JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2025
·
IF 6
Xiaobing Lu,Yancheng Zheng,Guoqing Zhang,Fuchang You
Although silica nanoparticles (NPs) have demonstrated potential for enhanced oil recovery (EOR), their individual application faces significant limitations including poor dispersion stability and elevated interfacial tension. A polyethylene glycol-bridged Gemini surfactant was synthesized and evaluated for its interfacial and emulsifying properties, with particular emphasis on its ability to enhance the oil displacement efficiency of NPs. FTIR and 1 H NMR characterization confirmed the successful synthesis of the novel Gemini surfactants (PEGnC). The results demonstrated an inverse correlation between critical micelle concentration (CMC) and spacer molecular weight, while interfacial activity was enhanced with increasing brine salinity. PEG6C (600 Da spacer) exhibited superior performance, achieving ultra-low interfacial tension (10 −2 -10 −3 mN/m) at 15–25 % NaCl concentrations while demonstrating optimal interfacial activity and emulsification capacity. The optimal PEG6C surfactant was subsequently combined with NPs to formulate a stable nanocomposite fluid, which maintained low viscosity and turbidity while achieving significantly reduced interfacial tension, indicating excellent dispersion stability and interfacial activity. The addition of PEG6C to NPs fluids could significantly improve the oil recovery efficiency of NPs fluids from 11.82 % to 30.66 %. This work establishes a promising strategy for combining Gemini surfactants with NPs to develop high-performance EOR systems.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Mengyuan Li,Jinling Guo,Jiaming Ge,Jingwen Yao,Lin Ma,Zheng Li,Xiangli Han,Ming Liu,Fei Tian,Jing Zhao
The application prospects of magnetic nanocomposites in cancer treatment and diagnosis are extensive, as they enable targeted drug delivery to tumors. Herein, a novel therapeutic strategy was proposed for oral squamous cell carcinoma (OSCC), in which polyethylene glycol-folic acid (FA-PEG) was modified on nanocomposites by combining Fe 3 O 4 and layered double hydroxide (LDH) to obtain a drug carrier for the targeted delivery of the anticancer drug berberine (Ber). We have confirmed that FA-PEG/Fe 3 O 4 @LDH exhibited a high drug loading capacity for Ber and excellent biocompatibility. Moreover, it demonstrated remarkable pH-responsive drug release (Ber release of 3.87% and 53.77% within 48 h at pH 7.4 and 5.0, respectively). The cellular experiments demonstrated that FA-PEG/Fe 3 O 4 @LDH@Ber exhibited significant inhibition of cellular activity, while the targeted release of Ber effectively depleted the overexpressed GSH and promoted ROS generation, thereby facilitating oxidative stress and inducing mitochondrial dysfunction in CAL27 cells, thus promoting apoptosis of CAL27 cells. Therefore, FA-PEG/Fe 3 O 4 @LDH can be used as a potential pH-controlled release drug delivery system which has great significance for the targeted therapy of OSCC.
✓ 已验证
产品关联
DOI
高影响因子
Materials
·
2025
·Vol. 18
·期 11
·2568
·
IF 3.2
Xiaoling Xie,Xin Sun,Wanming Lin,Xiaofeng Yang,Ruicong Wang
The hypoxic microenvironment is the main challenge for the repair of damaged tissue, and oxygen supply is an effective means of alleviating hypoxia. In this study, a series of core–shell-structured calcium peroxide/poly(ethylene glycol)@silica (CPO@SiO2) nanoparticles are prepared to generate oxygen steadily. The size of the CPO@SiO2nanoparticles ranges from 205 to 302 nm, with a narrow polydispersity index (PDI). In this system, the nano CPO core acts as the oxygen source to improve hypoxia, while the SiO2shell layer serves as the physical barrier to control the oxygen-generating rate and improve biocompatibility. The results suggest that the thickness of the SiO2shell layer can be modulated by adjusting the amount of tetraethyl orthosilicate (TEOS). The prepared CPO@SiO2nanoparticles show a controlled oxygen-generating rate. Moreover, compared with CPO, the CPO@SiO2nanoparticles have good biocompatibility. To assess the modulating effects for the hypoxic microenvironment, L929 cells are co-cultured with CPO@ SiO2nanoparticles under hypoxia. The results suggest that the CPO@ SiO2nanoparticles can support the cell survival under hypoxia. Moreover, they can effectively decrease oxidative stress damage and reduce the levels of expression of hypoxia-induced superoxide dismutase (SOD) and malondialdehyde (MDA). Therefore, the prepared CPO@ SiO2nanoparticles with controlled oxygen-generating properties could be a promising candidate for repairing damaged tissue.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYST
·
2025
·
IF 3.3
Yingyi Wu,Yanchun Li,Qian Guo,Yang Chen,Dongming Song,Aifeng Jiang
Diethylene glycol dinitrate(DEGDN) propellant, as a key material for the power source of weapon systems, the research on its aging characteristics is of great significance for ensuring the safety and reliability of weapons. This study systematically analyzed the thermal reaction mechanism of DEGDN propellant using the thermogravimetry-differential scanning calorimetry-quadrupole mass spectrometry (TG-DSC-QMS), and investigated the changes in the components of DEGDN propellant under humidity and temperature aging conditions by using high-performance liquid chromatography (HPLC). The results show that during the humidity and temperature aging process, the main aging characteristics of the DEGDN propellant are the continuous loss of nitrate ester plasticizers. Among them, the consumption rate of DEGDN is the fastest, followed by nitroglycerin. Further research revealed a significant linear correlation between the color change of the extraction solution and the loss of components in the propellant. Based on this, this study established a quantitative relationship model between the content of DEGDN and the RGB parameters of the propellant solution, providing a new idea and feasible research direction for the rapid detection of propellant components.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2021
·
IF 5.89
Xu Yan,Zhang Zheng,Wang Hehui,Zhong Wu,Sun Chengmei,Sun Wei,Wu Hongwei
Osteosarcoma is a malignant tumor that often occurs in adolescents and children. Zoledronic acid, a new-generation bisphosphonate, has been widely used as an antitumor drug to inhibit bone metastasis. However, the rapid renal elimination results in low effective concentrations. Meanwhile, high-dose intravenous zoledronic acid administration leads to severe side effects. The present study fabricated an organic–inorganic hybrid nanoparticle as the carrier of zoledronic acid. The rod-like nanoparticle, which had 150-nm length and 40-nm cross-sectional diameter, consisted of a hyaluronic acid/polyethylene glycol (HA-PEG) polymer shell and a nano-hydroxyapatite (nHA) core, with zoledronic acid molecules loading on the surface of nHA and clearance of HA-PEG shell. The nanoparticle was characterized by microscopic analysis, in vitro release study, cytotoxicity analysis, and in vivo immune response examination. Results showed that the compact and stable structure could achieve high drug loading efficiency, sustained drug release, and great biocompatibility. In vitro and in vivo experiments revealed the low cytotoxicity and acceptable immune response under low-dose nanoparticle treatment, indicating its potential application for future osteosarcoma therapeutic strategies.
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2025
·
IF 4.7
Baoer Fan,Jia Guo,Siqi Zhang,Yingying Wang,Yaqi Tao,Wei Zheng,Kun Chen,Wen Tang
Wound infection causes excessive inflammation, delays healing, and may lead to severe complications. An ideal dressing should release antibacterial agents on demand to eradicate pathogens locally. Enzyme-responsive drug release systems are highly biocompatible and specific, yet their application in chitosan hydrogels has been limited by imprecise control over release profiles, mechanical properties, and potential drug resistance from premature leakage. Herein, we developed a dual-enzymatically responsive chitosan hydrogel for the on-demand release of antibacterial nanoparticles (ANPs). By synthesizing a series of hydroxyphenyl- and N-acetyl-modified glycol chitosan (HPPA-GC), we tuned the hydrogel stiffness and lysozyme degradation kinetics. Broad-spectrum ANPs were encapsulated via photo-cross-linking. Lysozyme, abundant in infected wounds, triggered hydrogel degradation and ANP release in vitro. When applied to S. aureus-infected full-thickness wounds in mice, the ANP-loaded hydrogel effectively combated infection and accelerated healing. This study demonstrates a robust and biocompatible platform for enzyme-triggered antimicrobial delivery, showing promise for the future development of smart wound dressings.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Metabolic Engineering Communications
·
2018
·
IF 0
Xiaojing Jia,Robert M. Kelly,Yejun Han
( R )-acetoin is a four-carbon platform compound used as the precursor for synthesizing novel optically active materials. Ethylene glycol (EG) is a large-volume two-carbon commodity chemical used as the anti-freezing agent and building-block molecule for various polymers. Currently established microbial fermentation processes for converting monosaccharides to either ( R )-acetoin or EG are plagued by the formation of undesirable by-products. We show here that a cell-free bioreaction scheme can generate enantiomerically pure acetoin and EG as co-products from biomass-derived D -xylose. The seven-step, ATP-free system included in situ cofactor regeneration and recruited enzymes from Escherichia coli W3110, Bacillus subtilis shaijiu 32 and Caulobacter crescentus CB 2. Optimized in vitro biocatalytic conditions generated 3.2 mM ( R )-acetoin with stereoisomeric purity of 99.5% from 10 mM D -xylose at 30 °C and pH 7.5 after 24 h, with an initial ( R )-acetoin productivity of 1.0 mM/h. Concomitantly, EG was produced at 5.5 mM, with an initial productivity of 1.7 mM/h. This in vitro biocatalytic platform illustrates the potential for production of multiple value-added biomolecules from biomass-based sugars with no ATP requirement.
✓ 已验证
DOI
PubMed
Collagen and Leather
·
2024
·Vol. 6
·期 1
·1-14
·
IF 0
Wang Lili,Zhang Shanshan,Yang Fan,Chen Xian,He Huixia,Liu Zaiman,Xiao Jianxi
The reconstruction of critical-size calvarial defects remains a fundamental challenge. Recombinant collagen has gained significant attention in bone tissue engineering owing to its remarkable bioactivity and non-immunogenicity. Herein, we have for the first time developed a bioactive poly(ethylene glycol)-chondroitin sulfate-triple helical recombinant collagen (PEG-ChS-THRC) hydrogel for enhanced bone regeneration in cranial defects. A simple and mild crosslinking reaction of two-arm polyethylene glycol active ester (NHS-PEG-NHS), adipic dihydrazide modified chondroitin sulfate (ChS-ADH) and triple helical recombinant collagen (THRC) leads to the formation of the PEG-ChS-THRC hydrogel. The hydrogel demonstrates interconnected porous structures, enhanced mechanical strength, diminished swelling ratios and adjustable biodegradability. It possesses exceptional biocompatibility and bioactivity, significantly facilitating cell proliferation, adhesion, migration, and osteogenic differentiation of BMSCs. Micro-computed tomography (micro-CT), magnetic resonance imaging (MRI) and histological characterization of rat models with critical-size cranial defects have consistently demonstrated that the PEG-ChS-THRC hydrogel significantly promotes bone tissues regeneration. The innovative bioactive scaffold provides a remarkably improved remedy for critical-size cranial defects, holding greatly promising applications in the fields of bone tissue regeneration. Graphical Abstract
✓ 已验证
DOI
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Guoxiu Wang,Yonglei Chen,Congjie Pan,Hongli Chen,Sanyuan Ding,Xingguo Chen
Owing to their high specific surface area , tunable pore sizes, excellent chemical/thermal stability and ability to allow easy modification of the nature of the surface, covalent organic frameworks (COFs) have shown great promise in membrane separation . However, until now, rapid preparation of self-standing COFs membrane has still been a great challenge. In this work, a polyethylene glycol-assisted space-confined strategy for rapid and simple synthesis of imine-linked self-standing COF (TB-DA COF) membranes was developed for the first time. By using this strategy, the molecular organic building unit 1,3,5-tri-(4-aminophenyl)benzene (TB) is confined in a thin layer of polyethylene glycol in conjunction with molecular organic building unit 2,5-dimethoxyterephthalaldehyde (DA). Therefore, the condensation reaction between TB and DA can occur directly without slow diffusion process. In addition, the amorphous-to-crystalline interconversion process can be completed rapidly. Based on this, the imine-based TB-DA COF membrane with high crystallinity can be synthesized within 2 min, which has been the fastest strategy for preparation of COFs membrane to date. The synthesized TB-DA COF 2 membrane showed an excellent rejection (>96%) for dye molecules. This work opens a new fabrication route for COF-based membranes.
✓ 已验证
DOI
高影响因子
CHINESE CHEMICAL LETTERS
·
2014
·
IF 1.178
Chang-Lei Liu,Gang Wu,Si-Chong Chen,Jiao You,Yu-Zhong Wang
Poly( p -dioxanone)-block-polyethylene glycol diblock copolymers functionalized with pyrene moieties (Py-PPDO-b-PEG) at the chain ends of PPDO blocks were synthesized for preparing anisotropic micelles with improved stability. The micellization and crystallization of the copolymers were investigated by nano differential scanning calorimetry (Nano DSC), transmission electron microscopy (TEM), UV–vis spectrophotometery, fluorophotometer, and dynamic light scattering (DLS), respectively. The results indicated that the aggregation of pyrene induced by intermolecular interaction lead to micellization of Py-PPDO-b-PEG at much lower concentrations than those of PPDO-b-PEG copolymers without pyrene moieties. The aggregation of pyrene moieties may also serve as nucleation agent and therefore enhance the crystallization rate of PPDO blocks. Fluorescence measurements by using Nile Red as the fluorescent agent indicated that the micelles of Py-PPDO-b-PEG have high stability and load capacity for hydrophobic molecules.
✓ 已验证
DOI
高影响因子
Acta Biomaterialia
·
2016
·
IF 6.008
Jiang Wu,Zecong Xiao,Chaochao He,Jingjing Zhu,Guanglong Ma,Guangzhi Wang,Hongyu Zhang,Jian Xiao,Shengfu Chen
Nonfouling materials such as neutral poly(ethylene glycol) (PEG) and zwitterionic poly(sulfobetaine methacrylate) (pSBMA) are ideal biocompatible materials for drug, especially protein drug delivery. The interaction behavior of protein between the nonfouling materials could cause great impact on their future applications, such as controlled release drug delivery systems. In this work, we investigated the diffusion behavior of the fluorescence-labeled model proteins (bovine serum albumin (BSA) and lysozyme (LYZ)) in nonfouling PEG, pSBMA and mixed PEG-SBMA hydrogels (SBMA:PEG 4:1, SBMA:PEG 1:4). It was observed that these four hydrogels showed varied diffusion behavior for either negatively charged BSA or positively charged LYZ due to protein-polymer interaction and the free water content in hydrogel matrix. The relatively stronger interaction between protein-PEG than protein-pSBMA could increase protein loading efficiency and control release rate by changing ratio of PEG to SBMA in the hybrid hydrogel. Moreover, it is further demonstrated the free water (freezable water) content in low cross-linked hydrogel, not the equilibrium water content (EWC), is a more accurate parameter to reflect the diffusion behavior of protein molecules . Thus, these results together provide new insights of the interactions between protein molecules and nonfouling polymers as well as the bio applications of the nonfouling polymeric hydrogels. Statement of Significance This work shows that the relative stronger interaction between protein-PEG than protein-pSBMA could increase protein loading efficiency and control release rate by the change ratio of PEG to SBMA in the hydrogel, while the free water (freezable water) content in low cross-linked hydrogel, not the equilibrium water content (EWC), is a more accurate parameter to reflect the diffusion behavior of protein molecules. The impact of this work (i) gains some new insights of the interactions between protein molecules and nonfouling polymer matrixes for protein drug delivery; (ii) prompts to apply the weak PEG-protein interactions to protein drug loading and release; (iii) provides a new fundamental understanding of free water in hydrogel for protein diffusion.
✓ 已验证
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2017
·Vol. 164
·期 6
·A1321
·
IF 3.259
Chaolumen Wu,Taoran Li,Chenbo Liao,Qingkai Xu,Yuancheng Cao,Lei Li,Jun Yang
Triethylene glycol dimethyl ether (G3) is evaluated as an electrolyte solvent for non-aqueous lithium-oxygen (Li-O2) batteries. A liquid electrolyte of 1 M LiTFSI in G3 shows lower viscosity, higher oxygen solubility and diffusion, higher ionic conductivity and lithium ionic transference number compared to the conventional liquid electrolyte of 1 M LiTFSI in tetraethylene glycol dimethyl ether (G4). Then the Li-O2 battery using the G3-based electrolyte shows better cycling stability and higher rate capability compared to the battery using the G4-based electrolyte. At a higher current density of 2.5 A gcarbon−1, the discharge capacity of the battery using the G3-based electrolyte is about 1472 mAh gcarbon−1, which is about four times higher than that of the battery using the G4-based electrolyte. At current density of 1 A gcarbon−1 with a fixed capacity of 1000 mAh gcarbon−1, the battery using the G3-based electrolyte can be operated stably for 80 cycles, while only 20 cycles are achieved by using the G4-based electrolyte. Therefore, we think the G3-based electrolyte could be a proper alternative electrolyte to the conventional G4-based electrolyte for the development of Li-O2 batteries.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）