JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2016
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IF 3.782
Hui Zhang,Jiangkang Xu,Liang Xing,Jianbo Ji,Aihua Yu,Guangxi Zhai
Doxorubicin (DOX) is one of the most common chemotherapeutic agents for the treatment of various cancers, but its clinical usage is limited by dose-dependent cardiotoxicity. We have recently synthesized a series of Chondroitin sulfate/poly ( d , l -lactideco-glycolide) block copolymers (Chs- b -PLGA) with different length of hydrophobic block by an end-to-end coupling strategy. The structure of the amphiphilic block copolymers with low critical micelle concentration (∼28 mg/L) were confirmed by 1 H NMR. The copolymers could self-assemble into stable micelles in aqueous environment with homogeneous size distribution and negative zeta potential . The hemolytic study indicated their excellent blood compatibility and potential application for intravenous administration. DOX can be efficiently encapsulated by the Chs- b -PLGA micelles. The DOX-loaded micelles showed a sustained and pH dependent drug release behavior. The cytotoxicity assay showed no associated toxicity with blank micelles while concentration-related cell inhibition with DOX-loaded micelles. Moreover, fast cellular uptake of DOX-loaded micelles was observed by fluorescent microscope. In vivo pharmacokinetics study showed that the Chs- b -PLGA micelles could significantly prolong the blood circulation time of DOX. The maximum tolerated dose (MTD) of DOX-loaded micelles in Kunming mice was about 2-fold higher of the MTD of free DOX, indicating a high tolerance of the DOX-loaded micelles. In conclusion, the Chs- b -PLGA micelles would be a potentially useful drug delivery system for cancer therapy.
研究领域:
药剂学
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药物递送
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纳米医学
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高分子科学
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癌症治疗
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生物医学工程
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Fermentation-Basel
·
2026
·Vol. 12
·期 1
·
IF 3.3
Fenghao An,Yanchun Feng,Da Li,Mei Hua,Xiuquan Wang,Xifei Xu,Yuguang He,Xinyu Miao,Mubai Sun,Honghong Niu
As one of the few carotenoid-producing microorganisms,Rhodotorula mucilaginosaremains underexplored for its antioxidant activity. This study investigated the effects ofR. mucilaginosaJAASSRY on D-galactose-induced aging mice. The high-dose JAASSRY (HR) significantly increased body weight by 9.89% compared to the model group (AM), while reducing organ indices of the spleen, liver, kidneys, and brain (p< 0.01). Compared with the AM group, the HR group exhibited increased serum activities of SOD (20.26%), GSH-Px (9.03%), and CAT (133.01%), with a 24.87% decrease in MDA level. In brain tissue, SOD, GSH-Px, and CAT activities increased by 79.49%, 8.45%, and 60.23%, respectively, while MDA decreased by 8.29%.R. mucilaginosaJAASSRY also dose-dependently alleviated structural damage in the hippocampus and spleen and improved motor strength and learning-memory capacity. Furthermore,R. mucilaginosaJAASSRY increased the abundance ofLactobacillusand reducedProteobacteria,Helicobacter, andOscillospira, while enhancing antioxidant capacity by modulating nucleotide, lipid, and carbohydrate metabolism.LactobacillusandPediococcuswere positively correlated with memory latency and CAT/SOD activities (p< 0.05), whereasActinormycesandDehalobacteriumshowed negative correlations. Notably, HR performed comparably or superiorly to β-carotene in improving cerebral oxidative stress and beneficial microbiota, suggesting its potential in neuroprotection and gut–brain axis regulation. In conclusion,R. mucilaginosaJAASSRY mitigates aging-related oxidative damage and behavioral deficits by modulating gut microbiota structure and function, demonstrating its promise as a β-carotene alternative in animal husbandry and functional foods.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·
IF 12.2
Chaoyu Tong,Yang Song,Daniel Schlenk,Jing Liu
1,4-Dichlorobenzene (1,4-DCB), a widely used household insect repellent and fungicide, has been epidemiologically linked to ulcerative colitis, yet its potential mechanisms remain poorly understood. In this study, juvenile male mice developed colonic inflammation following exposure to 1,4-DCB at doses of 0.03–3 mg/kg/day, a range corresponding to the human estimated daily intake (EDI) and relevant internal exposure levels in adolescents. This was evidenced by increased fecal moisture (by 12.22%–18.21%) and colon weight (17.57%–38.33%), shortened colon length (13.51%–24.88%), crypt expansion, and connective tissue hyperplasia. 1,4-DCB exposure upregulated the colonic expression of regenerating family member 3 gamma (Reg3γ), a key antimicrobial peptide that targets Gram-positive bacteria. This upregulation was accompanied by gut microbiota dysbiosis, elevated colonic levels of lipopolysaccharide (LPS) and pro-inflammatory cytokines, as well as decreased levels of tight junction proteins. Microbiota depletion alleviated these colitis symptoms induced by 1,4-DCB. In human colonic cells, we further validated LPS-induced inflammation and impaired permeability as well as identified vitamin D receptor (VDR) as a potential primary molecular target for 1,4-DCB. Overall, this study provides the first evidence that environmentally relevant levels of 1,4-DCB induce colonic inflammation through the VDR-Reg3γ-gut microbiota axis. These findings highlight the potential colonic health risk posed by this prevalent indoor pollutant.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2026
·
IF 6.7
Siwei Sun,Xinxin Zhang,Haitao Yu,Ying Xie
NiFe alloy is regarded as a promising electrocatalyst for water splitting owing to its superior conductivity, tunable electronic structure, and abundant active sites. Nevertheless, its practical application is hindered by slow water dissociation kinetics and unfavorable adsorption of hydrogen intermediates. Herein, we develop a composite catalyst, denoted as Co/Ni 3 Fe@NC-3 through a coordination-pyrolysis route, where ZIF-67-derived Co nanoparticles are anchored on Ni 3 Fe@NC porous nanosheets. In 1 M KOH, the catalyst exhibits remarkable bifunctional activity, requiring overpotentials of 67 mV for HER and 240 mV for OER at 10 mA cm −2 . Notably, a symmetric electrolyzer based on this catalyst (Co/Ni 3 Fe@NC-3) (+||−) achieves overall water splitting at a low voltage of 1.499 V (10 mA cm −2 ), superior to the commercial Pt/C||RuO 2 benchmark (1.592 V), and sustains stable operation for 100 h at 100 mA cm −2 . In-situ electrochemical impedance spectroscopy (EIS) indicates that Co incorporation optimizes the interfacial electronic structure, leading to faster charge transfer and reduced impedance. Density functional theory (DFT) calculations and experimental results further demonstrate that Co-induced interfacial electron redistribution upshifts the d-band centers ( E d ) of Ni/Fe sites, strengthens the adsorption of H* and H 2 O, and thus synergistically enhances both HER and OER performance. This study highlights the effectiveness of interface engineering and electronic structure modulation, providing a viable strategy for designing advanced NiFe-based water-splitting catalysts.
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Biomaterials Advances
·
2023
·
IF 0
Xiaoyu Xia,Han Li,Xianbing Xu,Chao Wu,Zhenyu Wang,Junjie Yi,Guanghua Zhao,Ming Du
Recombinant human H-ferritin nanocage (rHuHF) loaded with natural antioxidative lycopene molecules (LYC) was successfully constructed for the first time, aiming to enrich LYC in the brain and explore the regulation mechanism of this nanoparticles on neurodegeneration. Here, the mouse model was constructed via D-galactose-induced neurodegeneration based on behavioural analysis, histological observation, immunostaining analysis, Fourier transform infrared microscopy, and Western blotting analysis for the regulation of rHuHF-LYC. rHuHF-LYC improved the behaviour of mice in a dose-dependent manner. Besides, rHuHF-LYC can attenuate neuronal damage, maintain the number of Nissl body, increase the level of unsaturated fat, inhibit the activation of glial cells, and prevent excessive accumulation of neurotoxic proteins in the hippocampus of mice. More importantly, synaptic plasticity was activated in response to the regulation of rHuHF-LYC with excellent biocompatibility and biosafety. This study proved the validity of the direct use of natural antioxidant nano drugs for treating neurodegeneration, providing a promising therapeutic option against further imbalances in the degenerative brain microenvironment.
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PubMed
Polymers
·
2023
·Vol. 15
·期 10
·2274
·
IF 5
Zipeng He,Binhua Mei,Hongmei Chu,Yanjun Hou,Haijun Niu
In this study, six conjugated oligomers containing D–A structures were synthesized using the Stille coupling reaction and named PHZ1–PHZ6. All the oligomers utilized demonstrated excellent solubilities in common solvents and notable color variations in the domain of electrochromic characteristics. By designing and synthesizing two electron-donating groups modified with alkyl side chains and a common aromatic electron-donating group, as well as cross-binding them with two electron-withdrawing groups with lower molecular weights, the six oligomers presented good color-rendering efficiencies, among which PHZ4 presented the best color-rendering efficiency (283 cm2·C−1). The products also demonstrated excellent electrochemical switching-response times. PHZ5 presented the fastest coloring time (0.7 s), PHZ3 and PHZ6 presented the fastest bleaching times (2.1 s). Following 400 s of cycling activity, all the oligomers under study showed good working stabilities. Moreover, three kinds of photodetectors based on conducting oligomers were prepared, and the experimental results show that the three photodetectors have better specific detection performances and gains. These characteristics indicate that oligomers containing D–A structures are suitable for use as electrochromic and photodetector materials in the research.
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JOURNAL OF MEMBRANE SCIENCE
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2023
·
IF 9.5
Yang Li,Bingxuan Ji,Ziyang Chen,Zhenghua Zhang
Secondary effluent from municipal wastewater treatment plants can be used to produce reclaimed water through membrane distillation (MD), providing a potential solution to the current global water crisis. However, membrane fouling over extended periods of operation reduces the separation performance of MD systems and significantly shortens the operational life-span of the membrane. Herein, in order to overcome these limitations, a novel surface-modified PTFE membrane was fabricated by depositing polydopamine and grafting dextro ( d )-tyrosine (Tyr/PDA@PTFE). This synergistic coating was designed to reduce surface hydrophobicity of the PTFE membrane and provide anti-adhesive properties for bacteria, while enhancing flux and anti-fouling performance during MD. The Tyr/PDA@PTFE membranes demonstrated enhanced MD performance and the Tyr-300/PDA@PTFE membrane (with d -tyrosine coating solution concentration of 300 μM) exhibited the best MD performance during direct contact membrane distillation (DCMD) of the secondary effluent, with the highest flux (49.1 LMH) compared with the pristine PTFE membrane (34.7 LMH), achieving a flux increase of 41.5%. Long-term DCMD operation showed that the Tyr-300/PDA@PTFE membrane exhibited improved anti-fouling performance compared with the pristine PTFE membrane, with 43.8% flux decay observed after three cycles of use, while the pristine PTFE membrane was unable to complete three cycles of use with an 87.2% decrease in flux observed by middle of the third round. The quality of permeate formed by the Tyr/PDA@PTFE membranes during MD, indicated that they could be operated stably for three cycles of use over a 40 h period, intercepting organic matter in the feed solution. The Tyr-300/PDA@PTFE membrane was especially effective for the removal of low molecular weight and humus-like substances, achieving rejection rates of 89.5% and 86.7%, respectively. Additionally, the Tyr/PDA@PTFE membrane carried the more negative charge and exhibited a high level of resistance to bio-adhesion. This study demonstrates the feasibility of use of this novel Tyr/PDA@PTFE membrane in MD, for the effective treatment of secondary effluent from wastewater treatment plants and the production of reclaimed water.
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ACS Applied Polymer Materials
·
2022
·
IF 4.855
Xue Lan,Wenjing Sun,Xin Wang,Wei Xu,Yoji Horii,Jiandang Liu,Hongjun Zhang,Bangjiao Ye,Tiancheng Mu,Xiaozheng Lan
We demonstrate anion (chloride and fluoride ions) transfer in an organic ionic plastic crystal (OIPC), diethyldimethylammonium d-camphorsulfonate, and the role of defects in ion conduction. The phase transitions, crystalline structures, dynamics, and ion transfer mechanisms of the pure material and the doped mixtures were investigated using a combination of differential scanning calorimetry, X-ray diffraction, solid-state nuclear magnetic resonance spectroscopy, and electrochemical impedance spectroscopy. The doped mixtures show minor modifications in thermal behaviors and solid phase structures to the host material. The ion mobility of the pure material in the plastic phase was assigned mainly to cations. The fluoride salt-doped mixture has drastically enhanced conductivity at all tested temperatures, and the chloride salt-doped mixture displays a strong temperature-dependent behavior. Ionic conductivity measurements suggest transfer mechanisms through crystalline phases. The pure material and doped mixtures exhibit similar defect volumes and concentrations, and both factors are phase-dependent, as determined using positron annihilation lifetime spectroscopy. The conductivity displays dependence on not only the defect volume but also the target ion volume. The relationships between the defect volume and the conductivity qualitatively follow the Cohen–Turnbull free volume model, while critical volumes were very large. For the first time in OIPCs, the size of the target ions was found to significantly influence ionic conductivity.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2022
·
IF 9.965
Shaoda Huang,Jinyan Wang,Hongyin Hu,Yang Li,Fangping Xu,Fang Duan,Han Zhu,Shuanglong Lu,Mingliang Du
The methanol-poisoning of electrocatalysts at the cathodic part of direct methanol fuel cells (DMFCs) can severely degrade the overall efficiency. Therefore, engineering cathodic catalysts with outstanding oxygen reduction activity, and simultaneously, superior methanol tolerance is greatly desired. Herein, bimetallic palladium-copper (PdCu) nanoplates with the optimized d-band center are designed as promising cathodic catalysts for DMFCs. It shows outstanding oxygen reduction activity with a mass activity (MA) of 0.522 A mg Pd −1 in alkaline electrolyte, overwhelming the benchmarked commercial Pt/C and Pd/C. Meanwhile, it has prominent stability with only 4.0 % loss in MA after continuous 20 K cycles. More importantly, the PdCu nanoplates are almost inert toward methanol oxidation and show excellent anti-methanol capability. The theoretical calculations reveal that the downshift of d-band center in PdCu nanoplates and the electronic interaction between Pd and Cu atoms could effectively lower the methanol adsorption energy, thus leading to enhanced methanol tolerance. This work highlights the important role of tuning the electronic structure and optimized geometry of electrocatalysts to simultaneously boost their oxygen reduction activity, stability, and methanol tolerance for their future application in DMFCs.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Chaobo Feng,Bing-Qiang Lu,Yunshan Fan,Haijian Ni,Yunfei Zhao,Shuo Tan,Zhi Zhou,Lijia Liu,Jordan A. Hachtel,Demie Kepaptsoglou,Baohu Wu,Denis Gebauer,Shisheng He,Feng Chen
Amorphous inorganic solids are traditionally isotropic, thus, it is believed that they only grow in a non-preferential way without the assistance of regulators, leading to the morphologies of nanospheres or irregular aggregates of nanoparticles . However, in the presence of (ortho)phosphate (Pi) and pyrophosphate ions (PPi) which have synergistic roles in biomineralization , the highly elongated amorphous nanowires (denoted ACPPNs) form in a regulator-free aqueous solution (without templates, additives, organics, etc). Based on thorough characterization and tracking of the formation process (e.g., Cryo-TEM, spherical aberration correction high resolution TEM, solid state NMR , high energy resolution monochromated STEM-EELS), the microstructure and its preferential growth behavior are elucidated. In ACPPNs, amorphous calcium orthophosphate and amorphous calcium pyrophosphate are distributed at separated but close sites. The ACPPNs grow via either the preferential attachment of ∼2 nm nanoclusters in a 1-dimension way, or the transformation of bigger nanoparticles, indicating an inherent driving force-governed process. We propose that the anisotropy of ACPPNs microstructure, which is corroborated experimentally, causes their oriented growth. This study proves that, unlike the conventional view, amorphous minerals can form via oriented growth without external regulation, demonstrating a novel insight into the structures and growth behaviors of amorphous minerals.
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高影响因子
MOLECULES
·
2020
·Vol. 25
·期 23
·5778
·
IF 3.267
Yangke Wanyan,Xixi Xu,Kehang Liu,Huidan Zhang,Junai Zhen,Rong Zhang,Jumei Wen,Ping Liu,Yuqing Chen
Inhibition of the glycolytic pathway is a critical strategy in anticancer therapy because of the role of aerobic glycolysis in cancer cells. The glycolytic inhibitor 2-Deoxy-d-glucose (2-DG) has shown potential in combination with other anticancer agents. Buforin IIb is an effective antimicrobial peptide (AMP) with broad-spectrum anticancer activity and selectivity. The efficacy of combination treatment with 2-DG and buforin IIb in prostate cancer remains unknown. Here, we tested the efficacy of buforin IIb as a mitochondria-targeting AMP in the androgen-independent human prostate cancer cell line DU145. Combining 2-DG with buforin IIb had a synergistic toxic effect on DU145 cells and mouse xenograft tumors. Combination treatment with 2-DG and buforin IIb caused stronger proliferation inhibition, greater G1 cell cycle arrest, and higher apoptosis than either treatment alone. Combination treatment dramatically decreased L-lactate production and intracellular ATP levels, indicating severe inhibition of glycolysis and ATP production. Flow cytometry and confocal laser scanning microscopy results indicate that 2-DG may increase buforin IIb uptake by DU145 cells, thereby increasing the mitochondria-targeting capacity of buforin IIb. This may partly explain the effect of combination treatment on enhancing buforin IIb-induced apoptosis. Consistently, 2-DG increased mitochondrial dysfunction and upregulated Bax/Bcl-2, promoting cytochrome c release to initiate procaspase 3 cleavage induced by buforin IIb. These results suggest that 2-DG sensitizes prostate cancer DU145 cells to buforin IIb. Moreover, combination treatment caused minimal hemolysis and cytotoxicity to normal WPMY-1 cells. Collectively, the current study demonstrates that dual targeting of glycolysis and mitochondria by 2-DG and buforin IIb may be an effective anticancer strategy for the treatment of some advanced prostate cancer.Keywords:buforin IIb;2-Deoxy-d-glucose;mitochondria;glycolysis;prostate cancer
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Membranes
·
2021
·Vol. 11
·期 8
·612
·
IF 4.106
Zhan Gao,Zhihao Yu,Xiaoli Zhang,Shougang Fan,Huiyu Gao,Caini Liu,Qixing Zhou,Huaiqi Shao,Lan Wang,Xiaoyan Guo
The thorny issue of membrane biofouling in membrane bioreactors (MBR) calls for new effective control measures. Herein, D-amino acid (DAA) was employed to mediate MBR membrane biofouling by inhibiting biofilm information and disintegrating formed biofilm. Different DAA control ways involving membrane property, DAA-adding timing, and DAA-control mode were explored through experiments and the multiple linear regression model and the response surface methodology. The optimized DAA control ways were acquired, involving DAA used as an active agent, and the DAA-adding timing of 4 h cultured before running, as well as both hydrophilic and hydrophobic membrane, resulting in an approximately 40.24% decrease in the membrane biofouling rate in comparison with the conventional MBR. DAA is an efficient membrane biofouling mediating approach for MBR under optimized control ways combination and a facile solution for solving membrane biofouling in actual membrane systems.Keywords:membrane bioreactor;membrane biofouling;D-amino acid;control way;model evaluation
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高影响因子
危险品化学品经营许可证（带存储）