Nature Communications
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2022
·Vol. 13
·期 1
·1-12
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IF 17.694
Su Yuanjie,Li Weixiong,Cheng Xiaoxing,Zhou Yihao,Yang Shuai,Zhang Xu,Chen Chunxu,Yang Tiannan,Pan Hong,Xie Guangzhong,Chen Guorui,Zhao Xun,Xiao Xiao,Li Bei,Tai Huiling,Jiang Yadong,Chen Long-Qing,Li Fei,Chen Jun
Polymer-ceramic piezoelectric composites, combining high piezoelectricity and mechanical flexibility, have attracted increasing interest in both academia and industry. However, their piezoelectric activity is largely limited by intrinsically low crystallinity and weak spontaneous polarization. Here, we propose a Ti 3 C 2 T x MXene anchoring method to manipulate the intermolecular interactions within the all- trans conformation of a polymer matrix. Employing phase-field simulation and molecular dynamics calculations, we show that OH surface terminations on the Ti 3 C 2 T x nanosheets offer hydrogen bonding with the fluoropolymer matrix, leading to dipole alignment and enhanced net spontaneous polarization of the polymer-ceramic composites. We then translated this interfacial bonding strategy into electrospinning to boost the piezoelectric response of samarium doped Pb (Mg 1/3 Nb 2/3 )O 3 -PbTiO 3 /polyvinylidene fluoride composite nanofibers by 160% via Ti 3 C 2 T x nanosheets inclusion. With excellent piezoelectric and mechanical attributes, the as-electrospun piezoelectric nanofibers can be easily integrated into the conventional shoe insoles to form a foot sensor network for all-around gait patterns monitoring, walking habits identification and Metatarsalgi prognosis. This work utilizes the interfacial coupling mechanism of intermolecular anchoring as a strategy to develop high-performance piezoelectric composites for wearable electronics.
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Biomedical Materials
·
2024
·Vol. 19
·期 6
·065004
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IF 3.9
Zhao Qianjuan,Shan Rong,Liu Shengxi,Liu Xuanhao,Liu Bin,Song Fuxiang
Artificial bone is the alternative candidate for the bone defect treatment under the circumstance that there exits enormous challenge to remedy the bone defect caused by attributes like trauma and tumors. However, the impact of pore size discrepancy for regulating new bone generation is still ambiguous. Using direct 3D printing technology, customized 3D polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) artificial bones with different structural pore sizes (1.8, 2.0, 2.3, 2.5, and 2.8 mm) were successfully prepared, abbreviated as the 3D PCL/β-TCP. 3D PCL/β-TCP exhibited a 3D porous structure morphology similar to natural bone and possessed outstanding mechanical properties. Computational fluid dynamics analysis indicated that as the structural pore size increased from 1.8 to 2.8 mm, both velocity difference (from 4.64 × 10−5 to 7.23 × 10−6 m s−1) and depressurization (from 7.17 × 10−2 to 2.25 × 10−2 Pa) decreased as the medium passed through. In vitro biomimetic mineralization experiments confirmed that 3D PCL/β-TCP artificial bones could induce calcium–phosphate complex generation within 4 weeks. Moreover, CCK-8 and Calcein AM live cell staining experiments demonstrated that 3D PCL/β-TCP artificial bones with different structural pore sizes exhibited advantageous cell compatibility, promoting MC3T3-E1 cell proliferation and adhesion. In vivo experiments in rats further indicated that 3D PCL/β-TCP artificial bones with different structural pore sizes promoted new bone formation, with the 2.5 mm group showing the most significant effect. In conclusion, 3D PCL/β-TCP artificial bone with different structural pore sizes could promote new bone formation and 2.5 mm group was the recommended for the bone defect repair.
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BIOORGANIC CHEMISTRY
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2026
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IF 5.1
Meng Liu,Peng Jiang,Binghui Ruan,Yunfei Cui,Junjie Zhang,Yuxiu Ye,Dongting Zhangsun,Sulan Luo,Yong Wu
Antimicrobial resistance (AMR) is an increasing global concern, while the development of new antibiotics remains limited. Antimicrobial peptides (AMPs) offer an alternative due to their broad-spectrum and membrane-targeting features, but their translation is restricted by instability and cytotoxicity. Here, we describe a β-turn engineering strategy that incorporates a Pro-Gly motif and aromatic residues to create a short, disulfide-free β-hairpin-like AMP (W2PG). W2PG showed broad-spectrum activity (MIC 4–8 μM) with low hemolysis and cytotoxicity, along with improved protease and serum stability. It caused concentration-dependent membrane permeabilization and depolarization, consistent with molecular dynamics simulations indicating aromatic-assisted anchoring and stable insertion. In murine infection models, W2PG achieved efficacy comparable to polymyxin B without observable organ toxicity. These results suggest that β-turn-guided design can balance stability, selectivity, and activity, providing a useful scaffold for peptide antibiotic development.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2023
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IF 6.1
Sai Li,Yacheng Hao,Qunyu Gao
β-cyclodextrin (β-CD)-based emulsion gels encapsulated with nutrition for three-dimensional (3D) printing are promising, while obstacles such as low bioaccessibility of bioactive compounds and the molding process in food manufacturing hinder their application. This study intended to develop stable composite emulsion gels using the complexes of chitosan (CS) and octenyl succinic anhydride (OSA)-modified β-CD (OCD) to conquer these challenges. The esterification of OSA generated more negatively charged OCD and ester groups, which aided in the combination of OCD and CS through enhanced electrostatic and hydrogen bonding interactions. The addition of CS improved the emulsification properties of the complexes and acted as a bridge link in the aqueous phase, thereby increasing the gel strength of the composite emulsion gels. Moreover, the encapsulation of β-carotene destabilized the strength of the emulsion gels by lowering the interfacial tension. The emulsion gel stabilized by OCD3/CS-0.75% at an initial pH not only successfully encapsulated β-carotene and presented the highest bioaccessibility of 41.88 ± 0.87% in the in vitro digestion but also showed excellent 3D printability. These results provided a promising strategy to enhance the viscoelasticity of β-CD-based emulsion gels and accelerate their application in bioactive compound delivery systems and 3D food printing.
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Scientific Reports
·
2019
·Vol. 9
·期 1
·1-11
·
IF 4.011
Geng Qianqian,Li Tian,Wang Xin,Chu Weijing,Cai Mengling,Xie Jingchan,Ni Hanwen
In this work, the inclusion complexes of hydrophobic herbicide bensulfuron-methyl (BSM) with β-cyclodextrin (β-CD) and (2-hydroxypropyl)-β-CD (2-HP-β-CD) were prepared and characterized. Phase solubility study showed that both β-CD and 2-HP-β-CD increased the solubility of BSM. Three-dimensional structures of the inclusion complexes were simulated by the molecular docking method. The docking results indicated that guest BSM could enter into the cavities of host CDs, folded, and centrally aligned inside the inclusion complexes. The benzene ring of the guest molecule was close to the wide rim of the host molecules; the pyrimidine ring and side chains of the guest molecule were oriented toward the narrow rim of the host molecule. The inclusion complexes were successfully prepared by the coprecipitation method. The physiochemical characterization data of 1 H NMR, FT-IR, XRD, and DSC showed that the guest and host molecules were well included. BSM had lower soil adsorption and higher herbicidal activity in the complexation form with β-CD or 2-HP-β-CD than in the pure form. The present study provides an approach to develop a novel CDs-based formulation for hydrophobic herbicides.
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FOOD CONTROL
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2026
·
IF 7
Yingjie Yang,Nan Xiao,Shanguang Guo,Minmin Ai
Liquid egg white protein (EWP) readily undergoes undesirable photooxidation triggered by endogenous photosensitizers such as riboflavin during routine shipping and ambient storage, which deteriorates the functional quality of liquid egg products. This study employed β-cyclodextrin (β-CD) to encapsulate β-carotene (β-C), which was subsequently incorporated into liquid egg white to suppress photosensitizer activity and quench ROS within EWP. Results showed that β-CD encapsulates the polyene chain and β-ionone ring of β-C within its hydrophobic cavity, driven primarily by hydrophobic interactions. The 2:1 β-CD/β-C composite showed superior thermal stability and a high thermal decomposition temperature of 425 °C. This complex may gradually release β-C to quench singlet oxygen ( 1 O 2 ) and scavenge triplet riboflavin ( 3 RF), thereby preventing ROS from attacking EWP side chains, inhibiting protein cross-linking, and lowering viscosity. The 4:1 β-CD/β-C-EW preserves bulk EWP structure but causes partial amino acid oxidation and fast β-C breakdown from surplus free β-CD, even with high starting β-C levels. In comparison, optimal host-guest matching in the 2:1 formulation securely entraps β-C within cyclodextrin cavities, preserving greater β-C retention and the minimum riboflavin fluorescence throughout storage. In contrast, the physical mixture group of β-CD and β-C due to the inclusion lag, and the pure β-C group due to easy oxidation inactivation, show decreasing protective effects with storage time. The 2:1 β-CD/β-C complex effectively suppresses photooxidative damage in EWP, providing a basis for controlling photooxidation of egg white during processing and storage.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2026
·
IF 2.4
Xinjun Zhou,Jing Jiang,Xiaopeng Chen,Chenghong Wu,Linlin Wang,Xiaojie Wei,Liyuan Tan,Jiezhen Liang
Isothermal vapor–liquid equilibrium data were measured for the binary systems related to α-pinene + myrcene, α-pinene + β-caryophyllene, and myrcene + β-caryophyllene using static headspace gas chromatography at 313.2, 323.2, and 333.2 K. The experimental data were correlated with the nonrandom two-liquid (NRTL) and universal quasichemical (UNIQUAC) models to obtain the binary interaction parameters. The small deviations demonstrated great agreement between the models and the experimental data. Moreover, the NRTL model showed marginally superior predictive accuracy in data association compared with the UNIQUAC model. The three binary systems exhibited simple phase behaviors with no azeotrope formation. In addition, the molecular surface charge profile and the binary energies of these systems were used to validate the strength of the σ-profile and to elucidate the role of intermolecular interactions in vapor–liquid equilibrium.
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FOOD CHEMISTRY
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2026
·
IF 10.4
Zhu-Jun Zhang,Ling-Yi Gao,Yi-Nan Du,Miao-Miao Luo,Ce Wang,Bin Lai,Jia-Nan Yan,Hai-Tao Wu
gcSGs and smSGs exhibited more susceptibility to CaHMB than scSGs or sbSGs. • The water retention ability of surimi gels decreased due to CaHMB hydration effect. • The substation of NaCl by CaHMB promoted the protein aggregation with dense network. • CaHMB promoted the unfolding of MP heads and tails in different type of surimi gels. • CaHMB could inhibit the MHC degradation of scSGs, smSGs, and sbSGs. The improvement of gel properties in low-salt surimi is vital for constructing health-oriented products. In this work, calcium β-hydroxy-β-methylbutyrate (CaHMB) was used to substitute sodium chloride to fabricate various low-salt surimi gels derived from freshwater and marine fish. Results indicated that grass carp surimi gels (gcSGs) and Spanish mackerel surimi gels (smSGs) presented superior gel performance with homogeneous microstructures in the presence of CaHMB. Remarkably, they exhibited the greatest textual properties in Na-L/Ca-H groups with increments of 32%–56%, compared with those in Na groups. The water retention capacity and thermal stability of samples were affected by CaHMB, as corroborated by 12.1%–19.4% reduction in water holding capacity and 5.4%–31.4% decrease in critical temperature than those of Na groups. CaHMB promoted unfolding of protein heads and tails in freshwater fish and marine fish surimi gels, respectively. Overall, replacing sodium salts with CaHMB was effective for producing surimi with high quality and nutrition. Download: Download high-res image (287KB) Download: Download full-size image
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Journal of Water Process Engineering
·
2022
·
IF 7.34
Jun Zhang,Xi Quan,Fu Li,Chenxi Zhen,Linlin Yin,Wei Zuo,Yu Tian
Ferrate is increasingly used as an oxidant for chemical oxidation of pharmaceuticals and personal care products (PPCPs) in reclaimed water. However, the instability of ferrate in aqueous solution and its low content of active ingredients have limited its application in water purification . In this paper, a novel β-cyclodextrin encapsulated potassium ferrate composite (KFO@β-CD) is synthesized for the first time using a thermomelting-condensation method and used to degrade carbamazepine (CBZ). This study evaluates and demonstrates the superior stability, sustained release behavior and hygroscopic characteristics of KFO@β-CD. In-depth investigations show that KFO@β-CD with a mass ratio of 10:1 can degrade 85.2 % of CBZ in 60 min. Analyzing the transformation pathways of CBZ has shown that Fe(VI) performed more reactive with olefinic double bond owing to electron-rich organic moieties, which convert carbamazepine to oxidized products with low molecular weight . These results significantly improve the state of our knowledge about this highly efficient and stable oxidant, which is likely to be useful for further degradation of PPCPs.
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Nanomaterials
·
2017
·Vol. 7
·期 12
·448
·
IF 3.553
Dandan Ju,Feng Song,Yingdong Han,Wenjing Cui,Aihua Zhou,Shujing Liu,Xueqin Wang,Ming Feng,Chengguo Ming
We synthesized the uniform core-shell microstructured compounds with hexagonal phase NaYF4:Er/Yb microrods as the core and hexagonal phase NaLnF4(NaYbF4, NaLuF4:Yb/Tm, NaYF4:Yb/Er, NaYF4:Eu) as the shell based on the hydrothermal reaction. These microscale core-shell structures provided a platform for the spatially confining optical process while possessing high luminescence efficiency. The thickness of the shell could be controlled by adjusting the amounts of shell precursor, which significantly affected the intensity of the shell dopant ions emission and the emission color of core-shell upconversion luminescence (UCL). The uniform NaYF4@NaLnF4(Ln = Y, Lu, Yb) microrods, with a series of rare-earth ions doped into the core and shell layer at various doping concentrations, achieved color-tuning of the upconversion (UC) emission and dual-mode emission at the single-microcrystal level, thus allowing the efficient utilization of core-shell microcrystals in the photonics and security labeling. This study suggests a new class of luminescent materials in the microscopic field.Keywords:NaYF4microcrystals;microscale core-shell structures;multicolor tuning;dual-mode emission
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2025
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IF 6.2
Qiaochun Chen,Zening Zhang,Weiqi Qiu,Qian Zhou,Mingfu Wang
The inhibitory mechanisms of flavonoids suppressing the formation of foodborne β-carboline heterocyclic amines, Harman and Norharman, remain unclear. In this study, structure–activity and correlation analyses linked the distinct inhibitory effects of spice-containing flavonoids on β-carboline formation (13.36–86.98%) to their phenolic hydroxyl groups and antioxidant capacity. The pronounced decrease in free radicals and reduced consumption of tetrahydro-β-carbolines (THβCs) in flavonoid-containing model systems indicated a radical scavenging mechanism that prevented the oxidation of THβC into β-carbolines. Concurrently, the significant reductions in formaldehyde, acetaldehyde, and THβCs levels revealed an additional pathway that flavonoids captured aldehydes to form adducts, thus diminishing THβC formation. Two major adducts, tryptophan–formaldehyde–flavonoid and flavonoid–formaldehyde–flavonoid, were identified by UPLC-MS/MS analysis. These mechanisms were verified in soy sauce brine systems, though their inhibitory efficacy was weakened by preexisting THβCs and β-carbolines, and the limited aqueous solubility of hydrophobic flavonoids. This work deepens insight into flavonoid-mediated inhibition of β-carboline formation and underscores their prospective application in controlling foodborne toxicants.
研究领域:
食品化学
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毒理学
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天然产物
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生物化学
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抗氧化研究
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Advanced Science
·
2026
·
IF 14.1
Yueyang Li,Sifei Yu,Kaidong Lu,Yujie Zhang,Mingjie Dong,Yan Peng,Liang Xue,Waleed Alam,Yuxuan Shui,Yi Zhou,Wuyunhan Ma,Meng Bao,Peiming Li,Peiyi Luo,Tiezhan Lu,Jiajia Li,Kang Zhang,Yuying Wang,Shuchen Yang,Nuoya Yin,Francesco Faiola,Zilong Gao,Jingfeng Zhou,Fei Zhao,Yali He,Magdalena J. Koziol
Amyloid-beta (Aβ) aggregation, mitochondrial dysfunction, and cognitive decline are hallmarks of Alzheimer's disease (AD), but its initiating molecular events remain unknown. Given that RNA modifications regulate neurodevelopment and neurodegeneration, we explore their functional role in 5xFAD mice, an Aβ AD model. We discover that N1-methyladenosine (m1A) is the most altered RNA modification, and that its regulator demethylase, ALKBH3 is upregulated. Strikingly, Alkbh3 reduction decreases Aβ plaques and restores cognition. Conversely, elevated ALKBH3 levels, observed in AD patients, compromise neuronal morphology and mitochondrial function by impairing mitophagy (degradation of dysfunctional mitochondria), a known driver of neuronal dysfunction. Mechanistically, we reveal that ALKBH3 removes m1A from PINK1 mRNA, the mitophagy master regulator. Given that ALKBH3 is elevated in human AD, causally linked to mitophagy impairment, and confers neuroprotection when depleted, we present ALKBH3 as a mechanistically validated therapeutic target in AD.
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