RSC Advances
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2017
·Vol. 7
·期 85
·53996-54001
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IF 3.108
Anna Zheng,Ling Su,Zheng Li,Guijin Zou,Xiang Xu,Yong Guan
To break through the industrial development bottlenecks of anionic polymerization in the field of polar monomers, poly n-hexyl methacrylate (PHMA) was prepared at 0 °C, 30 °C, and 60 °C with potassium tert-butoxide (t-BuOK) as the initiator in tetrahydrofuran (THF) and the conversions were almost complete. Gel permeation chromatography (GPC) analysis of poly n-hexyl methacrylate indicated that t-BuOK existed in numerous states when dissolved in THF, including different types of association and ion-pairs. A series of block copolymers of n-hexyl methacrylate (n-HMA) and methyl methacrylate (MMA), PMMA-b-PHMA (Mn 8200–16 200) and PHMA-b-PMMA (Mn 19 100–9500) were synthesized at 0 °C, and conversions were close to 100%. The results of dynamic mechanical analysis (DMA) indicated that there were two glass transition temperatures, −10 to 0 °C for the PHMA block and 100 to 110 °C for the PMMA block. Furthermore, the competing behaviors of n-HMA and MMA in copolymerization were investigated by one-shot feeding of two types of monomers at 0 °C, 30 °C, and 60 °C. The kinetics curves and 13C-NMR analysis of the copolymers indicated that the polymerization of n-HMA in the copolymerization was significantly dominant over that of MMA at set temperatures. The results in this study provided the possibility to realize anionic polymerization of methacrylate esters on a commercial scale.
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Small Science
·
2024
·
IF 11.1
Yi Zhang,Zida Zheng,Zhixing Gan,Rui Huang,Xiaowei Zhang
Luminescent solar concentrators (LSCs) are highly valued in transparent photovoltaics for their versatility and adaptability as effective large-area sunlight collectors. However, constructing LSCs as efficient, long-term stable, and easily malleable power-generating units still remains a challenge. Herein, high photostability, high photoluminescence quantum yield ( Φ PL ), and Stokes-shifted emission are achieved in tetra(t-butyl)rubrene/off-stoichiometry thiol-ene (TBRb/OSTE) hybrids by incorporating TBRb molecules into OSTE polymers. To demonstrate their potentials in LSCs, a luminescent solar concentrator integrated photovoltaics (LSCIPV) is created using a one-step synthesis that combines the preparation of TBRb/OSTE hybrids, coupling with the silicon solar cell, and the encapsulation of both components. The LSCIPV demonstrates remarkable flexibility and the integration of an ethylene tetrafluoroethylene film contributes to a hydrophobic surface and antireflection effect, resulting in an external photon efficiency ( η ext ) of 4.9% and a power conversion efficiency of 1.04% for the 100 cm 2 device. The LSCIPV exhibits good photostability over 800 h of UV light exposure. Monte Carlo ray-tracing simulations indicate that an optimized TBRb-based LSCIPV can potentially achieve an η ext of 1.3%, even for a large device with an area of 1 m 2 .
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2012
·
IF 1.693
Yuan-Yuan Che,Jian Shen,Jun-Chao Zhou,Chao-Hong He
The thermal conductivity of ammonium sulfate + water, ammonium nitrate + water, and ammonium sulfate + ammonium nitrate + water is of great significance in the national defense industry and military engineering for manufacturing of various energetic chemicals. The measurements, covering a temperature range from (278.15 to 333.15) K, have been performed by a transient hot-wire technique over a wide range of concentrations. The densities of ternary aqueous solutions of ammonium sulfate + ammonium nitrate are also presented at the same temperature covering different portions of ammonium sulfate and ammonium nitrate. The thermal conductivities of binary aqueous solutions of ammonium salts are correlated by polynomial functions in terms of temperature and weight fraction for the purpose of interpolation. The Aseyev equation in terms of weight fraction is also used to represent the thermal conductivities of ternary mixtures of these compounds. The ideal mixing rule of Young has been successfully applied to correlate the ternary densities of aqueous ammonium sulfate + ammonium nitrate solutions based on relevant binary solution properties. The agreement between the correlation and the experimental data is pretty good.
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Experimental Hematology & Oncology
·
2025
·Vol. 14
·期 1
·1-17
·
IF 13.5
Ren Xueting,Wu Jinpeng,Li Jing,Zhai Zhen,Li Xiang,Guan Feng,Wang Meng,Ma Xiaobin,Tan Zengqi,Kang Huafeng,Lin Shuai
Background The abundance of PD-L1 on the surface of tumor cells is a critical factor in sensitizing these cells to T cell-mediated immune killing. While abnormal glycosylation of PD-L1 is known to influence its expression and function, the precise regulatory mechanisms remain unclear.Methods This study utilized bioinformatics analysis to explore the role of MGAT3, a key gene involved in the formation of the bisecting GlcNAc structure, in breast cancer (BC). Experimental approaches were employed to increase bisecting GlcNAc levels in BC cells, followed by assessments of PD-L1 expression, CD8+ T cell-mediated cytotoxicity, extracellular vesicle (EV)-associated PD-L1, and PD-L1/PD-1 interaction. Additionally, forskolin, a bisecting GlcNAc agonist, was combined with anti-PD-L1 antibody to evaluate its antitumor effects in vivo.Results MGAT3 was found to be expressed at low levels in BC tissues but positively correlated with CD8+ T cell infiltration. Elevating bisecting GlcNAc levels in BC cells significantly enhanced the cytotoxic efficacy of CD8+ T cells. High bisecting GlcNAc modification promoted PD-L1 degradation via the lysosomal pathway, reducing PD-L1 expression and its binding to PD-1. Furthermore, increased bisecting GlcNAc levels reduced PD-L1 in tumor cell-derived EVs, impairing the EVs’ ability to block CD8+ T cells and indirectly enhancing T cell cytotoxicity. The combined use of forskolin and anti-PD-L1 antibody significantly increased CD8+ T cell abundance and activity, achieving a more effective antitumor response in vivo.Conclusion sThese findings demonstrate that enhancing bisecting GlcNAc modification in BC cells promotes PD-L1 degradation and inhibits its binding to PD-1, thereby boosting CD8+ T cell-mediated cytotoxicity, providing a promising strategy for immune modulation in BC therapy.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2025
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IF 6.1
Sheng-Quan Su,Gui-Yuan Xiong,Chun-Yan Yao,Xiao-Ling Liu,Yin-Yin Xia,Jin-Yun Long,Xiu-Kuan Li,Liang-Mei Wang,Long Yi,Wu-Wei Xu,Wu-Qiang Lu,Qian-Qian Li,Ting Hu,Hao Liu,Ke-Xue Wang,Peng Luo,Tong-Jian Cai
T-2 toxin, classified as a mycotoxin, harms immune and cognitive systems. Recently, an increasing number of studies have focused on the neurotoxic effects of T-2 toxin. However, there is still a need for a better understanding of the molecular mechanisms involved. In this study, we aimed to elucidate the protective effect of resveratrol (Res) supplementation against T-2 toxin-induced spatial learning and memory impairment and to investigate the communication mechanisms between the gut and the brain. Mice received a single intraperitoneal dose of T-2 toxin (4 mg/kg) followed by Res (100 mg/kg) administered via the same route. The Morris water maze and novel object recognition tests demonstrated that T-2 toxin had a profound negative impact on spatial learning and memory in mice. However, the administration of Res successfully mitigated the cognitive impairments caused by T-2 toxin and notably enhanced the levels of brain-derived neurotrophic factor (BDNF), synaptophysin I (SYN1), and postsynaptic density protein 95 (PSD-95). Moreover, Res demonstrated a protective effect against T-2 toxin-induced damage to hippocampal tissue. Simultaneously, it played a pivotal role in restoring gut microbiota equilibrium and maintaining the integrity of intestinal tight junctions, effectively curbing both localized and systemic inflammation triggered by T-2 toxin exposure. In conclusion, our findings suggest that resveratrol may alleviate T-2 toxin-induced spatial learning and memory deficits, possibly via gut-brain axis modulation.
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ARCHIVES OF DERMATOLOGICAL RESEARCH
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2025
·Vol. 317
·期 1
·1-16
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IF 2.1
Lin Ling,Li Wei,Gao Xinjing,Li Qian,Zhou Xin,Liu Weiyu,Zhong Xuelian,Yang Yunqing,Zhang Xibao,Luo Quan
Psoriasis represents a chronic inflammatory skin disease occurring globally. We investigated the role of plasma exosomal microRNA (miR)- 148a- 3p and its target gene Bim in psoriasis. Plasma exosomes (Exos) and CD4 + T cells were extracted from psoriatic patients. miR- 148a- 3p expression in Exos and CD4 + T cells of psoriatic patients, the proportions of CD4 + T cell subsets, and the contents of anti-inflammatory/pro-inflammatory factors were determined by RT-qPCR, flow cytometry and ELISA. The correlation between plasma exosomal miR- 148a- 3p and CD4 + T cell subsets in psoriatic patients was analyzed by Pearson’s analysis. The psoriatic mouse was treated with Exos/antagomir miR- 148a- 3p. Histopathological changes in the skin were observed. The CD4 + T cell subset levels, serum cytokine contents and miR- 148a- 3p expression in the blood were measured. The miR- 148a- 3p-Bim targeted binding relationship was predicted and verified by Starbase database and dual-luciferase assay. The Bim expression in psoriatic mice was determined. Psoriatic patients had highly-expressed miR- 148a- 3p in both Exos and CD4 + T cells, and abnormal CD4 + T cell subsets and cytokine levels. Plasma exosomal miR- 148a- 3p was correlated with the CD4 + T cell subsets in psoriatic patients. Exos caused down-regulated miR- 148a- 3p level in skin tissues of mouse, regulated CD4 + T cell function and aggravated the symptoms in psoriatic mice. miR- 148a- 3p repression partially reversed the role of Exos in CD4 + T cell function and psoriasis-like symptoms. Exos-carried miR- 148a- 3p targeted Bim in CD4 + T cells of psoriatic mice. Plasma exosomal miR- 148a- 3p targeted Bim to affect the dysfunction of CD4 + T cells in psoriatic mice, thereby aggravating the psoriasis-like symptoms.
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ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Xiangyu Deng,Wei Guan,Xiangcheng Qing,Wenbo Yang,Yimei Que,Lei Tan,Hang Liang,Zhicai Zhang,Baichuan Wang,Xiangmei Liu,Yanli Zhao,Zengwu Shao
Conventional therapeutic approaches to treat malignant tumors such as surgery, chemotherapy, or radiotherapy often lead to poor therapeutic results, great pain, economic burden, and risk of recurrence and may even increase the difficulty in treating the patient. Long-term drug administration and systemic drug delivery for cancer chemotherapy would be accompanied by drug resistance or unpredictable side effects. Thus, the use of photothermal therapy, a relatively rapid tumor elimination technique that regulates autophagy and exerts an antitumor effect, represents a novel solution to these problems. Heat shock protein 90 (HSP90), a protein that reduces photothermal or hypothermic efficacy, is closely related to AKT (protein kinase B) and autophagy. Therefore, it was hypothesized that autophagy could be controlled to eliminate tumors by combining exogenous light with a selective HSP90 inhibitor, for example, SNX-2112. In this study, an efficient tumor-killing strategy using graphene oxide loaded with SNX-2112 and folic acid for ultrafast low-temperature photothermal therapy (LTPTT) is reported. A unique mechanism that achieves remarkable therapeutic performance was discovered, where overactivated autophagy induced by ultrafast LTPTT led to direct apoptosis of tumors and enabled functional recovery of T cells to promote natural immunity for actively participating in the attack against tumors. This LTPTT approach resulted in residual tumor cells being rendered in an “injured” state, opening up the possibility of concurrent antitumor and antirecurrence treatment.
研究领域:
肿瘤学
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治疗学
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免疫学
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生物医学工程
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JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6.8
Ming Zhang,Yan Chen,Shuaiqi Feng,Yanqin He,Zhifang Liu,Ning Zhang,Qingpeng Wang
The inflammatory microenvironment is a central driver of tumor metastasis, intimately associated with the promotion of epithelial–mesenchymal transition (EMT) and immune suppression. Here, transferrin-modified carprofen platinum(IV) nanoparticles Tf-NPs@CPF2–Pt(IV) with promising antiproliferative and antimetastatic properties were developed, which activated by inhibiting inflammation, suppressing EMT, and activating immune responses besides causing DNA injury. The nanoparticles released the active ingredient CPF2–Pt(IV) in a sustained manner and offered enhanced pharmacokinetic properties compared to free CPF2–Pt(IV) in vivo. Additionally, they possessed satisfactory tumor targeting effects via the transferrin motif. Serious DNA damage was induced with the upregulation of γ-H2AX and P53, and the mitochondria-mediated apoptotic pathway Bcl-2/Bax/caspase3 was initiated. Inflammation was alleviated by inhibiting COX-2 and MMP9 and decreasing inflammatory cytokines TNF-α and IL-6. Subsequently, the EMT was reversed by inhibiting the Wnt/β-catenin pathway. Furthermore, the antitumor immunity was provoked by blocking the immune checkpoint PD-L1 and increasing CD3+ and CD8+ T lymphocytes in tumors.
研究领域:
癌症研究
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纳米技术
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药理学
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免疫学
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分子生物学
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2010
·
IF 1.695
Xueqiao Xie,Juan Han,Yun Wang,Yongsheng Yan,Guowu Yin,Weisheng Guan
Experimental liquid−liquid equilibrium (LLE) binodal curves, tie-lines, and plait points were obtained for the PPG400 + salt (K3PO4, K2CO3, and K2HPO4) + H2O systems at T = 298.15 K. The Merchuk equation was used to correlate the binodal data of the investigated systems. Also, the effect of salt on the phase-forming ability has been studied based on the effective excluded volume (EEV) values from fitting the binodal data to the binodal model developed by Guan, and the salting-out abilities of the anions are in the order of PO43− > HPO42− > CO32−, which may be related to the Gibbs free energy of hydration of the ions (ΔhydG). Furthermore, tie-line compositions were correlated using the Setschenow-type, Othmer−Tobias, and Bancroft equations, and the parameters are reported.
研究领域:
化学
·
生物学
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Applied Materials Today
·
2026
·
IF 7
Xiaowan Zhao,Qikai Qiao,Yuanqing Li,Aiqin Zhang,Hong Guo,Jing Guo,Haixia Zhang,Jianjun Lu
To address the issue of secondary contamination caused by the lack of antibacterial properties in polypropylene (PP) meltblown nonwoven fabrics while preserving its core filtration performance, this work employed an immersion-ultrasonic method to construct Ag@T-ZIF-8 antibacterial materials with a core-shell structure. Subsequently, PP/Ag@T-ZIF-8-G composite meltblown fibers was prepared via covalent modification and meltblown spinning technology. The systematic characterization of Ag@T-ZIF-8 was conducted in terms of its chemical structure, microstructure, and photocatalytic antibacterial performance. The effects of Ag@T-ZIF-8 on the antibacterial, filtration and comfort properties of the composite melt-blown nonwoven fabrics were investigated, and the enhancement mechanisms of antibacterial and filtration were revealed. The results indicate that Ag@T-ZIF-8 exhibits a uniform core-shell structure with a particle size of 40∼50 nm and a specific surface area of 531.83 m²/g. At an antibacterial concentration of 200 mg/L, it achieves a 99.99% antibacterial rate against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) within 8 min in the dark or 4 min under illumination. Compared with PP meltblown nonwoven fabrics, it demonstrates 73.31% in filtration efficiency for particles with a pressure drop of only 37.3 Pa. When Ag@T-ZIF-8 loading reaches 1 wt%, the composite meltblown fabrics completely eliminates E. coli and S. aureus after 160 min of illumination or 240 min in the dark. This outstanding comprehensive filtration performance stems from a synergistic filtration mechanism combining mechanical filtration, ionic adsorption, and dual-mode antibacterial action under light or dark condition. Integrating superior filtration capabilities, broad-spectrum antibacterial properties, and wear comfort, PP/Ag@T-ZIF-8-G meltblown nonwoven fabrics deliver a highly efficient integrated antibacterial-filtration solution for the medical protective field.
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Journal of Energy Storage
·
2026
·
IF 10.7
Xiaochen Wu,Yongtao Zhao,Rui Yang,Jiaxuan Feng,Sujuan Cheng,Ning Liu,Teng Long,Pengchao Si
Silicon anodes for advanced lithium-ion batteries (LIBs) are promising due to intrinsic advantages including ultrahigh theoretical capacity (4200 mAh g −1 ), near-optimal Li + /Li potential (∼0.4 V), abundant availability and environmental benignity. However, practical application is hindered by severe intrinsic challenges: drastic volume expansion (>300%), unstable solid-electrolyte interphase (SEI) formation, and sluggish reaction kinetics. To address these limitations, we fabricated a novel Si@T-Nb₂O₅@Carbonized-coxial carbon nano fiber composite via a scalable hydrothermal-electrospinning approach, featuring silicon nanoparticles encapsulated in a nitrogen-doped porous carbon matrix with an engineered T-Nb₂O₅ interphase layer. Theoretical simulations demonstrate that the T-Nb₂O₅ interphase promotes Li + diffusion and reduces the energy barrier at carbon/Si interfaces. The optimized electrode exhibits excellent cycling stability and high-rate performance (1030.1 mAh g −1 after 100 cycles at 0.2 A g −1 ; 507.7 mAh g −1 after 500 cycles at 2.0 A g −1 ). Notably, flexible pouch cells maintain stable LED illumination under repeated mechanical deformation, indicating great practical potential. This integrated electrospinning strategy provides a scalable manufacturing platform for high-energy flexible batteries.
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JOURNAL OF CHEMICAL THERMODYNAMICS
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2015
·
IF 2.679
Lingxiao Chen,Jiayi Chen,Zihao Song,Guokai Cui,Yingjie Xu,Xuhong Wang,Jian Liu
Densities and viscosities of binary mixtures of 8-hydrogen-1,8-diazabicyclo[5,4,0]-undec-7-enium imidazolide ([HDBU]IM) and 8-butyl-1,8-diazabicyclo[5,4,0]-undec-7-enium imidazolide ([BDBU]IM) ionic liquids (ILs) with water were measured at temperatures from T = (293.15 to 313.15) K. Excess molar volumes V E and viscosity deviations Δ η of the mixtures were calculated to study the intermolecular interactions and structural factors between ILs and water. The results show that the V E values of the two mixtures are negative over the whole composition range, while the Δ η values have positive deviations, indicating that the hydrogen bonding interactions between IL and water are dominant in the mixtures. Moreover, the absolute values of V E (| V E |) of {[HDBU]IM (1) + H 2 O (2)} system are larger than those of {[BDBU]IM (1) + H 2 O (2)} system at the same condition, indicating that the hydrogen bonding interactions between [HDBU]IM and water are stronger than those between [BDBU]IM and water. Both | V E | and Δ η values of the mixtures decrease with the increasing temperature, resulting from the decreasing the hydrogen bonding interactions between IL and water. Other derived properties of the studied systems, such as the apparent molar volumes , partial molar volumes, excess partial molar volumes, Gibbs free energy of activation for viscous flow , and excess Gibbs free energy of activation for viscous flow were also calculated from the experimental values.
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危险品化学品经营许可证（带存储）