ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Xiaolan Yin,Cheng Zhang,Junshuai Cui,Lili Chen,Hongyan Cui,Liuwei Zhang,Sheng Lin,Yan Zhao,Ming Zhang,Haidong Li,Jingyun Wang,Qixian Chen
Protein therapeutics have garnered significant enthusiasm for oncological applications, owing to their exquisite specificity and intrinsic bioactivity. Yet, proteins remain constrained by limited transcellular permeability and proteolytic susceptibility during delivery. To circumvent these impediments, we engineered a redox-responsive protein prodrug, RP-ss-PK, via covalent conjugation of cytotoxic proteinase K (PK) to a multifunctional polymer, RGD-PEG-ss-NPC. This linear hetero-difunctional PEG scaffold contains a cyclic RGD peptide at the α-terminus for integrin-mediated tumor targeting and a 4-nitrophenyl ethyl carbonate (NPC) group at the ω-terminus for site-specific conjugation to amine-rich lysine residues on PK. An internal disulfide linker (–ss–) renders the prodrug cleavable in the presence of intracellular glutathione (GSH). Upon systemic administration, RP-ss-PK selectively accumulates within neoplastic lesions via RGD−integrin (αvβ3/αvβ5) recognition. Endocytosis exposes the disulfide tether to the cytosolic glutathione milieu, triggering reductive cleavage and subsequent liberation of native, fully active PK. The unleashed protease initiates indiscriminate proteolysis that precipitates rapid tumor cell death, accompanied by plasma-membrane permeabilization. This membrane disruption facilitates the extracellular release of damage-associated molecular patterns (DAMPs), thereby igniting anti-tumor immunity and remodeling the tumor microenvironment. Collectively, this prodrug paradigm not only amplifies the tumor-selective delivery of protein therapeutics but also exemplifies a facile, broadly applicable strategy for intracellular activation and functional restoration of protein cargos. Our findings establish RP-ss-PK as a versatile platform poised for the targeted protein treatment of diverse pathologies.
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PubMed
高影响因子
JOURNAL OF RARE EARTHS
·
2026
·
IF 9.6
Cuiping He,Chang Liu,Jingxing Cao,Jixin Sun,Yuning Zhang,Jie Liu,Zhanchao Wu
In this work, a tunable white light-emitting Ba 2.96–2 x K x Ce x P 4 O 13 :0.04Eu 2+ ( x = 0.00–0.16) phosphor was synthesized via solid-state reactions. The phosphor phase selection depends on Ce 3+ doping concentration in Ba 3 P 4 O 13 host. Under 340 nm excitation, Ba 2.96 P 4 O 13 :0.04Eu 2+ phosphor exhibits a broad asymmetric cyan emission centered around 450 nm in the absence of Ce 3+ doping. However, when Ce 3+ ions are introduced, the emission spectrum of Ba 2.96 P 4 O 13 :0.04Eu 2+ phosphor becomes broader and the maximum emission peak shifts to 550 nm. This phenomenon is attributed to the phase transition of Ba 2.96 P 4 O 13 :0.04Eu 2+ from low-temperature phase to high-temperature phase. Temperature-dependent photoluminescence measurements reveal that low-temperature phase phosphors exhibit superior thermal stability compared to high-temperature phase phosphors. Eventually, a white light-emitting diode device was fabricated by combining the Ba 2.64 Ce 0.16 K 0.16 P 4 O 13 :0.04Eu 2+ phosphors with 365 nm light-emitting diode (LED) chip, which exhibits a high color rendering index of 91.61 and a low correlated color temperature of 4230 K. As reported, white-emitting Eu 2+ and Ce 3+ co-doped phosphors have potential applications in solid-state lighting. The crystal-phase engineering approach provides a guide for optimizing and designing novel single composition white-emitting phosphor materials.
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Journal of Hazardous Materials Advances
·
2026
·
IF 9.1
Yongjiong Ni,Keyi Xu,Liqin Zhong,Suleiman Shemsa Khalfan,Kejin Zhou,Jing Deng,Xiaoyan Ma,Stefanos Giannakis,Daniel L. Gallagher,Andrea M. Dietrich
The widespread use of additives introduces emerging contaminants, including acesulfame (ACE) and p-arsanilic acid (p-ASA), into agricultural systems, where their co-occurrence may affect crop development. This study investigated the individual and combined effects of ACE and p-ASA on rice during early growth. Rice seeds were exposed under controlled conditions to ACE (0.5–50 μM) and p-ASA (10 μM), either individually or in combination. Germination was assessed after 4 and 7 d, whereas biomass and physiological and biochemical responses, including α-amylase, β-amylase, soluble protein, superoxide dismutase (SOD), peroxidase (POD), and malondialdehyde (MDA), were evaluated after 14 d. After 4 d, ACE alone caused small, non-significant reductions in germination, whereas only the highest combined exposure (50 μM ACE + 10 μM p-ASA) significantly reduced germination relative to the control. After 7 d, germination rates ranged from 97.22 ± 3.90% to 99.44 ± 1.36%, with no significant differences among treatments, indicating that the initial co-exposure effect was transient. In contrast, seedling biomass was inhibited by up to 22.05% after 14 d, with inhibition increasing with ACE concentration. ACE alone generally increased enzyme activities and MDA levels while reducing soluble protein content. Co-exposure to p-ASA reduced α-amylase, β-amylase, and POD activities below control levels while increasing SOD activity and MDA accumulation. A higher-than-additive increase in MDA was observed only at the highest combined exposure, indicating enhanced lipid peroxidation, whereas lower ACE concentrations produced additive effects. Overall, ACE and p-ASA had limited and transient effects on germination but impaired seedling growth and altered enzymatic and oxidative-stress responses. These findings demonstrate that the effects of contaminant mixtures are strongly concentration dependent and cannot be inferred solely from the responses to the individual compounds.
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ACS Sensors
·
2026
·
IF 10.9
He-Jie Wang,Hao-Nan Chen,Xuan-Yu Yang,Fei-Long Gong,Ke-Feng Xie,Shi-Zhong Wei,Yong-Hui Zhang
The development of highly sensitive and reliable hydrogen detection technology is a critical prerequisite for the safe and large-scale application of green hydrogen energy. Pd-based metal oxide semiconductor sensors exhibit decent sensing performance; however, their development for hydrogen detection is hindered by competitive adsorption of hydrogen and oxygen on the surface and sluggish reaction kinetics due to limited active interfaces. Here, a series of Pd nanoparticle-decorated, K+ interstitial doping WO3 nanosheets (PdNP-K/WO3-x) were synthesized. The optimized PdNP-K/WO3-15 sample exhibited exceptional H2 sensing performance, including a high response (Ra/Rg = 1235.94 to 50 ppm H2) at a low temperature of 130 °C, with fast response/recovery. This enhancement stems from synergistic effects where K+ interstitial doping increases electron density and oxygen vacancies in WO3, improving charge transfer and strengthening the W-O-Pd interface. The resulting electron-rich environment also shifts the d-band center of Pd, enhancing hydrogen desorption and spillover, while reducing competitive oxygen adsorption to free up more Pd active sites. The material also showed promising room-temperature sensing, indicating strong application potential and providing a theoretical basis for designing high-performance alkali metal ion-doped metal oxide materials.
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高影响因子
Materials Today Chemistry
·
2026
·
IF 7.4
Jingxian Yu,Yiye Tan,Hongyan Li
Bi 3+ /K + co-doping act as “dual pillars” to stabilize the layered structure. • Intercalated Bi 3+ increase the KTO interlayer spacing and stabilize the lattice. • Initial coulombic efficiency of Bi-KTO far exceeds that of other Ti-based materials. • K + /Bi 3+ synergy enhances potassium storage and cycling stability. Potassium-ion batteries (PIBs) are increasingly recognized as an important candidate for next-generation energy storage technology attributed to the advantages of sufficient potassium reserves, suitable redox potential, and environmental friendliness. The research of high-performance anode materials represents an essential factor in the development of PIBs. Among these, titanium (Ti)-based materials, known for their structural stability and environmental friendliness, face challenges including limited capacity and slow kinetics. To address these issues, in this work, we propose a synergistic “dual pillars” strategy that incorporates K + pre-intercalation and Bi 3+ doping into Ti-based materials, thereby enhancing their potassium storage performance. K + stabilizes the layered framework, while Bi 3+ further expands the interlayer spacing and optimizes the electronic structure, significantly improving both structural stability and ion diffusion kinetics. The Bi-KTO has a capacity reaching 106.2 mAh g −1 at 0.1 A g −1 and maintains 63 mAh g −1 after over 1500 cycles under 0.2 A g −1 . In particular, the initial coulombic efficiency of Bi-KTO is relatively high compared with other reported KTO-based anodes. At 0.2 A g −1 , the full cell retained 32.5 mAh g −1 after 500 cycles, surpassing most reported KTO-based anode for PIBs. These findings provide valuable insights for future in-depth investigations about KTO-based materials. Download: Download high-res image (340KB) Download: Download full-size image
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Duoshuang Xu,Jiacheng Dong,Yanhua Rao,Yongteng Long,Yanan Bie,Nannan Liu,Xingxing Tang
Development of a K + / Mg 2+ device : Silica nanowires were co‑functionalized with CB18C6 and EDTA to fabricate a CB18C6&EDTA/SiNWs/GMP ion selective device. • Improvement in selectivity : The synergistic effect of CB18C6 and EDTA greatly enhances K⁺/Mg²⁺ selectivity up to 331.16 compared with single ligand device. • K + Preferred Conductance : The fabricated device displays preferential K⁺ conductance in KCl and MgCl₂ mixed solution against varying Mg²⁺ concentrations. • Device Stability : The device keeps stable K⁺/Mg²⁺ selectivity under diverse ion concentrations and after long term storage. • Practical applicability : The K⁺/Mg²⁺ selectivity of the device is well maintained under simulated human body pH conditions. Biomimetic ion channels have attracted extensive attention for ion separation applications owing to their nanoscale or even sub-nanoscale confined structures, as well as the ease of surface functionalization. K + and Mg 2+ are indispensable biological ions involved in a wide range of physiological processes necessary for normal life activities. Due to the similar hydrated ionic radius and high water solubility of K + and Mg 2+ , it remains difficult to separate these ions using conventional materials. To address this challenge, herein we report a functionalized glass micropore (GMP) in which silica nanowires (SiNWs) were introduced into the GMP to serve as a supporting framework, followed by functionalization of the SiNWs with 4′-Carboxybenzo-18-crown-6 (CB18C6) and ethylenediaminetetraacetic acid (EDTA). The constructed functionalized GMP takes advantage of the excellent size matching between the cavity of CB18C6 and the radius of K + , together with the chelation effect of EDTA toward Mg 2+ . Through the synergistic effect of these two functional molecules, highly efficient ion sieving was achieved. Under the same solution volume conditions, the optimal selectivity was obtained when the mass ratio of CB18C6 to EDTA was 4:1, with the selectivities of K + / Na + , K + / Mg 2+ , and K + / Ca 2+ reaching 1.51, 331.16, and 98.16, respectively. The proposed functionalised GMP recognises K + based on the properties of the functional molecules, exhibiting excellent ion sieving performance between target ions and competing ions. This work provides a new research strategy for precise K + / Mg 2+ separation technology. Download: Download high-res image (134KB) Download: Download full-size image Schematic illustration of K + / Mg 2+ ion sieving in a functionalized GMP based on SiNWs, achieved through the synergistic effect of CB18C6 and EDTA. The diagrams are not drawn to scale.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2019
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IF 2.298
Bingbing Liu,Behnaz Asadzadeh,Weidong Yan
The solubility of (−)-epigallocatechin gallate (EGCG) peracetate in 12 pure solvents (methanol, ethanol, 1-propanol, 1-butanol, 2-propanol, 2-butanol, 1-pentanol, 1-hexanol, 2-methoxyethanol, 2-ethoxyethanol, 2-propoxyethanol, and 2-butoxyethanol) was measured using the static method at the temperature range 278.15–318.15 K under atmospheric pressure. The solubility of EGCG peracetate in the selected solvents increased with increasing temperature in 12 solvents, and the most notable change was found in methanol. The obtained solubility data were correlated with the van’t Hoff equation, the modified Apelblat equation, the λh equation, and the nonrandom two-liquid model. Furthermore, solid forms of EGCG peracetate in 12 pure solvents were studied by a scanning electron microscope and X-ray powder diffraction. The obtained solubility values would be helpful in the purification and crystallization process of EGCG peracetate.
研究领域:
化学
·
药学
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高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2020
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IF 2.369
Lijiang Guo,Hongxia Li
The solubility of the RbCl–CsCl–H2O ternary system has been investigated at the temperature range from 298.15 to 348.15 K by two different methods, namely, the Flow-Cloud-Point (FCP) method and the Isothermal Dissolve Equilibrium (IDE) method. The measured solubility for this ternary system at 298.15 K by FCP method is consistent with the reported result in literature. The measured solubility results for this ternary system at 323.15 K by the FCP and IDE, two different methods that are consistent with each other, which indicated the results are more reliable. Meanwhile, the measured liquid–wet solid–solid lines proved that the equilibrium solid phases are two types of solid solutions (Rb,Cs)Cl(ss) and (Cs,Rb)Cl(ss) rather than pure salts (RbCl and CsCl) reported in literature. For the first time, the solubility of the RbCl–CsCl–H2O ternary system at 308.15 and 348.15 K has been measured by IDE method. The measured results shown that the equilibrated solid phases in this ternary system at 308.15 and 348.15 K are two types of solid solution (Rb,Cs)Cl(ss) and (Cs,Rb)Cl(ss), at RbCl rich side and CsCl rich side, respectively.
研究领域:
无机化学
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溶液热力学
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物理化学
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高影响因子
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
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2020
·Vol. 2020
·期 42
·4007-4014
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IF 2.529
Lu Qi,Zhaohui Chen,Lu Li,Qun Jing,Na Li,Zhongqi Jiang,Xiaoyu Dong,Ming-Hsien Lee
Two homologous new mixed-metal phosphates K 2 PbBi 2 (PO 4 ) 2 (P 2 O 7 ) ( I ) and Rb 2 CdBi 2 (PO 4 ) 2 (P 2 O 7 ) ( II ) were successfully synthesized in A 2 BBi 2 (PO 4 ) 2 (P 2 O 7 ) (A = K, Rb, B = Pb, Cd) system through the traditional high-temperature solid-phase method. The single crystal structures of the two compounds are shown to be the unique three-dimensional (3D) framework composed of different types of layers, but not isomorphic. We compared series compounds A 2 PbBi 2 (PO 4 ) 2 (P 2 O 7 ) (A = K, Rb, Cs), which are isomorphic and crystallize in the same space group Pnma . It is noteworthy that they are distinct different in degree of structural disorder, which is tuned by A-site cations. The effect of A-site cations is recognized by analyzing the disorder degree in three related structures and other available 182 mixed-metal phosphates. To the best of our knowledge, such structural analysis is rarely reported in inorganic phosphates and the cation modulation strategy can be used to guide structural disorder according to the difference-value (D-value) of cation radii. Furthermore, the syntheses, thermal analysis, relevant spectroscopic measurements and theoretical calculations for I and II compounds were also discussed. Graphical Two new mixed-metal phosphates K 2 PbBi 2 (PO 4 ) 2 (P 2 O 7 ) and Rb 2 CdBi 2 (PO 4 ) 2 (P 2 O 7 ) were firstly reported and the cation size effect has substantial influence on the crystal structural disorder combining with the title compounds and 182 phosphates.
研究领域:
无机化学
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材料科学
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晶体学
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固态化学
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2018
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IF 3.141
Junhui Liu,Anfeng Zhang,Xiao Jiang,Min Liu,Jie Zhu,Chunshan Song,Xinwen Guo
Conversion of CO2 by hydrogenation into higher hydrocarbons has attracted much attention due to the continuous increasing concentration of CO2 in the atmosphere. Fe5C2 was used as the active site and mixed with K-modified supports for CO2 hydrogenation to synthesize value-added hydrocarbons. A series of supports were tested, and the alkaline Al2O3 was the best choice for light olefins and C5+ hydrocarbons. The transformation of product selectivity at time on stream demonstrated that potassium migrated into Fe5C2 during reaction. The selectivity of C2+ is 69.2% containing 35.8% C2–C4= and 29.1% C5+ value-added hydrocarbons with the 31.5% CO2 conversion (H2/CO2 = 3). When the ratio of H2 and CO2 was switched to 4, CO2 conversion improved to 40.9%, and the C2+ selectivity to 73.5%, containing 37.3% C2–C4= and 31.1% C5+ value-added hydrocarbons. The mixture catalysts can be directly used without any reduction before reaction, reducing the consumption H2 and simplifying the operation.
研究领域:
催化化学
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能源化学
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环境科学
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材料化学
·
工业催化
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Yuting Lin,Yuran Li,Shining Wang,Jianshan Wang,Yanbin Cui,Tingyu Zhu
Blast furnace gas as a vital secondary energy in iron and steel industry, necessitates efficient removal of carbonyl sulfide (COS) to realize clean high-value utilization. However, conventional Al 2 O 3 catalysts suffer from low hydrolytic activity and poor sulfur resistance, limiting their industrial application. This work systematically elucidates the mechanisms of K coordination and hierarchical pore on COS hydrolysis. EXAFS and DFT reveal that appropriate K doping induces highly dispersed K species with four-coordinated K species featuring K-O-Al bonds, which increase the electron cloud density of O atom in surface hydroxyl groups (-OH) and significantly enhance the COS conversion by over 50%. For hierarchical pore catalysts, the introduction of expanding agent breaks the dense stacking of alumina particles, exposes more Al atoms and increases [AlO 6 ] coordination content, which synergistically enriches active -OH sites. More importantly, the interconnected hierarchical porous channels accelerate gaseous H 2 S desorption and effectively mitigate surface sulfur deposition, enabling the catalysts to maintain over 90% COS conversion for 8 h. This work provides atomic-level insights into K coordination and hierarchical pore, offering a rational strategy for designing high-efficiency and sulfur-resistant COS hydrolysis catalysts for blast furnace gas purification.
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高影响因子
Materialia
·
2026
·
IF 3.1
Fengyun Liu,Jialiang Zhang,Lu Li
(K,Na)NbO₃-based ceramics are widely regarded as a promising type of lead-free piezoelectric materials to replace the current lead-containing ones. However, due to polymorphic phase transitions, achieving a desirable comprehensive piezoelectric performance of high piezoelectric coefficient d ₃₃ and large electromechanical coupling factors k p , k t and k 33 along with good thermal stabilities (which are characterized by minimal temperature dependence and ageing degradation) in them is extremely challenging. The poled and subsequently thermally-stabilized <001>-textured 0.98(K₀.₄₈Na₀.₅₂)₀.₉₉Li₀.₀₁(Nb₀.₉₈Sb₀.₀₂)O₃–0.02(Bi₀.₅₀Na₀.₅₀)ZrO₃ ceramic was recently identified as an effective solution to the issue. It possesses a d ₃₃ of 405 pC/N along with k ₚ ≈ 0.80, k ₜ ≈ 0.60, k ₃₃ ≈ 0.88 at room temperature, and its piezoelectric properties are of weak temperature dependence across a broad operational range and show remarkable retention even after thermal ageing at 250 °C. Particularly, its d ₃₃ has an average of 425 pC/N with the variation ≤ ± 6.5% from room temperature to 100 °C, and its k ₜ keeps almost constant between -60 °C and 110 °C. In general, this ceramic exhibits an outstanding comprehensive performance that well competes to those of benchmark commercial piezoceramics such as PZT-5A and PZT-5H, indicating the great potential for advanced ultrasonic applications. Analysis reveals that the excellent piezoelectric properties originate from the synergistic effect of crystallographic anisotropy and an engineered, dense domain structure of orthorhombic phase. Meanwhile, the remarkable thermal ageing stability is possibly attributed to the relaxed crystal structure and the stabilized domain structure, both facilitated by the repeated orthorhombic-tetragonal phase transitions in the thermal treatment.
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