INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yun Liu,Ziying Zhang,Yu Xia,Mengnan Ran,Qing Wang,Quanxin Wu,Wenhua Yu,Cao Li,Shiying Li,Ning Guo
In addition to tumor cells, M2-like tumor-associated macrophages (TAMs) also promote tumor progression. Accordingly, the strategy of targeted depletion or repolarization of M2-like TAMs becomes attractive. Here, we report a dual-targeting nanoagent SAMMH to tumor cells and M2-like TAMs for combinatorial tumor treatment. After co-loading the sonosensitizer spafloxacin (SPX) and oxidative phosphorylation inhibitor atavaquone (ATO) into hollow MnO 2 , the addition of Fe 3+ and tannic acid-immobilized hyaluronic acid (HA) caused the formation of SAMMH through generating metal-polyphenol networks (MPNs) coatings outside. In vitro endocytosis assays demonstrated the efficient internalization of SAMMH by both tumor cells and M2-like TAMs through the specific CD44-HA interactions. The GSH-sensitive degradation of SAMMH results in the continuous release of SPX and ATO. Meanwhile, SAMMH could catalyze the endogenous H 2 O 2 to extra O 2 , thus improving the therapeutic effect via the combination of Mn 2+ -induced CDT and O 2 -generation/O 2 -economy dual-enhanced sonodynamic therapy (SDT). Interestingly, SAMMH had a good targeted M2-like TAMs depleting capacity and could promote M2-to-M1 TAMs transformation by CDT-enhanced SDT, leading to a combinational anti-tumor effect. This dual-targeting nanoagent is a promising candidate to achieve CDT-enhanced SDT against both tumor cells and M2-like TAMs, thus providing new insights for the development of highly effective antitumor therapeutics.
研究领域:
癌症治疗
·
纳米医学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2024
·
IF 12.8
Feilong Zhao,Zhibo Jia,Liyang Zhang,Guodong Liu,Junfei Li,Jianming Zhao,Yajie Xie,Lu Chen,Hongyu Jiang,Wei He,Aiyuan Wang,Jiang Peng,Yudong Zheng
The inflammatory microenvironment and inferior chondrogenesis are major symptoms after cartilage defect. Although various modifications strategies associated with hydrogels exhibit remarkable capacity of pro-cartilage regeneration, the adverse effect by prolonging inflammation is still formidable to hamper potential biomedical applications of different hydrogel implants. Herein, inspired by the repair microenvironment of articular cartilage defects, an injectable, immunomodulatory, and chondrogenic L-MNS-CMDA hydrogel is prepared through grafting vinyl and catechol groups to chitosan macromolecules using amide reaction, then further loading MnO 2 nanosheets (MNS). The double crosslinking of photopolymerization and catechol oxidative polymerization endows L-MNS-CMDA hydrogel with preferable mechanical property, affording a suitable mechanical support for cartilage defect repair. Additionally, the robust tissue adhesion capability stemming from catechol groups guarantees the long-term retention of the hydrogel in the defect site. Meanwhile, L-MNS-CMDA hydrogel decomposes exogenous and intracellular H 2 O 2 into O 2 and H 2 O, to effectively alleviate cellular oxidative stress caused by long-term hypoxia. Under the synergies of catechol groups and MNS, L-MNS-CMDA hydrogel not only inhibits macrophages polarizing into M1 phenotype, but encourages them turn into M2 phenotype, thereby, reconstructing an immunization friendly microenvironment to ultimately enhance cartilage regeneration. Predictably, the hydrogel markedly induces rat bone marrow mesenchymal stem cells differentiating into chondrocytes by expressing abundant glycosaminoglycan and type II collagen. A cartilage defect model of rat knee joint indicates that L-MNS-CMDA hydrogel visually regulate the early inflammatory response of post-implantation, and facilitate cartilage regeneration and recovery of joint function after 12 weeks of post-implantation. All in all, this multifunctional L-MNS-CMDA hydrogel exhibits superior immunomodulatory and chondrogenic properties, holding immense clinical potential in the treatment of cartilage defects.
研究领域:
生物医学工程
·
组织工程
·
再生医学
·
骨科
·
免疫学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Sihan Wang,Tao Peng,Qingyi Meng,Xiaoli Zhu,Liuchuan Guo,Kai Yao,Zheng Wang,Pimiao Zheng,Zhenhui Ren,Zhiwei He,Jing Zhang,Haiyang Jiang
A novel impedance biosensor was developed based on the interdigitated microelectrodes using H 2 O 2 to reduce SiO 2 @MnO 2 nanocomposites into Mn 2+ , resulting in significant impedance changes in the rapid and ultrasensitive detection of Salmonella typhimurium ( S . typhimurium ). The captured S . typhimurium monoclonal antibodies (MAb 1 ) were assembled on the outer layer of the magnetic beads (MBs) for specific enrichment and isolation of S . typhimurium cells in complex samples. The recognized S . typhimurium monoclonal antibodies (MAb 2 ) were immobilized on the surface of the SiO 2 @MnO 2 nanocomposites, which could react with the MBs- S . typhimurium conjugates to form the MBs- S . typhimurium -SiO 2 @MnO 2 sandwich complexes. The MnO 2 on the surface of the sandwich complexes was reduced into Mn 2+ by using H 2 O 2 achieving obvious impedance change that could be detected by the interdigitated microelectrodes. The recoveries for S . typhimurium cells at the concentrations between 2.0 × 10 1 and 2.0 × 10 5 CFU/mL were 83.1 %–97.0 % in the spiked milk samples. The limit of detection of this biosensor for S . typhimurium cells in the spiked milk samples was 21 CFU/mL. This approach possesses the merits of simple operation, high sensitivity, and low cost, potentially enabling this device to be a lab-on-a-chip for rapid screening of foodborne pathogens.
研究领域:
生物传感器
·
食品安全
·
纳米技术
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2019
·
IF 3.218
Sihao Yan,Chenguang Tang,Xuemin Wang,Hang Zhang,Zhao Yang,Cui Zhang,Shuangxi Liu
Hierarchical MnO 2 arrays with nanowire-built multitripod structures were successfully deposited on porous carbon nanofibers (PCNFs) by a simple electrospinning followed by redox reaction . The unique multitripod architectures of MnO 2 nanowire arrays pave well-developed network for rapid electron transfer and improve entire mechanical stability. Additionally, this hierarchical porosity of PCNFs substrate is favorable for guaranteeing sufficient penetration of electrolyte ions. Benefiting from all synergistic effects, the as-prepared MnO 2 /PCNFs flexible electrode exhibits a specific capacitance of 512 F g − 1 at 1 mA cm − 2 , a super rate capability (460 F g − 1 at 50 mA cm − 2 ) and cycling stability. Moreover, a fabricated symmetrical coin device delivers a specific energy density of 51.2 Wh kg − 1 maintaining the power density of 585.3 W kg − 1 and still keep 15.2 Wh kg − 1 even at the ultra-high power density of 59.7 kW kg − 1 . These hierarchical MnO 2 arrays comprising unique nanowire-built multitripod structures show potential prospects for future advanced energy storage devices.
研究领域:
材料科学
·
纳米技术
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
Advanced Therapeutics
·
2022
·Vol. 5
·期 12
·2200108
·
IF 5.003
Wen-Jie Zheng,Ze-Lei Zhou,Qi-Yan Lv,Xiaojie Song,Wen-Xing Zhang,Hui-Fang Cui
Tumor hypoxia greatly restricts photodynamic therapy (PDT) efficiency. Photothermal therapy (PTT) implemented at high temperatures induces local skin burning and surrounding tissue damage. Herein, an near-infrared (NIR)- and H 2 O 2 -double responsive heat- and O 2 -generating core–shell–shell AuNRs@MnO 2 @SiO 2 nanocarrier with Au nanorods (AuNRs) as core and MnO 2 as sandwiched nanolayer is developed to realize enhanced photodynamic/photothermal combined tumor therapy at mild-hyperthermia temperatures. Coating poly- l -lysine on AuNRs is capable of preventing AuNRs from aggregation and facilitating the on-site growth of MnO 2 . The mesoporous SiO 2 nanoshell provides large loading sites for payload indocyanine green (ICG). The MnO 2 nanolayer greatly enhances the singlet oxygen ( 1 O 2 ) generation efficiency of ICG both in testing tubes and in cancer cells. Consequently, the O 2 -enhanced PDT endows the AuNRs@MnO 2 @SiO 2 -ICG nanoparticles (NPs) dramatically stronger antitumor effect both in vitro and in vivo. Their tumor growth inhibition ratio (67.6%) is significantly higher than that of AuNRs@SiO 2 -ICG (28.5%) after one dose intratumor injection and NIR irradiation. Together with their good biosafety, the AuNRs@MnO 2 @SiO 2 -ICG is promisingly translational. The multifunctionality should provide the AuNRs@MnO 2 @SiO 2 NPs a nanocarrier platform for various therapeutic agents to modulate the tumor microenvironment and enhance tumor therapy efficiency.
研究领域:
纳米技术
·
癌症治疗
·
生物医学工程
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2019
·Vol. 29
·期 45
·1903850
·
IF 15.621
Yaru Cheng,Fan Yang,Kai Zhang,Yiyi Zhang,Yu Cao,Conghui Liu,Huiting Lu,Haifeng Dong,Xueji Zhang
Here, in terms of the highly reactive oxidative hydroxyl radical (•OH) generation ability of isoniazid (INH) catalyzed by Mn 2+ ion and the photothermal effect of WSSe nanoflakes, a WSSe/MnO 2 -INH nanocomposite for synergistic anticancer treatment is developed. Advanced INH-induced •OH formation ability is systemically demonstrated in the presence of manganese and relevant non-Fenton-type mechanism, and good photothermal conversion efficiency of the WSSe/MnO 2 nanocomposite. After modifying with mitochondria-targeted triphenylphosphonium bromide (TPP) moieties and camouflaging with cancer cells membrane (WSSe/MnO 2 -INH-TPP@CM), it confers a sequential cell-to-mitochondria targeting ability. In vivo X-ray computed tomography and magnetic resonance tumor imaging capability of the nanocomposite are also revealed. The mitochondria-targeted oxidative damage and photothermal therapy by WSSe/MnO 2 -INH-TPP@CM results in excellent anticancer treatment efficacy both in vitro and in vivo. This is the first exploration of the possibility of non-Fenton-type •OH formation for anticancer treatment, which opens new opportunities for ROS-based and combined cancer treatment strategies.
研究领域:
纳米技术
·
癌症研究
·
药学
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2022
·
IF 5.532
Alan Meng,Xiaocheng Hong,Yue Zhang,Wenman Liu,Zhenhui Zhang,Liying Sheng,Zhenjiang Li
Research on flexible biosensors is mainly concentrated on their application in acquiring information on physical signals including temperature, pH, and so on. However, there are hardly any studies on using flexible biosensors for assaying biomolecules and biomarkers caused diseases. Herein, a free-standing flexible sensor is designed for H 2 O 2 sensing and cancer biomarker assaying, in which reduced graphene oxide and carbon nanotubes (rGO-CNT) flexible hybrid film is first obtained through self-assembly, then MnO 2 nanoflowers and Co nanospheres are anchored on rGO-CNT by electrodeposition . rGO-CNT has good flexibility and conductivity . MnO 2 uniformly distributed on rGO-CNT has excellent catalytic performance towards H 2 O 2 . Co not only improve the conductivity, but also supply a second active material for H 2 O 2 sensing. Profiting from these advantages, MnO 2 –Co/rGO-CNT sensor shows an expanded detection range, high sensitivity, low detection limit, excellent repeatability, reproducibility, stability and selectivity. Surprisingly, it can maintain 100% of the original signal after folding 100 times, indicating deformation stability. Moreover, it can real-time monitor H 2 O 2 released by HepG2 cells. The strategy of introducing flexible substrate material and transition metals as well as transition metal compounds provides new insight into the design of flexible electrodes and greatly promote the development of real-time detection of cancer biomarkers.
研究领域:
生物传感器
·
电化学
·
癌症研究
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2018
·
IF 5.116
Xiaopeng Yang,Zhensong Qiao,Feng Liu,Shuhua Yang,Liqiang Zhang,Bingqiang Cao
In this work, we report a birnessite-MnO 2 /ramsdellite-MnO 2 /F_ SnO 2 (FTO) composite planar electrode with 3D peony-like micro-structure for micro-supercapacitors (m-SCs), which is prepared via an original series resistor electrochemical deposition (SRED) of MnO 2 and subsequent secondary-growth. The composite electrode achieves an excellent specific capacitance of 1261 F g -1 at 10 A g −1 and extraordinary cycling stability with a significant 304% capacity retention after 10000 GCD cycles. Different from conventional cases, even though it is Mn +4 , the MnO 2 prepared by the SRED would undergo a secondary-growth with phase transition process during the GCD cycling, which could dramatically improve the pseudocapacitance performance by surface/inner-surface and diffusion-controlled insertion capacity aspects. The mechanism is in-depth discovered by deconvolution of double-layer and Faradaic insertion capacity at different stages of the phase transition, and first principle calculation based on density functional theory (DFT). The secondary-growth process also offers a fabulous self-repairing feature of the SC electrode materials , which caters the maintenance-free and long-life requirement of the m-SCs application. Scan rate dependency of the bulk and the surface/near-surface pseudocapacitance is confirmed via de-convoluted the total capacities and the redox peaks of CV curves with different scan rates.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 31
·期 27
·2101579
·
IF 18.808
Xiaofan Shen,Xiaona Wang,Yurong Zhou,Yanhong Shi,Liming Zhao,Hehua Jin,Jiangtao Di,Qingwen Li
Rechargeable Zn-MnO 2 batteries are boosted by the reversible intercalation reactions in mild aqueous electrolytes, but they still suffer from cathode degradation. Herein, Zn-MnO 2 batteries with high durability and high energy density are achieved by supplementing MnO 2 deposition and dissolution in a mild aqueous electrolyte. The main finding is that adjusting Mn 2+ concentration to a critical range enables a reversible MnO 2 /Mn 2+ redox conversion without the involvement of oxygen evolution. This can recycle the by-products from MnOOH disproportionation (MnOOH → MnO 2 + Mn 2+ ), resulting in a battery with extremely high durability (16 000 cycles without obvious capacity fading), high energy density (602 Wh kg −1 based on the active mass of the cathode), and high-rate capacity (430 mAh g −1 at 19.5 A g −1 ). The utilization of a 3D carbon nanotube foam skeleton can accommodate the volume change during MnO 2 deposition/dissolution and provide paths for efficient charge and mass transport. This work provides a feasible way to push the development of Zn-MnO 2 batteries in mild aqueous electrolytes.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2025
·
IF 9.5
Xinyang Zhang,Xiaoyu Yang,Yingjun Wei,Dewei Wang,Yuhong Chen
Aqueous zinc–manganese dioxide (Zn–MnO2) batteries hold great promises for large-scale energy storage but face several challenges, such as dendrite formation on the anode and structural instability of the cathode. Herein, we propose an aqueous tellurium–manganese dioxide (Te–MnO2) battery, which employs carbon-supported tellurium (C@Te) to replace the Zn metal anode coupled with vanadium-doped MnO2 (Mn1−xVxO2) cathode, as an alternative to overcome the intrinsic limitations of conventional Zn–MnO2 batteries. Notably, Mn1−xVxO2 can be produced through a room-temperature redox method, enabling effective V5+ ion doping in various α-, β-, γ-, and δ-MnO2 polymorphs. The resulting Mn1−xVxO2 exhibits enhanced structural stability due to the suppressed Jahn–Teller distortion and improved electronic conductivity resulting from V 3d/O 2p orbital hybridization. Consequently, the Mn1−xVxO2 cathode delivers a high specific capacity of 323.7 mAh g−1 at 0.1 A g−1 and 93.5% capacity retention after 1000 cycles at 0.5 A g−1, which significantly surpass those of the pristine MnO2 (P-MnO2). Mechanistic investigations and theoretical calculations further unveil a synergistic mechanism involving enhanced electron transport, optimized ion adsorption, and improved structural stability, demonstrating that V5+ doping promotes reversible H+/Zn2+ co-intercalation. Our study shows that Te–MnO2 batteries can offer a viable alternative to conventional Zn–MnO2 batteries and afford a universal synthesis strategy for Mn1−xVxO2.
研究领域:
储能
·
材料科学
·
电化学
·
电池技术
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Huizhen Lv,Yu Song,Zengming Qin,Mingyue Zhang,Duo Yang,Qing Pan,Zhihui Wang,Xinjian Mu,Jianming Meng,Xiaoqi Sun,Xiao-Xia Liu
The disproportionation of the Jahn-Teller (J-T) active manganese oxides (Mn 3+ ) often leads to uncontrollable Mn 2+ dissolution, which has been identified as one of the major causes of the performance degradation in conventional Zn-MnO 2 batteries. Herein, we use the “unwanted” disproportionation of the Mn 3+ cations to realize effective MnO 2 /Mn 2+ transformation, achieving high specific capacity (550 mAh g −1 ) and good cycling stability (5000 cycles without capacity decay) in a Zn-MnO 2 hybrid battery with mild aqueous electrolytes. Mechanism study shows that MnO 2 is deposited on the cathode during charging, H + /Zn 2+ insertion and disproportionation occur sequentially during discharging, leading to Mn 2+ dissolution. The generated high-valence manganese oxides via disproportionation further experience reduction-disproportionation-dissolution, which proceeds repeatedly in the expanded discharge potential to 0 V vs. Zn 2+ /Zn, resulting in the complete dissolution of the cathodic materials. Our results provide the fundamental understanding on the controversial mechanisms of Zn-MnO 2 batteries with mild aqueous electrolytes and highlight the effect of disproportionation in pushing the electrochemical performance of the promising Zn-MnO 2 hybrid batteries.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Congzhu Liu,Xunan Yang,Zhen Yu,Jia Pu,Meiying Xu
Manganese dioxide (MnO 2 ), as a catalyst in composting processes, can accumulate in soil over multiple fertilization. However, its impact on crop growth remains to be explored. In this study, a pot experiment was conducted to investigate the impacts of MnO 2 on the tomato plant performance across various growth stages. Results showed that MnO 2 reduced the plant height, leaf number and length by 35.53 %, 27.61 %, and 37.00 %, respectively, and decreased the fruit weight (23.16 %) and sugar-acid ratio (29.7 %) of fruits compared to the MnO 2 -free control. The adverse impacts of MnO 2 on plant growth might be attributed to the inhibition of microbial activity in soil reflected by the reduction of soil urease (9.30 %) and acid phosphatase (12.52 %) activities, which decreased the efficiency of nutrients conversion and uptake. The decrease of nutrient elements in roots resulted in oxidative stress in the plant, inhibiting the plasma membrane H + -ATPase activity thereby reducing the translocation of nutrients (e.g., calcium, magnesium, and phosphorus) translocation from roots to leaves. Furthermore, the phytohormones indolebutyric acid, gibberellin, and jasmonic acid of leaves were disturbed. This study reveals the risks associated with the application of MnO 2 -containing organic fertilizers.
研究领域:
农业科学
·
植物生理学
·
土壤学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）