JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Shuo Lu,Qiliang Mei,Jiayi Chen,Zhe Wang,Wenhong Li,Chunyan Feng,Xuefeng Li,Jinfeng Dong
Hypothesis Shear-thickening micelles were mostly made of cationic surfactants , but shear-thickening was rarely reported in the zwitterionic/anionic surfactants. Since wormlike micelles were essential in shear-thickening systems, it should be common for the hybrid wormlike micelles formed by zwitterionic/anionic surfactants, and their fundamental features need to be clarified. Experiments The micellization of zwitterionic surfactant homologies alkyl dimethyl amidopropyl hydroxyl sulfobetaine (AHSB) and sodium dodecyl sulfate (SDS) in brine was studied, and various environmental factors were considered systematically. Light scattering, rheology, zeta potential , 1 H NMR and cryo-TEM techniques were employed to characterize the AHSB/SDS wormlike micelles. Findings AHSB/SDS hybrid wormlike micelles were formed in a wide x SDS region to endow them with apparent viscosities, in which the electrostatic and hydrophobic interactions between AHSB and SDS molecules were critical. AHSB with the longer tail, the higher c AHSB and c NaCl were advantageous to enhance the viscosity because of the longitudinal growth of wormlike micelles. The shear-thickening AHSB/SDS samples were commonly composed of unbranched wormlike micelles with various length, and the shear-induced alignment of wormlike micelles was the major cause as verified by cryo-TEM. Moreover, the quantitative relationships on the critical shear rate ɣ̇ c were established, and the activation energies were obtained from the temperature-dependent ɣ̇ c .
研究领域:
物理化学
·
材料科学
·
界面化学
✓ 已验证
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2020
·
IF 7.727
Houbing Zhang,Hongjun Li,Zhiting Cao,Jinzhi Du,Lifeng Yan,Jun Wang
Polymeric micelles hold great potential for anticancer drug delivery. Sufficient integrity of polymeric micelles after intravenous injection is critical for successful drug delivery to solid tumors , but accurate measurement of the in vivo micellar integrity remains challenging. Methods based on Förster resonance energy transfer (FRET) to monitor the in vivo micellar integrity are frequently used. However, the self-quenching effect of these FRET fluorophores used has been improperly ignored and has caused inaccurate measurements. Herein, we report a FRET-based approach using the large Stokes shift (LSS) fluorophores NBD-X and MS735 as the donor and acceptor, respectively, to investigate the integrity of polyethylene glycol- block -poly(ε-caprolactone) (PEG-PCL) micelles. We established a mathematical formula for the integrity calculation, and an in vitro verification experiment showed that the formula results exactly matched the simulated results. Our results demonstrated that PEG-PCL micelles gradually dissociated in blood circulation, but approximately 60% of the micelles in plasma remained intact 72 h after intravenous ( i.v. ) injection. This LSS fluorophore-based FRET approach can be used to accurately monitor the integrity of nanoparticles , and this study demonstrates that most of PEG-PCL micelles maintain their aggregation state during blood circulation for anticancer drug delivery.
研究领域:
药剂学
·
生物医学工程
·
肿瘤学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2012
·Vol. 2
·期 31
·11953-11962
·
IF 0
Dali Wang,Xiuying Huan,Lijuan Zhu,Jinyao Liu,Feng Qiu,Deyue Yan,Xinyuan Zhu
A new type of salt/pH dual-responsive micelles based on supramolecular amphiphilic brush copolymers, poly(2-hydroxyethyl metharylate)-g-(poly(ε-caprolactone)-adenine:uracil-poly(ethylene glycol)) (PHEMA-g-(PCL-A:U-PEG)) was developed for the anticancer drug delivery owing to the fact that the tumor tissues show low pH and high salt concentration. The supramolecular structure of brush copolymer was confirmed by variable-temperature 1H NMR and Fourier transform infrared spectroscopy (FTIR). Doxorubicin (DOX) as a model anticancer drug was efficiently loaded into the supramolecular micelles (up to 70%) due to the compact structure of brush polymer. The cumulative release profile of the DOX-loaded micelles showed a low level of drug release (about 20 wt% in 25 h) at pH 7.4 with a low salt concentration, and was significantly accelerated at a lower pH (5.0) and a high salt concentration (over 70 wt% in 6 h), exhibiting an salt/pH dual-responsive controlled drug release capability. Methyl tetrazolium (MTT) assay showed that DOX-loaded micelles had high anticancer efficacy against Hela cancer cells and blank micelles had a very low cytotoxicity. These supramolecular brush copolymer micelles possess many favorable traits, such as low cytotoxicity and excellent biodegradability, adequate drug loading capacity, and rapid drug release in response to the intracellular level of pH and salt concentration, which endow them as a promise candidate for delivering anticancer drugs.
研究领域:
高分子化学
·
药剂学
·
肿瘤学
✓ 已验证
DOI
REACTIVE & FUNCTIONAL POLYMERS
·
2016
·
IF 2.725
Guiyou Wang,Lingmei Zhang
In this study, well-defined double-hydrophilic triblock copolymers , consisting of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly( N , N -diethylamino-2-ethylmethacrylate) (PDEAEMA), were synthesized and characterized. The molecular weights of the copolymers were controllable. In the basic environments, the copolymers can self-assemble into the PDEAEMA core and PEG corona micelles in aqueous solution with an average size of 40–180 nm. The low critical micelle concentration (CMC, about 10 − 3 mg mL − 1 ) of copolymers investigated in pH 7.4 aqueous solution confirmed the adequate thermodynamic stability of their self-assembly. As shown in the cytotoxicity assay, the copolymers have good biocompatibility. Doxorubicin (DOX) was encapsulated into the triblock copolymer micelles . The drug loading efficiency and entrapment efficiency values of DOX-loaded micelles reached 8.14% and 88.6%, respectively. The DOX release of the drug-loaded micelles depends on the pH values. These phenomena indicated that the double-hydrophilic PDEAEMA – PEG – PDEAEMA triblock copolymers have a potential application in the drug delivery.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2017
·Vol. 219
·期 2
·1700427
·
IF 2.5
Pan Yuan,Zheng Ruan,Le Liu,Tuanwei Li,Titao Jing,Lifeng Yan
Supramolecular self-assembly of polymeric molecules for sharp-pH-sensitive (SPS) nanoparticles is an especially important application in biology. Here, amphiphilic polypeptide copolymers are synthesized and spontaneously assembled to micelles in aqueous solution, and protonation of the tertiary amine groups in the side-chain of the copolymer under weak acid causes the micelle disassembly, which is sharp-pH-sensitive, and the responsive pHs can be adjusted by adding salts. Size and morphologic change of the polymeric micelles are characterized by means of dynamic lighting scattering, transmission electron microscope (TEM), and atomic force microscope (AFM) in sequential pH alterations. It is found that the Hofmeister ions play a key factor in controlling the subtle interaction of different noncovalent bonds among polypeptide molecules during their self-assembly or disassembly. The physical property exploration of the SPS micelles may provide a new chance for the development of dynamic, complex nanostructures in various pH-responsive applications.
研究领域:
生物材料学
·
高分子化学
·
纳米医学
✓ 已验证
DOI
高影响因子
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
·
2021
·Vol. 25
·期 03
·262-270
·
IF 1.811
Shanlei Guo,Bo Gao,Dongni Li
Combination therapies for the treatment of cancer have attracted wide attention. The poor selectivity and biocompatibility of photosensitizers (PS) limit the use of combination therapies in chemotherapy and photodynamic therapy (PDT) for cancer. In this work, the Gender PS (mPEG- b -PLA-S-S-ZnPC), asymmetric zinc(II) phthalocyanine (ZnPC) and mono-methoxy oxygen-based polyethylene glycol-polylactic acid (mPEG-b-PLA) were designed and synthesized for PDT through disulfide bond (-S-S-). The amphipathic PS could be self-assembled into a micelle in aqueous solution, and paclitaxel (PTX) was encapsulated in the core of the micelle for chemotherapy (PTX/mPEG- b -PLA-S-S-ZnPc). The PTX/mPEG- b -PLA-S-S-ZnPc micelle was spherical with a uniform diameter of about 184 nm. At the first 48 h, the release behaviors of ZnPC and PTX at 10 mmol / L GSH were 30% and 75.2%, respectively. These results suggested that GSH-responsive PTX/mPEG- b -PLA-S-S-ZnPc micelle was an active ingredient in combination therapies for cancer.
研究领域:
药学
·
肿瘤学
·
生物材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2015
·
IF 7.705
Wei Chen,Fenghua Meng,Ru Cheng,Chao Deng,Jan Feijen,Zhiyuan Zhong
It is still a major challenge for targeted cancer chemotherapy to design stable biodegradable micellar drug delivery systems which show a rapid and complete intracellular drug release. Here, reversibly core-crosslinked pH-responsive biodegradable micelles were developed based on poly(ethylene glycol)-poly(2,4,6-trimethoxybenzylidene-pentaerythritol carbonate- co -pyridyl disulfide carbonate) [PEG-P(TMBPEC- co -PDSC)] copolymers and investigated for intracellular doxorubicin (DOX) release. PEG-P(TMBPEC- co -PDSC) copolymers formed micelles with a small size of 58.6 nm were readily crosslinked by the addition of dithiothreitol (DTT). Notably, in vitro release studies showed that under physiological conditions only ca. 19.9% of DOX was released from the reversibly crosslinked micelles in 24 h at a low micelle concentration of 40 μg/mL. The release of DOX was accelerated at pH 5.0 or in the presence of 10 mM glutathione (GSH) at pH 7.4, in which 64.2% and 44.1% of DOX was released, respectively, in 24 h. The drug release was further boosted at pH 5.0 and 10 mM GSH, with 98.8% of DOX released in 12 h. Moreover, DOX release was also facilitated by a 4 h incubation at pH 5.0 followed by incubation at pH 7.4 with 10 mM GSH. Confocal microscopy indicated that DOX was delivered and released into the nuclei of RAW 264.7 cells following a 12 h incubation with DOX-loaded reversibly crosslinked micelles. MTT assays revealed that DOX-loaded reversibly crosslinked micelles had much higher antitumor activity than irreversibly crosslinked controls, with low IC 50 values of 1.65 and 1.14 μg/mL for HeLa and RAW 264.7 cells, respectively, following a 48 h incubation. The blank crosslinked micelles had a low cytotoxicity of up to a concentration of 0.8 mg/mL. These reversibly crosslinked pH-sensitive biodegradable micelles with superior extracellular stability but activated intracellular drug release provide a novel platform for tumor-targeting drug delivery.
✓ 已验证
DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 38
·21613-21620
·
IF 2.936
Xiaoteng Zhou,Lingxiao Li,He Qin,Bo Ning,Junpei Li,Chengyou Kan
A series of amphiphilic PDMAEMA–SS–PCL chains with variable ratios of hydrophilic poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) to hydrophobic poly(ε-caprolactone) (PCL) were prepared via ring-opening polymerization, in which the two different moieties were linked via a disulfide bond with reduction responsiveness. After cross-linking by the photodegradable o-nitrobenzyl linkage, the amphiphilic chains could self-assemble into microspheres, branched cylindrical micelles and vesicles, which were responsive to the reduction agent DL-dithiothreitol and UV light irradiation through different mechanisms.
研究领域:
高分子化学
·
纳米医学
·
药物递送
·
生物材料
·
智能材料
·
自组装
·
还原响应
·
光响应
✓ 已验证
DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2018
·Vol. 20
·期 17
·12175-12181
·
IF 3.906
Qintang Li,Jiao Wang,Nana Lei,Minhao Yan,Xiao Chen,Xiu Yue
In recent years, aggregates formed in deep eutectic solvents (DESs), especially micelles, have attracted much attention. In this study, the phase behaviours of a cationic surfactant, cetylpyridinium bromide (CPBr), in two DESs, choline chloride + glycerol (ChG) and choline chloride + ethylene glycol (ChEG), were investigated in wide concentration and temperature ranges. With the help of small angle X-ray scattering, polarized optical microscopy and rheological measurements, the structures and properties of various aggregates were characterized. The micelles, hexagonal phase, bicontinuous cubic phase and lamellar phase were observed with the increase of CPBr concentration. Such rich phase behaviours were due to the large cohesive energy densities of DESs. Comparative studies in water and ethylammonium nitrate were carried out to explore how well DESs acted as self-assembly media.
研究领域:
软物质物理
·
胶体化学
·
自组装
·
物理化学
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2011
·
IF 3.068
Xiujuan Huang,Yan Xiao,Meidong Lang
Comicellization of a star block copolymer poly( ε -caprolactone)- block -poly(diethylamino)ethyl methacrylate (S(PCL- b -PDEAEMA)) and a linear block copolymer methoxy poly(ethylene glycol)- block -poly( ε -caprolactone) (mPEG- b -PCL) was developed to enhance the stability and lower the cytotoxicity of the micelles. The two copolymers self-assembled into the mixed micelles with a common PCL core surrounded by a mixed PDEAEMA/mPEG shell in aqueous solution. This core–shell structure was transformed to the core–shell–corona structure at high pH due to the collapse of the PDEAEMA segment. The properties of the polymeric micelles were greatly dependent on the weight ratio of the two copolymers and the external pH. As increasing the mPEG- b -PCL content, the size and the zeta potential of the mixed micelles were lowered while the pH-dependent stability and the biocompatibility were improved. Moreover, an increase in pH accelerated the release of indomethacin (IND) from the mixed micelles in vitro . These results augured that the mixed micelles could be applied as a stable pH-sensitive release system.
研究领域:
高分子科学
·
药物递送
·
纳米医学
·
生物材料
·
胶体与界面化学
✓ 已验证
DOI
高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
·
2015
·
IF 0.809
Hongchuan Wu,Zhiguo Li,Long Bai,Libin Zhu,Jiyou Gu
The blocked terminal-isocyanate (NCO) aqueous polyurethane micelles were prepared by using the 2,6-hexamethylene diisocyanate (HDI), polyethylene glycol (PEG), dimethylol propionic acid (DMPA), and 2,4,6-trichlorophenol (TCP) as blocking agent. This paper was focused on the kinetics research of the TCP blocking terminal-NCO of pre-polymer, which occurred during the preparation process of TCP blocked aqueous polyurethane micelles. The kinetics parameters were obtained in the absence and presence of dibutyl tin dilaurate (DBTDL) as catalyst, respectively. Furthermore, the mechanism for TCP blocking terminal-NCO of pre-polymer was explored. The results showed that the blocking reaction was second order reaction, and the reaction activation energy was 43.890 KJ/mol without catalyst. In the presence of DBTDL, the blocking reaction activation energy was reduced to 34.412 KJ/mol, and the reaction rate was improved significantly. In addition, TCP blocking terminal-NCO of pre-polymer could be ascribed to the nucleophilic addition between nucleophilic phenolic hydroxyl of TCP and the carbon atom of -NCO group.
研究领域:
高分子化学
·
反应动力学
·
材料科学
✓ 已验证
DOI
高影响因子
CHINESE JOURNAL OF CHEMISTRY
·
2013
·Vol. 31
·期 6
·745-751
·
IF 0.917
Yifei Wang,Daoyong Chen
Here we report novel shear-sensitive polymeric large compound micelles (LCMs) formed by self-assembly of glutathione end-capped poly(4-vinylpyridine) (GP4VP) in water containing 4 vol% methanol. The amphiphile prefers to form the kinetically stabilized LCMs due to the small length ratio of the hydrophilic part to the hydrophobic part; the encapsulation of the hydrophilic part within LCMs causes only a small enthalpy loss from a thermodynamic view. Sheared by vortex flows generated by vigorous stir, the LCMs evolve to thick wall vesicles, thin wall vesicles, broken vesicles and "pearl-necklace" structures consecutively. The high flexibility of the LCMs and the internal tension caused by the encapsulation of the hydrophilic part are responsible for the high shear sensitivity of the LCMs.
研究领域:
高分子化学
·
胶体与界面科学
·
纳米材料
·
自组装
·
流变学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）