COLLOID AND POLYMER SCIENCE
·
2025
·
IF 2.3
Zhang Jingyan,Wang Zhengkai,Yue Yuxing,Ning Yishuo,Xu Pengyuan,Fan Weixiang,Xuan Han,Zhou Haiou,Sun Mei,Wang Xianbiao,Wang Ping,Yang Mingdi
Hydrogels with fully physical networks process significant advantages as convenient injection, self-healing, and biodegradable properties probably accompanied with unfavorable mechanics, adhesiveness, and drug-loading characteristics. In this study, N -acryloyl glycinamide (NAGA)–grafted gelatin decorated with photosensitive N′ -(2-nitrobenzyl) ( NB ) moiety, denoted as GN, was synthesized via a convenient one-step Michael addition. The GN hydrogels in terms of gelatin physical reinforcement was conveniently constructed via UV-induced NB group separation and dual -amide discharge. Also released are curcumin drugs loaded into hydrophobic NB groups via hydrophobic association. Contrastive analysis on a series of GN hydrogels with different degrees of substitution (DS) was performed. As a result, the GN-5 hydrogel with moderate DS (~ 41.2 ± 1.3%) possessed the overall optimal performance with the highest final storage modulus, maximal compression stress, most dense pore structure, and minimal swelling deformation. In addition, the fully physical networks thoroughly assisted in degradation, fast self-healing, and thermo-reversible adhesiveness. Most importantly, the further curcumin release achieved via heating induced H-bonding destruction, and the Ritger-Peppas model best described the dynamic drug release traces during the four kinetic models, which show great application potential in the field of biomedical materials. Graphical The fully physically reinforced gelatin hydrogels afford as a periodic curcumin delivery system with convenient injection, fast self-healing, thoroughly degradation, and thermo-reversible adhesion.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Dan Han,Lihua Ji,Mingzhou Lu,Dingran Li,Xiangling Sheng,Jiaxing Zhang,Cheng Wang
The demand for high-quality, nutritious, and sustainable food products has led to a significant interest in the development of durable and effective emulsions. Pickering emulsions are promising candidates but the currently adopted stabilizers still have limitations. Here in this study, we introduce a novel egg derived reconstituted lipid nanoparticles ( E -rLNPs) as stabilizer for Pickering emulsions. The lipids extraction from de-oiled egg yolk powder was firstly optimized using response surface methodology by Box–Behnken Design and then prepared into E -rLNPs by a straightforward solvent-diffusion method. The E -rLNPs were found to form stable Pickering emulsions that can resist to various environmental stresses. Moreover, the optimal Pickering emulsion offers excellent protection and significantly improves the oral availability of curcumin. This research presents a promising approach for the development of functional foods and nutraceuticals, showcasing the potential of natural food-derived rLNPs as stabilizers for Pickering emulsions, thereby advancing delivery technologies in the food science.
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高影响因子
Crystals
·
2025
·Vol. 15
·期 6
·512
·
IF 2.4
Shixin Fan,Wenling Zheng,Shizhao Ren,Wangchuan Xiao,Fenghua Chen,Rongrong Xue
Amorphous solid dispersion (ASD) technology is popularly used for enhancing the solubility of poorly water-soluble drugs. Drug molecules in ASDs can be dispersed in the form of either amorphous (AASD) or molecular (MASD) forms. The boundary between AASDs and MASDs (A–M boundary) is defined as the drug concentration at which the existence of MASDs obviously influences the physicochemical properties of ASDs. In this work, fluorescence spectroscopy based on the aggregation-caused quenching (ACQ) phenomenon was used to determine the A–M boundary of curcumin (CUR) ASDs prepared via neat ball milling. The relationship between the fluorescence intensity and the loading of CUR in the sample is consistent with the Stern–Volmer equation. For the CUR ASDs with PVP, the samples with CUR loading below 10% show significantly increased fluorescence and have a higher solubility (~178 μg·mL−1), suggesting the A–M boundary is around 10%. Similar A–M boundaries around 10% were also observed for CUR ASDs with PVPVA, Soluplus, HPMC, and HPMCAS. It is of great significance to define the A–M boundary of ASDs for guiding pharmaceutical ASD formulas by balancing drug loading, stability, and solubility.
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CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Jing-Bo Hu,Shu-Juan Li,Xu-Qi Kang,Jing Qi,Jia-Hui Wu,Xiao-Juan Wang,Xiao-Ling Xu,Xiao-Ying Ying,Sai-Ping Jiang,Jian You,Yong-Zhong Du
Based on the abnormally increased expression of CD44 receptors on renal tubule epithelial cells during ischemia/reperfusion-induced acute kidney injury (AKI), we developed a hyaluronic acid-curcumin (HA-CUR) polymeric prodrug targeting to epithelial cells and then relieving oxidative stress damages. The water solubility of HA-CUR was significantly enhanced and approximately 27-fold higher than that of CUR. Cellular uptake test showed HA-CUR was preferably internalized by H 2 O 2 -pretreated tubular epithelial (HK-2) cells compared with free CUR benefiting from the specific binding between HA and CD44 receptors. Biodistribution results further demonstrated the increased accumulation of HA-CUR in kidneys with 13.9-fold higher than that of free CUR. Pharmacodynamic studies indicated HA-CUR effectively ameliorated AKI, and the exact mechanism was that HA-CUR protected renal tubule epithelial cells from oxidative stress damage via inhibiting PtdIns3K-AKT-mTOR signaling pathway. Taken together, this study provides a new therapeutic strategy for the treatment of AKI based on the pathogenesis of the disease.
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Journal of Food Measurement and Characterization
·
2025
·
IF 3.3
Xu Wei,Li Lala,Xin Yingying,Kang Mengyao,Li Penglin,Luo Denglin,Zhang Lihua
This study develops novel antimicrobial camellia oil composite films based on konjac glucomannan (KGM) and κ-carrageenan (KC) incorporated with a curcumin (CUR)-loaded camellia oil nanoemulsion to address food packaging safety and sustainability. The composite solutions and films were systematically characterized. The results demonstrate that the integration of KGM significantly enhanced the rheological characteristics of the composite solution, while also improving the hydrophilicity of the resulting composite film. Thermogravimetric analysis (TGA) revealed that 0.4% KGM elevated the maximum thermal degradation temperature to 250.23 °C, significantly enhancing thermal stability. Fourier transform infrared (FTIR) and X-ray diffraction (XRD) analyses further demonstrated that KGM and KC established a stabilizing network structure through hydrogen bonding interactions. Confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM) indicated that KGM concentrations between 0.1% and 0.3% promoted uniform emulsion droplet dispersion and a smooth film surface. It is noteworthy that when the concentration of KGM was 0.1%, the composite film showed a zone of inhibition of 4.64 mm against Escherichia coli and 4.67 mm for Staphylococcus aureus , which were significantly larger than those of other formulations. In summary, this research presents a theoretical framework designed to enhance the development of high-performance, multifunctional antimicrobial packaging materials, with the objective of fostering sustainable food practices.
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PHYTOTHERAPY RESEARCH
·
2025
·
IF 6.3
Bingqing Liang,Fengxian Shi,Can Jin,Min Chen,Yuxiao Niu,Anhong Li,Weihua Xu,Zhongping Ning,Fengfeng Xue,Xinming Li,Yuzhong Yan
Curcumin, a highly hydrophobic phenolic compound, has demonstrated potent anticancer activity. However, poor water solubility and a short biological half-life hinder its clinical application. We developed Curcumin-loaded Pluronic F-127 nanoparticles to enhance the bioavailability of Curcumin. It has been reported that excessive autophagy is considered to be the main mechanism of death of various cancer cells. The aim of this study is to investigate whether the Curcumin-loaded Pluronic F-127 nanoparticles exert anti-colon cancer effects by modulating autophagy and explore the specific regulatory mechanism. The proliferative, migratory and apoptotic activity of CT26 cells was assessed by CCK-8 assay, wound healing assay and flow cytometry, respectively. In addition, levels of reactive oxygen species (ROS) were examined by DCFH-DA assay in vitro. ATP levels were detected by the ELISA. The expression levels of autophagy-related proteins and apoptosis-related proteins were visualized by western blotting. Curcumin-loaded Pluronic F-127 nanoparticle inhibited the proliferation of CT26 cells and the growth of colon tumours by promoting cellular autophagy. In addition, Curcumin-loaded Pluronic F-127 nanoparticle reduced mitochondrial membrane potential and impaired mitochondrial function by increasing ROS levels, disrupting ATP biosynthesis. Then the decreased ATP/AMP ratio activated the AMPK/mTOR/ULK1 autophagy signalling pathway and induced autophagy-dependent apoptosis in CT26 cells. Intriguingly, the apoptosis and excessive autophagy induced by Curcumin-loaded Pluronic F-127 nanoparticle were reversed after pretreatment with the antioxidant N-acetyl-L-cysteine. Curcumin-loaded Pluronic F-127 nanoparticle induced autophagy-dependent apoptosis through ROS-AMPK/mTOR/ULK1 signalling in colon cancer cells. Our study offers new insights for colon cancer treatment advancement.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Lei Nie,Xiaoyue Ding,Yingsong Zhao,Peng Ding,Meili Zhao,Yuanna Sun,Yanfang Sun,Guohua Jiang
Multifunctional hydrogel dressings, with their robust antibacterial and anti-inflammatory properties, represent a great potential in biomaterials for wound care. Injectable and self-healing hydrogels that mimic the natural extracellular matrix of tissues offer a promising strategy for effective wound repair. This study designs a hydrogel based on the formation of a dynamic cross-linking network within the hydrogel matrix through the Schiff base reaction between the synthesized polymers L-hydroxyproline-conjugated chitosan (LHCS) and oxidized pullulan (OPL). The fabricated LP hydrogels preserve the porous interconnected microstructure, excellent self-healing capacity, and injectability, suitable swelling capability, robust mechanical strength, and outstanding tissue adhesion. Moreover, curcumin was encapsulated in Polyether F127 (Pluronic F127) micelles to obtain curcumin loaded PF127 (Cur-PF127) micelles and then incorporated into LP hydrogel to fabricate the composite hydrogels. The composite hydrogels exhibit effective antibacterial properties and antioxidant abilities, admired hemostatic effect and hemocompatibility, excellent cytocompatibility and cell pro-migration ability. In addition, in vivo evaluation confirmed that curcumin loaded hydrogels could facilitate the regeneration of epithelial and hair follicles, increase the collagen production, alleviate the inflammatory response via the downregulation of the tumor necrosis factor-α (TNF-α), and reduce the fibrosis, thus promote the wound repair process. This work offers a promising facile approach for the development of the composite hydrogel as wound dressing in wound healing applications.
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FOOD CONTROL
·
2025
·
IF 6.3
Mingrui Zhou,Mengqi Chen,Youwei Ai,Wenfu Hou,Yang Yi,Hongxun Wang,Yahong Han
Petroleum-based packaging materials raise serious environmental and food safety concerns, driving the development of sustainable smart packaging derived from natural polymers. In this study, natural pigment-zein-chondroitin sulfate-epigallocatechin gallate-ι-carrageenan (NZCEC) nanoparticles were fabricated and incorporated into κ-carrageenan-based films to enhance their functional properties. The effects of NZCEC addition on the films' physicochemical stability, intermolecular interactions, antioxidant activity, and responsiveness to ammonia and acetic acid vapors were systematically evaluated, along with their application in preserving mandarin fish ( Siniperca chuatsi ). Scanning electron microscopy revealed good compatibility between κ-carrageenan and moderately loaded NZCEC nanoparticles. Incorporation of NZCEC significantly improved the film's optical properties (opacity increased from 4.10 to 23.32 A mm −1 ) and reduced its water vapor permeability (from 8.23 × 10 −9 to 6.93 × 10 −9 g m −1 s −1 Pa −1 ). Moreover, the antioxidant activity was markedly enhanced (from 1.75 % to 77.65 %), along with notable responsiveness to ammonia and acetic acid. Storage trials with mandarin fish demonstrated that the smart film effectively delayed fish spoilage. Additionally, the film displayed distinct chromatic variations in response to freshness, allowing continuous assessment of food quality. These results establish NZCEC nanoparticle-reinforced κ-carrageenan films as a promising intelligent packaging material with improved stability, responsiveness, and food preservation performance.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2025
·Vol. 172
·期 8
·087515
·
IF 3.3
Yuelan Fang,Suxiang Feng,Xiaokun Li
Curcumin is extensively utilized across various domains including the food, pharmaceuticals, and chemical industries. However, excessive curcumin intake may induce tissue necrosis, thereby posing a substantial threat to human health, making rapid and precise detection of curcumin levels paramount. Here, tetranitro nickel phthalocyanine (NiPc) was synthesized via a solid-phase method. Subsequently, it underwent an azo condensation reaction with p-phenylenediamine (PPDA) under the assistance with potassium hydroxide. This process was used to fabricate a nickel phthalocyanine-based covalent organic framework material (PPDA-NiPc COF). Herein, NiPc serves as the acceptor unit (A) with high electron-accepting capability, while PPDA functions as the donor unit (D) to provide electrons. The D-A architecture established through imine bond formation, which significantly enhances photogenerated charge carrier separation and transfer. The photoelectrochemical sensor constructed based on two-dimensional COF exhibits remarkable sensitivity for curcumin detection. It demonstrates a favorable linear response within the concentration range of 0.05 to 50 μM, with a detection limit as low as 1.46 nM. Moreover, this detector possesses superior stability and reproducibility and enables accurate quantification curcumin in real samples. This study not only expands COF material applications in photoelectrochemical sensing but also provides a novel strategy for detecting curcumin.
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MOLECULES
·
2014
·Vol. 19
·期 6
·7287-7307
·
IF 2.095
Yali Zhang,Leping Zhao,Jianzhang Wu,Xin Jiang,Lili Dong,Fengli Xu,Peng Zou,Yuanrong Dai,Xiaoou Shan,Shulin Yang,Guang Liang
Curcumin has been reported to possess multiple bioactivities, such as antioxidant, anticancer, and anti-inflammatory properties, however the clinical application of curcumin has been significantly limited by its instability and poor metabolism. Modification of curcumin has led to discovery and development of lots of novel therapeutic candidates. In recent years acute and chronic inflammation has been the focus of numerous studies in various diseases. Here, we synthesized a series of asymmetrical curcumin analogs with highin vitrochemical stability, and their anti-inflammatory activity was evaluated in LPS-stimulated macrophages. According to the bio-screening results and QSAR analysis, these analogs exhibited potent activities against LPS-induced TNF-α and IL-6 release. Among the analogs of the potent anti-inflammatory activity, compounds3b8and3b9exhibited significant protection and possess enhanced anti-inflammatory activity thereby attenuated the LPS-induced septic death in mice.Keywords:curcumin;asymmetrical curcumin analogs;anti-inflammation;QSAR;cytokines
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JOURNAL OF PERIODONTAL RESEARCH
·
2021
·Vol. 56
·期 4
·656-666
·
IF 4.419
Ya Zhao,Zhiwei Zheng,Menghan Zhang,Yi Wang,Rongdang Hu,Weijia Lin,Chenyang Huang,Chuchu Xu,Jianzhang Wu,Hui Deng
Background and objective The application of curcumin is limited by its instability. Mono-carbonyl analogues of curcumin (MCACs) are structurally stable, yet the intermediate bridging ketones in their skeletons account for increased toxicity. This study aimed to synthesize and screen MCACs that exhibit low cytotoxicity and high antioxidant ability, and the effects of MCACs on experimental periodontitis were also investigated. Materials and methods The cytotoxicity of MCACs on MC3 T3-E1 was determined by MTT assay. The antioxidant capacity was investigated by the cell viability against H 2 O 2 -induced damage and the level of reactive oxygen species (ROS) and malondialdehyde (MDA). The localization and protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) was detected by immunofluorescence and western blot, respectively. In addition, MCAC was intragastrically administrated in rats with ligature-induced experimental periodontitis. The effects were assessed by bone resorption, as well as the immunohistology staining of inflammatory and oxidative stress markers. Results MCACs with cyclopentanone and containing pyrone showed lower toxicity than natural curcumin were synthesized ( 1A - 10A , 1H - 10H ), among which, 1A exhibited the most potent cytoprotective effect against H 2 O 2 -induced damage. Such effects could be explained by the reduced MDA and ROS level, possibly through the nucleus translocation of Nrf2 and the induction of HO-1. Micro-CT results further indicated that 1A significantly reduced bone loss, along with an increased level of Nrf2 and HO-1, and decreased TNF-α and IL-1β. Conclusion The present study has synthesized a novel antioxidant MCAC 1A with good biosafety and stability. MCAC 1A could serve as a host response modulator with preventive and protective effects on periodontitis.
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CELL AND TISSUE BANKING
·
2021
·Vol. 22
·期 3
·443-451
·
IF 1.522
Kang Bo Kyoung,Yu Zheyuan,Chen Weiming,Jiang Taoran,Shim Yoong-hun,Gao Jiaman,Zhou Guangdong,Cao Dejun
Engineered cartilage has several applications in treating cartilage ossification, however, its use is restricted clinically. We explored the feasibility of engineered cartilage in constructing tissues using gelatin/curcumin nano-fiber membranes as scaffolds in subcutaneous models. We constructed cartilage with gelatin nano-fiber membrane (control group) and gelatin/curcumin nano-fiber membrane (experimental group) as scaffolds. After the material was implanted into the back of BALB/c mice, gross view observation was performed. Histological examination was performed 3 and 12 weeks after implantation in vivo, and cartilage formation at different time points was compared. Gross observation showed that compared to the control group, the vascularization of nearby tissues in the experimental group was significantly inhibited. The Scanning electron microscope observation showed that the chondrocytes in both groups adhered well. The growth curve of the chondrocytes showed that curcumin had no significant effect on cell growth. Histological observation showed that the cell-material complexes in both groups had cartilage lacuna formation at 3 and 12 weeks. However, compared with that of the control group, the experimental group showed obvious absorption and thicker cartilage matrix with more homogenization. Gelatin/curcumin scaffolds were successfully used to construct engineered cartilage tissues in subcutaneous animal models. Our findings demonstrate that curcumin-loaded scaffolds have great clinical applications.
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