MATERIALS CHARACTERIZATION
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2021
·
IF 4.342
Kangkang Yuan,Qing Cui,Jie Li,Xiaotong Jin,Chengshun Li,Xingxiang Ji,Zhongjian Tian,Xinqiang Wang
A compositionally complex (Ca, Sr, Ba)ZrO 3 (CC-CSBZ) fibrous membrane with perovskite structure was successfully prepared via a simple electrospinning method. The formation, phase transformation and microstructure evolution of CC-CSBZ fibers were fully discussed. X-ray diffraction, Raman spectra and transmission electron microscopy analyses confirmed the formation and phase transformation of CC-CSBZ solid solution at high temperatures. Scanning electron microscopy results indicated that a slower grain growth rate and more stable high-temperature microstructure were achieved for CC-CSBZ fibers compared with previous BaZrO 3 and CaZrO 3 fibers. CC-CSBZ fibrous membrane also exhibited excellent flexibility at 1000 °C and high thermal stability at 1200 °C. Furthermore, an average near infrared reflectivity of 98% at least at room temperature was obtained for CC-CSBZ fibrous membrane heat-treated from 800 to 1400 °C. For the slow grain growth rate, excellent high-temperature stability and near infrared reflectance, CC-CSBZ fibrous membrane would be a promising and novel ceramic fiber product for high temperature applications.
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Bioactive Materials
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2021
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IF 14.593
Yunjian Yu,Yufei Zhang,Yijie Cheng,Yuxia Wang,Zeyuan Chen,Haonan Sun,Xiaosong Wei,Zhuang Ma,Jie Li,Yayun Bai,Zhongming Wu,Xinge Zhang
The efficacious delivery of antimicrobial drugs to intractable oral biofilms remains a challenge due to inadequate biofilm penetration and lack of pathogen targeting. Herein, we have developed a microenvironment-activated poly(ethylene glycol) (PEG)-sheddable nanoplatform to mediate targeted delivery of drugs into oral biofilms for the efficient prevention of dental caries. The PEGylated nanoplatform with enhanced biofilm penetration is capable of deshielding the PEG layer under slightly acidic conditions in a PEG chain length-dependent manner to re-expose the bacteria-targeting ligands, thereby facilitating targeted codelivery of ciprofloxacin (CIP) and IR780 to the bacteria after accumulation within biofilms. The nanoplatform tends to induce bacterial agglomeration and suffers from degradation in the acidic oral biofilm microenvironment, triggering rapid drug release on demand around bacterial cells. The self-modulating nanoplatform under near-infrared (NIR) irradiation accordingly displays greatly augmented potency in oral biofilm penetration and disruption compared with drugs alone. Topical oral treatment with nanoplatforms involving synergetic pharmacological and photothermal/photodynamic trinary therapy results in robust biofilm dispersion and efficacious suppression of severe tooth decay in rats. This versatile nanoplatform can promote local accumulation and specific drug transport into biofilms and represents a new paradigm for targeted drug delivery for the management of oral biofilm-associated infections.
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高影响因子
Journal of Materials Chemistry B
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2022
·Vol. 10
·期 23
·4501-4508
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IF 7.571
Xi Xiao,Bingzhu Zheng,Qiang Zheng,Zijie Lu,Dong Cen,Xiujun Cai,Xiang Li,Renren Deng
Peroxynitrite anion (ONOO−), a product derived from reaction between reactive oxygen species (ROS) and nitric oxide (NO), is considered to be a more toxic reactive species than most ROS for cancer photodynamic therapy (PDT). To promote the PDT effect, a viable method is to develop rational strategies for efficient ONOO− generation at targeted tumor sites. Herein, a heterostructure nanocomposite containing ZnO-coated lanthanide nanoparticles (LnNPs) is reported for ONOO−-based PDT. In this nanocomposite, Nd3+-doped LnNPs are employed to realize efficient NIR-light-triggered ROS generation by activating the triplet state of chlorin-e6 (Ce6) photosensitizers via a direct lanthanide-to-triplet sensitization mechanism. Meanwhile, ZnO in the composite catalyzes the decomposition of S-nitrosoglutathione (GSNO) to generate NO in the tumor microenvironment. The coupled system allows the combination of photo-induced ROS and NO to produce ONOO−, leading to drastically promoted cancer cell apoptosis and tumor growth inhibition. This study establishes a new apoptosis-inducing PDT agent, which is potentially active in drug resistant malignancies.
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高影响因子
CERAMICS INTERNATIONAL
·
2023
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IF 5.2
Ziyang Wu,Jinmeng Xiang,Changheng Chen,Zexun Li,Xianju Zhou,Yuehui Jin,Chongfeng Guo
As a new generation of near-infrared (NIR) light source, phosphor-converted NIR light emitting diodes (NIR pc-LEDs) have broad application prospects in biological tissue imaging, night vision and chemical composition analysis . However, most NIR emitting phosphors are still limited to short-wavelength, narrow-band emission and low efficiency. Here, based on the multi-site occupation strategy, the NIR phosphor Mg 2 LaTaO 6 :Cr 3+ (MLT:Cr 3+ ) achieves an efficient broadband NIR emission with the full width at half maximum (FWHM) of 203 nm in the range of 600–1300 nm under the excitation of 468 nm blue light. The phosphor MLT:0.01Cr 3+ not only exhibits an excellent internal quantum efficiency (IQE) of 85.6 %, but also has good thermal stability and remains about 64.2 % photoluminescence (PL) intensity of room temperature at 423 K. Furthermore, the MLT:0.01Cr 3+ phosphor was combined with a blue LED chip to fabricate the NIR pc-LED device, and its potential applications were successfully realized in information encryption, bioimaging and the qualitative or quantitative analysis of mixture of ethanol and water.
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Inorganic Chemistry Frontiers
·
2021
·Vol. 8
·期 10
·2624-2633
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IF 6.569
Man Zou,Yajie Zhao,Binbin Ding,Fan Jiang,Yeqing Chen,Ping'an Ma,Jun Lin
The generation of reactive oxygen species (ROS) is often limited by the overexpression of glutathione (GSH) in the tumor microenvironment (TME) and the penetration depth of visible light. In view of this, we designed biodegradable Cu/ZIF-8 shell-coated lanthanide-doped nanoparticles and loaded with a photosensitizer (Rose Bengal), and fabricated a NIR-triggered nanocomposite NaYF4:20%Yb, 2%Er@Cu/ZIF-8/RB@F127 (UCZRF) for the synergistic treatment of CDT and PDT. Interestingly, the UCZRF nanostructures can specifically release RB and Cu2+ in the acidic tumor microenvironment (TME). Cu2+ depletes GSH to effectively change the amount of ROS produced by RB under 980 nm laser irradiation, and Cu+ from the reduction reaction of GSH reacts with excess hydrogen peroxide (H2O2) in the TME to generate hydroxyl radicals (⋅OH) with high oxidation activity. In such a simple nanosystem, we enhance the anti-tumor effect of CDT and PDT by improving the efficiency of ROS generation.
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高影响因子
Frontiers in Chemistry
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2021
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IF 5.221
Feng Qilong,Zheng Wenjing,Pu Jie,Chen Qiaoli,Shao Wei
The availability of colloidal nano-materials with high efficiency, stability, and non-toxicity in the near infrared-II range is beneficial for biological diagnosis and therapy. Rare earth doped nanoparticles are ideal luminescent agents for bio-applications in the near infrared-II range due to the abundant energy level distribution. Among them, both excitation and emission range of Er3+ ions can be tuned into second biological window range. Herein, we report the synthesis of ∼15 nm LiYF4, NaYF4, and NaGdF4 nanoparticles doped with Er3+ ions and their core-shell structures. The luminescent properties are compared, showing that Er3+ ions with single-doped LiYF4 and NaYF4 nanoparticles generate stronger luminescence than Er3+ ions with doped NaGdF4, despite the difference in relative intensity at different regions. By epitaxial growth an inert homogeneous protective layer, the surface luminescence of the core-shell structure is further enhanced by about 5.1 times, 6.5 times, and 167.7 times for LiYF4, NaYF4, and NaGdF4, respectively. The excellent luminescence in both visible and NIR range of these core-shell nanoparticles makes them potential candidate for bio-applications.
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高影响因子
BIOCHEMICAL ENGINEERING JOURNAL
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2021
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IF 3.978
Xinli Li,Mengru Chen,Yanbao Zhao,Lei Sun
In this work, S S bond-doped porous silica nanoparticles with CuS nanocores (CuS/OS) were prepared as drug carriers for chemical-photothermal synergistic therapy and redox/pH/light triple-response drug release. The synthesized CuS/OS carriers have dendritic pore structure with particle size of about 100 nm. Tiopronin (MPG) was used as model drug to evaluate the release performance of the carrier. Chitosan (CS) and green fluorescent curcumin (Cur) were used as plugs to seal the loaded drug, which endows the CuS/OS carrier with pH-responsive release and monitoring properties. The obtained MPG-loaded CuS/OS-CS-Cur has pH/GSH/NIR triple responsive release and redox-responsive degradation. The introduction of CuS nanocores gives the CuS/OS system a good photothermal therapy function. The CuS/OS-CS-Cur and its degradation products have good biocompatibility.
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高影响因子
Applied Materials Today
·
2021
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IF 10.041
Jihao Ruan,Qili Yu,Haomin Cui,Xing Qin,Limei Qin,Shuai Chen,Dechao Niu,Cunyi Fan
ABSTRACT Oxidative stress is considered an efficient therapeutic target in the progression of osteoarthritis (OA). Unfortunately, the current drug delivery system for the reactive oxidative species (ROS) scavengers is still unsatisfactory due to their insufficient responsiveness and rapid joint clearance. In this study, we design and develop a smart anti-oxidative agent by constructing a dual-responsive hybrid micelle with free radical scavenger melanin in the micellar core and polydopamine on the shell (designated as DHMP/M) for photoacoustic imaging-guided knee OA therapy. The resulting DHMP/M displays a unique long-term controlled-release behavior involving the slow and persistent release under endogenous ROS stimuli and short-burst release capability triggered by exogenous near-infrared (NIR) light. More importantly, DHMP/M possesses excellent free radical scavenging capacity and protective effects in chondrocytes in vitro and in in vivo rat OA models. Additionally, DHMP/M exhibits efficacious photoacoustic (PA) imaging for adjusting the therapy on demand. The RNA-Seq assay of rats further shows a significant reduction of TLR-2 in the OA cartilage, revealing that DHMP/M can protected OA from inflammation via TLR-2/MAPK/Akt signaling. Consequently, the present ROS/NIR dual-responsive melanin delivery platform together with PA imaging-monitoring provides a precise theranostic strategy for OA therapy.
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高影响因子
Biomaterials Science
·
2021
·Vol. 9
·期 16
·5542-5550
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IF 6.843
Lan Fang,Jie Wang,Xueliang Ouyang,Binbin Liang,Liying Zhao,Dechun Huang,Dawei Deng
Multi-functionality has been a constant pursuit in the development of next-generation drug carriers, as it will bring the potential for combination therapy by integrating diverse therapeutic modes. In this work, FeSe2 nanosheets (NSs) have been prepared as a bifunctional platform to investigate their use in synergistic cancer therapy. Bifunctional FeSe2 NSs exhibit exceptional Fenton-like activity that generates cytotoxic hydroxyl radical (˙OH) and strong broad photothermal performance including the second-infrared (NIR-II) spectral range, wherein the ˙OH production can be enhanced by NIR-II light irradiation. Furthermore, doxorubicin (DOX) was conjugated onto NSs via a pH-responsive hydrazone bond to achieve preferential drug release in an acidic microenvironment. Upon intratumoral administration, these bifunctional drug-carrying FeSe2 NSs showed an NIR-II irradiation-reinforced strong tumor suppression effect, and no obvious toxicity to normal tissues was observed. This study provides a new paradigm for the design of advanced drug carriers relying on their inherent physicochemical properties.
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高影响因子
JOURNAL OF LUMINESCENCE
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2021
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IF 3.599
Dangli Gao,Yuqian Liang,Jie Gao,Hong Xin,Long Wang,Sining Yun,Xiangyu Zhang
Applications of rare-earth (Re)-doped upconversion (UC) micro/nanocrystals in varying areas have sparked a growing, constant demand for deliberate control over the luminescent profile and lifetime. A general strategy for adjusting UC luminescence is to control the dopant Re 3+ concentration. However, the progress of elevating dopant concentration is significantly limited owing to frequently encountering severe concentration quenching. Herein, by designing UC system using Tm 3+ with super long intermediate energy level lifetime and Yb 3+ with a simple two-level structure as a activator/sensitizer combination, we have achieved the unusually intense deep ultraviolet (UV) UC emissions at 290 nm and 345 nm, near UV emission at 361 nm, visible blue emissions at 452 nm and 478 nm, and near infrared (NIR) emission at 803 nm in NaYF 4 :Yb/Tm microtubes under 980 nm excitation. The luminescence intensity reaches about 56 times and 8 times enhancement for the UV and blue emission, respectively, with the increase of dopant Yb 3+ contents from 20 to 80 mol%. While luminescence lifetimes for all emissions decrease, particularly, for NIR emission at 803 nm, from 1507 μs down to 384 μs. Importantly, upon 980 nm irradiation, these UC NaYF 4 :Yb/Tm microtubes exhibit superior optical performance as a promising candidate of advanced anti-counterfeiting applications and other applications including UV light triggered reactions and multiplexing information storage.
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COMPOSITES SCIENCE AND TECHNOLOGY
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2021
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IF 8.528
Yan-Qin Wang,Yu Zhu,Jing-Hui Wang,Xiao-Na Li,Xiao-Gang Wu,Yi-Xian Qin,Wei-Yi Chen
Recently, artificial intelligence has driven the development of shape memory hydrogels (SMHs) with complicated environmental sensitive abilities. However, current SMHs possess fundamental limitations in terms of their responsive performance and mechanical properties , which severely limits their practical applications. Herein, a triple-network composite hydrogel with Fe 3+ , NIR light, and thermal responsive abilities is fabricated and developed as multi-SMHs, named as PDA/CMC-Fe 3+ /PVA hydrogel. In this hydrogel system, the interpenetrating triple network are formed by chemically-physically co-crosslinked polyvinyl alcohol (PVA) networks, and physically crosslinked carboxymethyl cellulose (CMC)-Fe 3+ network. In addition, polydopamine (PDA), which is introduced into the hydrogel system by in-situ polymerization way, could not only serve as an energy converter to endow the hydrogel with NIR-based responsive ability, but also enhance its mechanical strength . Remarkably, the as-prepared PDA/CMC-Fe 3+ /PVA hydrogels with the optimized compositions exhibit relatively excellent mechanical properties (tensile strength = 163.48 ± 10.42 kPa, elastic modulus = 45.42 ± 3.96 kPa, toughness = 165.02 ± 7.01 kJ/m 3 ) due to the synergistic effect of the triple-network and PDA doping. Moreover, the composition of the hydrogel is optimized to realize a stable temporary shape and rapid recovery to the permanent shape, which is controlled by Fe 3+ , NIR irradiation, and thermal stimulus. The resultant hydrogels exhibit not only multi-stimulus responsive abilities, but also programmable multi-shape memory properties. The versatile shape memory properties endow potential for the materials to be used in the field of artificial intelligence.
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ACS Applied Materials & Interfaces
·
2020
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IF 8.758
Qi Wang,Yishun Ji,Jinsheng Shi,Lili Wang
As a newly emerging treatment strategy for many diseases, hydrogen therapy has attracted a lot of attention because of its excellent biosafety. However, the high diffusivity and low solubility of hydrogen make it difficult to accumulate in local lesions. Herein, we develop a H2 self-generation nanoplatform by in situ water splitting driven by near-infrared (NIR) laser. In this work, core–shell nanoparticles (CSNPs) of NaGdF4:Yb,Tm/g-C3N4/Cu3P (UCC) nanocomposites as core encapsulated with zeolitic imidazolate framework-8 (ZIF-8) modified with folic acid as shell are designed and synthesized. Due to the acid-responsive ZIF-8 shell, enhanced permeability and retention (EPR) effect, and folate receptor-mediated endocytosis, CSNPs are selectively captured by tumor cells. Upon 980 nm laser irradiation, CSNPs exhibit a high production capacity of H2 and active oxygen species (ROS), as well as an appropriate photothermal conversion temperature. Furthermore, rising temperature increases the Fenton reaction rate of Cu(I) with H2O2 and strengthens the curative effect of chemodynamic therapy (CDT). The excess glutathione (GSH) in tumor microenvironment (TME) can deplete positive holes produced in the valence band of g-C3N4 in the g-C3N4/Cu3P Z-scheme heterojunction. GSH also can reduce Cu(II) to Cu(I), ensuring a continuous Fenton reaction. Thus, a NIR-driven H2 production nanoplatform is constructed for H2-mediated cascade-amplifying multimodal synergetic therapy.
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高影响因子
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