Advanced Science
·
2025
·
IF 14.1
Junhong Li,Wenxing Lv,Ziwei Han,Yike Li,Jinqi Deng,Yanjuan Huang,Shuo Wan,Jiashu Sun,Bo Dai
Chemo-immunotherapy, combining systemic chemotherapeutic drugs and immune checkpoint blockers, is a promising paradigm in cancer treatment. However, challenges such as limited induction of immune responses and systemic immune toxicity have hindered its clinical applications. Here, a zeolite imidazolate framework-8 (ZIF-8) that encapsulates mitoxantrone (MIT), an immune cell death (ICD)-inducing chemotherapeutic agent (MIT@ZIF-8), is synthesized using a one-pot aqueous-phase process. ZIF-8 serves as a dual-functional nanomaterial for chemo-immunotherapy: a carrier to enhance tumor uptake of MIT for improved chemotherapy efficacy, and a pyroptosis inducer to amplify MIT-induced ICD for augmented anti-tumor immune responses. As a result, in vivo administration of MIT@ZIF-8 markedly inhibits tumor growth in both immunologically “hot” colon cancer and immunologically “cold” prostate cancer. Moreover, MIT@ZIF-8 treatment increases the abundance of cytotoxic CD8 + T cells and reduces the amount of immunosuppressive regulatory T cells in tumors, thereby enhancing anti-tumor immunity and sensitizing prostate cancer to anti-CTLA-4 immunotherapy. In summary, MIT@ZIF-8 offers a highly translational approach for chemo-immunotherapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2018
·
IF 4.229
Aisheng Huang,Bo Feng
Pristine graphene oxide (GO) sheets were pretreated with polyethyleneimine (PEI) to prepare PEI-modified GO (PEI-GO), which was further inserted with ZIF-8 crystals to form a novel PEI-GO@ZIF-8 nanocomposite for CO 2 capture. The good dispersion of PEI and interlayer growth of ZIF-8 within the GO sheets is helpful for high CO 2 adsorption. Therefore, the PEI-GO@ZIF-8 nanocomposite show high surface area and enhanced CO 2 adsorption capacity . The adsorption capacity of the PEI-GO@ZIF-8 nanocomposite was six times higher than that of the pristine GO and ZIF-8. The CO 2 /N 2 adsorption selectivity was significantly improved due to amine groups loading which provide more sites for CO 2 adsorption. The preferential adsorption of CO 2 over N 2 makes PEI-GO@ZIF-8 nanocomposite be a promising candidate in the field of CO 2 capture.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Xiaodong Qian,Congling Shi,Mei Wan,Honglei Che,Junyi Li
To improve the interface interaction between MXene and the polymer matrix, CoNi-ZIFs were adopted to modify MXene through an in situ preparation method. The nanohybrid flame retardants were introduced into epoxy polymers (EPs) to improve the thermal stability, flame resistance, and smoke reduction capabilities of the EP nanocomposites. Based on the above design, the nanohybrid flame retardants exhibit excellent synergistic flame retardant effects. Compared with the MXene and CoNi-ZIF-based EP nanocomposites, the performance in terms of thermal stability, flame resistance, and smoke reduction capabilities of EP/CoNi-ZIF/MXene nanocomposites has been significantly improved. 2 wt % CoNi-ZIF/MXene in EP can improve the residual carbon content of nanocomposites to 18.78% at high temperature and reduce the peak heat release rate (pHRR) by 22.68%, and the release of the smoke production rate (SPR), CO, and CO2 for the nanocomposites is also inhibited simultaneously. The notable decrease in the fire risk of EP largely stems from the catalytic carbonization of transition metals and the synergistic and physical barrier effects of the CoNi-ZIF/MXene nanohybrids.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2024
·
IF 2.6
Wang Jian Ming,Chu Xue Qing,Zeng Han
Hemoglobin (Hb)-based electrodes were fabricated using a Co-based complex with cobalt nitrate hexahydrate and 2-methylimidazole as fundamental elements to accommodate enzymes via the conventional solvothermal method. The binding of redox protein molecules to metal–organic framework-based complexes occurred through a synergistic effect of hydrogen bonding and competitive complexation, resulting in a partially oriented arrangement of metalloprotein molecules with enhanced hydrophilicity. The Hb–Co complex was formed via a typical electrostatic quenching mode with a moderate binding capacity. The native heme site within Hb and the cofactor of the enzyme ligated with ZIF-67 were involved in the electron shuttle process. The former electro-active site displayed favorable electrochemical activity (apparent heterogeneous electron transport rate: 0.1 s –1 ). The inherent configuration of the cofactor in the protein and abnormal electrocatalytic activity of the incorporated protein were considerably maintained. The electrocatalytic efficiency could be affected by both the protein and the Co-based complex. The key step in restraining the electrochemical sensing performance was the H 2 O 2 mass transfer procedure. Graphical abstract The schematic illumination to the preparation procedure of hemoglobin-based electrode on the basis of Co element based MOF material: ZIF-67 as protein carrier via the collaborative effect of the hydrogen bond interaction and the competitive coordination between heme protein and elements in ZIF-67 as well as hemoglobin-induced electro-catalytic H 2 O 2 reduction.
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS RESEARCH BULLETIN
·
2024
·
IF 5.3
Haoliang Wen,Bo Lei,Weidong Zhang
The rational design of hollow-structured composite absorbing materials is emerging as a promising approach for enhancing microwave performance. The present study successfully synthesized a series of ZIF-67/MoS 2 composites with adjustable size range using a two-step method and achieved the formation of magnetically responsive Co/C/MoS 2 hybrids through high temperature pyrolysis. The findings demonstrated that ZIF-67/MoS 2 (1:12) exhibited a wide effective attenuation bandwidth (EAB) (5.60 GHz from 12.40 GHz to 18.0 GHz) with a thickness of 2.4 mm, and minimum reflection loss (−43.46 dB) at 2.1 mm. However, Co/C/MoS 2 hybrid possessed the better EAB (5.95 GHz from 11.61 GHz to 17.56 GHz) at 1.2 mm and minimum reflection loss (−51.83 dB) at a thickness of 1.0 mm. The ingeniously synthesized ZIF-67/MoS 2 and Co/C/MoS 2 composites, hence, unravel themselves as a promising and exceedingly efficient contender for lightweight microwave absorption.
✓ 已验证
产品关联
DOI
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2024
·Vol. 50
·期 7
·3153-3177
·
IF 2.8
Hao Xiaohong,Zheng Xiangsheng,Zhang Qi,Da Xiongzhi,Wang Yan
The main objective of this study was to produce biodiesel utilizing Fe 3 O 4 @ZIF-8-CRL as biocatalyst, employing high acid value waste oil. Candida Rugosa lipase (CRL) was immobilized onto a magnetic ZIF-8 organometallic framework through physical adsorption, resulting in significantly enhanced stability and chemical compatibility. The study extensively investigated the impacts of enzyme dosage, alcohol-to-oil ratio, ultrasonic power, temperature, time, and the addition of deep eutectic solvents on the conversion of fatty acid ethyl esters. The findings revealed that under the conditions of biocatalyst addition of 5.7 wt.%, alcohol–oil ratio of 6:1 mmol/g, ultrasonic power of 87.297 W, reaction temperature of 40 °C, and reaction time of 2 h, the innovative biocatalyst facilitated a conversion efficiency of fatty acid ethyl esters reaching 82.06 ± 1.63%, with a retention rate of 74.52% after three cycles. Additionally, characterization of the biocatalyst using a vibrating sample magnetometer and scanning electron microscopy demonstrated its favorable magnetic recovery potential and morphology. Coupled with its straightforward and efficient synthesis, this biocatalyst proves to be competitive in the catalysis of biodiesel preparation.
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Shenzhen Cong,Si Sun,Yijing Zhang,Ming Wang,Zhehua Jia,Youhua Zhao,Huan Pang
Metal–organic framework (MOF) membranes offer a wide range of applications, including simultaneous hydrogen generation and decarbonization. The permselectivity of gas molecules can be considerably increased by optimizing the oriented of MOF membranes, and it is possible to construct MOF membranes with high permeance and high selectivity. Here, chelation-assisted interfacial growth is used to prepare ZIF-L membranes for H 2 /CO 2 separation. The growth rate of the ZIF-L crystal plane is regulated by optimizing the interface Zn 2+ diffusion, and a ZIF-L membrane with preferred orientation is constructed for efficient separation of H 2 /CO 2 . The optimized ZIF-L membrane has an H 2 permeance of over 2000 GPU, and the H 2 /CO 2 selectivity exceeds 30. Additionally, the prepared ZIF-L membrane exhibits outstanding operating stability and tolerance, making it a promising candidate for industrial applications.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Wufeng Wu,Changdie Cao,Yali Zhao,Qibin Xia,Yanying Wei
Sulfur hexafluoride (SF 6 ) is widely utilized as an insulating gas in power systems because of its outstanding dielectric insulation and arc-quenching properties, which presents significant value and necessity for recycling from both environmental impact and economic benefit. However, conventional thermally driven methods for SF 6 recovery suffer from high energy consumption, urgently necessitating the development of alternative separation techniques that operate under ambient conditions and reduce energy consumption. Herein, a stiffer EZIF-8 is employed as fillers in mixed matrix membranes (MMMs) for efficient SF 6 recovery. EZIF-8 is synthesized under an electric field, which is mainly composed of ZIF-8_ Cm phase. The fabricated MMMs exhibit an excellent N 2 /SF 6 selectivity of 182 with N 2 permeability of 278 Barrer, showing an 18-fold improvement in selectivity compared to that of the pure polymer membranes. Importantly, for both typical insulation gas mixture (70 % N 2 /30 % SF 6 ) commonly used in gas insulated switchgear and 100 h long-term operation, the MMMs are able to maintain steady operation with a relatively high N 2 permeability and N 2 /SF 6 selectivity, demonstrating the promising potential for the efficient recovery of SF 6 especially at low concentrations.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2025
·Vol. 15
·期 15
·11503-11510
·
IF 4.6
Ping Li,Xiaolin Yue,Anhong Li,Can Cui,Lan Wang,Wenyuan Tan
Cobalt 2-methylimidazole (ZIF-67) has been broadly explored for its applications in the treatment of antibiotics in wastewater. However, ZIF-67 in powder form is difficult to recover. In the study, ZIF-67 and Polyvinylidene Fluoride (PVDF) were blended via electrospinning to prepare ZIF-67/PVDF membrane for adsorption of ciprofloxacin (CIP). The ZIF-67/PVDF membrane demonstrated outstanding adsorption efficiency for CIP, with a maximum adsorption capability of 4087.5 μg cm−2. The adsorption performance of ZIF-67/PVDF remains stable across a wide pH range and is unaffected by ionic interference. The ZIF-67/PVDF adsorbent follows pseudo-second-order kinetics and the Langmuir model. Furthermore, thermodynamic research indicates the adsorption of CIP is a spontaneous and exothermic process. It is proposed that the adsorption mechanism of CIP onto ZIF-67/PVDF involves electrostatic interactions, hydrogen bonding, π–π interactions, coordination bonding, and hydrophobic interactions.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Zhiwen Lei,Jianwen Feng,Yu Yang,Jinlai Shen,Weide Zhang,Chaoyang Wang
Zeolitic imidazolate frameworks (ZIFs) possess tremendous potential in various adsorption and catalysis areas for their particular structures. However, the dispersibility and acid stability of ZIFs are important issues hindering their applications. To address these challenges, a transparent polydimethysiloxane (PDMS) coating was constructed to heterogeneously anchor the Cu doped ZIF-67 (Cu/ZIF-67) nanoparticles on melamine sponge surface, achieving a PDMS-coated ZIF three-dimensional composite sponge. Thus PDMS coating could also effectively protect ZIFs from acid damage to prolong the service life of photocatalyticity. It was demonstrated that the composite sponges were able to repeatedly (over 40 cycles) degrade Sudan I dyes with remarkable photocatalytic efficiency (>97%). More importantly, the ion impenetrability of PDMS coating made the ZIFs based composite a longer term catalytic life than unprotected Cu/ZIF-67 under acid condition. Incidentally, due to the introduction of rough ZIFs and hydrophobic PDMS coating, the obtained sponge also exhibits super-hydrophobicity (158.5°), great compressibility and excellent oil/acid water separation performance. We expect that such a polymer coating strategy could act as a novel inspiration for extending the applications and life span of ZIF-based composites.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL RESEARCH
·
2024
·
IF 1
Lei Yang,Tangxuan Xu,Chenghao Li,Yuezhu Yang,Jing Huang
The zinc(II) bis-(8-hydroxyquinoline) (Znq2) has excellent photoluminescence properties, and its fluorescence emission can be significantly quenched by Fe3+ in water. To accelerate the detection response of Znq2 to Fe3+, a luminescent metal–organic framework Znq2@ZIF-8 based on guest molecular luminescence was constructed by growing zeolite imidazolate framework-8 (ZIF-8) on the outer surface of Znq2. The results show that the prepared Znq2@ZIF-8 has an octahedral core–shell structure, a particle size of approximately 1–3 μm, an enhanced specific surface area of 1105.41 m2 g−1, and with a stable green luminescence at 495 nm. A fluorescence analytical method was developed for the detection of Fe3+ in water, the correlation coefficients were significant in the Fe3+ concentration range of 0–600 μmol L−1, and the limit of detection was as low as 3.89 μmol L−1. The spiked recoveries of tap water samples demonstrated that the method could be applied to practical applications. The mechanism of fluorescence detection is that Fe3+ participates in the competitive coordination of Znq2@ZIF-8 metal centers, leading to the collapse of the crystal structure, meanwhile, Fe3+ produces a certain degree of competitive absorption of the excitation light of Znq2@ZIF-8. This method was applied for the detection of Fe3+ in water with good selectivity, anti-interference ability, and has the potential to be used as a rapid detection method.
研究领域:
分析化学
·
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
MATERIALS LETTERS
·
2019
·
IF 3.019
Fei-Fei Wang,Zan Liu,Zhi-Lin Cheng
In this study, the zeolitic imidazolate frameworks-8 (ZIF-8) with nano- and micro-sized morphologies was successfully fabricated by solvothermal method. The dispersibility of as-obtained ZIF-8 in oil was studied. As an application, the tribological behavior of the as-obtained ZIF-8 in the based oil was investigated. The nano- and micro-sized morphologies of as-obtained ZIF-8 were conductive to reduce the friction coefficient and wear, and raise the carrying capacity in the base oil. In addition, the friction reducing mechanism was proposed.
研究领域:
材料科学
·
摩擦学
·
化学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）