COLLOID AND POLYMER SCIENCE
·
2015
·Vol. 293
·期 6
·1615-1621
·
IF 1.865
Zheng Yi,Wang Baojie,Liu Mei,Jiang Keyong,Wang Lei,Yu Yueqin
Biodegradable N -maleyl gelatin (N-MAGEL) was synthesized with gelatin (GEL) and maleic anhydride (MAH) by acylation. With Bis-acrylamide (Bis) cross-linker, a series of cross-linked poly ( N -isopropylacrylamide-co- N -maleyl gelatin) [P(NIPAAm-co-N-MAGEL)] hydrogels were prepared, and their lower critical solution temperature (LCST), water content, swelling/deswelling kinetics, drug delivery behaviors, and enzymatic degradation properties were investigated. As weight ratios of N-MAGEL/NIPAAm in hydrogel were increasing, water content increased, and it had no significant influence on LCST of hydrogel in spite of the weight ratios reaching 30:70. In the swelling/deswelling kinetics, hydrogels with higher weight ratios of N-MAGEL/NIPAAm exhibited faster swelling rate and slower deswelling rate. Drug delivery for bovine serum albumin (BSA) research indicated that increasing weight ratios of N-MAGEL/NIPAAm in hydrogels contribute to raising release time and cumulative release ratios. Lastly, hydrogels with higher weight ratios of N-MAGEL/NIPAAm degraded rapidly in phosphate-buffered saline (PBS) containing papain.
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BIOMATERIALS
·
2012
·
IF 7.404
Meirong Huo,Aifeng Zou,Chengli Yao,Yong Zhang,Jianping Zhou,Jing Wang,Qinnv Zhu,Jing Li,Qiang Zhang
In this study, a ligand-PEG-lipid conjugate , octreotide-polyethene glycol-deoxycholic acid (OCT(Phe)-PEG-DOCA, or OPD) was successfully synthesized and used as a targeting molecule for N-deoxycholic acid-O, N-hydroxyethylation chitosan (DAHC) micelles for efficient cancer therapy. DAHC micelles exhibited good loading capacities for doxorubicin (DOX), a model anti-cancer drug, and the modification of OPD showed no significant effect on drug load while slightly increasing the particle size and partly shielding the positive charges on the surface of micelles. Accelerated release rate of DOX from micelles were also observed after OPD modification and the release profile exhibited pH-sensitive properties. Compared with DAHC-DOX micelles, OPD-DAHC-DOX micelles exhibited significantly stronger cytotoxicity to MCF-7 cells (SSTRs overexpression) but with hardly any difference from WI-38 cells (no SSTRs expression). The results of flow cytometry and confocal laser scanning microscopy further revealed that OPD-DAHC-DOX micelles could be selectively taken into tumor cells by SSTRs-mediated endocytosis . In vivo investigation of micelles on nude mice bearing MCF-7 cancer xenografts confirmed that OPD-DAHC micelles possessed much higher tumor-targeting capacity than the DAHC control and exhibited enhanced anti-tumor efficacy and decreased systemic toxicity. These results suggest that OPD-DAHC micelles might be a promising anti-cancer drug delivery carrier for targeted cancer therapy.
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ACTA CHIMICA SLOVENICA
·
2021
·Vol. 68
·期 1
·102-108
·
IF 1.735
Yu-Mei Hao
A mononuclear copper(II) complex, [CuL] (1), and a phenolato-bridged trinuclear zinc(II) complex, [Zn3Cl2L2(DMF)2] (2), where L is the deprotonated form of N,N'-bis(4-bromosalicylidene)propane-1,3-diamine (H2L), have been prepared and characterized by elemental analyses, IR and UV-Vis spectroscopy, and single crystal X-ray diffraction. The Cu atom in complex 1 is in square planar coordination, while the terminal and central Zn atoms in complex 2 are in square pyramidal and octahedral coordination, respectively. The antibacterial activities of the complexes have been tested on the bacteria Staphylococcus aureus and Escherichia coli, and the yeast Candida parapsilosis.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2026
·Vol. 46
·期 10
·118263
·
IF 6.3
Binbin Fan,Wei Sun,Dengke Zhao,Bohan Wang,Shuo Zhao,Feng Hu,Jie Zhang,Yiyao Ge,Zhipeng Xie,Kexin Chen,Guanghua Liu
Achieving a balance between high thermal conductivity and mechanical property remains a critical challenge for sintered reaction-bonded Si₃N₄ (SRBSN) ceramics. This work investigates the effects of α- and β-Si₃N₄ additions on nitridation behavior, microstructural evolution, and properties of SRBSN ceramics. The results reveal fundamentally different roles of α- and β-Si₃N₄ during nitridation and sintering. Moderate α-Si₃N₄ addition suppresses the α→β transformation, inducing localized grain growth and a bimodal microstructure at 20 wt%. In contrast, β-Si₃N₄ markedly promotes the α→β transformation and heterogeneous nucleation. The sample with 30 wt% β-Si₃N₄ exhibits a pronounced bimodal grain structure with 20.2 % coarse elongated grains (>6 μm), a maximum mean aspect ratio of 1.89, an ultrathin grain-boundary film (∼2.2 nm), and a nitrogen-rich intergranular phase. Consequently, a high thermal conductivity of 114 W·m⁻¹ ·K⁻¹ is achieved while maintaining a flexural strength of 791 ± 29 MPa and a fracture toughness of 9.0 ± 0.3 MPa·m 1/2 .
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FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Yingying Liu,Xue Wang,Yun Zhang,Danyang Zhang,Lei Zhu,Hongping Chen,Yunfeng Chai
2-Bromo- N,N -dimethylethanamine was used for fatty acids derivatization for the first time. • The derivatization method is simple, sensitive and exhibits minimal reagent residue. • The changes of 26 FFAs in different processing stages of black tea were profiled. • C16:0, C18:0, C18:2 and C18:3 displayed the most pronounced changes in black tea processing. As important precursors to aromatic substances in black tea processing, fatty acids deserve quantitative detection throughout the manufacturing procedure. We present a liquid chromatography/quadrupole orbitrap mass spectrometry method based on pre-column derivatization, which allows the simultaneous determination of 44 free fatty acids (FFAs, C3-C24). In this method, 2-bromo- N , N -dimethylethanamine was first used as a new derivatizing reagent. The derivatization system is simple and exhibits minimal reagent residue. After derivatization, the detection sensitivity of FFAs was increased by 2–4 orders of magnitude with satisfactory limit of quantitation (0.1–5 pg). Using this method, a total of 26 FFAs in black tea samples were identified and their dynamic changes at different processing stages were profiled. Among them, palmitic acid (C16:0), stearic acid (C18:0), linoleic acid (C18:2) and linolenic acid (C18:3) displayed the most pronounced changes in content and may therefore act as key indicators for monitoring black tea manufacture. Specifically, C16:0 and C18:0 exhibited a fluctuating downward trend (from 254.0 to 133.4 and 292.9 to 83.7 mg kg −1 , respectively), whereas C18:2 and C18:3 increased with fluctuations (from 18.8 to 55.0 and 13.6 to 69.2 mg kg −1 , respectively). Download: Download high-res image (142KB) Download: Download full-size image
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MINERALS ENGINEERING
·
2026
·
IF 6
Xiaoqing Weng,Daozhong Li,Yingxin Chen,Hongqiang Li,Dongsheng He,Richard M. Kasomo,Qian Chen,Shaoxian Song
TTPC was first applied for reverse flotation of potassium feldspar from apatite. • TTPC exhibited superior selectivity for potassium feldspar over a wide pH range. • The collection mechanism involved electrostatic interactions and coordination complexation. • TTPC enabled efficient purification of raw phosphate rock via simultaneous reverse flotation. The simultaneous reverse flotation separation of potassium feldspar and dolomite from apatite is of great significance for the high-value development of phosphorus chemical industry. Nevertheless, the lack of effective and highly selective potassium feldspar collectors limits the widespread application of this method. In this study, (tri-n-butyl)-n-tetradecylphosphonium chloride (TTPC) was employed as a collector for the flotation separation of potassium feldspar from apatite. The pure mineral flotation experiments demonstrated that TTPC exhibited excellent collection ability and selectivity for potassium feldspar over a wide pH range (3–8) and low dosage. Further mechanistic analyses, including zeta potential, adsorption capacity, Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS), revealed that the [-R 4 P] + groups in TTPC could combine with the surface oxygen ion (O 2– ) sites of potassium feldspar, thus selectively adsorbing onto the potassium feldspar surface through electrostatic interactions and coordination complexation. More notably, the synergistic use of TTPC and fatty acid collectors in the simultaneous reverse flotation system effectively reduced the contents of potassium feldspar and dolomite in raw phosphate rock and obtained phosphate concentrate with the phosphorus pentoxide (P 2 O 5 ) grade increased from 23.28% to 27.38% and the recovery of 92.97%, which achieved the purification of phosphate rock and was superior to the conventional ether amine collector. Overall, this work provides new insights into the advanced application of simultaneous reverse flotation for phosphate rock purification. Download: Download high-res image (129KB) Download: Download full-size image
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ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Ruizhi Tang,Shujuan Ma,Quan Bai,Yangyang Bian,Zichao Tang,Junjie Ou
Host–guest interactions by artificially synthesized macrocyclic molecules, such as cucurbit[n]uril (CB[n], n refers to the number of glycoluril units), exhibited comparable affinity to natural biological interactions, offering orthogonal selectivities. These unique high-affinity interactions are crucial in bioseparation, particularly in the separation of complex biomacromolecules. However, to date, the application of supramolecular systems in bioseparation remains insufficient and challenging. In this work, a site-specific host–guest interaction-based method by CB[6] and CB[7] was developed for the selective enrichment of basic peptides, and their recognition for basic lysine/arginine (K/R) residues exhibited distinct selectivity. Although they both exhibited affinity to basic peptides, CB[6] tended to bind to peptides containing multiple K/R residues, while CB[7] preferred to adsorb peptides containing both phenylalanine residues and basic K/R residues. This difference was attributed to their distinct cavity sizes. Furthermore, CB[6]-containing monolith was employed for the enrichment of basic peptides from mouse liver sample digested with Staphylococcus aureus protease V8 (Glu-C). It is noteworthy that basic peptides containing 3–4 K/R residues can be successfully enriched, whereas those with more than 5 K/R residues cannot be effectively eluted. It was also observed that 1043 unique peptides were newly identified from 2.5 μg of mouse liver after the capture of basic peptides, with a markable increase in the identification coverage (31%). These newly identified peptides are generally more acidic and shorter than those depleted by CB[6], with median isoelectric point (pI) values of 5.8 and 7.0 and median lengths of 10 and 16 amino acids, respectively.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Jing Gao,Hao Dong,Peichao Zhang,Kunpeng Gao,Haipeng Su,Jianan Sun,Xiangzhao Mao
Whole-enzyme cascade degradation of crystalline α-chitin is a long-term pursuit, which has been hampered by low transformation efficiency and heterogeneous products. Here, a novel β-N-acetylglucosaminidase (NAGase) from Sulfuriroseicoccus oceanibius, designated Sohex, was biochemically characterized. The enzyme demonstrated high hydrolytic activity toward N-acetyl chitooligomers (N-acetyl COSs) and exhibited promotive effects on crystalline α-chitin degradation. Furthermore, a whole-enzyme cascade degradation system based on lytic polysaccharide monooxygenases (LPMOs), chitinases, and Sohex was developed for N-acetyl-D-glucosamine (GlcNAc) production. This system achieved a maximum conversion rate of 45.93%, with GlcNAc purity reaching 99.99%. The addition of Sohex significantly enhanced α-chitin degradation efficiency, achieving conversion rates of 1.37-fold and 2.46-fold compared to the LPMOs + chitinases system and the sole chitinases system, respectively. Moreover, the promotion mechanisms of Sohex in conjunction with LPMOs and chitinases were elucidated, making the cascade system a promising strategy for converting crystalline α-chitin into high-purity GlcNAc.
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高影响因子
MATERIALS AND STRUCTURES
·
2026
·Vol. 59
·期 4
·225
·
IF 3.9
Chen Mengzhu,Xu Chao,Hao Tingyu,Ran Bo,Li Kefei,Yu Linwen
To improve the durability of reinforced concrete in chloride-rich environments, the corrosion inhibition performance and mechanisms of N,N-dimethylethanolamine (DMEA) and calcium nitrite (CN) were systematically investigated. Their effectiveness was evaluated in simulated concrete pore (SCP) solutions and in reinforced concrete specimens subjected to laboratory wet–dry cycles and marine splash zone exposure. Electrochemical measurements demonstrated that both inhibitors delayed chloride-induced de-passivation of steel, increased the critical chloride threshold, and enhanced passive film stability. Optimal dosages were identified as 1.5 wt% for DMEA and 3.0 wt% for CN. These dosages increased the charge-transfer resistance ( R ct ) from 8.34 × 10 3 Ω·cm 2 (control) to 2.49 × 10 6 and 3.08 × 10 6 Ω·cm 2 , respectively, achieving high corrosion inhibition efficiencies of approximately 99.7%. Furthermore, the critical chloride threshold was increased from 0.17 to 0.34 M for 1.5% DMEA and 1.44 M for 3.0% CN, representing improvements of 1.0 and 7.4 times relative to the control. Surface analyses revealed that DMEA forms a thin, hydroxyl-rich organic layer through surface adsorption, whereas CN promotes the development of a dense, oxide-enriched passive film. Quantum chemical calculations and molecular dynamics simulations further elucidated their distinct inhibition mechanisms: DMEA strongly adsorbs via hydroxyl coordination, forming a physical barrier, while CN facilitates Fe 2+ oxidation to Fe 3+ , thereby stabilizing the passive film. These findings advance the understanding of organic and inorganic corrosion inhibitors in reinforced concrete and provide both theoretical and experimental support for their rational application in aggressive environments.
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Journal of Physical Chemistry Letters
·
2026
·Vol. 17
·期 33
·9746-9755
·
IF 4.5
Lan Zhineng,Wan Meng,Yan Huilin,Huang Hao,Liu Benyu,Lu Yi,Yang Yingying,Suo Yi,Zhang Guanzheng,Du Shuxian,Zhang Qiang,Wang Zhiwei,Jiang Tongtong,Sun Changxu,Qu Shujie,Yan Luyao,Cui Peng,Li Meicheng
Stability degradation plagues both
regular n-i-p and inverted p-i-n
perovskite solar cells (PSCs), with the organic hole transport layer
(HTL) constituting a key restricting factor. Poly(triarylamine) (PTAA)
possesses intrinsic polymer characteristics and excellent thermal
stability, rendering it a competitive candidate for high-performance
PSCs applicable to both device structures. However, challenging p-doping
procedures and vulnerability to humidity restrict its utilization.
Herein, we introduced a hydrophobic dilauroyl peroxide (DP) with oxidation
ability and a long-chain alkanes structure into the PTAA. Upon cleavage
of the peroxide bond (−O–O−) of DP, two decanoyl
free radicals are generated. These radicals seize the lone pair of
electrons on the N atom of the triarylamine in PTAA, oxidizing PTAA
into a positively charged radical PTAA •+ , thereby
achieving p-type doping of PTAA. This doping process enhances the
electrical properties and transport characteristics of PTAA. Besides,
the introduction of long-chain alkyl groups enhances the hydrophobicity
of the PTAA film, increasing the water contact angle from 60.18 °
to 80.39 ° . As a result, the champion PCE of n-i-p PSCs increased
from 23.49% to 24.82%, while that of p-i-n PSCs increased from 25.26%
to 26.04%. Moreover, the humidity stability and thermal stability
of the PSCs are enhanced. As a result, after the PSC aged for approximately
4752 h at 25 ° C and 45% relative humidity, it still maintained
97% of its initial PCE.
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JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Li-Hui Liu,Jia-Yan Zhang,Guang-Xuan Tang,Yu-Hong Huang,Xiang-Qing Xie,Jun Geng,Hui-Xiong Lü,Hui Li,Yan-Wen Li,Ce-Hui Mo,Hai-Ming Zhao,Quan-Ying Cai
Endophytic bacteria can degrade toxic phthalate (PAEs). Nevertheless, the colonization and function of endophytic PAE-degrader in soil-crop system and their association mechanism with indigenous bacteria in PAE removal remain unknown. Here, endophytic PAE-degrader Bacillus subtilis N-1 was marked with green fluorescent protein gene. Inoculated strain N-1- gfp could well colonize in soil and rice plant exposed to di-n-butyl phthalate (DBP) as directly confirmed by confocal laser scanning microscopy and realtime PCR. Illumina high-throughput sequencing demonstrated that inoculated N-1- gfp shifted indigenous bacterial community in rhizosphere and endosphere of rice plants with significant increasing relative abundance of its affiliating genus Bacillus than non-inoculation. Strain N-1- gfp exhibited efficient DBP degradation with 99.7% removal in culture solutions, and significantly promoted DBP removal in soil-plant system. Strain N-1- gfp colonization help plant enrich specific functional bacteria (e.g., pollutant-degrading bacteria) with significant higher relative abundances and stimulated bacterial activities (e.g., pollutant degradation) compared with non-inoculation. Furthermore, strain N-1- gfp displayed strong interaction with indigenous bacteria for accelerating DBP degradation in soil, decreasing DBP accumulation in plants and promoting plant growth. This is the first report on well colonization of endophytic DBP-degrader Bacillus subtilis in soil-plant system and its bioaugmentation with indigenous bacteria for promoting DBP removal.
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Journal of Cleaner Production
·
2023
·
IF 11.1
Qingwen Fan,Chaoyun Song,Peng Fu
The widespread proliferation of modern portable electronic devices has necessitated the development of functional materials with high-efficiency microwave absorption properties. In this study, we utilized biomass-derived jujube shells as a carbon source and employed a nitrogen-doping process to modify carbon materials, resulting in the fabrication of outstanding microwave-absorbing biomass-based nitrogen-doped porous carbon. Additionally, we discussed the influence of different nitrogen sources on material structure and microwave absorption performance. These N-doped porous carbon materials exhibited excellent specific surface areas, particularly Org-N, which facilitated the formation of conductive networks and the multi-stage reflection and scattering of microwave. Moreover, N-doping created numerous defect sites and heterogeneous structures, improving impedance matching , thus promoting dipole polarization and interface polarization effects , which accelerated electron migration and interlayer hopping, contributing to the attenuation of microwave energy. The lowest reflection loss for Org-N, Inorg-N, and Mixed-N reached −27.3 dB, −40.9 dB, and −45.6 dB, respectively. Mixed-N exhibited optimal microwave absorption performance at 9.9 GHz with d = 2.4 mm and achieved an effective absorption bandwidth (EAB 10 ) of 3.0 GHz (11.0 GHz–14.0 GHz) at d = 2.0 mm. Additionally, the enhancement of polarization relaxation effects was elucidated by examining the charge density distribution in molecular models featuring various N-doping forms. Consequently, biomass-derived N-doped porous carbon materials emerge as lightweight and highly efficient functional materials for microwave absorption purposes.
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