with potential applications in glioma-targeted drug delivery.
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JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Xiaoju Yan,Shirong Cheng,Cong Ma,Junyu Li,Guodong Wang,Chengyu Yang
Sodium tetraborate pentahydrate (STB) was intercalated into graphene oxide (GO) nanosheets to form a nanocomposite (STB@GO). Subsequently, it was self-assembled on a substrate membrane to prepare STB@GO nanofiltration membrane. The properties of the STB@GO powder samples and the nanofiltration membrane were studied using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), contact angle (CA), and zeta potential . When the STB concentration was 1.0 g/L in the cross-linking reaction, the membrane was described as the STB 2 @GO membrane and exhibited a large interlayer space ( d -spacing = 1.347 nm), high hydrophilicity (CA = 22.2 ° ), and high negative potential (zeta = −18.0 mV). Meanwhile, the pure water flux of the membrane was significantly increased by 56.60% than that of the GO membrane. In addition, the STB 2 @GO membrane exhibited a favorable capability for dye rejection,98.52% for Evans blue (EB), 99.26% for Victoria blue B (VB), 91.94% for Alizarin yellow (AY), and 93.21% for Neutral red (NR). Furthermore, the STB 2 @GO membrane performed better in dye separation under various types and concentrations of dye, pH values, and ions in solution. Thus, this study provides a promising method for preparing laminated GO nanofiltration membranes for dye wastewater treatment .
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ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Xinyi Yang,Zhenzhen Cai,Dezhong Li,Da Lei,Yushu Li,Guangfa Wang,Jun Zhang,Xincun Dou
Although a set of functional molecules with the D-π-A structure has been explored as optical probes for the detection of target analytes, it remains a great challenge to elaborately design a single probe for distinguishing different analytes by their intrinsic oxidation or reduction capabilities and thus to generate distinct optical responses. Here, a unique TCF-based probe (DMA-CN) containing two unsaturated double bonds in the π-conjugation bridge and TCF with different reaction activities that could be cut off by KMnO4 and NaClO in varying degrees was developed, causing remarkably distinguishable responses for both fluorescence and colorimetric channels to discriminate KMnO4 and NaClO from each other. The fluorescence and colorimetric limits of detection (LODs) of the proposed DMA-CN toward KMnO4 were calculated as 60 and 91 nM, respectively, while those for NaClO were 13.3 and 214 nM, and all the optical signal change can be observed within 1 s with good specificity. Based on the proposed probe design strategy, a well-fabricated test strip was proven to be promising for the rapid, in-field detection and risk management. We expect that the present probe design methodology would provide a powerful strategy for efficient probe exploration, especially for discriminating the substances with similar oxidizing properties.
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高影响因子
DALTON TRANSACTIONS
·
2022
·Vol. 51
·期 39
·15111-15120
·
IF 4.569
Jiao Wang,Linlin Zhang,Yuanyuan Wang,Yongjian Niu,Dong Fang,Qingxiao Su,Cheng Wang
Electrocatalytic nitrate reduction offers a sustainable route to ammonia synthesis and wastewater treatment. However, the nitrate-to-ammonia conversion remains inefficient due to the sluggish kinetics and diverse side reactions. Herein, well-faceted CuNi nanocrystals with Ni-rich surfaces and favorable d-band centres were synthesized with the assistance of γ-cyclodextrin via a solvothermal process. When used as catalysts for nitrate electroreduction, they delivered an ammonia yield of 1.374 mmol h−1 mg−1 (0.5496 mmol h−1 cm−2) at −0.3 V with the faradaic efficiency and selectivity reaching 94.5% and 65.0%, respectively, surpassing pure Cu or Ni nanocrystals and most reported catalysts. Such excellent performances originated from the optimal geometric and electronic structures and special element distribution, which optimized the adsorption behaviors and accelerated the reaction kinetics. A NO3−–NO2−–NH3 pathway was proposed with the chemical process following the initial electron transfer process as the rate-determining step. This work sheds light on the design of efficient catalysts to achieve carbon neutrality through simultaneous geometric and electronic structure modulation.
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高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2017
·
IF 1.174
Lei Guo,Yangdong Hu,Lianying Wu,Chen Liang,Weitao Zhang
To achieve green hydrolysis technology of hemicellulose through repeated using hydrolysate, the hydrolysis of hemicellulose in corncob was studied. The influence of repeated use of corncob hydrolysate on concentrations of d -xylose and l -arabinose was investigated. The loss rates of d -xylose in the prepared d -xylose solutions both with and without corncob, and repeated using corncob hydrolysate under identical acidity condition were discussed. The result shows that d -xylose concentration and l -arabinose concentration are all gradually increasing with the growing time of repeated use of corncob hydrolysate. After the fifth repetition, the concentrations of d -xylose and l -arabinose are 196.7 g·L − 1 and 22.0 g·L − 1 , respectively. Substance inhibiting the degradation of d -xylose is generated during repeated use of corncob hydrolysate, and the production is further proved by the change of d -xylose concentration and the loss rate of d -xylose over heating time.
研究领域:
生物技术
·
化学工程
·
可持续化学
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Journal of Materials Chemistry C
·
2019
·Vol. 7
·期 33
·10379-10388
·
IF 6.641
Tao Hua,Keyi Zhang,Zu-Sheng Huang,Lingyun Wang,Hao Tang,Herbert Meier,Derong Cao
In this paper, the encapsulated insulated molecular wire (EIMW) and 2′,7′-bis(hexyloxy)spiro[cyclopenta[2,1-b:3,4-b′]dithiophene-4,9′-fluorene] (SPDF) were specifically designed as efficient anti-aggregation π-bridges for two novel D–A–π–A metal-free sensitizers (IBT1 and IBT2). Compared with the reference dye IBT3 with 3,3′-dihexyl-2,2′-bithiophene (DHBT) as an anti-aggregation π-bridge, both the dyes IBT1 with EIMW and IBT2 with SPDF as π-bridges can suppress intermolecular aggregation more efficiently. The π-bridge of SPDF shows the strongest anti-aggregation ability due to the rigid ‘T’ configuration among these dyes. Meanwhile, the π-bridge of EIMW shows better anti-aggregation ability than DHBT because of the larger steric hindrance of the former. Finally, when the dyes IBT1 and IBT2 are co-sensitized with IBT3, respectively, the new devices exhibit high efficiencies of 7.85% and 7.64%, respectively, which are comparable to that of N719 (7.85%). The results demonstrate that the dyes with EIMW and SPDF as anti-aggregation π-bridges are promising candidates for efficient DSSCs and dye aggregation can be effectively inhibited by structural engineering of the π-spacer.
研究领域:
材料科学
·
化学工程
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DYES AND PIGMENTS
·
2023
·
IF 4.5
Peiyu Wu,Shengxiong Zhang,Wenjun Zhang,Weijie Song
Dual functional electrochromic (EC)/electrofluorochromic (EFC) materials play a pivotal role in wearable and smart electronic equipments. Developing new materials with high performance of EC/EFC properties is still a big challenge. Here a new D-A structure polymer PPDOTTPD based on thieno(3,4-c)pyrrole-(4,6)dione ( TPD ) was synthesized by Stille coupling, and the EC/EFC properties were investigated for the first time. PPDOTTPD film exhibits reversible color changes from purple neutral state to transparent colored state in the process of reversible redox. Photophysical and electrochemical studies revealed that the polymer has outstanding EC properties, including high optical contrast (52%), fast response time (0.5 s/0.7 s), high coloring efficiency (427.1 cm 2 C −1 ) and good stability. What's more, PPDOTTPD exhibited EFC phenomenon. PPDOTTPD film showed an intense red near-infrared fluorescence with a peak of 672 nm, which gradually doped with the increase of applied potential with a maximum contrast ratio of 12.9. The EC/EFC dual-functional device based on PPDOTTPD was also successfully fabricated, which exhibited high optical and fluorescence contrast. The fine dual-functional performance indicates TPD can be further explored as potential acceptors for synthesizing high performance D-A molecules for intelligent optical devices.
研究领域:
材料科学
·
电子工程
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MOLECULES
·
2016
·Vol. 21
·期 8
·970
·
IF 2.465
Ying Han,Erli Tian,Dongbo Xu,Min Ma,Zixin Deng,Kui Hong
During our search for interesting bioactive secondary metabolites from mangrove actinomycetes, the strainStreptomycessp. 219807 which produced a high elaiophylin yield of 4486 mg/L was obtained. A new elaiophylin derivative, halichoblelide D (1), along with seven known analogues2–8was isolated and identified from the culture broth. Their chemical structures were determined by detailed analysis of 1D and 2D NMR and HRMS data. The absolute configuration of halichoblelide D (1) was confirmed by comparing the CD spectrum with those of the reported analogues. Compounds1–7exhibited potent cytotoxic activities against HeLa and MCF-7 cells with IC50values ranging from 0.19 to 2.12 μM.Keywords:mangrove actinomycetes;Streptomycessp. 219807;elaiophylin;cytotoxic
研究领域:
微生物学
·
药物化学
·
肿瘤学
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ELECTROCHIMICA ACTA
·
2026
·
IF 5.8
Xiang-Dong Xie,Biao Hu,Zhi-Sen Tan,Chuan Wang,Hao Li,Qin-Hao Zhang,Hui-Song Hu,Pan Liu,Lu Ren,Xin-Kun Suo,Fa-He Cao
D-leucine-modified Zr-V coating suppresses localized corrosion of ADC12. • D-leucine seals defects and limits H 2 O/Cl – transport in the coating. • SECM reveals reduced oxygen-consuming local corrosion reactions. • DFT confirmed strong D-leucine adsorption and Zr–O interfacial anchoring on ZrO 2 . ADC12 aluminum (Al) alloy is prone to localized corrosion because its heterogeneous surface microstructure and unstable native oxide film induce spatially non-uniform electrochemical reactions at the alloy/electrolyte interface. Herein, a green D-leucine-assisted zirconium-vanadium conversion coating was fabricated on ADC12 Al alloy via a simple chemical immersion process to regulate coating formation and interfacial electrochemical corrosion behavior. D-leucine acted as a bio-derived interfacial modifier to regulate the deposition, defect evolution and interfacial bonding of Zr-containing oxide/hydroxide species. Surface analyses confirmed the incorporation of D-leucine into the conversion layer and its chemical interaction with Zr-containing species mainly through carboxyl groups, thereby promoting organic-inorganic coupling, defect sealing and coating compactification. The optimized ZRCC+0.5D-AA coating exhibited a low corrosion current density of 4.71×10 −8 A·cm −2 and a corrosion rate of 5.17×10 −4 mm·y −1 , approximately 195 times lower than those of the untreated ADC12 substrate. Scanning electrochemical microscopy further confirmed that D-leucine modification effectively suppressed localized oxygen-consuming corrosion reactions and reduced electrochemical heterogeneity on the coated surface. No visible corrosion was observed after 96 h neutral salt spray exposure. DFT calculations revealed strong dissociative adsorption of D-leucine on monoclinic ZrO 2 (−111), with the vertical bidentate configuration showing a dissociative adsorption reaction energy of −9.88 eV and pronounced interfacial charge redistribution. These results demonstrate that D-leucine-assisted interfacial modification simultaneously regulates coating defects, interfacial anchoring, and local electrochemical activity, providing an effective chromium-free surface finishing and protection strategy for Al alloys. Download: Download high-res image (411KB) Download: Download full-size image D-leucine-assisted interfacial modification suppresses localized electrochemical corrosion of zirconium–vanadium conversion coatings on ADC12 aluminum alloy. D-leucine coordinates with Zr-containing species to form a compact organic–inorganic hybrid interface, sealing defect-assisted pathways and reducing H 2 O/Cl⁻ ingress. This limits mass transfer, charge-transfer reactions, cathodic oxygen reduction, and anodic Al dissolution at the coating/substrate interface. DFT and SECM results reveal strong interfacial anchoring and reduced oxygen-consuming local corrosion activity, leading to optimal long-term protection for the coating containing 0.5 g/L D-leucine.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Boheng Chen,Hongpo Liu,Huiyin Zheng,Che Liu,Zhuosen Wang,Yapeng Tian,Xinwei Cui
Lithium oxalate (Li 2 C 2 O 4 ) is regarded as a promising prelithiation agent due to its high specific capacity and cost-effectiveness. However, its intrinsically poor electronic conductivity and sluggish reaction kinetics result in a high lithium liberation potential (typically above 4.5 V), which challenges the stability of electrolytes and electrode materials, and deteriorates overall battery performance. In this work, the intermetallic NiBi 3 catalyst with metallic conductivity and strong interfacial interaction is introduced to promote the low-potential decomposition of Li 2 C 2 O 4 . Benefiting from the synergistic electronic effect between Ni and Bi, the incorporation of Bi effectively modulates the electronic structure of Ni sites via d – p orbital hybridization, thereby enhancing the adsorption and activation of Li 2 C 2 O 4 , weakening the Li 2 C 2 O 4 framework and facilitating its decomposition. When coupled with ultrahigh-Ni NCM96 cathodes, the NiBi 3 -Li 2 C 2 O 4 prelithiation system provides higher charge capacity (273.3 mAh g −1 ) and improved reaction kinetics compared to the pristine counterpart. Furthermore, full-cell configurations based on SiO x anodes exhibit enhanced lithium compensation capability, maintaining a capacity retention of 52.9% after 150 cycles at 0.5C. These results demonstrate that intermetallic NiBi 3 is an efficient catalyst for activating Li 2 C 2 O 4 and provides a viable strategy for developing high-performance cathode prelithiation systems. Download: Download high-res image (119KB) Download: Download full-size image
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POULTRY SCIENCE
·
2026
·Vol. 105
·期 5
·106672
·
IF 4.5
Guangxiao Zhang,Yawen Sun,Ling He,Bowen Zhao,Hongchao Jiao,Jingpeng Zhao,Xiaojuan Wang,Min Liu,Kelin Li,Hai Lin,Haifang Li
Vitamin D 3 (VD 3 ) is an essential fat-soluble micronutrient that regulates diverse biological processes. However, its long-term impact on avian intestinal development remains largely unknown. In this study, we detected that the VD 3 content was significantly lower in late-cycle production eggs (68 weeks old, termed “LP eggs”) compared to the peak-cycle production eggs (44 weeks old, named “PP eggs”) ( P < 0.05). Notably, the intestine index was reduced ( P < 0.05), and the intestinal expression of tight junction (TJ) proteins (Occludin and ZO-1) was decreased for chicks hatched from LP eggs versus those from PP eggs ( P < 0.05). Thus serial dosages of VD 3 (2.5, 5.0, or 7.5 μg VD 3 /egg) were injected into the amniotic cavity of embryos hatched from LP eggs on embryonic day 17 (E17). This intervention effectively improved hatchability, promoted intestinal development that persisted through 14-days post-hatch, and showed immuno-modulatory effects manifesting as Interleukin-6 ( IL-6 ) downregulation and Interleukin-10 ( IL-10 ) upregulation. Further in vivo and in vitro analysis revealed that VD 3 improved intestinal development by activating TJ-related genes ( P < 0.05), with vitamin D receptor (VDR) mediating these effects. Chromatin immunoprecipitation (ChIP) assays confirmed that 1,25-(OH) 2 D 3 strengthened VDR binding to promoter regions of Occludin and ZO-1 but decreased the interaction degree of VDR with the IL-6 promoter ( P < 0.05). These findings establish that in ovo injection of VD 3 is an efficacious perinatal intervention strategy, which significantly mitigates developmental constraints in late-phase poultry production through VDR-dependent intestinal barrier potentiation and immuno-homeostasis modulation.
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危险品化学品经营许可证（带存储）