Neuroscience Bulletin
·
2017
·Vol. 34
·期 1
·54-63
·
IF 2.624
Jing Peng-Bo,Cao De-Li,Li Si-Si,Zhu Meixuan,Bai Xue-Qiang,Wu Xiao-Bo,Gao Yong-Jing
Recent studies have shown that the chemokine receptor CXCR3 and its ligand CXCL10 in the dorsal root ganglion mediate itch in experimental allergic contact dermatitis (ACD). CXCR3 in the spinal cord also contributes to the maintenance of neuropathic pain. However, whether spinal CXCR3 is involved in acute or chronic itch remains unclear. Here, we report that Cxcr3
−/− mice showed normal scratching in acute itch models but reduced scratching in chronic itch models of dry skin and ACD. In contrast, both formalin-induced acute pain and complete Freund’s adjuvant-induced chronic inflammatory pain were reduced in Cxcr3
−/− mice. In addition, the expression of CXCR3 and CXCL10 was increased in the spinal cord in the dry skin model induced by acetone and diethyl ether followed by water (AEW). Intrathecal injection of a CXCR3 antagonist alleviated AEW-induced itch. Furthermore, touch-elicited itch (alloknesis) after compound 48/80 or AEW treatment was suppressed in Cxcr3
−/− mice. Finally, AEW-induced astrocyte activation was inhibited in Cxcr3
−/− mice. Taken together, these data suggest that spinal CXCR3 mediates chronic itch and alloknesis, and targeting CXCR3 may provide effective treatment for chronic pruritus.
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JOURNAL OF NANOPARTICLE RESEARCH
·
2016
·Vol. 18
·期 8
·1-11
·
IF 2.101
Wang Shanshan,Liu Zhonghui,Bartic Carmen,Xu Hong,Ye Jian
Surface-enhanced Raman scattering (SERS) tags show ultrasensitivity and multiplexing abilities due to strong and characteristic Raman signals and therefore can be utilized as optical labeling agents similar to fluorescent dyes and quantum dots for biosensing and bioimaging. However, SERS tags have the difficulty to realize quantitative analysis due to the uniformity and reproducibility issue. In this work, we have reported on a new type of SERS tag called Au rod-in-shell (RIS) gap-enhanced Raman tag (GERT). With the high-resolution transmission electron microscopy (TEM) and optical absorbance measurements, we have demonstrated the subnanometer sized gap junctions inside the RIS GERTs. SERS measurements and FDTD calculations show that the core–shell subnanometer gap geometry in the RIS GERTs not only generates strong SERS hot spots but also isolates SERS hot spots by Au shells to avoid the influence when the particle aggregates form, therefore showing better SERS uniformity and stronger SERS intensity than normal Au nanorods. Those RIS NPs exhibit great potential as the labeling agents for SERS-based bioimaging and biosensing applications.
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2013
·Vol. 116
·期 1
·469-476
·
IF 1.982
Wang L. P.,Wang T. B.,Gao C. F.,Lan X.,Lan X. Z.
Phase behaviors of dodecane–hexadecane ( n -C 12 H 26 –C 16 H 34 , C 12 –C 16 ) binary mixtures in bulk and confined in SBA-15 (pore diameters 3.8, 9.5, and 17.2 nm) are investigated using differential scanning calorimetry. According to the thermal analysis, the bulk mixtures belong to a system of partial miscibility with two solid solutions and a eutectoid in the range of mole fraction \( x_{{{\text{C}}_{ 1 6} }} \) = 0.1–0.8. Under confinement, phase behavior of C 12 –C 16 mixtures is distinct from the bulk. Inside pores of SBA-15 (3.8 nm), the solid mixtures has only a melting boundary. In the pores larger than 9.5 nm, phase behaviors of the mixtures show some resemblance to the bulk system. The growth of the phase diagram with the pore diameter clearly shows the size effect on the phase behavior of the confined mixtures. In comparison with those of chain length difference of pure components of two carbon atoms or less, C 12 –C 16 mixtures exhibit different phase behaviors not only in the bulk but also in the confined state.
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APPLIED SURFACE SCIENCE
·
2015
·
IF 2.711
Xiao-Qiong Wu,Xing-Wen Wu,Qing Huang,Jiang-Shan Shen,Hong-Wu Zhang
Developing hydrogel systems featured by catalytic active is of importance to construct highly effective platforms for removing environmental pollutants/hazardous substances or for bio-/chemosensing. Reported herein are our recent finding that Au nanoparticles could be in situ prepared in chitosan-Au III hydrogel system via photoreduction, and the as-prepared Au nanoparticles could be employed for the catalytic reduction of a series of nitroaromatic compounds by sodium borohydride (NaBH 4 ). Experimental conditions of synthesizing Au nanoparticles, including pH, concentration of Au III , and light irradiation time were systematically investigated. The as-prepared Au nanoparticles were characterized by UV–vis absorption spectroscopy, X-ray diffraction (XRD), transmission and field emission scanning electron microscopy (TEM and FESEM). This is the first example for in situ formed metal nanoparticles in chitosan hydrogel systems via photoreduction. The effectiveness of the as-prepared Au nanoparticles as nanocatalysts was evaluated by employing the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) by NaBH 4 as a model reaction. The catalytic reduction reaction was found to be very efficient and to follow a pseudo-first-order kinetics. The as-prepared Au nanoparticles demonstrated good reusability and stability. The reduction of a series of other nitroaromatic compounds including highly explosives 2,4,6-trinitrophenol (2,4,6-tNP) and 2,4,6-trinitrotoluene (2,4,6-tNT) was achieved by means of this catalytic system.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Chen Wang,Yan Zhu,Ling Zhao,Rui Wang,Jun Jin,Yansheng Gong,Huanwen Wang,Beibei He
Solid oxide electrolysis cells (SOECs) have emerged as a promising technology for CO 2 electrolysis. However, the sluggish kinetics of CO 2 electrolysis impedes their widespread commercialization. Here, a novel heterostructure of in-situ exsolved metal/high-entropy perovskite, Ni@Sr 2 Fe 1.0 Ti 0.2 Cr 0.2 Mn 0.2 Mo 0.2 Ni 0.2 O 6-δ (Ni@SFTCMMN), has been designed to enhance the efficiency of CO 2 electrolysis. The Ni@SFTCMMN, with its high-entropy configuration and embedded exsolution morphology, ensures high structural stability during continuous CO 2 electrolysis. As an application, the Ni@SFTCMMN-based electrolysis cell demonstrates a remarkable current density of 1.91 A cm −2 at 1.5 V and 800 °C, maintaining consistent performance over 160 h. By integrating theoretical calculation with experimental investigations, we aim to establish the link between the electronic structure of perovskite oxides with varying elemental compositions and the mechanism of the CO 2 reduction reaction. The findings from this work provide crucial insights into the role of conformational entropy strategies in CO 2 electrolysis and suggest potential pathways for developing efficient and durable cathode of SOECs.
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FITOTERAPIA
·
2024
·
IF 2.5
Li Wang,Yi-Xiao Chen,Xin-Jing Meng,Hai-Yang Liang,Ya-Dan Zhang,Hui-Hui Zhou,Yu-Hang Liu,Xiao-Yu Chen,Zhen-Hua Liu,Shi-Ming Li,Wen-Yi Kang
Patrinia punctiflora is a medical and edible Chinese herb with high nutritional and medicinal value. The continuing study of its chemical constituents led to the isolation of six iridoids, which were previously unreported compounds, patriscabioins P U ( 1–6 ). Their structures were characterized and confirmed with NMR (1D & 2D), HRMS, IR and UV. Among them, compound 5 was screened to evaluate its insulin resistance activity on an IR-HepG-2 cell model. Compound 5 had no cytotoxicity compared with the control group and could promote glucose uptake in IR-HepG-2 cells. Through further mechanism studies, the undescribed compound 5 could increase the expression levels of PI-3 K, p -AKT, GLUT4 and p -GSK3 β proteins. Moreover, the expression of PEPCK and G6Pase proteins, which are key gluconeogenic enzymes, was also inhibited. Thus, compound 5 promotes the transfer of GLUT4 to the plasma membrane by activating the PI-3 K/AKT signaling pathway, at the same time, promotes glycogen synthesis and inhibits the onset of gluconeogenesis, which in turn ameliorates insulin resistance.
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CHINESE JOURNAL OF CHEMISTRY
·
2024
·
IF 5.5
Danila A. Tatarinov,Jinfeng Xie,Qingyi Qian,Qingqing Wang,Nadezhda A. Maslova,Lyubov N. Borodina,Aleksandr P. Litvin,He Huang
Comprehensive Summary Inorganic lead halide perovskite (LHP) nanostructures, represented by formula CsPbX 3 (X = Cl, Br, I), have garnered considerable interest for their exceptional optical properties and diverse applications. Despite their potential, challenges such as environmental degradation persist. In-situ synthesis within protective materials pores is a promising way to address this issue. However, confining perovskite nanostructures into porous matrices during the synthesis can limit their photoluminescence quantum yield (PL QY) and tunability of optical properties. Various post-treatment approaches exist to improve the properties of LHP and achieve their desired functionalities, but these strategies have not been explored for LHP confined in mesoporous matrices. Here, we demonstrate the efficacy of in-situ post-synthetic treatments to improve the optical properties of CsPbBr 3 nanocrystals grown in nanoporous silica microspheres. Surface passivation with Br – ion-containing precursors boosts PL QY, while anion-assisted cation doping with Mn 2+ ions introduces a new PL band. The adjustment of precursor amount and doping duration enables precise control over the optical properties of LHP, while additional coating with a SiO 2 shell enhances their stability in polar solvents, expanding the potential applications of these composites.
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2025
·
IF 3.1
Ming Li,Hua Sun,Jin-Ling Song,Xing Sun,Wei Li
I3,II8-biapigenin is a biflavonoid compound with diverse pharmacological effects. The present study aimed to investigate the glucuronidation of I3,II8-biapigenin in the human liver microsomes (HLMs) and recombinant human UDP-glucuronosyltransferases (UGTs). Three glucuronidation metabolites of I3,II8-biapigenin were detected in HLMs. Both recombinant human UGTs and chemical inhibitors studies demonstrated that UGT1A1, UGT1A3, UGT1A9 and UGT1A10 were involved in the glucuronidation of I3,II8-biapigenin. The present investigation provided information for the drug-drug interaction potentials of I3,II8-biapigenin when co-administrated with UGTs inhibitors or inducers.
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PLANT JOURNAL
·
2025
·Vol. 121
·期 3
·e17248
·
IF 5.7
Xiaomeng Zhang,Xinquan Tian,Junyu Luo,Xiaoyang Wang,Shoupu He,Gaofei Sun,Ruidan Dong,Panhong Dai,Xiao Wang,Zhaoe Pan,Baojun Chen,Daowu Hu,Liru Wang,Baoyin Pang,Aishuang Xing,Guoyong Fu,Baoquan Wang,Jinjie Cui,Lei Ma,Xiongming Du
SUMMARY Phloridzin has various functions, including antioxidant properties and the treatment of diabetes, and has long been used in pharmaceutical and physiological research. The glycosylation of phloretin is a key step in the biosynthesis of phloridzin. In this study, a genome-wide association study (GWAS) based on phloridzin content was applied, and the key gene GhUGT88F3 for phloridzin-specific biosynthesis was identified in cotton. A single-base deletion in GhUGT88F3 in haplotype I caused a frameshift mutation, leading to premature translation termination and a significant reduction in phloridzin content. Molecular docking revealed important amino acid residues for GhUGT88F3's UDP-glucose transfer activity. Additionally, the transcription factor GhMYB330 was found to positively regulate GhUGT88F3 expression through population transcriptome analysis and LUC experiment. Moreover, phloridzin content was significantly elevated in both GhUGT88F3 and GhMYB330 overexpression transgenic plants. This study expands the diversity of UDP-glucosyltransferases in plants and offers a potential strategy for the sustainable production of bioactive compounds with therapeutic potential.
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2024
·Vol. 130
·期 7
·1-7
·
IF 2.5
Xing Zhuo,Song Julong,Pan Hong,Wang Juan
A series of CaMgGe 2 O 6 ceramics doped with Zn 2+ ions were designed and fabricated using the solid-state reaction method. The impact of cation doping on sintering behavior, crystal structure, microstructure, and dielectric properties was systematically investigated. Incorporating Zn 2+ ions into the crystal structure optimized the sintering process to enhance densification. Analysis of the crystal structure revealed slight changes in lattice parameters and unit cell volume upon introduction of Zn 2+ dopants, indicating successful incorporation without significant alteration to the overall structure. Microstructural characterization revealed that increasing Zn 2+ content resulted in a finer microstructure with a more uniform grain size distribution. Furthermore, substitution of Zn 2+ effectively reduced dielectric loss in CaMgGe 2 O 6 ceramics while maintaining a stable dielectric constant, making them suitable for high-frequency applications. Among all compositions tested, CaMg 0.8 Zn 0.2 Ge 2 O 6 exhibited exceptional performance with a Q × f value reaching 64,980 GHz along with an ε r of 7.88 and τ f of -36.9 ppm/°C.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Jingjing Wang,Dacheng Zhong,Xiaoyuan Wang
In air superhydrophilic/superoleophobic membranes display incomparable advantages for oil/water separation. However, such membranes are difficult to obtain on the basis of surface tension theory. In this study, poly(vinyl alcohol)/titanium dioxide@perfluorooctanoic acid (PVA/TiO 2 @PFOA) nanofibrous membrane was fabricated by the electrospinning technique, followed by UV-induced crosslinking and surface modification through an esterification reaction. The obtained membranes were easily wettable by water, and static oil contact angles for these membranes were found to be above 150° in air. The superhydrophilicity was primarily caused by the presence of Ti-OH groups on the membranes, which exhibited a strong affinity for water molecules. Surface enrichment of fluorocarbon groups accounted for the superoleophobicity of the membranes. These membranes showed excellent separation performance for various oil-in-water emulsions. The maximum permeate flux reached 3865.6 L·m −2 ·h −1 with a separation efficiency of 99.39%. The developed PVA/TiO 2 @PFOA membrane with in air superhydrophilic/superoleophobic property and good reusability displayed prospective potential in the remediation of oily wastewater.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 16
·1-12
·
IF 2.8
Xia Enjie,Zhang Hong,Tang Zhiruo,Xu Yilin,Wu Yanmei,Li Zhicheng
Solid polymer electrolytes (SPEs) with high ionic conductivity and electrochemical stability are crucial for the potential practical applications of solid-state lithium metal batteries. In SPEs based on polyvinylidene fluoride (PVDF), the addition of N , N -dimethylformamide (DMF) enhances ionic conductivity but reduces the electrochemical stable window. This work proposes a strategy to improve the stability of PVDF-based SPEs with high ionic conductivities using LiNO 3 additive. By adding 5% of LiNO 3 (comparing to the weight of LiTFSI lithium salt), the ionic conductivity of prepared PVDF-based SPEs achieves up to 10 −4 S cm −1 at 30 ℃. The assembled Li|SPE|NCM811 cells with the LiNO 3 -modified SPE film as separator maintained a capacity retention rate of 93.0% after 200 electrochemistry cycles induced at a current density of 0.5 C. The influence of LiNO 3 in the interface resistance, Li-ionic transfer number, solid electrolyte interface phase, and electrochemistry performance of LIBs is investigated.
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