JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2024
·
IF 1.9
Chengbo Liu,Jian Li,Chenyi Wang,Qiang Ren
Green technology for the fabrication of bio-degradable microspheres is exciting and needed. In this study, a new water-in-water Pickering emulsion green technology is proposed for the fabrication of the crosslinked starch microspheres with sodium tripolyphosphate as the crosslinker, polyethylene glycol aqueous solution as the continuous phase (PEG phase) and starch aqueous solution as the dispersed phase (starch phase). The factors that affect the morphology and particle sizes of cross-linked starch microspheres are investigated by laser scanning confocal microscope (LCM) and laser particle size analyzer. The results reveal that the particle sizes of crosslinked starch microspheres are increasing with increased starch concentration. The particle sizes of crosslinked starch microspheres show a first increase and then decrease trend with the increase of the concentration of PEG 20,000 in the PEG phase. The hydrophobic nano silica is used as an emulsifier to form water-in-water Pickering emulsion and shows an obvious effect on the morphology of starch microspheres. When the starch concentration is 20.00 wt%, PEG 20000 concentration is 32.56 wt%, the ratio of starch to PEG phase is 0.20 and the amount of silica is 5.00 wt% of starch, starch microspheres with regular shapes are obtained with the size of about 32.30 ± 0.22 µm. The fabricated cross-linked starch microspheres are non-crystalline and show good water and oil absorption performances. The application of fabricated crosslinked starch microspheres in the adsorption and release of Vitamin C is conducted. The maximum adsorption capacity of crosslinked starch microspheres for Vitamin C reaches 309.9 mg/g. Starch microspheres show a controlled release of Vitamin C in water. This study indicated that crosslinked starch microspheres can be fabricated through a green water-in-water Pickering emulsion technology and may find potential applications in degradable controlled-release microspheres.
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高影响因子
APPLIED CLAY SCIENCE
·
2024
·
IF 5.3
Hongcai Wang,Xiuqiong Chen,Cuiyu Gong,Yanan Bu,Ting Wu,Huiqiong Yan,Qiang Lin
Enclosing the pesticide in a carrier and releasing it based on environmental stimuli is proved to be a viable strategy for addressing pesticide losses and mitigating environmental contamination. Here, an interpenetrating network (IPN) composite hydrogels (OMt/Alg/PNIPAm) with light and temperature responses was prepared by the incorporation of clay material, organo-montmorillonite (OMt), via the free-radical polymerization of N-isopropyl acrylamide (PNIPAm) and its crosslinking as well as ionic crosslinking reaction of sodium alginate (SA) with FeCl 3 . The structure of OMt/Alg/PNIPAm was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), thermos gravimetric analysis (TGA) and rheometer. The hydrophobic pesticide λ-cyhalothrin (LC) was encapsulated in OMt and subsequently incorporated into the IPN structure of the composite hydrogels, ensuring the desirable mechanical properties, encapsulation efficiency and sustained release performances of the composite hydrogels. In addition, with the rising of OMt content, the IPN composite hydrogels exhibited a decrease in their swelling capacity, transparency, and temperature sensitivity. The OMt/Alg/PNIPAm with 9.0% OMt content displayed the highest loading rate for pesticides at 82.06% and the lowest release rate of pesticides at 3.90%. Furthermore, the IPN composite hydrogels possessed the ability to regulate the amount of pesticide release based on the variations in temperature and ambient light conditions. The resultant IPN composite hydrogels took advantage of the temperature responsiveness of PNIPAm, the light sensitivity of Fe 3+ -alginate hydrogel, and the adsorption capability of OMt, possessing great potentials in enhancing the utilization efficiency of hydrophobic pesticides through the development of effective and eco-friendly pesticide formulations.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xing Long,Yadan Luo,Zhi Luo,Yiyan Wu,Baojie Liu,Chengrong Qin,Chen Liang,Caoxing Huang,Shuangquan Yao
Microplastic contamination of low-density polyethylene mulch and nutrient loss from fertilizers present significant challenges in the crop-growing. In this study, the focus was on creating a biodegradable film that combines the advantages of plastic film, thermal insulation and water retention, as well as the controlled release of fertilizer. A key innovation was the efficient introduction of low molecular weight and low dispersibility of poplar lignin into chitosan and polyvinyl alcohol matrices. The lignin was extracted using deep eutectic solvents of binary carboxylic acids (choline chloride and maleic acid). The refined lignin was used as a superhydrophobic additive to improve the mechanical properties, hydrophobicity, and controlled nutrient release properties of the films through cross-linking. The mulch attained a tensile strength of 37.6 MPa, an elongation of 644.1 %, and a precise release of 53.1 % urea over 30 d at the ideal lignin content ratio (10 %). Furthermore, the film proficiently regulated soil temperature and moisture content. Successful enhancement of cabbage growth was achieved by actual measurements. This discovery provides innovative ideas for the development of nutrient slow-release high-strength integrated agricultural mulching films to promote sustainable, high-quality green agriculture.
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DOI
PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2024
·
IF 12.7
Guoyang Zhang,Dingyi Shi,Yiyao Wei,Mingqi Wang,Haohan Wang,Zhiqi Lin,Haihan Gao,Weixuan Lin,Hanyi Wang,Yonglin Guo,Yingyu Ge,Yi Lin,Yiwen Jiang,Xiaoyu Yan,Yuhao Kang,Liren Wang,Jinzhong Zhao,Weiyang Ying
Natural small-molecule drugs have promising potential to promote tissue regeneration in various fields. Therefore, maximizing drug efficiency while minimizing potential side effects is imperative. Peiminine, a natural product extracted from natural Fritillaria , is one of small-molecule drugs in the field of bone regeneration due to its good bone-promoting and anti-inflammatory abilities. However, its application is limited by a lack of biological activity, poor biocompatibility at high concentrations, and difficulty in achieving long-term slow-release and therapeutic effects. Extracellular vesicles (EVs) produced by preconditioned cells are considered to have special biological functions, and their potential to further retain, buffer, and transmit drug effects and expand the therapeutic effect has been widely studied. Thus, our study provides a drug-free bioengineering strategy by preconditioning bone marrow mesenchymal stem cells (BMSC) with Peiminine, then EVs, secreted as Peim-EVs, were extracted and combined with a decellularized extracellular matrix (dECM). The final EVs-dECM system with a spatiotemporally controlled release system was formed. In vitro studies demonstrated that Peim-EVs solved the problem of Peiminine biocompatibility and exhibited osteogenic and anti-inflammatory effects, which may be related to PI3K/AKT, MAPK/NF-κB, and Hippo signaling pathways. An in vivo model of rotator cuff injury in rats also showed that EVs-dECM had a good effect on rotator cuff repair. Combined with engineering strategy, this study provides verification and scenario expansion for drug application, especially for drug-free strategies that retain the biological effects of drugs, and has broad significance.
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高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Lukai Ma,Zijian Li,Linjing Li,Xianhong Bi,Gengsheng Xiao,Linlin Li
This study developed nanostructured lipid carriers (NLCs) using edible beeswax and flaxseed oil to encapsulate β-sitosterol. Structural analysis revealed the formation of a less ordered lipid matrix with reduced crystallinity compared to pure beeswax, contributing to a high encapsulation efficiency of 92 %. Optimal formulation (beeswax: flaxseed oil 3:2, Tween 80: Polyglycerol fatty acid(PGE) 4:1 totaling 7 % emulsifier) and processing parameters (10 min homogenization, 200 W ultrasonic power for 4 min) yielded stable nanoparticles maintaining physical stability for 40 days across varying pH and temperature. In vitro digestion demonstrated that the NLCs effectively protected β-sitosterol from gastric degradation and enabled controlled intestinal release, achieving significantly higher bioaccessibility (43.9 %) compared to free β-sitosterol (12.1 %). These results highlight beeswax-flaxseed oil NLCs as a promising delivery system for enhancing the bioaccessibility of hydrophobic bioactive in functional foods.
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PubMed
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Lu Xu,Yingge Wang,Xiangsong Chen,Lili Cao,Min Pang
Gelatin (GEL), pectin (PEC), carboxymethyl cellulose (CMC), and whey protein isolate (WPI) were employed to formulate hydrogels for stabilizing N-Acetylneuraminic Acid (NeuAc). GEL/WPI-NeuAc hydrogels, irrespective of the ratio, exhibited a flexible and smooth surface with a continuous three-dimensional network structure internally. Porosity of the three types of hydrogels increased from 3.69% to 86.92% (GEL/WPI), 41.67% (PEC/WPI), and 87.62% (CMC/WPI), rendering them suitable as carriers for NeuAc encapsulation. The dynamic swelling behavior of all hydrogels followed Schott's second-order kinetics model. The degradation performance of GEL, PEC, and CMC/WPI-NeuAc hydrogels was optimal at a 5: 5 ratio, with degradation rates of 80.39 ± 1.26%, 82.38 ± 1.96%, and 81.39 ± 1.57%, respectively. GEL, PEC, CMC/WPI-NeuAc hydrogels demonstrated decreased release rates of 44.56%, 31.04%, and 41.26%, respectively, compared to free NeuAc, post gastric digestion. The present investigation suggests the potential of GEL/WPI hydrogels as effective carriers for delivering NeuAc encapsulation.
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PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·Vol. 141
·期 28
·e55621
·
IF 2.7
Mengdong Zhang,Limei Yang,Landie Xie,Xiaoqiu Wen,Min Zhang,Lin Ma
Nanoformulation was an important strategy to reduce the use of pesticides and the impacts on the environment. However, complex process and high cost hurdled the application in agriculture. In this work, sodium lignosulfonate (SL) and cetyltrimethyl ammonium chloride (CTAC) were combined into nanoparticles and utilized as carriers for emamectin benzoate (EB), using a one-pot method at mild conditions. The structure of nanoparticle was investigated by dynamic light scattering, ζ-potential measurement, Fourier transform infrared spectroscopy, and transmission electron microscopy, and related to the loading and release properties. The mass ratio of SL and CTAC had great impacts on the structure of nanoparticle. The release of EB from SL-CTAC nanoparticles was pH-triggered. The retarding efficacy was enhanced in the medium of higher pH, due to the increased interaction between the EB and carrier. The incorporation into the nanoparticles greatly increased the insecticidal toxicity of EB. The median lethal concentration, against Spodoptera litura Fabricius larvae , of typical nanoformulation was 55% and 63% of that of conventional formulation emulsifiable concentrates after feeding for 24 and 48 h, respectively. The results indicated SL-CTAC nanoparticles were good candidates of nanovehicles with high efficiency and low-cost, which was of great significance to prompt the nanopesticides from laboratory investigation to agricultural application.
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高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
·
IF 4.9
Jinbo Liu,Yuting Hou,Yonghao Yang,Bin Wang,Xi Zhang,Yuan Tian,Gensheng Wu,Bin Gu,Zhonghua Ni,Gutian Zhao
Burst release and insufficient sustained release continue to pose significant challenges in the clinical application of pirfenidone-loading ureteral stents for treating ureteral strictures. Herein, we present a coaxial electrospun drug-loading membrane featuring an outer stabilizing sheath designed to reduce the initial burst release and enable sustained delivery of pirfenidone (PFD). The membrane consists of aligned microfibers with a core of poly(L-lactide-co-ε-caprolactone) (PLCL) encapsulating PFD, surrounded by a poly(L-lactic acid) (PLLA) sheath that acts as a diffusion-resisting and release controlling sheath. In vitro drug release experiments are conducted alongside with detailed physicochemical and mechanical analyses. The results demonstrate that the sheath effectively suppresses drug precipitation during the drying process after electrospinning. Consequently, it obviously decreases the initial burst release by about 22% in 3 hours and by around 11% in 48 hours compared with PLLA uniaxial drug-loading membrane. It is followed by a sustained release profile over 48 hours, with a total drug release exceeding 90%. Meanwhile, the molecular orientation relaxation is mitigated by about 29.9% within the first 24 hours by the sheath. Then, there is an approximately linear molecular orientation relaxation at the following stage. Furthermore, the membrane preserves its structural integrity and maintains desirable mechanical properties, such as strength and ductility, throughout the release period. These findings suggest that the stabilizing sheath is a promising method for modulating drug release profiles, offering a valuable platform for developing advanced covered stents.
研究领域:
生物医学工程
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药物递送系统
·
组织工程
·
高分子科学
·
泌尿外科学
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高影响因子
Journal of Materials Chemistry B
·
2013
·Vol. 1
·期 33
·4099-4109
·
IF 0
Pierre Dramou,Pengli Zuo,Hua He,Lien Ai Pham-Huy,Wenyue Zou,Deli Xiao,Chuong Pham-Huy,Theophilus Ndorbor
The preparation, characterization and application of novel anticancer “epirubicin” (EPI) water-compatible magnetic molecularly imprinted polymers (M-MIPs) like artificial antibodies by computational design and chemical synthesis as a carrier for drug delivery is described herein. Two monomers: methacrylic acid (MAA) and methacrylamide (MAM) were selected by computational simulation from the four chemicals used. Covalent and non-covalent bonds were evaluated by this technique based on the interaction mode and energy with template or solvent. Non-covalent bonding was predominant in all cases and major energy interaction was observed. The nanomaterials were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), and a vibrating sample magnetometer (VSM). The loading and controlled release studies performed showed a slight advantage for the M-MIP obtained from MAA than that from MAM at ambient temperature. However, the drug release in vitro was slightly better for the second M-MIP when the temperature increased to 50 °C. The water-compatible nanomaterial showed good pH-sensitive drug release profiles in vitro. Briefly, due to its magnetic property, amphiphilicity, good biomimetic recognition of EPI, high adsorption capacity and controlled release, the epirubicin M-MIPs synthesized in this study are suitable to be applied to a magnetic targeted drug delivery system.
研究领域:
药学
·
材料科学
·
生物医学工程
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DOI
ANALYTICA CHIMICA ACTA
·
2022
·
IF 6.911
Yan Yang,Zhuoqun Su,Di Wu,Jianghua Liu,Xianlong Zhang,Yongning Wu,Guoliang Li
Mycotoxin contamination is a serious global issue in food safety. The accurate detection of mycotoxins in complex samples, particularly via a portable detection system that realizes multi-analyte detection, remains a great challenge. Here, a polystyrene (PS)-mediated surface-enhanced Raman scattering (SERS) aptasensor was designed for ultrasensitive and simultaneous detection of multiple mycotoxins in food samples. First, the novel Raman tags were prepared using PS as nanocontainer to encapsulate abundant Raman reporters. The PS nanocontainer with Raman reporters was then functionalized by aptamer as an effective target-recognition platform. Second, the single-strand binding protein modified magnetic nanoparticles ( [email protected] ) were used as a magnetic capture substrate. When the target mycotoxin was present and recognized by its aptamer, the combination of PS-Apt and mycotoxins can hinder the binding between PS-Apt and [email protected] Consequently, after the magnetic separation and treatment by THF solution, fewer biological-silent reporter probes were released from PS, causing the reduction of SERS signal as a function of target mycotoxins concentration. Due to the high loading capacity of PS and the excellent signal conversion and amplification of aptamer-assisted SERS assay, the proposed strategy is reliable and ultrasensitive for the determination of multiple mycotoxins. The limit of detection was as low as 0.159 fg L −1 , 2.015 fg L −1 , and 1.561 fg L −1 for ZEN , OTA and AFB 1 , respectively. This strategy not only raises a new idea for designing novel Raman tag, but also broadens the application of SERS for multiple detection of trace target.
研究领域:
食品安全
·
分析化学
·
纳米技术
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PubMed
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 19
·4039-4049
·
IF 6.331
Hao Pan,Changcan Shi,Rongshuai Yang,Guanghui Xi,Chao Lu,Xuanxin Yang,Jie Chen,Xiaojie Wang,Lei Chen,Jingye Pan
Keratinocyte growth factor-2 (KGF-2) can regulate the proliferation and differentiation of keratinocyte, which plays a remarkable role in maintaining normal tissue structure and promoting wound healing. As an effective strategy, KGF-2 solution is widely used in the treatment of wounds in clinical applications. However, KGF-2 in solution cannot achieve sustained release, which results in drug loss and unnecessary waste. Polysaccharide hemostasis microspheres (PHMs) are an ideal drug loading platform due to their special “lotus seedpod surface-like” morphology and structure. Herein, to realize the controllable release of KGF-2, PHMs loaded with KGF-2 (KGF-2@PHMs) were prepared. It was found that the bioavailability of KGF-2 was improved greatly. Most importantly, KGF-2@PHMs can reduce inflammation and accelerate the wound healing process due to the controlled release of KGF-2. KGF-2@PHMs might be a potential alternative strategy for wound healing in future clinical applications.
研究领域:
药剂学
·
生物医学工程
·
组织工程
·
伤口愈合
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DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2013
·Vol. 23
·期 33
·4067-4078
·
IF 9.765
Xiao Zhang,Piaoping Yang,Yunlu Dai,Ping'an Ma,Xuejiao Li,Ziyong Cheng,Zhiyao Hou,Xiaojiao Kang,Chunxia Li,Jun Lin
Multifunctional nanocarriers based on the up-conversion luminescent nanoparticles of NaYF 4 :Yb 3+ /Er 3+ core (UCNPs) and thermo/pH-coupling sensitive polymer poly[( N -isopropylacrylamide)- co -(methacrylic acid)] (P(NIPAm- co -MAA)) gated mesoporous silica shell are reported for cancer theranostics, including fluorescence imaging, and for controlled drug release for therapy. The as-synthesized hybrid nanospheres UCNPs@mSiO 2 -P(NIPAm- co -MAA) show bright green up-conversion fluorescence under 980 nm laser excitation and the thermo/pH-sensitive polymer is active as a “valve” to moderate the diffusion of the embedded drugs in-and-out of the pore channels of the silica container. The anticancer drug doxorubicin hydrochloride (DOX) can be absorbed into UCNPs@mSiO 2 -P(NIPAm- co -MAA) nanospheres and the composite drug delivery system (DDS) shows a low level of leakage at low temperature/high pH values but significantly enhanced release at higher temperature/lower pH values, exhibiting an apparent thermo/pH controlled “on-off” drug release pattern. The as-prepared UCNPs@mSiO 2 -P(NIPAm- co -MAA) hybrid nanospheres can be used as bioimaging agents and biomonitors to track the extent of drug release. The reported multifunctional nanocarriers represent a novel and versatile class of platform for simultaneous imaging and stimuli-responsive controlled drug delivery.
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DOI
高影响因子
危险品化学品经营许可证（带存储）