Polymer Chemistry
·
2018
·Vol. 9
·期 29
·4063-4072
·
IF 4.927
Yan Chen,Yuting Gao,Lucília P. da Silva,Rogério P. Pirraco,Mengdi Ma,Liming Yang,Rui L. Reis,Jie Chen
The aim of this research was to develop thermo- and pH-responsive hydrogels based on H-bonds for the sustained release of the small-molecule model drug Methylene Blue (MB). The thermo- or pH-sensitive triblock copolymer based on PNIPAM or PAA was synthesized by sequential RAFT polymerization and hydrolysis. By tuning the temperature or pH, the copolymer was able to form diverse nanostructures, including core–shell micelles, electronegative or uncharged core–shell structures and 3D networks with the hydrophobic forces of PNIPAM or H-bonds between PAA and PNIPAM. Furthermore, the reversible sol–gel transition of the copolymers was modulated by temperature (∼37 °C), pH (∼5) and concentration (∼7 wt%). The drug release potential was evaluated via in vitro injection of copolymer hydrogels into a simulated human body device. The copolymer hydrogels exhibited a sustained drug release behavior and a low instantaneous drug concentration. The MTT studies revealed that there is no noticeable cytotoxicity of NDB or NDA hydrogels against cells. Thus, the tunable drug release efficiency suggests the possibility of PNIPAM- and PAA-based environment responsive hydrogels being applied as drug carrier systems.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
DOI
高影响因子
Materials Today Communications
·
2022
·
IF 3.662
Chenchen Xiong,Yang Zhou,Yanji Jin,Chao Liu,Pan Feng
Calcium silicate hydrates (C-S-H) are the strength sources of cement-based materials. However, the arbitrary packing of C-S-H particles at the nanoscale limit the mechanical properties considerably. In this study, we achieved high-order growth and improved mechanical properties of C-S-H by polymer addition and fine-tuning of the pH value. We found that a proper initial condition contributes to a uniform dispersion of colloidal C-S-H particles, which is essential for subsequent ordered growth. On the basis of stable dispersion, an accurate control of increasing pH values can induce the high-order and dense growth of C-S-H, which obtains a significantly higher elastic modulus as twice as traditional C-S-H. Furthermore, the polymer steric hindrance effect in low pH condition and templating effect of long chain in the higher pH condition explained the well-arranged growth of C-S-H with the interaction to polymer. We hope this highly ordered C-S-H may pave the way for designing tougher and more durable cement-based materials.
研究领域:
材料科学
·
土木工程
·
化学工程
·
纳米技术
✓ 已验证
DOI
高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
·
2024
·
IF 2.1
Yi Teng,Shu Wu,Xia Chen,Lu Bai,Qiuhua Wu,Guolin Zhang
New magnetic yolk-shell mesoporous silica nanoparticles (Fe3O4@V-mSiO2-PNVCL) were prepared by grafting temperature-sensitive amino-terminated poly (N-vinylcaprolactam) (PNVCL-NH2) on the surface of aldehyde-functionalized magnetic mesoporous silica nanoparticles (Fe3O4@V-mSiO2-CHO) through a Schiff base reaction. Various characterizations were used to confirm the structures, and the drug loading and release behaviors were studied. The drug loading was achieved as PNVCL stretched at room temperature and the drug loading content was up to 54.7% due to the large cavities. The encapsulation of drug from leakage in the blood environment was realized as PNVCL collapsed at physiological temperature. The fracture of pH-liable imine bonds in a slightly acidic tumor environment triggered the burst release of cargo. The Fe3O4@V-mSiO2-PNVCL showed super paramagnetic behavior (21.01 emu∙g−1) which could achieve magnetic targeting. The MTT assay confirmed that the nanoparticles exhibited low cytotoxicity. Furthermore, the cellular uptake experiments indicated that DOX-loaded nanoparticles were successfully internalized into cancer cells. Therefore, the composite nanoparticles are ideal choices for drug carriers.
研究领域:
纳米技术
·
药物输送系统
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生物医学工程
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材料科学
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生物化学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Qinfu Zhao,Peiyu Xie,Xian Li,Yue Wang,Ying Zhang,Siling Wang
A combination of multiple therapies is conducive to the treatment efficacy of cancer. Chemotherapy combined with magnetothermal therapy provides an outstanding synergy for cancer treatment. In this study, magnetic mesoporous silica nanoparticles (MMSN) were developed as a multipurpose nanoplatform for doxorubicin (DOX) delivery and magnetothermal treatment of cancer simultaneously. The MMSN were composed of Fe 3 O 4 and mesoporous silica as core and shell. The folic acid (FA) linked chitosan (CS) was conjugated at the outlets of MMSN (MMSN-SS-FA) using disulfide bonds to avert the premature release of the drug in mesopores of MMSN, target folate receptor-overexpressed cancer cells and increase the safety and physiological stability of MMSN. The temperature of the MMSN suspension could be elevated from 37 °C to 45 °C at the concentration of 1 mg/mL under an alternating magnetic field (AMF), which exceeded the tumor ablating temperature. The in vitro drug release proved that the DOX/MMSN-SS-FA displayed the redox/pH/AMF multiple-responsive release. The cellular uptake results indicated that the MMSN-SS-FA could target folate receptor-overexpressed HeLa cells. The DOX/MSNS-SS-FA with AMF had the highest cytotoxicity at the equivalent drug concentration towards HeLa cells with a combination index (CI) of 0.276, demonstrating the synergistic treatment effect of chemotherapy and magnetic-thermal therapy. Meanwhile, the DOX/MMSN-SS-FA+AMF showed the strongest tumor inhibitory effect of 84 % on tumor growth. Therefore, the constructed MMSN-SS-FA with good biocompatibility and biosafety can act as multifunctional nano-platforms for tumor treatment.
研究领域:
药剂学
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Ling Zhao,Yi Sun,Dionysios D. Dionysiou,Ying Teng
The application of reductants to accelerate the transformation from Fe(III) to Fe(II) has been proposed as a strategy to overcome the rate limitations of Fenton and Fenton-like processes. However, this strategy has been given little consideration to date in ligand-modified homogeneous Fenton-like (LMF) processes. Therefore, this study investigated the roles of ordinary reductants, namely gallic acid (GA), ascorbic acid (AA), acetylacetone (AAc), and three kinds of sulfhydryl compounds (SHs), in a pyrophosphate-modified Fenton-like (PMF) process for degrading polychlorinated biphenyls (PCBs) under circumneutral pH conditions. Interestingly, the inhibitory effects of SHs/AAc, the promoting effect of AA , and the inhibitory following with promoting effects of GA were observed on PCB degradation in the PMF process. The decrease of PP-Fe complex reactivity with decrease of pH and the scavenging effect of SHs/AAc caused their inhibitory effects, while the high reducibility of AA resulted in its promoting effect. The inhibitory pathways of GA in the initial stage were similar to those of SHs/AAc, whereas its promoting effect in the later stage was ascribed to the ligand exchange between GA and PP and the reducibility of GA towards Fe 3+ ions at pH 3.0. Results obtained in aqueous and soil systems under optimal reaction conditions further reveal that the application of suitable reductants, particularly AA, readily facilitates the development of the PMF process for the removal of refractory organic pollutants in natural environments.
研究领域:
环境化学
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催化
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水处理
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污染物降解
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2017
·Vol. 53
·期 4
·2351-2361
·
IF 2.599
Song Mei-Ru,Li Dong-Yao,Nian Fu-Yu,Xue Jin-Ping,Chen Juan-Juan
To improve the aqueous solubility and cancer targeting of the photosensitizers in photodynamic therapy (PDT), we encapsulated the photosensitizer in a biocompatibility and pH-sensitive drug delivery system, zeolitic imidazolate frameworks-8 (ZIF-8) nanospheres. Powder X-ray diffraction and electron microscopy show that our nanospheres are uniform and single-crystalline particles. Owing to the cleavage of zinc–ligand coordination bonds, more ZnPc–COOH were released much faster in the mild acidic conditions (pH 5.0 and 6.0) in comparison with physiological environment (pH 7.4). By incorporating ZnPc–COOH in ZIF-8, our nanospheres exhibited high singlet oxygen quantum yield and intracellular ROS generation. Cell viability experiments toward HepG2 cells demonstrated the low toxicity of ZIF-8 and the good anticancer efficacy of the nanospheres with low IC 50 values (4.2–4.9 μg/mL) under light illumination (670 nm, 1.5 J/cm 2 ). Collectively, these results suggested that our nanospheres are the promising pH-responsive drug delivery systems for PDT.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
癌症研究
·
药剂学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Zhanwei Yang,Jin Wang,Hualei Chen,Hecheng Meng,Xiaobing Guo,Shujuan Yu
Two low-methoxy pectins (LMPs) were obtained by local electrochemical pH modification using an H-type double-layer water bath sealed electrochemical cell at the voltage of 180 V for 3 h. The weight-average molecular weight (Mw) of citrus peel pectin (CPP) prepared in the anodic part at room temperature (CPP-A 5/RT ) and in the cathodic part at 5 °C (CPP-C 5/RT ) were 346 kDa and 328 kDa, respectively, and the degrees of methylation (DM) were 36.8 % and 11.9 %. Moreover, the second-order kinetic model was most appropriate for the degradation processes, as free radicals were generated in the anodic part and β -elimination occurred in the cathodic part. Subsequently, CPP-A 5/RT and CPP-C 5/RT were utilized to fabricate food packaging film blending with polyvinyl alcohol (PVA), bcZnO (ZnO coupled with bentonite and colophony) nanorods , and Ca 2+ ions by casting method. Then the prepared films were studied for their ability to maintain the freshness of strawberries. The addition of Ca 2+ ions and bcZnO nanorods increased the thickness, water contact angle (WCA), and mechanical properties of the composite films, while decreased water vapor permeability (WVP). Therefore, the CPP-based films, supplemented with bcZnO nanorods and crosslinked with Ca 2+ ions by “egg-box” model, can serve as an antibacterial food packaging material for food preservation.
研究领域:
食品科学
·
高分子材料
·
食品包装
·
电化学改性
·
纳米复合材料
·
农产品保鲜
✓ 已验证
DOI
高影响因子
Pharmaceutics
·
2020
·Vol. 12
·期 7
·680
·
IF 4.421
Jin Zhang,Xiaoyue Tang,Chuanqing Huang,Zeyu Liu,Yong Ye
Oleic acid (OA) as main component of plant oil is an important solvent but seldom used in the nanocarrier of anticancer drugs because of strong hydrophobicity and little drug release. In order to develop a new type of OA nanomaterial with dual responses to pH and near infrared light (NIR) to achieve the intelligent delivery of anticancer drugs. The novel OA copolymer (mPEG-PEI-(NBS, OA)) was synthesized by grafting OA ando-nitrobenzyl succinate (NBS) onto mPEGylated polyethyleneimine (mPEG-PEI) by amidation reaction. It was further conjugated with NaYF4:Yb3+/Er3+nanoparticles, and encapsulated doxorubicin (DOX) through self-assembly to make upconversion nanomicelles with dual response to pH and NIR. Drug release behavior of DOX, physicochemical characteristics of the nanomicelles were evaluated, along with its cytotoxic profile, as well as the degree of cellular uptake in A549 cells. The encapsulation efficiency and drug loading capacity of DOX in the nanomicelles were 73.84% ± 0.58% and 4.62% ± 0.28%, respectively, and the encapsulated DOX was quickly released in an acidic environment exposed to irradiation at 980 nm. The blank nanomicelles exhibited low cytotoxicity and excellent biocompatibility by MTT assay against A549 cells. The DOX-loaded nanomicelles showed remarkable cytotoxicity to A549 cells under NIR, and promoted the cellular uptake of DOX into the cytoplasm and nucleus of cancer cells. OA copolymer can effectively deliver DOX to cancer cells and achieve tumor targeting through a dual response to pH and NIR.
研究领域:
纳米技术
·
药学
·
癌症研究
·
材料科学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 22
·13177-13183
·
IF 3.108
Yunyun Huang,Bo Yu,Tuan Guo,Bai-Ou Guan
Ultrasensitive and in situ DNA detection at different pH values, ranging from 4.3 to 8.5, based on a microfiber with a graphene oxide linking layer was proposed and experimentally demonstrated. The graphene oxide coating over the silica microfiber provides a strong π–π interaction with the detected single-stranded DNA molecules, and induces an amplified surface refractive index modulation over the fiber, and finally leads to a wavelength shift of the optical interference fringe for interrogation. Using this strategy, in situ DNA measurement with a detection limit of up to 10−12 M and a linear response in the pH range from 4.3–8.5 has been achieved. Benefiting from its compact size, high sensitivity, and ease of use, together with remote operational ability, the proposed sensor opens up a multitude of opportunities for quantifying DNA in various hard-to-reach environments. It may supplement the existing DNA detection tools.
研究领域:
光学
·
生物传感
·
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Ruilin Su,Liangzhong Li,Jiatong Kang,Xinyu Ma,Da Chen,Xiaoyun Fan,Yang Yu
To develop a novel membrane with controllable wettability in response to external stimuli for intelligent oil/water separation is always in urgent demand. In this study, a pH-responsive nanofibrous membrane was prepared through the step-by-step modification of polyvinylidene fluoride (PVDF) electrospun nanofiber membrane , including mussel-inspired self-polymerization of polydopamine (PDA), immobilization of silver nanoparticles (AgNPs) and self-assembly of thiols. A rough membrane surface could be formed by the loading of AgNPs, and the subsequent introduction of HS(CH 2 ) 11 CH 3 /HS(CH 2 ) 10 COOH via metal-thiol coordination could endow the membrane with pH-responsive wettability. The surface of the membrane was able to quickly and reversely switch between superhydrophobicity and superhydrophilicity through simply applying pH stimulus at pH 7 and 13, respectively. The membrane can be applied for separating multiphase oil/water mixtures, achieving separation efficiency of over 99.2% for light oil/water mixture and 96.5% for heavy oil/water mixture with a stable flux of around 2500 L/m 2 ·h for water and 11,000 L/m 2 ·h for oil over the 10-cycle separation process. Meanwhile, the membrane exhibited separation efficiency of higher than 99% for all the tested oil-in-water emulsions, and the water flux of the membrane could be effectively recovered by water rinsing. Moreover, the membrane demonstrated a good structural stability against rigorous mechanical abrasion. The pH-responsive membrane could be potentially applied for smart and energy-saving separation and recycle of oil or water from oily wastewater.
研究领域:
材料科学
·
环境工程
·
纳米技术
·
化学工程
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 15
·2823-2831
·
IF 4.543
Dan Zhao,Xiaoqing Yi,Jiaqi Xu,Gongdao Yuan,Renxi Zhuo,Feng Li
Using the host–guest interaction between β-cyclodextrin (β-CD) and adamantane (Ad), and borate formation between phenylboronic acid (PBA) and cis-diols, a smart pH-responsible targeting drug delivery nanovehicle, PBA–PEG–CD/Ad-lys(Diol)–PCL, was prepared via one-step self-assembly. Under physiological conditions, the targeted PBA function could be restrained by binding PBA with diol components located at the interface of self-assemblies, and hydrophilic PEG segments could be shielded simultaneously. When the environmental pH decreased, the PBA groups could be unbound and exposed on the surface of self-assemblies, leading to recovery of its targeted function, as shown using fluorescence spectroscopy, in vitro cell toxicity, and uptake. Under acidic conditions, PBA–PEG–CD/Ad-lys(Diol)–PCL/Dox showed significantly increased uptake and toxicity toward HepG2 cells in comparison with the control group. The smart vehicles were further utilized to test their efficiency in overcoming drug resistance in chemotherapy. Compared with free Dox, PBA–PEG–CD/Ad-lys(Diol)–PCL delivered six times more Dox into MCF-7/ADR cells and showed greater toxicity toward the ADR cells. As a result, this may be a facile strategy toward constructing efficient targeting vehicles through the rational utilization of noncovalent interactions.
研究领域:
药剂学
·
纳米技术
·
药物递送系统
·
癌症研究
✓ 已验证
DOI
PubMed
高影响因子
CARBON
·
2019
·
IF 7.466
Haiyan Xu,Weihong Jia,Sili Ren,Jinqing Wang
A magnetically responsive multi-walled carbon nanotubes (M-MWCNTs) appropriate for acidic to alkaline conditions of crude O/W emulsion was designed and prepared via regulating the content of surface functional groups (such as -NH 2 , -OH and -COOH). The M-MWCNTs was confirmed as an efficient demulsifier and the corresponding demulsification efficiency achieved the highest when its dosage was increased to 400 mg/L. Significantly, the M-MWCNTs has superior demulsification performance under wide pH levels. What's more, the M-MWCNTs still has good demulsification efficiency after 5 cycles, suggesting it has high stability. The M-MWCNTs has strong interfacial activity, which can reach the oil-water interface and interact with asphaltenes . The synergistic π-π and/or n-π interaction of aromatics/functional groups of MWCNTs and asphaltenes as well as the electrostatic attraction between the M-MWCNTs and the asphaltenes promoted the oil separation from acidic crude O/W emulsion. In the neutral condition, the interfacial adsorption of π-π and/or n-π interactions was the main demulsification mechanism. Moreover, the electrostatic repulsion between the M-MWCNTs and crude O/W emulsion decreased due to the increase of amino groups under the alkaline condition. The protective film stabilizing the crude O/W emulsion was more facile broken, thusly promoting oil droplets separation from crude O/W emulsion.
研究领域:
环境科学
·
材料科学
·
化学工程
·
纳米技术
·
石油工程
·
胶体与界面化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）