ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Zhongxi Xie,Shuang Liang,Xuechao Cai,Binbin Ding,Shanshan Huang,Zhiyao Hou,Ping’an Ma,Ziyong Cheng,Jun Lin
Hypoxia and overexpression of glutathione (GSH) are typical characteristics of the tumor microenvironment, which severely hinders cancer treatments. Here, we design a novel biodegradable therapeutic system, O2–Cu/ZIF-8@Ce6/ZIF-8@F127 (OCZCF), to simultaneously achieve GSH depletion and O2-enhanced combination therapy. Notably, the doped Cu2+ doubles the O2 storage capacity of the ZIF-8 matrix, which makes OCZCF an excellent pH-sensitive O2 reservoir for conquering tumor hypoxia, enhancing the photodynamic therapy (PDT) efficiency of chlorin e6 (Ce6) under 650 nm laser irradiation. Moreover, the released Cu2+ can act as a smart reactive oxygen species protector by consuming intracellular GSH. The byproduct Cu+ will undergo highly efficient Fenton-like reaction to achieve chemodynamic therapy (CDT) in the presence of abundant H2O2. The accompanying O2 will further alleviate hypoxia. The in vitro and in vivo experimental data indicate that OCZCF could cause remarkable tumor inhibition through enhanced synergetic PDT and CDT, which may open up a new path for cancer therapy.
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PubMed
高影响因子
COMBUSTION AND FLAME
·
2018
·
IF 4.494
Guoqing Wang,Yuyang Li,Wenhao Yuan,Yizun Wang,Zhenbiao Zhou,Yingzheng Liu,Jianghuai Cai
Bio-butanol is an important alternative fuel and has many advantages in engine combustion . In the present work, laminar flame propagation of n- butanol/air and n- butanol/(14% O 2 /86% He) mixtures was investigated using a constant-volume combustion vessel at the unburnt temperature of 423 K, initial pressures of 1–20 atm and a series of equivalence ratios. Flame instabilities of n -butanol, including cellular instability and pulsating instability, were studied based on flame morphology. The unsteady transition from weak flame to normal flame was investigated based on the flame trajectories and this phenomenon became less perceptible in the flame with stronger combustion intensity and smaller Lewis number. The accelerated laminar burning velocity (LBV), thickened flame thickness, larger Markstein length and Markstein number indicate that the thermal diffusivity of n- butanol/O 2 /He flames are greatly enhanced by helium addition. The smaller densities and lower reactant concentrations result in the smaller laminar burning fluxes of n- butanol/O 2 /He flames than those of n -butanol/air flames. The high temperature kinetic model of n -butanol reported by Cai et al. was further developed with recent theoretical progresses on n -butanol reactions. The updated high temperature model was validated on the present experimental data and a vast amount of previous n -butanol combustion data . Sensitivity analysis was performed using the updated model under wide pressure and equivalence ratio ranges. The similarity in the sensitivities indicates that the sensitive reactions in n- butanol/air flames can be validated by using n- butanol/O 2 /He flames, which greatly compensates the problem that the n- butanol/air flames are susceptible to flame instabilities at high pressures. The weaker pressure dependence of the LBVs of n -butanol/O 2 /He flames indicates that their flame chemistry changes less to resist the pressure variation.
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高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2016
·
IF 5.393
Ting Liu,Lucheng Xue,Xin Guo,Jia Liu,Yu Huang,Chuguang Zheng
The reaction mechanisms of a mixture gas of HCl, O2, and SO2 in Hg0 adsorption on α-Fe2O3(001) surface are clarified by a group of adsorption experiments and theoretical calculations based on the density functional theory. The role of O2 in removing Hg0 is greatly influenced by the reaction temperature, meanwhile, the O atom coverage could affect the adsorption performance of Hg0. The dissociated O2 competes with the active sites of Cl species on Fe surface at low temperature, however, at medium temperature HCl and O2 could simultaneously facilitate the Hg0 transformation. Combined with the theoretical calculations, the role of SO2 and the probable pathways in removing Hg0 are discussed. Lower concentration of SO2 as well as HCl could dissociate on α-Fe2O3(001) surface, and the intermediates combine with gaseous Hg0, forming mercury–sulfur, mercury–chlorine compounds, and so forth. In addition, the different concentrations of SO2 are also discussed, and the corresponding X-ray photoelectron spectroscopy analysis on contrasted samples is conducted to research the morphological characterization, providing a reliable basis for judging the probable pathways of Hg0 transformation.
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高影响因子
Small
·
2016
·Vol. 12
·期 39
·5477-5487
·
IF 8.315
Zhifang Ma,Mengchao Zhang,Xiaodan Jia,Jing Bai,Yudi Ruan,Chao Wang,Xuping Sun,Xiue Jiang
Local hypoxia in tumors, as well as the short lifetime and limited action region of 1 O 2 , are undesirable impediments for photodynamic therapy (PDT), leading to a greatly reduced effectiveness. To overcome these adversities, a mitochondria-targeting, H 2 O 2 -activatable, and O 2 -evolving PDT nanoplatform is developed based on Fe III -doped two-dimensional C 3 N 4 nanofusiform for highly selective and efficient cancer treatment. The ultrahigh surface area of 2D nanosheets enhances the photosensitizer (PS) loading capacity and the doping of Fe III leads to peroxidase mimetics with excellent catalytic performance towards H 2 O 2 in cancer cells to generate O 2 . As such tumor hypoxia can be overcome and the PDT efficacy is improved, whilst at the same time endowing the PDT theranostic agent with an effective T 1 -weighted in vivo magnetic resonance imaging (MRI) ability. Conjugation with a mitochondria-targeting agent could further increase the sensitivity of cancer cells to 1 O 2 by enhanced mitochondria dysfunction. In vitro and in vivo anticancer studies demonstrate an outstanding therapeutic effectiveness of the developed PDT agent, leading to almost complete destruction of mouse cervical tumor. This development offers an attractive theranostic agent for in vivo MRI and synergistic photodynamic therapy toward clinical applications.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 15
·6745-6757
·
IF 2.7
Yingzi Lin,Ningning Sun,Qingyu Zhang,Lei Chen,Shengbo Sun,Hong Yang,Jing Chen,Qixuan Weng,Shuang Xue
To overcome the limitations of the Fe(II)-activated percarbonate process for ACT removal, this study introduced cysteine as a complexing agent into the Fe(II)/SPC system and enhanced the degradation efficiency of ACT. Investigations were conducted on the effects of pH, temperature, common anions (Cl−, HCO3− and NO3−) in the water column, and humic acid (HA) on the degrading efficiency of the Cys/Fe(II)/SPC system. The results showed that under ideal conditions, 99.9% removal of ACT at 0.05 mM could be achieved. Alkaline environments inhibited ACT degradation, whereas acidic environments promoted it. Electron paramagnetic resonance (EPR) successfully detected ˙OH and O2˙−, but no 1O2 radical signal was detected. Further research was carried out to determine how much ˙OH and O2˙− contributed to the oxidation process. The results showed that both ˙OH and O2˙− contributed to the degradation of the ACT, with ˙OH's contribution being particularly significant. Mass spectrometry analysis was used to determine the structure of the oxidation products. Vulnerable sites in ACT were predicted using density functional theory. Using LC-MS/MS analysis, seven intermediates of the Cys/Fe(II)/SPC degradation of ACT were individually identified. The results showed that the acetylamino group on ACT and the C–N bond on the benzene ring are susceptible to attack by ˙OH. The T.E.S.T. toxicity prediction model was used to predict the toxicity of ACT and its intermediates. The results showed a trend towards reduced acute toxicity and overall developmental toxicity.
研究领域:
环境科学
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水处理
·
化学工程
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分析化学
·
毒理学
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高影响因子
Catalysis Science & Technology
·
2020
·Vol. 10
·期 21
·7378-7385
·
IF 5.721
Mengna Ding,Fengyan Shi,Huijuan Zhu,Yuping Yang,Jiahui Zhong,Liulin Luo,Yuning Huo,Hexing Li
A hybrid Cu2O/TiO2 composite loaded on a Cu mesh (Cu2O/TiO2@Cu mesh) was developed via a supercritical solvothermal route. A uniformly distributed Cu2O/TiO2 p–n hetero-junction was stably coated on a Cu mesh, benefiting the visible-light harvesting. In comparison to electrochemistry and visible-light photocatalysis, the photoelectrochemistry process on the photoanode of the Cu2O/TiO2@Cu mesh presented improved bacterial inactivation activity for Acinetobacter baumannii. By means of the main active species of ˙O2− radicals, the photoelectrocatalytic process on the Cu2O/TiO2@Cu mesh also realized complete leakage of K+ ions, much stronger mineralization of the cell membrane and more efficient elimination of the self-recovery function, finally leading to cell death. In comparison, the electrochemistry process only led to the leakage of K+ ions without inactivation of bacteria, and the visible-light photocatalysis process induced partial leakage of K+ ions and cell mineralization after the death of most bacteria.
研究领域:
环境科学
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材料科学
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微生物学
·
光电催化
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高影响因子
CATALYSIS LETTERS
·
2025
·Vol. 155
·期 9
·1-16
·
IF 2.4
Hu Rui,Wang Haiyin,Luo Jiahui,Song Jianjun,Jia Haiyuan
Peroxymonosulfate (PMS)-based advanced oxidation processes (AOPs) have been proven to be an effective method for the removal of tetracycline in water. In this study, the Co 3 O 4 /molecular sieve catalyst synthesized by the incipient wetness impregnation method was used for PMS activation. The effect of specific surface area on the catalytic performance of Co 3 O 4 /molecular sieve catalyst was investigated and analyzed in detail by characterization techniques. In the Tetracycline hydrochloride (TCH) degradation experiment, the Co 3 O 4 /13X catalyst exhibited the highest specific surface area (490.584 m 2 /g) and provide abundant active sites, enabling 98.0% TCH degradation within 30 min under optimal conditions (1.5 g catalyst, 0.3 mM PMS, pH 8.0, 25℃), with a reaction rate constant (k obs ) of 0.0977 min -1 . In addition, the degradation mechanism of TCH was explored using electron paramagnetic resonance (EPR) spectroscopy and quenching experiments. It was confirmed that free radicals (SO 4 •− , •OH, O 2 •− ) and non-free radical species ( 1 O 2 ) generated during the reaction play a crucial role in the degradation process of TCH. In summary, the Co 3 O 4 /13X catalyst, when activating PMS, exhibits a remarkable synergistic effect on the degradation of TCH, and shows good repeatability and environmental adaptability. This study provides valuable insights into the design and optimization of catalysts for degrading antibiotic pollutants in water treatment processes. Graphical
研究领域:
环境科学
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催化
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水处理
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化学工程
·
污染物降解
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高影响因子
Nano Energy
·
2024
·
IF 16.8
Zuheng Jin,Xiao Zheng,Zhihong Zhu,Chuan Jiang,Sha Wu,Changzheng Hu,Laijun Liu,Liang Fang,Zhenxiang Cheng
Considering advanced oxidation techniques offer new opportunities for microbial degradation and inactivation, in this study, Z-type heterojunctions of Ba 1.4 Sr 3.6 NdNb 7 Ti 3 O 30 -N 2 /g-C 3 N 4 (BN 2 /CN) were successfully prepared using a solid-phase method and explored for their potential applications in tribocatalytic bactericidal inhibition. These results demonstrate that BN 2 /CN exhibits excellent inhibitory and inactivating effects on E. coli under tribocatalytic conditions. The UV–visible spectrum showed a gradual decrease in the survival rate of E. coli with the increase of tribocatalysis time, reaching an inactivation effect of 91% after 1 h, while fluorescence staining also confirmed that E. coli were essentially eliminated, with hardly any surviving bacteria observed under a laser confocal microscope . Hence, this study presents a novel catalytic approach for sterilization. Moreover, inhibition experiments demonstrated that the BN 2 /CN catalyst did not inhibit the growth of E. coli, tribocatalysis played a crucial role in the disinfection and sterilization processes . The inactivation of bacteria by BN 2 /CN catalyst was still above 90% after multiple cycles of sterilization experiments. Finally, we demonstrated that the production of •OH and •O 2 - during tribocatalysis is key to the inactivation of E. coli, thus achieving the desired effect of tribocatalytic sterilization.
研究领域:
催化
·
材料科学
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微生物学
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环境科学
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Yunxiang Bai,Xinxue Qiu,Deqiang Chen,Junwei Zheng,Liangliang Dong,Chunfang Zhang
Magnetic mixed matrix membranes (MMMs) show great potential for enhancing O 2 /N 2 separation efficiency by leveraging the inherent magnetic property differences between O 2 (paramagnetic) and N 2 (diamagnetic). However, one of the major challenges is the establishment and precise control of magnetic channels between magnetic fillers and polymer matrix. To address this issue, herein, ZIF-8 wrapped Fe 3 O 4 nanoparticles (Fe 3 O 4 @ZIF-8) were synthesized using a step-by-step assembly method, and then integrated into polymer of intrinsic microporosity (PIM-1) matrix to develop MMMs with well-defined magnetic channels for O 2 /N 2 separation. In comparison with Fe 3 O 4 , Fe 3 O 4 @ZIF-8 nanoparticles exhibited significantly enhanced compatibility with the polymer matrix, thereby facilitating uniform dispersion and improving interfacial adhesion. Gas permeation experiments revealed that the magnetic PIM-1/Fe 3 O 4 @ZIF-8 MMMs demonstrated enhanced O 2 /N 2 separation performance due to the combined effects of magnetic responsiveness and the presence of ZIF-8 magnetic channels. Under a magnetic field strength of 56mT, the magnetic MMM with a 4 wt% loading of Fe 3 O 4 @ZIF-8 exhibited optimal O 2 /N 2 separation performance with O 2 permeability of 710 Barrer and O 2 /N 2 selectivity of 3.64. These values represented a significant improvement of 42% and 24%, respectively, compared to pure PIM-1 membrane. Moreover, the simultaneous improvement of permeability and selectivity enabled the achievement of Robeson’s 2008 upper bound for O 2 /N 2 separation, underscoring the great potential of Fe 3 O 4 @ZIF-8 nanoparticles for designing magnetic MMMs with favorable structural attributes and exceptional separation efficiency.
研究领域:
材料科学
·
化学工程
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Shengqi Ding,Liang Wu,Xianxia Yuan
Electrocatalysts with appropriate electron coupling toward LiO 2 intermediates can exhibit superior oxygen reduction/evolution reaction kinetics in Li-O 2 batteries (LOBs). In this work, a charge redistribution strategy has been developed by constructing NiS/MoS 2 heterostructure nanosheet self-assembled hollow microspheres with an internal electric field to regulate the interaction with LiO 2 and then improve the electrochemical performance of LOBs. Density functional theory calculations and physicochemical characterizations reveal that the difference of work functions between NiS and MoS 2 promotes the electron redistribution in heterointerface via built-in electrical field, leading to increased electron density of interfacial Ni atom, thereby enhancing its electron coupling toward LiO 2 intermediates and promoting one-electron oxygen reduction/oxidation reaction kinetics. As a result, the NiS/MoS 2 -based LOBs exhibit evidently higher discharge capacity and much better cycling performance than the batteries using NiS and MoS 2 . This work provides a reliable charge redistribution strategy induced by build-in electric field to design efficient catalysts for LOBs.
研究领域:
材料科学
·
电化学
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PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2021
·
IF 9.078
Yang Zhan,Shao-hua Luo,Jian Feng,Lin Zhang,Xin Liu,Qing Wang,Ya-hui Zhang
The lithium-oxygen batteries (LOBs) have gained extensive interest in the past decade, but are plagued by slow reaction kinetics and induced large-voltage hysteresis. Therefore, developing extremely capable catalysts to enhance catalytic behavior and mitigate oxidation-reduction overpotential of LOBs is of huge challenge and significance. Attributable to their economically friendly and great activity, transition metal oxides (TMO) have incurred lots of attention as alternative electrocatalysts to replace the currently used noble metal-based catalysts. In this work, we fabricate a highly efficient TMO (the MIL-88A heated at 500 °C under protective flow, M8-Fe 3 O 4 @NC-500) electrocatalyst as advanced cathodes, which attributed to its unique structure, numerous dendritic-shaped carbon layer was anchored inplane into the micrometer-long spindle-shaped prisms with evenly distribution and contains abundant Fe–N/Graphitic N active sites. Therefore, the LOBs (based on M8-Fe 3 O 4 @NC-500/AB cathode) deliver superior electrochemical performance with large specific capacities of 14866.1 mAh g −1 , low overpotentials (1.31 V), and steady cycling stability (553 cycles, limited 500 mAh g −1 , under 0.05 mA cm −2 ). Our work provides a novel vision to rationally design and synthesize a powerful TMO electrocatalyst (with the 2D carbon nanosheet coating) for the LOBs cathode.
研究领域:
材料科学
·
电化学
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高影响因子
MOLECULAR PHARMACEUTICS
·
2025
·
IF 4.5
Xin Yue,Qian Lin,Xiaohang Liu,Zhaoyi Yu,Jiafeng Xu,Xuan Zhu,Jinyan Lin,Aijie Liu
The high intracellular glutathione (GSH) level, naturally hypoxic conditions within the tumor microenvironment, and limited reactive oxygen species (ROS) generation pose significant obstacles to the effectiveness of sonodynamic therapy (SDT). Overcoming these barriers through depletion of GSH and relieving hypoxia offer a promising strategy to enhance SDT effectiveness. Herein, we developed a dendritic tetra-sulfide-bridged mesoporous silica (DTSMO) that encapsulated both chlorin e6 (Ce6) and cerium via channel-limited in situ coordination and is subsequently cloaked with the macrophage cell membrane (MCM) to facilitate efficient reactive oxygen species (ROS)-based therapy via multispecies enzymatic activities. First, this nanosystem exhibited Ce(IV) ions to mimic catalase (CAT)-like activity, converting H2O2 into O2, thereby effectively alleviating tumor hypoxia. Meanwhile, the nanosystem possessed Ce (III)-based peroxidase (POD)-like activity, enabling the conversion of H2O2 into hydroxyl radicals (•OH) while simultaneously depleting GSH. Both in vitro and in vivo experiments demonstrated that GSH depletion exerted a powerful supplementary effect on CDT and SDT, achieving a tumor inhibition rate of up to 96%, without affecting normal tissues during treatment.
研究领域:
纳米医学
·
癌症治疗
·
活性氧
·
酶模拟
·
生物材料
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PubMed
高影响因子
危险品化学品经营许可证（带存储）