MEDICINAL CHEMISTRY RESEARCH
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2021
·Vol. 30
·期 12
·2228-2239
·
IF 1.965
Shang Fan-Fan,Wang Mei-Yuan,Ai Jiang-Ping,Shen Qing-Kun,Guo Hong-Yan,Jin Chun-Mei,Chen Fen-Er,Quan Zhe-Shan,Jin Lili,Zhang Changhao
Nineteen mycophenolic acid (MPA) derivatives were designed and synthesized, and their anti- Toxoplasma activity evaluated for the first time. Among them, N -propylimidazole-modified compound E5 demonstrated the strongest activity, and the IC 50 against HFF-1 (Human Foreskin Fibroblasts-1) cells following infection with T. gondii is 80.9 μM (MPA-211.5 μM) and its selectivity index is 2.2 (MPA-1.2). In vivo experiments, E5 can significantly inhibit the proliferation of tachyzoites in the abdominal cavity of mice acutely infected with T. gondii (inhibition rates 46.7%), and this inhibitory effect was greater than that of spiramycin (inhibition rates 31.3%) and MPA (inhibition rates 15.9%), this indicated that E5 had significant protective effects on the host during acute Toxoplasma infection. In addition, E5 can reduce the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the serum of infected mice, significantly increase the level of glutathione (GSH) in the liver, and significantly reduce the level of malondialdehyde (MDA), indicating that it has a hepatoprotective effect against T. gondii infection. Similarly, E5 can relieve hepatomegaly and splenomegaly induced by acute Toxoplasma infection. Spiramycin aggravated appetite loss in infected mice, while E5 did not. In summary, the results indicated that E5 has potential as a candidate anti- T. gondii drug.
研究领域:
药理学
·
寄生虫学
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药物化学
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DOI
高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2020
·Vol. 29
·期 5
·1460-1466
·
IF 2.572
Sun Ce,Wang Zanru,Wang Qiong,Cao Jun,Li Wenlong,Tan Haiyan,Zhang Yanhua
In this work, a series of polyurethane/montmorillonite (PU/MMT) nanocomposite films were prepared by in-situ polymerization method. The effect of MMT contents on the properties of the films was investigated using various test methods. MMT enhanced the thermal stability of the films, and the glass transition temperature of PU/MMT films was increased because MMT limited the movement of molecular chains of PU. MMT was well-dispersed in the nanocomposites because the agglomeration of MMT was inhibited by mechanical force. Especially in the PU/4% MMT nanocomposite, MMT showed the best dispersibility. This study showed that the addition of MMT effectively improved the properties of the PU/MMT nanocomposite films.
研究领域:
材料科学
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高分子化学
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DOI
高影响因子
BioChip Journal
·
2020
·Vol. 14
·期 4
·429-437
·
IF 2.309
Xiong Xiaolu,Zhang Junlin,Wang Zhou,Liu Chenchen,Xiao Wende,Han Junfeng,Shi Qingfan
In order to improve the efficiency of disease diagnosis and environmental monitoring, it is desirable to detect the concentration of proteins and metal ions simultaneously, since the current popular diagnostic platform can only detect proteins or metal ions independently. In this work, we developed a colorimetric microfluidic paper-based analytical device (µPAD) for simultaneous determination of protein (bovine serum albumin, BSA) and metal ions [Fe(III) and Ni(II)]. The µPAD consisted of one central zone, ten reaction zones and ten detection zones in one device, in which reaction solutions were effectively optimized for different types of chromogenic reactions. Fe(III), Ni(II) and BSA can be easily identified by the colored products, and their concentrations are in good accordance with color depth based on the established standard curves. The detection limits are 0.1 mM for Fe(III), 0.5 mM for Ni(II) and 1µM for BSA, respectively. Best of all, we demonstrated the efficiency of the µPAD with accurate detection of Fe(III), Ni (II) and BSA from river water samples within 15 minutes. The µPAD detection is efficient, instrument-free, and easy-to-use, holding great potential for simultaneous detection of cross type analytes in numerous diagnostic fields.
研究领域:
分析化学
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环境科学
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医学诊断
✓ 已验证
DOI
PubMed
高影响因子
WATER AIR AND SOIL POLLUTION
·
2022
·Vol. 233
·期 12
·1-19
·
IF 2.984
Song Guobin,Tong Liya,Chen Shuhua,Zhang Jing,Zhang Yi,Wang Haonan,Shi Yawei,Sun Ya,Ding Guanghui
In the present study, a series of amino functionalized magnetic multi-walled carbon nanotubes (MMWCNT-NH 2 ) have been prepared by using a facile one-pot solvothermal method and the sorptive removal of anionic dye Congo red (CR) from water was investigated. The composite prepared with triethylenetetramine was found to have higher removal efficiencies due to higher content of amino groups. Characterization analyses confirmed its excellent magnetic separation property and the successful introduction of amino groups on MMWCNTs. The adsorption processes were well fitted by the pseudo-second-order kinetic model, and a three-stage diffusion mechanism had been proved by the intra-particle diffusion model. The maximum adsorption capacities of CR on pristine MMWCNT and MMWCNT-NH 2 -3 were calculated to be 116.7 and 322.7 mg/g at 25 °C, respectively, indicating the great improvement of the adsorption performance after the amino functionalization. The adsorption of CR on MMWCNT-NH 2 -3 performed better under weak acidic conditions due to stronger electrostatic attraction. Several factors, including common anions, typical surfactants, and different organic matters, could suppress the adsorption of CR to varying degrees. Due to the electrostatic attraction and electron donor–acceptor interaction, the selective adsorption of anionic dye could be realized. The prepared MMWCNT-NH 2 -3 exhibited excellent reusability performance with five consecutive cycles. Therefore, MMWCNT-NH 2 -3 prepared in this study could be a promising adsorbent for the sorptive removal of anionic dye from wastewater.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2018
·Vol. 25
·期 29
·28942-28953
·
IF 2.8
Liu Wei,Zhong Xuan,Cheng Lei,Wang Jing,Sun Yongqi,Deng Yi,Zhang Zuotai
Removal of intracellular water in microbial cells remains a key issue for sludge disposal, and here, a novel method of enzymatic treatment with two enzymes, lysozyme and protease, was employed. Total internal reflection fluorescence microscope (TIRF) was applied to image the bacteria in sludge and quantify the evolution of sludge bacteria for the first time. The ratio of dead/live bacterial cells was always higher in the presence of lysozyme than in the presence of protease, indicating that lysozyme has higher activity in inducing bacterial cell degradation and releasing intracellular water. The compositions of extracellular polymeric substances (EPS) were further measured, and the results show that the dewatering performance of sludge is correlated both to the release of cell contents and the variations in EPS composition during cell degradation. Moreover, kinetic analysis demonstrated that the enzyme-catalyzed reaction was substantially completed within 1 h, i.e., the reaction was quite rapid during the first 1 h, and thereafter, it gradually reduced to stability. The mechanism of enzymatic treatment of sludge explored in this study thus not only enhanced the understanding of sludge deep dewatering but also provided significant methodological clues for the disposal of sludge.
研究领域:
环境微生物学
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污水处理
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生物化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2019
·Vol. 321
·期 3
·1093-1107
·
IF 1.186
Ma Zhili,Wang Yanfei,Liu Mouwu,Luo YiGe,Xie Xiaoqing,Xiong Zeng
Poly(cyclotriphosphazene-co-4,4′-diaminodiphenyl ether) crosslinked microspheres with active amino groups on the surface were prepared by one-step precipitation polymerization method. The as-prepared material were characterized by means of FTIR, XPS, XRD, EDS and SEM. The effects of pH, time of contact, dosage, initial concentration and temperature on the adsorption of uranium(VI) by the crosslinked microspheres were studied, and the adsorption mechanism was elucidated. Under the optimized adsorption conditions, the adsorption removal efficiency reached 97.03%. The experimental results fit the Langmuir isotherm model and adsorption processes comply with the pseudo-second-order kinetic model. Thermodynamic data revealed that the adsorption behavior of uranium(VI) on the microspheres was spontaneous and exothermic.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 12
·1-9
·
IF 6.232
Peng Bo,Fan Mimi,Xu Jiamei,Guo Yang,Ma Yongjun,Zhou Min,Bai Jialei,Wang Jingfeng,Fang Yanjun
Blue carbon dots (BCDs) and red gold nanoclusters modified by bovine serum albumin (BSA-Au NCs) were selected as luminescent nanomaterials, and the nanohybrid materials were successfully prepared and applied to the fluorescent measurement of copper ions. The prepared ratio fluorescent probe has two emission peaks near 452 and 654 nm under an excitation of 330 nm. The fluorescence intensity was gradually quenched because Au NCs was aggregated in the presence of Cu 2+ , resulting in a gradation of the fluorescent color from red to pink to purple to blue for visual detection. BCDs have almost the same fluorescence intensity due to their light stability and chemical inertness to Cu 2+ and serve as a background reference in the sensing system. Under the optimal condition, the detection limit (LOD) is 16 nM, the linear range is 0.05–1.85 μM, and the coefficient of determination R 2 is 0.9987 for copper determination. Compared with other single probes, the ratio fluorescent probe in the current study has good water solubility, low cytotoxicity, and is easy to synthesize. The nanoprobe provides a high-quality and sensitive visible light platform for monitoring copper ions.
Graphical abstract
研究领域:
分析化学
·
材料科学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
Bioresources and Bioprocessing
·
2021
·Vol. 8
·期 1
·1-14
·
IF 4.578
Gong Zhenggang,Yang Guangxu,Song Junlong,Zheng Peitao,Liu Jing,Zhu Wenyuan,Huang Liulian,Chen Lihui,Luo Xiaolin,Shuai Li
Abstract Lignin deposits formed on the surface of pretreated lignocellulosic substrates during acidic pretreatments can non-productively adsorb costly enzymes and thereby influence the enzymatic hydrolysis efficiency of cellulose. In this article, peanut protein (PP), a biocompatible non-catalytic protein, was separated from defatted peanut flour (DPF) as a lignin blocking additive to overcome this adverse effect. With the addition of 2.5 g/L PP in enzymatic hydrolysis medium, the glucose yield of the bamboo substrate pretreated by phenylsulfonic acid (PSA) significantly increased from 38 to 94% at a low cellulase loading of 5 FPU/g glucan while achieving a similar glucose yield required a cellulase loading of 17.5 FPU/g glucan without PP addition. Similar promotion effects were also observed on the n-pentanol-pretreated bamboo and PSA-pretreated eucalyptus substrates. The promoting effect of PP on enzymatic hydrolysis was ascribed to blocking lignin deposits via hydrophobic and/or hydrogen-bonding interactions, which significantly reduced the non-productive adsorption of cellulase onto PSA lignin. Meanwhile, PP extraction also facilitated the utilization of residual DPF as the adhesive for producing plywood as compared to that without protein pre-extraction. This scheme provides a sustainable and viable way to improve the value of woody and agriculture biomass. Peanut protein, a biocompatible non-catalytic protein, can block lignin, improve enzymatic hydrolysis efficiency and thereby facilitate the economics of biorefinery. Graphical abstract
研究领域:
生物化学
·
可再生资源与环境
✓ 已验证
DOI
高影响因子
CELLULOSE
·
2021
·Vol. 28
·期 6
·3505-3513
·
IF 5.044
Zhao Yan-Wen,Tian Mao-Zhang,Huang Pei
Characterized by low cost, flame resistance and mild processing procedure, freeze-dried clay aerogel is an ideal alternative for thermal insulation in building sector. However, the negatively charged surface of clay platelet and high freezing rate require the addition of a high amount of polymer to ensure the integrity of aerogel during freezing stage, which inevitably increases the density as well as the thermal conductivity of aerogel. Herein, we reported a green and versatile strategy to fabricate crack-free yet thermal insulative aerogel by introducing cellulose nanofibrils (CNFs) into starch/clay system. Owing to the abundant hydroxyl groups, high aspect ratio and excellent mechanical strength of CNFs, the CNF/starch/clay aerogels prepared exhibit enhanced crack resistance and compressive strength, enabling the reduction of starch content from 4 to 2% while maintaining the integrity of aerogel in the process of freezing. As a result, the density and thermal conductivity of aerogel significantly decrease from 0.12 to 0.05 g/cm 3 and 48.3 to 41.5 mW/mK respectively. Further crosslinked by glutaraldehyde, the CNF/starch/clay aerogels display improved moisture resistance, shape recovery and thermal stability. Being versatile and cost-effective, the present approach is thought-provoking for the up-scale production of freeze-dried clay aerogel for thermal insulation. Graphical abstract
研究领域:
材料科学
·
能源工程
✓ 已验证
DOI
高影响因子
Gut Pathogens
·
2022
·Vol. 14
·期 1
·1-11
·
IF 5.324
Brusselaers Nele,Pereira Marcela,Alm Johan,Engstrand Lars,Engstrand Lilja Helene
Background The effects of proton-pump inhibitors (PPIs) on the infant microbiome remain unclear. Swedish pilot cohort study to assess the longitudinal effect of long-term PPI on the infant gut microbiome, including ten newborn infants operated for esophageal atresia exposed to PPIs (mean 57 weeks), compared to healthy one-year-old controls. All children were born vaginally and were otherwise healthy. Within- and between sample diversity of the fecal microbiome was assessed using untargeted whole genome Shotgun metagenomics which sequences all the DNA in the sample and can capture genes rather than a taxonomic fingerprint.Results A longer duration of PPI-use was associated with considerable changes in evenness and high variation on diversity within samples compared to a shorter duration of use. The limited difference between baseline samples and controls suggests that this shift was most likely due to the drug exposure and not the underlying alterations on the microbiome. We found no associations with the number of antibiotic treatment episodes among the PPI-users.Conclusion Prolonged PPI-use may alter the early infant gut microbiome composition, especially those with the most prolonged duration of use.
研究领域:
医学
·
微生物学
·
儿科学
✓ 已验证
DOI
PubMed
高影响因子
PLANT AND SOIL
·
2013
·Vol. 370
·期 1
·345-354
·
IF 2.638
Wen Bei,Li Longfei,Liu Yu,Zhang Hongna,Hu Xiaoyu,Shan Xiao-quan,Zhang Shuzhen
Background and aims Perfluorinated compounds (PFCs) are of particular environmental concern. The migration of PFCs from soil to plants is a likely pathway for PFCs to enter the human food chain. This study aimed to investigate the uptake mechanisms of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) by maize ( Zea mays L. cv. TY2). Methods Hydroponic greenhouse experiments were performed. Results The kinetics of PFOS and PFOA uptake fitted Mechaelis-Menten equation well, suggesting their carrier-mediated influx processes. Uptake of PFOS was insensitive to metabolic inhibitors (NaN 3 and Na 3 VO 4 ). In contrast, treated with NaN 3 and Na 3 VO 4 reduced the uptake of PFOA by 83 and 43 % respectively. PFOS uptake was decreased by 31 % and 25 % when plants were treated with aquaporin inhibitors, AgNO 3 and glycerol, respectively, while aquaporin inhibitors had no effect on PFOA uptake. Anion channel blockers, 4, 4′-diisothiocyanostibene-2,2′-disolfonate (DID) and 5-nitro 2-(3-phenylpropylamine) benzoic acid (NPPB) inhibited the uptake of PFOS by 33 % and 30 %, respectively. Anion channel blocker anthracene-9-carboxylic acid (9-AC) decreased the uptake of PFOA by 28 %. No competitive uptake was found between PFOS and PFOA. Conclusions Uptake of PFOS and PFOA by maize may have different mechanisms.
研究领域:
环境科学
·
植物生理学
✓ 已验证
DOI
高影响因子
CHROMATOGRAPHIA
·
2016
·Vol. 79
·期 19
·1263-1269
·
IF 1.332
Wang Liang,Wu Minghuo,Wang Qixue,Zhan Jingjing,Chen Hongbo
Polyethylenimine (PEI) and 2,4,6,8-tetramethyl-2,4,6,8-tetrakis(propyl glycidyl ether)cyclotetrasiloxane (POSS–epoxy) were used as precursors for the preparation of organic-silica hybrid monolithic columns (PEI–POSS monolith) via epoxy–amine ring-opening polymerization (ROP). The high density of amine groups in PEI provides rich chromatographic interaction sites for the polar or acidic analytes in hydrophilic interaction (HILIC) and weak anion exchange (WAX) mechanisms. The column preparation conditions, such as the porogens, solvent and reaction temperature, were systematically investigated according to the morphology, permeability and column efficiency. The separation mechanisms of HILIC and WAX were evaluated with neutral polar compounds and halogen benzoic acids. Owing to the existence of reactive amine groups on the matrix surface, the PEI–POSS monolith is also an ideal starting material for the preparation of HILIC or strong anionic exchange (SAX) stationary phases by modification. The modification of PEI–POSS monoliths with iodomethane or bromoacetic acid via the nucleophilic substitution reaction could achieve the retention mechanisms of SAX or zwitterionic HILIC, respectively.
研究领域:
分析化学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）