ANALYTICAL CHEMISTRY
·
2026
·Vol. 98
·期 28
·20991-21004
·
IF 7.3
Wu Huihui,Xu Xinxin,Xu Liguang,Kuang Hua,Xu Chuanlai,Guo Lingling
Given the widespread use and potential health risks of
Napropamide
(Nap), establishing a rapid and sensitive detection method for its
residues is imperative. Herein, we designed novel haptens H1 and H2
via a computer-assisted strategy. H1, with a long-chain carboxyl extension,
generated a high-sensitivity recombinant antibody (rAb) 2A4 (IC 50 = 1.64 ng/mL), outperforming hapten H2-derived rAb 3D7 (IC 50 = 5.08 ng/mL). Molecular docking (MD) showed that the enhanced
hydrogen bond donor capacity of hapten H1 formed a hydrophilic binding
pocket, with key interactions (a strong hydrogen bond between SER
A-103 and TYR B-96 and π–π stacking with TRP B-50)
ensuring the high sensitivity of rAb 2A4, validating rational hapten
design. To validate the reliability of MD predictions, alanine scanning
mutagenesis was further performed in this study, with the experimental
results further confirming the critical roles of the key amino acid
residues in antibody recognition. Based on rAb 2A4, a dual T-line
colloidal gold test strip was developed with a calculated limit of
detection of 18.72–36.54 μg/kg for cabbage, watermelon,
soybean, and peanut samples. The quantitative results were consistent
with Liquid Chromatography-Tandem Mass methods, demonstrating high
sensitivity and user-friendliness, suitable for high-throughput monitoring.
Therefore, this study provides a practical tool for rapidly detecting
Nap in food.
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高影响因子
ACS Applied Bio Materials
·
2025
·
IF 4.7
Zhao Wang,Khawar Ali Shahzad,Ding Li,Boyu Cai,Zilin Huang,Maoxiang Xu,Jiaojiao Li,Dong Chen,Fei Tan
Monascin, a natural and safe drug, exhibits potent anti-inflammatory, hypolipidemic, and antioxidative effects. However, their therapeutic potential and underlying mechanisms in allergic rhinitis (AR) remain unexplored. The intranasal delivery of monascin for treating AR faces the challenge of rapid clearance. Herein, to achieve sustained and prolonged release, we developed monascin-encapsulated poly(lactic co glycolic acid) nanoparticles (PLGA-MS) by the mechanical double emulsion technique, enabling effective local delivery of monascin for the treatment of AR. Histopathological staining, flow cytometry, ELISA, and network pharmacology were used to assess therapeutic effects and potential mechanisms of monascin in treating AR. In vitro and in vivo experiments revealed that PLGA-MS exhibited enhanced stability, excellent drug encapsulation capacity, and sustained drug release. PLGA-MS treatment showed a significant therapeutic effect in AR mice by decreasing inflammatory cells in nasal tissue and regulating IgE, histamine, and a variety of cytokines. PLGA-MS treatment decreased T helper 2 cells (Th2) and T helper 17 cells (Th17) while promoting and increasing Tregs (regulatory T cells). Further analysis showed elevated levels of IL-10 and TGF-β expression in Tregs post-treatment. Results of the CCK-8 assay, pathological analysis of vital organs, and serum analysis of liver and kidney functions demonstrated the biosafety of PLGA-MS. Additionally, network pharmacology identified immune response pathways that may support PLGA-MS’s immunomodulatory effects in AR. Our study presented a biomaterial-facilitated intranasal delivery system for monascin, offering an effective therapeutic strategy for AR.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·Vol. 24
·期 1
·382
·
IF 15
Jiang Zhou,Li Yuning
Lung cancer (LC) remains a leading cause of cancer-related mortality worldwide, and the limited efficacy of immunotherapy due to treatment resistance underscores the urgent need for new therapeutic strategies. In the present study, CD93-targeted poly(lactic-co-glycolic acid) (PLGA) nanoparticles encapsulating resveratrol (CD93-NPs@RSV) were developed to remodel the metabolic fitness of CD8 + tumor-infiltrating lymphocytes. The nanoparticles were precisely engineered and characterized using dynamic light scattering, transmission electron microscopy, and in vivo imaging, which confirmed their stability and tumor-targeting capability. Mechanistic studies revealed that CD93-NPs@RSV suppressed CD93 expression, facilitated apoptosis-inducing factor (AIF) mitochondrial translocation, and activated oxidative phosphorylation (OXPHOS), thereby enhancing T cell function in the tumor microenvironment. Transcriptomic and proteomic analyses further confirmed regulation of the CD93-AKT-PAK5-AIF signaling axis. In a Lewis LC model, CD93-NPs@RSV significantly inhibited tumor progression and displayed strong synergy with anti-PD-1 therapy, resulting in improved survival outcomes. Collectively, our study demonstrates that CD93-NPs@RSV provide a powerful nanotechnology-driven approach to reverse immunotherapy resistance by reprogramming T cell metabolism. These findings establish a promising paradigm for precision cancer immunotherapy and underscore the translational potential of targeted nanomedicine in overcoming therapeutic bottlenecks in LC. Graphical abstract The alternative text for this image may have been generated using AI.
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CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Fei Long,Qixiang Zhang,Junjie Shi,Li Wen,Yonghui Wu,Ziqi Ren,Zunyu Liu,Yixin Hou,Ke Mao,Ke Niu,Nishuang Liu,Zhi Zhang,Luying Li,Jun Su,Fei Long,Yihua Gao
Aqueous zinc-ion batteries (AZIBs) are a green, low-cost and high-safety energy storage technology. Although MoS 2 is a promising electrode material, low conductivity and poor stability still limit their application in AZIBs. Constructing conductive heterostructures is an effective strategy to overcome these problems. Herein, metallic 1 T-MoS 2 nanosheets are innovatively combined with conductive Ti 3 C 2 MXene, resulting in enlarged 1 T-MoS 2 interlayers (from 9.5 to 9.9 Å) and enhanced hydrophilicity. This novel 1 T-MoS 2 /Ti 3 C 2 MXene heterostructure exhibits exceptional high-rate capability (284.3 mAh/g at 0.10 A/g with 105.2 mAh/g at 10.00 A/g) and long-term cycling stability (93.2 % capacity retention after 3000 cycles). High capacity comes from the expanded ion storage space caused by the extended layer spacing of the metallic 1 T-MoS 2 . Outstanding rate capability thanks to ultrafast electrons and ions transport from Ti 3 C 2 MXene. Prominent long-term cycling stability is attributed to the efficient synergistic effect of 1 T-MoS 2 and Ti 3 C 2 MXene in the 3D interconnected networks. As a proof of concept, the wearable quasi-solid-state Zn-ion battery employing the 1 T-MoS 2 /Ti 3 C 2 MXene cathode exhibits stable electrochemical performance under different bending conditions. This work explores a new route to design high-performance layered cathode materials for AZIBs.
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CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Ying Lv,Hui Pan,Jingyi Lin,Zhixin Chen,Yao Li,Hua Li,Mei Shi,Renjie Yin,Shenmin Zhu
Molybdenum disulfide (MoS 2 ) has become a promising low-cost alternative to Pt catalyst for electrochemical Hydrogen evolution reactions (HER). However, the poor conductivity and limited active sites of thermodynamically stable 2H-Phase MoS 2 hinder its catalytic performance. Utilizing phase engineering to convert 2H MoS 2 to metallic 1 T MoS 2 is an effective strategy to improve the catalytic activity of MoS 2 . The commonly used synthetic and phase engineering methods such as electrochemical exfoliation involve using a complicated synthesis route or under strict experimental conditions or both. Herein, we develop a one-pot hydrothermal method to in-situ synthesize a 2D (1 T MoS 2 )/2D (GO) heterostructure with a face-to-face contact between the ultrathin MoS 2 (few layers) and Graphene oxide (GO). The content of 1 T MoS 2 in the prepared 1 T MoS 2 /GO reaches as high as 76.7%. When used as a catalyst, 1 T MoS 2 /GO exhibited an outstanding HER performance, with a small overpotential of 209 mV at a cathode current density of 10 mA cm −2 , and an extremely low Tafel slope of 45.5 mV Dec −1 , which is very close to that of Pt/C (40.0 mV Dec −1 ). Moreover, it demonstrated an excellent stability after a storage of 212 days in air. The high electrocatalytic performance could be attributed to the high 1 T-phase content in the MoS 2 , as the 1 T phase provides numerous active sites and improves the electronic conductivity of the catalyst. Strong interactions between 1 T MoS 2 and GO substrate stabilizes the structure of the 1 T MoS 2 and allows rapid charge transfer kinetics. This work proposes a facile and effective strategy for the design and synthesis of transition metal chalcogenides with high HER performance.
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POLYMER BULLETIN
·
2019
·Vol. 77
·期 9
·4507-4522
·
IF 1.858
Liu Huijun,Zhang Jianing,Ding Ke,Chen Xiangning,Han Tao
This study aimed to establish a purifying immunoaffinity column (IAC) for four kinds of Fusarium toxins (zearalenone, deoxynivalenol, T-2, and HT-2) simultaneously using poly-glycidyl methacrylate–divinylbenzene [P(GMA–DVB)] as the column matrix. The P(GMA–DVB) microsphere was synthesized using glycidyl methacrylate (GMA) and diethylbenzene (DVB) at an optimal polymerization temperature of 80 °C, the initiator 2,2′-azodiisobutyronitrile concentration of 2.50 g/mL H 2 O, and the DVB-to-GMA ratio of 3:5 (wt.). The polymerized P(GMA–DVB) microspheres were modified with 1,6-hexanediamine, activated with glutaraldehyde, and coupled with the four toxin monoclonal antibodies. The coupling rate of the activated resin was calculated to be 95.95%. The maximum capacity of the IACs was 264 ng deoxynivalenol, 231 ng T-2, 210 ng HT-2, and 292 ng zearalenone. After eight uses, the maximum capacity had no obvious decrease. The recovery of the four Fusarium toxins on the P(GMA–DVB) IAC was 70.03–85.39% in flour, with the relative standard deviations of 4.67–15.93%. The IACs were applied to the actual flour samples.
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Nano Energy
·
2023
·
IF 17.6
Shule Huang,Gui Wang,Xinmiao Xuan,Moran Qin,Jieming Huang,Lirong Wang,Xiaoming Zhang,Nan Wang,Junwei Zhang,Zhipeng Hou,Xingsen Gao,Zhang Zhang,Junming Liu
Piezoelectricity in 2D transition metal dichalcogenides (TMDs) has gathered significant interest due to their massive exposure of unsaturated edge sites and high piezoelectric modulus. Nevertheless, the piezoelectricity in 1 T′ phase TMDs is inhibited by its center symmetry of space group. Herein, to break the shackles of piezoelectric polarization, we synthesize a piezoelectric material composed of an atomic molybdenum array bound to distorted 1 T′ ReS 2 (MDR). The phase transition from 1 T′ to distorted 1 T′ (D-1 T′) removes the special Peierl's distortion of ReS 2 , breaking its center symmetry and allowing for piezoelectric generation. Remarkably, MDR exhibits a large piezoelectric coefficient ( d 33 ) value of 15.45 pm/V, which is an order of magnitude higher than those reported in other TMDs. Combining with excellent piezocatalytic activity, a 0D/3D di-piezoelectric porous electret featuring an enhanced quantum confinement piezoelectric effect based on the MDR quantum dots (QDs) and inverse opal g-C 3 N 4 (IOCN) is demonstrated for high-efficiency piezoelectric catalysis.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2019
·
IF 2.298
Kui Wu,Ya Jun Li
The solubility and solution thermodynamics of azacyclotridecan-2-one in different solvents are indispensable for the purification and performance improvement of crystalline products in industry. In this paper, the solid–liquid equilibrium of azacyclotridecan-2-one in 15 pure solvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, ethyl acetate, acetone, toluene, acetonitrile, dichloromethane, 1,2-dichlorobenzene, cyclohexanone, and tetrahydrofuran) from 273.15 to 323.15 K at atmospheric pressure was measured. The mole fraction solubility increased with the increase in temperature in all solvents studied. The modified Apelblat equation, Van’t Hoff equation, Buchowski–Ksiazczak λh equation, and nonrandom two-liquid (NRTL) activity coefficient model were used to correlate the experimental data. Consequently, some association parameters were obtained. As a result, the NRTL model provided the best fitting. The solubility data provide the basic data for the design and optimization of the azacyclotridecan-2-one crystallization process.
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RSC Advances
·
2017
·Vol. 7
·期 85
·53996-54001
·
IF 3.108
Anna Zheng,Ling Su,Zheng Li,Guijin Zou,Xiang Xu,Yong Guan
To break through the industrial development bottlenecks of anionic polymerization in the field of polar monomers, poly n-hexyl methacrylate (PHMA) was prepared at 0 °C, 30 °C, and 60 °C with potassium tert-butoxide (t-BuOK) as the initiator in tetrahydrofuran (THF) and the conversions were almost complete. Gel permeation chromatography (GPC) analysis of poly n-hexyl methacrylate indicated that t-BuOK existed in numerous states when dissolved in THF, including different types of association and ion-pairs. A series of block copolymers of n-hexyl methacrylate (n-HMA) and methyl methacrylate (MMA), PMMA-b-PHMA (Mn 8200–16 200) and PHMA-b-PMMA (Mn 19 100–9500) were synthesized at 0 °C, and conversions were close to 100%. The results of dynamic mechanical analysis (DMA) indicated that there were two glass transition temperatures, −10 to 0 °C for the PHMA block and 100 to 110 °C for the PMMA block. Furthermore, the competing behaviors of n-HMA and MMA in copolymerization were investigated by one-shot feeding of two types of monomers at 0 °C, 30 °C, and 60 °C. The kinetics curves and 13C-NMR analysis of the copolymers indicated that the polymerization of n-HMA in the copolymerization was significantly dominant over that of MMA at set temperatures. The results in this study provided the possibility to realize anionic polymerization of methacrylate esters on a commercial scale.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2012
·
IF 1.693
Yuan-Yuan Che,Jian Shen,Jun-Chao Zhou,Chao-Hong He
The thermal conductivity of ammonium sulfate + water, ammonium nitrate + water, and ammonium sulfate + ammonium nitrate + water is of great significance in the national defense industry and military engineering for manufacturing of various energetic chemicals. The measurements, covering a temperature range from (278.15 to 333.15) K, have been performed by a transient hot-wire technique over a wide range of concentrations. The densities of ternary aqueous solutions of ammonium sulfate + ammonium nitrate are also presented at the same temperature covering different portions of ammonium sulfate and ammonium nitrate. The thermal conductivities of binary aqueous solutions of ammonium salts are correlated by polynomial functions in terms of temperature and weight fraction for the purpose of interpolation. The Aseyev equation in terms of weight fraction is also used to represent the thermal conductivities of ternary mixtures of these compounds. The ideal mixing rule of Young has been successfully applied to correlate the ternary densities of aqueous ammonium sulfate + ammonium nitrate solutions based on relevant binary solution properties. The agreement between the correlation and the experimental data is pretty good.
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高影响因子
International Journal of Nanomedicine
·
2017
·
IF 4.3
Lianru Zhang,Rutian Li,Hong Chen,Jia Wei,Hanqing Qian,Shu Su,Jie Shao,Lifeng Wang,Xiaoping Qian,Baorui Liu
Cell membrane-derived nanoparticles are becoming more attractive because of their ability to mimic many features of their source cells. This study reports on a biomimetic delivery platform based on human cytotoxic T-lymphocyte membranes. In this system, the surface of poly-lactic- co -glycolic acid nanoparticles was camouflaged using T-lymphocyte membranes, and local low-dose irradiation (LDI) was used as a chemoattractant for nanoparticle targeting. The T-lymphocyte membrane coating was verified using dynamic light scattering, transmission electron microscopy, and confocal laser scanning microscopy. This new platform reduced nanoparticle phagocytosis by macrophages to 23.99% ( P =0.002). Systemic administration of paclitaxel-loaded T-lymphocyte membrane-coated nanoparticles inhibited the growth of human gastric cancer by 56.68% in Balb/c nude mice. Application of LDI at the tumor site significantly increased the tumor growth inhibition rate to 88.50%, and two mice achieved complete remission. Furthermore, LDI could upregulate the expression of adhesion molecules in tumor vessels, which is important in the process of leukocyte adhesion and might contribute to the localization of T-lymphocyte membrane-encapsulated nanoparticles in tumors. Therefore, this new drug-delivery platform retained both the long circulation time and tumor site accumulation ability of human cytotoxic T lymphocytes, while local LDI could significantly enhance tumor localization.
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高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2017
·
IF 3.648
Jing Zhang,Taotao Fu,Chunying Zhu,Youguang Ma
Densities and viscosities of glycine, L-alanine, L-valine, L-threonine and L-arginine in aqueous (0.1–0.5) mol·kg − 1 myo -inositol solutions were measured at T = (293.15, 303.15, 313.15 and 323.15) K and p = 0.101 MPa. The volumetric properties such as the apparent molar volume ( V φ ), the limiting partial molar volume ( V φ 0 ), the limiting partial molar volumes of transfer (Δ tr V φ 0 ), the limiting apparent molar expansibility ( E 2 0 ), Hepler's constant and the isobaric thermal expansion coefficient ( α 2 ) were calculated through density. The viscometric properties such as the B -coefficient, the free energies of activation per mole of solvent (Δ μ 1 0 ≠ ) and solute (Δ μ 2 0 ≠ ) were obtained from the experimental viscosity data. The derived parameters hydration number and solvation number were also calculated through apparent molar volume and B -coefficient. From the volumetric and viscometric properties, the solute-solute and solute-solvent interactions in the studied systems were analyzed on the basis of co-sphere overlap model and transition state theory . Finally, the group contribution method was applied to calculate the contribution of (NH 3 + , COO − ), CH 2 , OH and CNHNHNH 2 of amino acids to V φ 0 , B -coefficient and Δ μ 2 0 ≠ .
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危险品化学品经营许可证（带存储）