CHEMISTRY OF MATERIALS
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2020
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IF 9.567
Linyuan Lian,Moyan Zheng,Peng Zhang,Zhi Zheng,Kang Du,Wen Lei,Jianbo Gao,Guangda Niu,Daoli Zhang,Tianyou Zhai,Shengye Jin,Jiang Tang,Xiuwen Zhang,Jianbing Zhang
Self-trapped excitons (STEs) in metal halide materials are attracting an increasing level of interest due to their unique light emission properties. Light emission from STEs in metal halides is usually associated with excited-state structural deformation, which lowers the symmetry of local structures, as seen for the STEs in a wide range of materials systems. Here, we reveal a prototypic STE-associated structural “distortion” that, however, enhances the symmetry of local structures, in a series of all-inorganic copper(I)-based halides Cs3Cu2X5 (X = Cl, Br, or I). We further find that the emission peaks of Cs3Cu2X5 blue-shift when the halogen changes from Cl to Br to I, which is the opposite of the trends found in traditional halide perovskites. This phenomenon is attributed to a synergetic combination of the significant change in band gap associated with structural deformation and a strong excitonic effect. Due to the highly localized electron and hole upon photoexcitation, Cs3Cu2Cl5 shows an extremely long and temperature-sensitive photoluminescence (PL) lifetime among metal halide materials with STEs. Remarkably, strong green emission with a PL quantum yield exceeding 90% is found in Cs3Cu2Cl5, opening the way to designing light emission compounds based on local symmetry-enhancing STE mechanisms.
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MOLECULAR CRYSTALS AND LIQUID CRYSTALS
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2020
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IF 0.512
Chanchan Xu,Lu Lu,Le Lv,Jiandong Guo,Chaoyun Luo,Dawei Luo,Wei Liu
A new zero-dimensional (0D) silver (I) chloride based coordination complex 0 D-Ag2Cl2(L) (1, L = (oxybis(2,1-phenylene))bis(diphenylphosphine)) has been prepared by mixing the silver(I) salt and a bidentate P-ligand at room temperature in solution. 1exhibits a band gap of 3.5 eV and a decomposition temperature (Td) of 280 °C. Such a high Td for molecular complex is a result of the strong Ag-P bonding and the “chelating effect” of the metal of the bidentate P-ligand. It has been used as an efficient photocatalyst for the degradation of organic dyes in water.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2022
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IF 4.326
Xiaoying Gao,Yunjia Liu,Ke Zhang,Jinlan Weng,Rongqing Chen,Xiaoyi Zhang,Zhipeng Wang,Shenghong Yang,Jian Liu
External light stimuli strategy under conventional conditions achieves a sustainable future due to its controllable spatial and temporal precision coupled with environmental friendliness. Herein, atomic Cu(I)-carbon nitride (Cu-CN) was synthesized and served as specific light-stimuli oxidase mimics for total antioxidant capacity (TAC) assay. Singlet oxygen (1O2) and hydroxyl radical (·OH) are the main intermediates, which can oxidize 3,3′,5,5′-tetramethylbenzidine (TMB) into its blue oxidant and therefore improve photothermal signal generation. Based on the intrinsic light responsiveness and photothermal conversion property, we established a colorimetric and photothermal dual-mode sensing platform. The proposed dual-mode assay presented a specific assay of ascorbic acid with LOD of 0.28 μM and 0.15 μM, respectively. This platform was further successfully applied to assess TAC of fruits and beverages. It is believed that the intelligently modulated activity and dual-mode detection function of such atomic enzyme mimics can offer a promising strategy for other analytical assays in high repeatability and reproducibility.
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MOLECULAR PHARMACEUTICS
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2022
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IF 5.364
Han Sun,Ruihua Guo,Yanhui Guo,Jitao Song,Zhiliang Li,Fengling Song
As the most successful clinically approved photosensitizers, porphyrins have been extensively employed in the photodynamic therapy (PDT) of cancers. However, their poor water solubility, aggregation-induced self-quenching on ROS generation, and a low tolerance for a hypoxic condition usually result in unsatisfied therapeutic outcomes. Therefore, great efforts have been dedicated to improving the PDT efficacy of porphyrin-type photosensitizers in treating hypoxic tumors, including combination with additional active components or therapies, which can significantly complicate the therapeutic process. Herein, we report a novel water-soluble porphyrin with O-linked cationic side chains, which exhibits good water solubility, high photostability, and significantly enhanced ROS generation efficacy in both type-I and type-II photodynamic pathways. We have also found that the end charges of side chains can dramatically affect the ROS generation of the porphyrin. The cationic porphyrin exhibited high in vitro PDT efficacy with low IC50 values both in normoxia and hypoxia. Hence, during in vivo PDT study, the cationic porphyrin displayed highly effective tumor ablation capability. This study demonstrates the power of side-chain chemistry in tuning the photodynamic property of porphyrin, which offers a new effective strategy to enhance the anticancer performance of photosensitizers for fulfilling the increasing demands for cancer therapy in clinics.
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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
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2023
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IF 3.6
Deng Shanshan,Gao Yuan,Lv Mengting,Li Xinyu,Ma Yulin,Guo Yuchen,Li Tiejun,Zhang Yuefan
Chronic cerebral hypoperfusion (CCH) is the leading cause of chronic cerebral dysfunction syndrome with its complex pathological mechanisms involving cortical and hippocampal neuronal loss, white matter lesions, and neuroinflammation. I-C-F-6 is a septapeptide, which has anti-inflammatory and anti-fibrotic effects. This study aimed to evaluate the neuroprotective effect of I-C-F-6 in chronic cerebral hypoperfusion (CCH)-induced neurological injury. C57BL/6 J mice were subjected to bilateral common carotid artery stenosis (BCAS), and BV2 microglia cells were induced with oxygen-glucose deprivation (OGD). In vivo, mice were divided randomly into four groups: Sham, BCAS, GBE (30 mg/kg), and I-C-F-6 (0.5 mg/kg). In vitro, microglia were divided randomly into four groups: control, OGD, I-C-F-6 (25 μg/mL), and Shikonin (800 nmol/L). Through LFB, TUNEL, and NeuN staining, we found that I-C-F-6 was able to mitigate myelin pathology and reduce the number of apoptotic neurons. Furthermore, immunofluorescence staining revealed that I-C-F-6 was able to reduce microglia clustering and downregulate NF-κB p65. We also observed a significant downregulation of M1 phenotype microglia signature genes, such as TNF-α, iNOS, and upregulation of anti-inflammatory cytokines, such as Arg-1 and IL-10, indicating that I-C-F-6 may mainly reduce polarization towards the M1 phenotype in microglia. Notably, I-C-F-6 downregulated the expression of NF-κB signaling pathway-related proteins IKK-β and NF-κB p65, as well as pro-inflammatory cytokines IL-1β and iNOS. In conclusion, I-C-F-6 can improve neurological damage, alleviate neuroinflammation, and inhibit microglia polarization to the M1 phenotype via the NF-κB signaling pathway.
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International Journal of Polymer Science
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2023
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IF 3.3
Chunhai Ke,Xuanyuan Lu,Jiahua Ni,Ruicong Li,Qi Chen,Zhaoxiang Peng
There has been an increase in the incidence of meniscus injuries worldwide, as well as growing needs for injectable hydrogels with the potentials to promote in situ meniscal tissue repair. This work developed poly(N-isopropylacrylamide)-collagen I composite hydrogels, with a series of different collagen I contents. The hydrogels were injectable under room temperature and started to solidify around 32°C due to their thermosensitivities, meeting the requirements of the intended applications. The addition of collagen I to the poly(N-isopropylacrylamide) provided physical reinforcement to the hydrogels. Rheological characterizations showed that, under room temperature, the complex viscosity, the storage modulus, and the loss modulus, respectively, increased from Pa•s to Pa•s, from Pa to Pa, and from Pa to Pa, as the collagen I content in the hydrogel increased from 0% to 1%. Cell proliferation tests and high-density culture also revealed that collagen I promoted bioactivity of the hydrogels and induced fibrochondrocyte phenotype of the chondrocytes. The expressions of collagen I protein and collagen I a1 gene in the PNIPAm-0.5Coll group were 3.50-fold and 3.64-fold of those in the PNIPAm group. In contrast, the expressions of collagen II protein and collagen II a1 gene were less prominent (respectively, 2.36-fold and 3.34-fold in the PNIPAm-0.5Coll group compared with the PNIPAm group). This phenotyping was believed to be conducive to the regeneration of meniscal tissues. The findings of this study have provided an important basis for future in vivo studies and clinical applications of this type of composite hydrogels.
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MICROCHEMICAL JOURNAL
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2023
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IF 4.8
Shuqian Wang,Jinli Qin,Yin Liang,Youai Ye,Shushu Li,Yamei Guo,Xiao Yang,Yong Liang
This paper proposes a selective strategy for quantitative detecting cardiac troponin I (cTnI) in clinical serum samples by using Raman spectroscopy combined with magnetic molecularly imprinted polymers (MMIPs). The signature peptide was selected as a template for molecular imprinting due to its chemical stability and small molecular mass. MMIPs were synthetized with the signature peptide as template and methylacrylic acid as monomer in presence of vinyl-modified magnetic particles. MMIPs with high magnetic character and adsorption properties were able to be stained by Coomassie Brilliant Blue G-250 after the target template was specifically captured, which showing a characteristic absorption peak at Raman shift 1610 cm −1 . The Raman signal intensity at 1610 cm −1 showed a linear relationship in the 0.01 to 100 ng·mL −1 concentration range. The recovery of cTnI in serum were 92.7–111.2 % with relative standard deviation in the range of 2.51 % to 8.52 %. This paper has important practical application for preliminary rapid detection of cTnI in clinical serum samples.
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DALTON TRANSACTIONS
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2023
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IF 4
Shuang Wang,Mengjie Yao,Yuye Cheng,Kai Ding,Minghao Dou,Hongyu Shao,Shuaitong Xue,Shenjie Li,Yanyan Chen
By providing the spatial separation of the active sites and retaining high oxidative and reducing capacity, the direct Z-scheme heterostructure is considered the most potential structure for yielding photo-electric response. However, challenges still exist in the directional transfer of charge carriers between two semiconductors in direct Z-scheme structures. In this regard, by constructing the Vzn defect and p–n junction, a direct Z-scheme ZnxCd1−xS@ZnS-NiS heterostructure was obtained for the regulated electronic structure, which ensured high-yield hydrogen properties. The Zn vacancy in the partially-coated ZnS shell led to the Vzn energy level, and the addition of NiS led to the p–n structure, which caused a drastic downshift of the band edge potentials in comparison to that of pristine CdS. This variation gave rise to a staggered band edge alignment between ZnxCd1−xS and NiS, resulting in the variation of charge transfer kinetics from type-I to direct Z-scheme. Through careful characterization, it was found that the optimal photocatalytic hydrogen precipitation activity reached 16 683.6 μmol g−1 h−1, which was 70 times that of CdS, and this improvement was considered to form a spatial barrier, providing a clear direction and path for carrier transmission.
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JOURNAL OF ORGANOMETALLIC CHEMISTRY
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2023
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IF 2.3
Yi-Fan Tan,Guang-Min Liang,Kun Zhou,Jiu-Yu Ji,Li-Ping Zhao
A new three-dimensional (3D) supramolecular compound, [Ag(dppe)(CF 3 COO)] n ( 1 ), was prepared by using Ag(I) as the silver source and dppe as the organic ligand through the self-assembly approach. The bridging dppe ligand makes compound 1 appear as a one-dimensional (1D) wavy chain consolidated by the intramolecular hydrogen bonds. Two adjacent 1D chains are expanded to a two-dimensional (2D) layer passing through the intermolecular C H···π interaction between the dppe ligands, and the 2D layers further weave into a 3D supramolecular structure via another intermolecular C H···π interactions between the dppe ligands. The precise structure of 1 was determined by single crystal X-ray diffractometer (SCXRD), and it was well-characterized by Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) spectroscopy, powder X-ray diffraction (PXRD), thermogravimetric analysis (TG) and differential thermogravimetry analysis (DTG), and UV–vis diffuse reflectance spectrum. In addition, the photocurrent response, electrochemistry characteristic and photodegradation of 1 were investigated. The degradation efficiency (82 %) of 1 as catalyst to degrade methylene blue (MB) was significantly higher than that without catalyst.
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ANALYTICAL BIOCHEMISTRY
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2023
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IF 2.9
Qinhong Yin,Xiaolan Yang,Lihua Yang,Dezhi Yang,Yaling Yang,Yanqin Zhu
As newly developed synthetic enzymes with exceptional catalytic capabilities and outstanding stability, nanozymes have drawn considerable interest in the realm of sensing. Using a simple hydrothermal process, iodine and copper-doped carbon dots (Cu,I-CDs) with simulated enzymes were fabricated in the current investigation. Cu,I-CDs demonstrate peroxidase-mimicking function together with high catalytic effectiveness due to aforementioned features. This led to generation of a colorimetric sensor for quick and accurate quantitative assessment of morphine (MOR). The outcomes showed the method's usefulness for the colorimetric detection of MOR. The linear range for MOR detection is 0.25–25 μg/mL having a reduced detection limit of 64 ng/mL. This sensor's successful use in the analysis of MOR in biological material is more noteworthy.
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SCIENCE OF THE TOTAL ENVIRONMENT
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2023
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IF 9.8
Zhishuang Yang,Tianjing Lan,Hongyan Luo,Pei Li,Mingshu Wang,Renyong Jia,Shun Chen,Mafeng Liu,Xinxin Zhao,Qiao Yang,Ying Wu,Shaqiu Zhang,Juan Huang,Xumin Ou,Sai Mao,Qun Gao,Di Sun,Bin Tian,Anchun Cheng,Dekang Zhu
Antimicrobial resistance remains an utmost concern in human and veterinary medicine, impacting humans, animals, and the environment while significantly influencing the principles of One Health. While Riemerella anatipestifer ( R. anatipestifer ) is recognized as a waterfowl pathogen with multidrug-resistant properties, the specifics of its lincosamide resistance mechanism are inadequately understood. In this study, we identified a novel lincosamide resistance gene, lnu (I), in R. anatipestifer RCAD0121, and investigated its potential origin, transfer mechanisms, and dissemination status through genomic epidemiology. This exhibited 74.80 % amino acid identity with a previously reported gene, lnu (H). PCR analysis revealed lnu (I) prevalence in at least 44 R. anatipestifer isolates collected from multiple provinces in China. Furthermore, genomic mining unveiled 56 lnu (I) sequences within publicly available databases, primarily originating from environmental sources. In addition, members of the family Flavobacteriaceae were the dominant (16/56, 28.57 %) bacteria carrying the lnu (I) gene, with Flavobacterium exhibiting a similar GC content as lnu (I). Notably, specific instances of the lnu (I) gene were linked to mobile genetic elements within human and animal pathogenic bacteria. These findings suggest that Flavobacterium species within the environment could serve as potential ancestral sources of the novel lnu (I) gene, which has undergone mobilization events toward pathogenic bacteria.
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DYES AND PIGMENTS
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2023
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IF 4.5
Tongsheng Huang,Xin Hu,Shiyu Huang,Dong Liu,Lihua Chen,Qinghua Wu,Weifeng Zhu,Xiaoyong Zhang,Meiying Liu,Yen Wei
Photodynamic therapy (PDT) is a promising treatment regime for cancer therapy with some advantages such as minimal invasiveness, high spatiotemporal selectivity, and negligible drug resistance. Developing Type I photosensitizer (PS) is a viable strategy to overcome the limitations of conventional O 2 -dependent Type Ⅱ PS, whereas there are still significant challenges. Herein, we report the synthesis of β -cyclodextrin-based fluorescent hyperbranched polymer ( β -CD-HPG-DEP) through a one-step anionic ring-opening polymerization between β -cyclodextrin ( β -CD), glycidol and a fluorescent molecule DEP. The potential utilization of β -CD-HPG-DEP as the agent for cancer phototheranostics was also investigated in detail. The results demonstrated that β -CD-HPG-DEP possesses excellent water dispersibility, good biocompatibility, high reactive oxygen species (ROS) generation efficiency mainly via Type I mechanism, and extraordinary fluorescence imaging capability. Meanwhile, β -CD-HPG-DEP has great potential to serve as drug delivery vehicle since the cyclodextrin unit has many hydroxyl groups, thus providing a promising strategy for designing and fabrication of multifunctional theranostics. Considering the simple synthesis route, ready designability and multifunctional potential of anionic ring-opening polymerization, as well as good biocompatibility of resultant polymer, we believe the strategy developed in this work could also be a rational route to synthesize multifunctional composites for various biomedical applications.
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