Burns & Trauma
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2025
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IF 9.6
Yang Shuhao,Hu Qianshui,Hu Yingkun,Pu Zhengguang,Lan Yixuan,Wu Haoming,Zhu Gaohui,Gao Zhixiang,Yang Jianye,Tan Shuai,Hu Ning,Hu Xulin,Qin Leilei
BackgroundInfectious bone defects are characterized by persistent bacterial invasion and an immune microenvironment imbalance, which significantly hinders bone regeneration. Recently, numerous bone repair materials have been developed to address the complex pathological microenvironment associated with infectious bone defects. However, dynamic changes in the defect size after infectious debridement pose a significant challenge for achieving effective bone integration of artificial bone grafts.MethodsUsing low-temperature printing combined with the freeze-drying technology, a shape-memory scaffold with a biomimetic porous structure of cancellous bones was fabricated by compositing left-handed poly(L-lactic acid)-trimethylene carbonate (PLLA-TMC) with citric acid-modified hydroxyapatite (CHA). The scaffold (PT/CHA) was further coated with a metal-polyphenol network tannic acid-magnesium (TA-Mg) on its surface through the "mussel" effect, enabling the sequential treatment of infectious bone defects.ResultsThe scaffold can adaptively integrate with defect interfaces at the physiological temperature (37°C), achieving superior bone integration performance. The incorporation of citric-acid-modified hydroxyapatite effectively optimizes the polymer-inorganic phase printing ink system, significantly enhancing the mechanical strength and mineralization capacity of the scaffold. Meanwhile, the external tannic-acid-magnesium metal-polyphenol coating (TA-Mg) demonstrates excellent pathogen clearance properties both in vitro and in vivo. It also influences macrophage polarization to regulate the immune microenvironment, ultimately promoting bone regeneration in infectious bone defects.ConclusionsThe PT/CHA@TA-Mg scaffold achieves bone integration through adaptive filling and enables the multi-stage treatment of infectious bone defects via antibacterial, immune-regulatory and osteogenic differentiation.
研究领域:
生物医学工程
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组织工程
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骨再生
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感染性疾病
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生物材料
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免疫调节
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PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Qinbo Jiang,Huilan Zhang,Quancai Sun,Ye Peng,Hui Zhang
Foods with high-starch porous structures have a high glycemic index (GI), posing health risks. Replacing traditional starch networks with dietary fiber-based porous skeletons promotes a low-GI diet. Herein, regenerated silk fibroin (RSF) and polyphenol complex nanoparticles were embedded into the sodium alginate (SA) cryogel by covalent and noncovalent approaches. Nanoparticles were fabricated by covalent interactions between RSF and polyphenols (proanthocyanidin (PA) and quercetin (QUE)) using a bottom-up method under alkaline conditions. Heating and non-heating treatment on pre-solutions caused Maillard reactions and hydrogen bonding between nanoparticles and the SA matrix. The noncovalent embedding of RSF-PA nanoparticles greatly improved the mechanical properties of the cryogels, with the compressive strength increasing from 24.41 to 139.83 kPa. Cryogels with covalently embedded nanoparticles had higher polyphenol release rates, antioxidation, and antibacterial activities (11.2 mm of inhibition zone against S. aureus ). This work promotes the development of low GI functional diets from dietary fiber-based porous matrices.
研究领域:
食品科学
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生物材料
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功能食品
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纳米技术
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高分子化学
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Sustainable Materials and Technologies
·
2024
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IF 8.6
Wei Tan,Chunlong Zuo,Yin Tian,Lu Bai,Lina Jiang,Jieyun Zhao,Xiaoyu Liu,Yuanlin Ren,Xiaohui Liu
The white pollution caused by non-degradable plastics poses a serious threat to human society and the environment, thus developing biodegradable material is urgent. In this work, a novel phosphonitrile hybrid metal-polyphenol network was constructed and used for the preparation of flame retardant , UV resistant and antibacterial multifunctional polyvinyl alcohol composite (PVA@HCPD-Ag). The limiting oxygen index (LOI) value of PVA@HCPD-Ag was improved to 33.5%, while the peak heat release rate (PHRR) and total heat release (THR) decreased by 35.62% and 47.76%. Besides, the ultraviolet protection factor (UPF) value of PVA@HCPD-Ag was significantly improved from 4.63 of the original PVA to 482.79, while the tensile strength was increased by 10.23%. Furthermore, the inhibition efficacy of PVA@HCPD-Ag for E. coli and S. aureus was up to 98.12% and 99.99%. This work explored the synergistic flame retardant effect of in-situ reduced Ag 0 and phosphonitrile crosslinked polyphenol network and proposed an advanced strategy for developing high value-added functionalized PVA materials.
研究领域:
高分子材料科学
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功能材料
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纳米复合材料
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生物医用材料
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环境友好材料
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DOI
高影响因子
ANALYTICAL LETTERS
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2022
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IF 2.267
Qi Cheng,Ling Zhang,Lulu Lei,Hui Huang,Yongxin Li
Nanomaterials with natural enzyme-like activities have attracted widespread interest and hence their development is significant. Here, a copper Prussian blue analogue named Cu-HCF was prepared and its polyphenol oxidase (PPO)-like activity was investigated for the first time. Cu-HCF nanozyme showed nearly 7-fold higher substrate affinity than natural PPO and was more stable under alkaline conditions, high temperature, high salt concentrations, and long-time storage. The catalytic activity of Cu-HCF nanozyme was reduced by pyrophosphate (PPi). Alkaline phosphatase (ALP) hydrolyzed PPi to orthophosphate (Pi) and hence the PPO-like activity of Cu-HCF nanozyme was restored. A method was therefore developed for selective determination of the ALP activity. The linear range was from 1 to 50 mU/mL with a limit of detection (LOD) of 0.35 mU/mL. This approach was validated in human serum samples, showing its potential in diagnostic applications.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Yijing Hu,Zhihao Chen,Yidan Ding,Yanchao Xu,Hongjun Lin,Wei Yu,Jiaheng Teng,Liguo Shen,Yang Jiao,Bao-Qiang Liao
The traditional layer-by-layer (LBL) self-assembly method used to prepare nanofiltration (NF) membranes with polyelectrolytes often suffers from low permeability caused by the restricted free volume of the selective layer. Furthermore, substrate surfaces typically require rigorous chemical treatment with potent acids or bases to achieve the necessary charge for adsorbing the initial polyelectrolyte layer. To address these issues, a green and straightforward aqueous immersion method was utilized in this investigation to form a coating of plant polyphenol tannic acid (TA) on the substrate surface. The TA coating served as an intermediary for the LBL self-assembly of negatively charged 2-dimensional material MXene nanosheets and positively charged polyethyleneimine (PEI), resulting in a well-structured NF membrane. By utilizing a 4-bilayer number, 0.05 mg/mL MXene concentration, 1.0 mg/mL PEI concentration, and PEI molecular weight of 1800 g mol −1 , an NF membrane with an ultrahigh pure water permeance of 204.0 L m −2 h −1 bar −1 and 99.9% Evans Blue rejection was produced. Furthermore, the membrane possesses an ultra-high dye/salt separation factor of 758.1, surpassing most of the previously reported data. The innovative plant polyphenol-mediated MXene and PEI LBL self-assembly strategy proposed can be applied not only in NF membrane preparation but also in inspiring the design of advanced MXene composite materials for environmental and energy applications.
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Food Packaging and Shelf Life
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2022
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IF 8.749
Xingzi Lan,Tingting Luo,Zhixin Zhong,Dongchao Huang,Chengfeng Liang,Yurong Liu,Han Wang,Yadong Tang
Gelatin nanofibrous membrane has attracted increasing attention as biodegradable and edible food packaging. However, the lack of bioactivity and the weak water resistance of gelatin nanofibrous membrane severely limits its application in food preservation. Therefore, in this study, antioxidant agent tea polyphenol (TP) and antibacterial agent ε-poly ( L -lysine) (ε-PL) were incorporated into gelatin nanofibrous membrane. To enhance the water resistance, the TP and ε-PL loaded gelatin nanofibrous membrane was cross-linked at high temperature. And the antibacterial activity and antioxidant activity of gelatin/TP/ε-PL nanofibrous membrane after cross-linking were investigated. The results showed that the gelatin/TP/ε-PL nanofibrous membrane exhibited homogenous bead-free structure. The UV–vis spectra confirmed the successful incorporation of TP and ε-PL into nanofibers . The water contact angle of the gelatin/TP/ε-PL nanofibrous membrane after cross-linking was increased. The fabricated nanofibrous membrane could prevent microbial penetration. And the nanofibrous membrane still exhibited excellent antibacterial activity and antioxidant activity after cross-linking. Finally, the MTT assay demonstrated the biocompatibility of nanofibrous membrane. The above results suggested that the prepared gelatin/TP/ε-PL nanofibrous membrane exhibited great potential in bioactive food packaging.
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ACS Applied Materials & Interfaces
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2022
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IF 10.383
Huiyu Yang,Jingyi Zhou,Zijiang Duan,Bin Lu,Bo Deng,Weilin Xu
Structural coloration is an important way to realize eco-friendly dyeing of textiles. Structural colored cotton fabric was obtained by fabricating a polydopamine (PDA) film on the white cotton fabric at different polymerization reaction times. PDA is prone to generate capillary tension during film formation, which damages the uniformity and interfacial bonding force of the film. Multiple hydrogen bonds will form between the lactam group of polyvinylpyrrolidone (PVP) and the phenolic hydroxyl group of PDA. The introduced hydrogen bonds will effectively enhance the interfacial bond strength and lead to structural color with high color fastness. The surface morphology of double-layer aggregates of the PDA film on structural colored cotton fabric was revealed by scanning electron microscopy. The chemical constitution of the PDA film and PVP was investigated by Fourier transform infrared spectroscopy and X-ray diffraction. The color characteristics of structural colored cotton fabrics were analyzed by UV–vis reflectance spectroscopy and spectrophotometry.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2022
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IF 5.895
Bei Yan,Lei Chen,Yanhui Wang,Jiacheng Zhang,Hui Zhao,Qinglian Hua,Shengjie Pei,Zihang Yue,Hui Liang,Huaqi Zhang
In this work, the protective effect of apple polyphenol extract (APE) on hepatic steatosis was investigated. Thirty-two C57BL/6J mice were assigned randomly to control group, hepatic steatosis group, lovastatin group, and APE group. After 8 weeks of intervention, APE supplementation markedly decreased the body weight gain, liver weight, liver index, epididymal adipose weight, epididymal adipose index, serum, and hepatic lipid levels. Hematoxylin and eosin staining revealed that APE supplementation alleviated histopathological changes of hepatic steatosis. Western blot revealed that APE downregulated the protein levels of GRP78, IRE1α, p-IRE1α, XBP1, PERK, p-PERK, p-eIF2α, ATF6, PPAR-γ, SREBP-1c, FAS, and ACC1. In conclusion, this study found that APE inhibited IRE1α-XBP1, PERK-eIF2α, and ATF6 signaling pathways to alleviate endoplasmic reticulum stress, thereby improving HFD-induced hepatic steatosis.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 5
·3452-3467
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IF 4.682
Du Chunxiao,Liu Gaoyang,Qu Zhongji,Wang Wei,Yu Dan
Over the years, graphene oxide (GO) with unique permeability and selectivity has been extensively researched for hydrophilic enhancement modification, especially as the separation layer of oil–water separation composite membranes. However, the poor stability caused by hydration of GO, and the low water flux caused by the lamellar compaction limit its application. In this study, a surface modification strategy based on metal polyphenol coordination was proposed to address these problems by co-deposition of tannic acid-graphene oxide (TA-GO) and TiO 2 on electrospun polyvinylidene fluoride (PVDF) membrane. TiO 2 was inserted into GO layers to expand the interlayer spacing and prevent membrane compaction. Moreover, the interlayer force was enhanced by TA and Fe 3+ through covalent bonds, cation-π, and coordination bond. The results demonstrated that the underwater oil contact angle of resultant composite membrane reached 152.5°. In addition, it has a high flux (243.11 L/h·m 2 ·bar) and oil (> 98%)/salt (> 47%) rejection, which can be maintained even after ultrasonic treatment for 30 min. This work proposed a practical and environmental approach to construct a steady GO-modified hydrophilic membrane. Graphical abstract
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2021
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IF 5.268
Shaoyin Wei,Daozhen Zhou,Jianghui Qin,Bo Peng,Xingjie Zan
Capsules have hollow cores and closed wall structures, and they have attracted considerable interest due to their wide applications and significance in life science. The engineering process of bioinspired capsules and related applications have earned heavy concerns. However, the mechanism of capsule formation is often ignored. Herein, based on polyornithine (POR) and tannic acid (TA), two facile strategies to engineer bioinspired capsules were proposed, and the formation mechanisms were deeply explored. We found that the oxidized state of TA had a profound influence not on the thickness or permeability of the formed capsule but on the mechanism and generation process. Compared to TA/POR capsules produced from TA without oxidization ( TA/POR), capsules produced from TA with preoxidization ( o TA/POR) had thicker shells with higher impermeability. The dominant construction mode in the shells of TA/POR capsules was electrostatic interactions but became Schiff base bonds in o TA/POR capsules. The permeability of o TA/POR displayed pH reversibility and strong pH dependence, with 100% permeability at lower pH and 100% impermeability at pH 7, completing loading/releasing kinetics in minutes at pH 4. We believe these findings contribute to knowledge of bioinspired capsules from engineering processes and formation mechanisms, extending their applications in various fields, such as in drug delivery, artificial cells, and sensors.
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Foods
·
2021
·Vol. 10
·期 11
·2765
·
IF 4.35
Fanghua Guo,Rong Tsao,Chuyao Li,Xiaoya Wang,Hua Zhang,Li Jiang,Yong Sun,Hua Xiong
As a processing by-product, green pea hull (GPH) was found to be rich in phenolic components in our previous studies. In this study, UHPLC-LTQ-OrbiTrap-MS (Ultra performance liquid chromatography-linear ion trap orbitrap tandem mass spectrometry) technique was used to quantify polyphenols, and DSS (sodium dextran sulfate)-induced colitis mouse model was established to explore the effect of GPH extracts on colitis. The results showed that quercetin and its derivatives, kaempferol trihexanside and catechin and its derivatives were the main phenolic substances in the extract, reaching 2836.57, 1482.00 and 1339.91 µg quercetin/g GPH extract, respectively; GPH extracts can improved inflammatory status, repaired colonic function, regulated inflammatory factors, and restored oxidative balance in mice. Further, GPH extracts can activate Keap1-Nrf2-ARE signaling pathway, regulate downstream antioxidant protease and gut microbiota by increasing F/B value and promoting the growth ofLactobacillaceaeandLachnospiraceae, and improve the level of SCFAs (short-chain fatty acids) to relieve DSS-induced colitis in mice. Therefore, GPH may be a promising dietary resource for the treatment of ulcerative colitis.Keywords:polyphenols;colitis;UHPLC-LTQ-OrbiTrap-MS;GPH extracts;Keap1-Nrf2;gut microbiota
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2021
·Vol. 102
·期 9
·3771-3780
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IF 3.639
Yuefang Sun,Lei Zhou,Tao Liao,Junping Liu,Kaibo Yu,Liqiang Zou,Wei Zhou,Wei Liu
BACKGROUND Polyphenol oxidase (PPO) is considered to have a key role in the food industry because it initiates enzymatic browning in the processing and storage of fruit and vegetables. Increasing numbers of benzoic and cinnamic acid derivatives have been found to be efficient inhibitors of polyphenol oxidase, but a comparison study on activity and action mechanism is lacking. In this study, 18 benzoic acid and cinnamic acid hydroxy derivatives were selected and investigated. RESULTS Three substrates, four activators and 11 inhibitors were identified from benzoic and cinnamic acid derivatives. 2,4-Dihydroxycinnamic acid and benzoic acid showed the strongest inhibitory effect on PPO, with IC 50 of 0.092 and1.425 mmol L −1 , respectively. Benzoic acid reversibly inhibited PPO in a competitive manner, while 2,4-dihydroxycinnamic acid showed a mixed-type inhibition. Both of them showed that static-type fluorescence quenching and electrostatic interaction were the main driving force in the bonding process. Compared with benzoic acid, 2,4-dihydroxycinnamic acid more easily formed hydrogen bonds in the active site of PPO, making the interaction more stable. CONCLUSION Comparative analysis showed that the inhibition effect of cinnamic acid hydroxyl derivatives on PPO was stronger than that of benzoic acid derivatives. Benzoic acid and 2,4-dihydroxycinnamic acid were the strongest inhibitors. PPO inhibitors identified from benzoic and cinnamic acid derivatives are expected to be promising inhibitors for controlling fruit and vegetable browning. © 2021 Society of Chemical Industry.
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