Materials Today Communications
·
2025
·
IF 4.5
Gengsheng Shi,Wenqin Yin,Jing Luo,Song Lin,Linluo Zhang,Yuan He,Hui Ding
This study developed transferrin (Tf) -functionalized magnetic nanoparticles (Tf-MNP-PEG-PLGA-Cur) to enhance curcumin (Cur)’s therapeutic potential for lung cancer. Tf-MNP-PEG-PLGA-Cur was synthesized by chemically coupling Tf (tumor-targeting ligand) to the surface of MNP-PEG-PLGA-Cur. Its size and morphology were measured, in vitro drug release was evaluated via dialysis, oral bioavailability and tissue distribution were studied in rats and mice. Cytotoxicity to normal cells was tested by CCK-8, A549 cell uptake was observed by confocal laser microscopy, and in vitro anti-lung cancer activity was studied using MTT assay. In vivo, its distribution in tumor-bearing nude mice was detected by near-infrared imaging, followed by measuring tumor growth and histopathological observation. Tf-MNP-PEG-PLGA-Cur nanoparticles had a small size (137.39 ± 3.72 nm, PDI 0.224 ± 0.010) with a biphasic release pattern, longer half-life (P<0.05), and 186% relative oral bioavailability. It promoted Cur accumulation in tissues, especially liver and spleen. Both Tf-MNP-PEG-PLGA-Cur and Cur showed good cytocompatibility. Tf-MNP-PEG-PLGA-Cur enhanced curcumin's anti-lung cancer activity in vitro and in vivo, indicating good tumor-targeting. H&E staining showed it protected nude mice's vital organs and inhibited tumor growth. Tf-MNP-PEG-PLGA-Cur is a promising polymeric sustained-release curcumin preparation, improving oral bioavailability and anti-lung cancer activity.
✓ 已验证
产品关联
DOI
高影响因子
POLYMER
·
2021
·
IF 4.43
Hongyu Zhu,Yu Liu,Dongxu Gu,Zikun Rao,Yang Li,Jianyuan Hao
It is a challenging work to design novel responsive materials by controlling the secondary structure of polypeptide , especially β-sheet. We designed and synthesized a novel dual responsive diblock copolymer of methyl poly (ethylene glycol)- b -poly (O-benzyl- l -threonine) (mPEG- b -PBnLT). The copolymer solutions exhibited unusual and reversible gel-to-sol-to-gel transition behavior with temperature, and the transition temperature window could be easily adjusted by changing copolymer concentration or PBnLT block length . It was confirmed that low temperature gel-to-sol transition was due to the disassembly of the preliminary β-sheet layered nano-assemblies that induced the transformation of self-organized morphology from nanosized fibrils to spherical aggregates, while the high temperature sol-to-gel transition was ascribed to the dehydration of PEG segments. The disassembly of β-sheet structures was caused by the change in the polarity of the pendant benzyl ether bond of PBnLT block in water with temperature. This stimuli-responsiveness of secondary self-assembled nanostructures and the corresponding change in macroscopic phase transition inspires a brand-new strategy for structural design and functional control of polypeptide materials.
研究领域:
高分子科学
·
材料化学
·
纳米技术
·
智能材料
·
生物聚合物
✓ 已验证
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2026
·
IF 12.4
Yicheng Zhu,Ting Wang,Ni Zhu,Changduo Wang,Yaming Guo,Yujie Zhang,Jiajia Shi,Chunxiao Qi,Chao Liu,Rong Fu,Jing Yang
The intravenous delivery of mesenchymal stromal cells (MSCs) is often limited by pulmonary entrapment and poor survival under oxidative stress in inflammatory environments. To overcome these challenges, a multifunctional cell-surface engineering strategy driven by the synergistic coordination of polyethylene glycol (PEG), epigallocatechin gallate (EGCG), and magnesium (Mg 2+ ) was adopted in this study. PEG and EGCG were first covalently coupled to form the polymer, PEG-EGCG, in which PEG provides “stealth” shielding, and EGCG facilitates mild membrane insertion and Mg 2+ coordination. The resulting PEG-EGCG–Mg complex self-assembled on MSCs, forming a stealth layer and a metal–phenolic network. This P-E-Mg@MSCs design significantly reduced cell adhesion to endothelium and collagen, thereby diminishing pulmonary trapping and leading to increased bone marrow accumulation in a murine model of immune-mediated aplastic anemia (AA). Furthermore, the coating conferred potent antioxidant and anti-inflammatory properties, thereby improving MSC survival under oxidative stress. In AA mice, treatment with P-E-Mg@MSCs restored peripheral blood counts, reduced bone marrow adiposity, and modulated immune imbalance by upregulating regulatory T cells and downregulating cytotoxic CD8 + T cells, thereby outperforming unmodified MSCs. This work presents a versatile coating platform that integrates adhesion inhibition, microenvironment modulation, and metal-ion coordination to enhance the systemic delivery and therapeutic efficacy of MSCs for regenerative and immunomodulatory applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 8
·6516-6522
·
IF 3.289
Yan Li,Zhiyong Wu,Dou Du,Haiqing Dong,Donglu Shi,Yongyong Li
In photodynamic therapy (PDT), selective activation of the photosensitiser in tumor-relevant conditions is highly desirable to avoid side effects. In this study, a graphene quantum dot (GQD) nanosystem, composed of a redox-triggered cleavable PEG shell, was designed and developed for selective recovery of photoactive chlorine e6 (Ce6) in tumor-relevant conditions. In this unique system, the planar π conjugated structure of GQD enables efficient quenching of the photochemical properties of Ce6 in terms of fluorescence and singlet oxygen generation. Once exposed to tumor relevant glutathione (GSH), the disulfide-linked PEG shell undergoes reductive cleavage and subsequent detachment from the GQD scaffold, leading to accelerated release of Ce6 with recovered photoactivity. MTT study against HeLa cells demonstrated the high PDT efficacy of Ce6, regulated by elevated GSH concentration. The studies on in vivo/ex vivo imaging and photodynamic efficacy demonstrated superior biocompatibility of the GQD nanosystem compared with the widely reported graphene oxide (GO)-based nanovehicle. Intravenously injected GQD–SS–PEG/Ce6 showed effective suppression of tumor growth.
研究领域:
纳米医学
·
癌症治疗
·
生物材料科学
·
光化学
·
药学
✓ 已验证
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2023
·
IF 6.2
Xiqin Yang,Ping Chen,Xi Zhang,Hao Zhou,Zhen Song,Wenlong Yang,Xiliang Luo
A simple tactic for electrochemical determination of a typical biomarker for breast cancer, human epidermal growth factor receptor 2 (HER2), was presented via the construction of a low fouling sensing interface functionalized with polyethylene glycol (PEG) and peptide. The HER2 biosensor was developed based on an electrode modified by the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) and Au nanoparticles (AuNPs) as the sensing substrate, and followed by the immobilization of an antifouling PEG and a peptide with both recognizing and antifouling properties. Thanks to the combined antifouling effect of the PEG and peptide, and the specific recognizing ability of the peptide to the target HER2, the developed electrochemical biosensor exhibited strong antifouling performances in complex biofluids, such as human blood and serum, and it was capable of assaying target HER2 within a very wide linear range (1.0 pg mL −1 to 1.0 μg mL −1 ), with an ultralow limit of detection (0.44 pg mL −1 ). The combination of two kinds of antifouling biomaterials (PEG and peptide) offered an effective strategy for the development of low fouling sensing platforms suitable for practical assay in complex biotic environments.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Hongwei Ren,Yize Liu,Ruoyao Zhang,Yi Zheng,Tengda Zhao,Jing Han,Chunmao Chen,Erhong Duan
Naphthenic acids (NAs) are toxic components in refinery wastewater and in oil sands process water. The presence of NAs in aqueous environments would cause serious environmental problems. Development of a rapid method for screening and determination of trace NAs is urgent. In this work, a near-infrared fluorescence carbon quantum dots (CQDs) was successfully synthesized with p -phenylenediamine (PPD) and polyethylene glycol 400 (PEG 400) by the hydrothermal method. It showed a good fluorescence response to NAs with good detectability. The limit of detection was calculated to be 0.16 mmol‧L −1 , with a linear range from 0.5 to 15 mmol‧L −1 . The detection mechanism of NAs and CQDs was also proposed with in situ infrared spectrometer . This work provides new insights into the fluorescence detection of CQDs in the petrochemical industry, broadening the application of CQDs in the detection of environmental organic pollutants .
✓ 已验证
产品关联
DOI
高影响因子
PROCESS BIOCHEMISTRY
·
2023
·
IF 4.4
Xiaoxuan Cai,Miaoen Huang,Xixiang Huang,Huan Liu,Tianji Wang,Li Li,Weiguang Yang,Hui Luo,Yingnian Lu
The organism Sipunculus nudus L is a good resource for marine peptides because of its rich protein. However, the disadvantage of biological peptides is their short metabolic half-life, therefore, structural modification of peptides is necessary. In this research, the enzymatic hydrolysis of Sipunculus nudus L was performed using trypsin and then peptides were isolated and purified from the hydrolysates, four novel tripeptides were identified by LC-MS-MS as Ser-Arg-Pro (SRP, m/z = 358.39), Pro-Arg-Pro (PRP, m/z = 368.43), Arg-Pro-Ala (RPA, m/z = 342.39), and Lue-Pro-Lys (LPK, m/z = 356.46), their ACE inhibitory activity was investigated with IC 50 value as following 0.046, 0.42, 0.97, and 6.54 mM, respectively. Because of its highest ACE inhibitory activity, SRP was further selected to modify the chemical structure for a sustained release agent DSPE-PEG-SRP. Compared with 7 h of free SRP, the release of DSPE-PEG-SRP in vitro was approximately 120 h. The ACE inhibition rate of SRP released from the synthetic product and the raw material SRP was almost the same, molecular docking demonstrated that ACE inhibitory activity was attributed to the formation of hydrogen bonds between SRP and ACE active sites . In conclusion, DSPE-PEG-SRP, a novel sustained release agent, has great potential and is expected to be further applied to treat hypertension.
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Rui Jing,Huanzhi Zhang,Chaowei Huang,Fucai Su,Bojing Wu,Zongxu Sun,Fen Xu,Lixian Sun,Yongpeng Xia,Hongliang Peng,Xiangcheng Lin,Bin Li,Yongjin Zou,Hailiang Chu,Pengru Huang,Erhu Yan
To improve phase-change behavior and thermal conductivity of the PEG-based polymeric SSPCMs, a series of SSPCMs with double cross-linking networks were constructed by introducing GO and hydroxylated h-BN into the polymer molecular chains of PEG-based SSPCMs through grafted polymerization and self-assembly. GO was the main hard supporting skeleton for the PEG segment, and h-BN as 2D thermal enhanced cells continuously was linked on the GO nano-sheets, forming into double cross-linking networks with PEG segments, which has good structural stability and regularity. Thus, the SSPCMs possessed good phase-change properties, excellent thermal reliability, and high thermal conductivity. Microscopies confirmed the successfully constructed chemical structure of the SSPCMs. Energy-storage capacities of the SSPCMs could reach 149.62 J/g, which displayed no obvious change after 100 thermal cycles, suggesting a good thermal cycling stability. Moreover, thermal conductivity of the prepared SSPCMs was enhanced by 71% compared with pure PEG, showing a good heat transfer efficiency. Therefore, this study represents a creative strategy towards the development of SSPCMs for thermal energy storage and thermal management applications.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Jingjing Wang,Jun Wei
Zr(IV)-crosslinked carboxymethyl cellulose/carboxymethyl chitosan hydrogels were prepared using polyethylene glycol (PEG) as pore-forming agent. The hydrogels exhibited porous structure and the pore size increased with the PEG content. The obtained hydrogels were used as adsorbents for removal of phosphate from aqueous solutions. The hydrogel prepared with most amount of PEG displayed largest adsorption amount of phosphate. This result might be attributed to improvement of surface area and pore volume caused by introduction of PEG, which could boost exposure of adsorption sites in the hydrogel and enhance the diffusion of phosphate into interior of the hydrogel. The phosphate adsorption achieved equilibrium within 400 min and the removal process followed pseudo-second-order kinetic model. The maximum adsorption capacity was reached at pH = 2.0, and the adsorption capacity gradually increased with temperature. In the presence of coexisting anions, SO 4 2− ions exerted much more negative effect on phosphate adsorption than Cl − and NO 3 − ions. The phosphate adsorption mechanism was related to electrostatic interaction, ligand exchange and ion exchange. Moreover, the hydrogel exhibited relatively stable adsorption capacity after six adsorption/desorption cycles. The present study presented a facile method for preparing an excellent hydrogel adsorbent for phosphate removal from aqueous solutions.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2021
·
IF 7.267
Dan Wei,Chunxian Wu,Gan Jiang,Xinxin Sheng,Yuhui Xie
To counter the underutilization and pollution relative to lignin, a novel strategy was adopted, where lignin was introduced as a modifier to enhance graphene aerogel (GA), resulting in the lignin-modified graphene aerogel (LGA) with an ultralow density (2.80 g/cm 3 ). With the help of lignin, a well-defined 3D porous structure was successfully constructed in LGA with homogenous distribution of lignin, which was beneficial for supporting and extending GA skeleton that originally displayed significant shrinkage. The LGA skeleton achieved an extraordinarily high absorption of PEG (~99.0 wt%), which was higher than that of GA-based form-stable phase change materials whose absorption rate was already topped. Meantime, PEG@LGA exhibited not only reinforced light absorption in the whole light range from NIR to UV light benefitting to solar-to-thermal conversion, but also improved thermal stability and reusability as well as high latent heat efficiency (96.71%) and relative latent heat efficiency (98.41%). The material shows great potentials in energy storage and thermal management whose fabrication method at the same time paves a facile way for lignin utilization and valorization.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2020
·
IF 4.3
Lei He,Lutao Yang,Luxia Zhang,Zhe Wang,Hongjie Cheng,Xiaoguang Wang,Jianrong Lv,Jun Zhang,Hong Mo,Jian Shen
The high salinity of oilfield-produced water caused by the presence of metal ions, such as Ca 2+ and Mg 2+ , has a significantly adverse effect on oil recovery. It is crucial to remove these metal ions efficiently before the oilfield wastewater is reinjected down into the oil wells. To address this issue, we prepared a PEG/Fe 3 O 4 /GO-NH 2 nanoadsorbent by aminating GO, incorporating magnetic Fe 3 O 4 nanoparticles and coating with PEG (PEG = poly(ethylene glycol); GO-NH 2 = aminated graphene oxide). We investigated the removal ratios of the nanoadsorbent for Ca 2+ and Mg 2+ . The respective removal ratios for Ca 2+ and Mg 2+ reached 69.8 % and 61.1 % at 10 min, indicating that the nanoadsorbent was capable of efficiently removing Ca 2+ and Mg 2+ . We also evaluated the reusability of the nanoadsorbent by recycling and reusing it 5 times. At the fifth recycling run, the nanoadsorbent retained relatively high reuse rates (79.1 % for Ca 2+ , 69.5 % for Mg 2+ ) and removal ratios (69.5 % for Ca 2+ , 64.3 % for Mg 2+ ), suggesting that the nanoadsorbent possessed relatively high reusability. Oilfield wastewater treated with the nanoadsorbent was employed for oil recovery in core displacement experiments. The oil recovery efficiency significantly increased by 11.8 % compared with untreated oilfield wastewater. Therefore, the PEG/Fe 3 O 4 /GO-NH 2 nanoadsorbent exhibits considerable potential for the treatment of oilfield wastewater to enhance oil recovery.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2020
·
IF 4.049
Jiaxuan Fan,Zikai Liu,Jing Li,Wenfeng Zhou,Haixiang Gao,Sanbing Zhang,Runhua Lu
It is necessary to establish a rapid, simple and environmentally friendly detection method for benzoylurea pesticides (BUs) in environmental water samples because of their toxicity in environmental circulation. Herein, a novel polyethylene glycol (PEG) modified magnetic covalent organic framework material based on the Schiff base reaction was prepared (PEG/Fe 3 O 4 @SNW-1). This material was used as a sorbent for enriching five BUs by magnetic solid phase extraction prior to detection via high-performance liquid chromatography. After the optimization of several parameters (such as the salinity, extraction time, amount of sorbent, desorption time, etc.) that influenced the recovery of the magnetic solid phase extraction process, the limits of detection (S/N = 3) were defined as less than 1.0 μg L −1 , and the limits of quantitation (S/N = 10) were calculated as being lower than 3.4 μg L −1 . A satisfactory linear range of 5–1000 μg L −1 was achieved. Finally, the proposed method was applied to analyze benzoylurea pesticides in three environmental water samples. These results indicated that the proposed method was feasible and demonstrated the potential application of the PEG/Fe 3 O 4 @SNW-1 material for detecting similar pesticide residues in environmental water samples.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）