MATERIALS CHEMISTRY AND PHYSICS
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2019
·
IF 2.781
Yi Wu,Yuting Wu,Xuchu Lv,Wu Lei,Yong Ding,Chenglong Chen,Jingjing Lv,Shasha Feng,Shen-Ming Chen,Qingli Hao
Herein, a sensitive sensing platform for acetaminophen based on palladium and multi-walled carbon nanotube nanocomposites and its electrochemical detection mechanism were presented in the first time. Transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy were utilized to characterize the morphology and structure of Pd-MWCNTs composite. Through the computer simulation, the Gaussian 09 and Multiwfn methods were used to study the redox mechanism of AP. Further electrochemical performance of AP was carried out by cyclic voltammetry (CV). The experimental results illustrated that Pd-MWCNTs modified electrode amplified the redox current of AP. Quantitative detection of AP by the DPV method revealed that the oxidation peak current of AP showed an acceptable linear response of 0.5 μM–100 μM with a detection limit of 0.13 μM (S/N = 3). The modified electrode also exhibited a good recovery in real sample detection.
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JOURNAL OF CLUSTER SCIENCE
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2019
·Vol. 31
·期 2
·337-346
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IF 2.125
Zhao Chenyu,Jiao Junfeng,Zhou Wencui,Zhang Yong,Liu Han,Yang Xiaogang,Pandi Boomi,Cai Yurong
In this study, a new HAP/rGO/AuNPs-AO modified carbon electrode (GCE) was fabricated for amperometric detection of ascorbic acid. The HAP/rGO/AuNPs composite was prepared by one-step hydrothermal method. The large specific surface area, strong adsorption and excellent biocompatibility of HAP nanowires enabled fast, stable and accurate detection of ascorbic acid. As array of quantum dot, AuNPs had strong electrocatalytic activity in addition to good adsorption to enzymes, which could provide high sensitivity and low limit of detection for biosensor. Then rGO ensured that current signal could be quickly transferred from the composite to electrode. Under the optimum conditions, the prepared biosensor demonstrated a wide linear range from 0.39 to 36 mM (R 2 = 0.99845), a low limit of detection (3.39 μM, S/N = 3) and a high sensitivity (15.949 mA moL −1 ) with good selectivity, stability (10.8%) and repeatability (3.9%), which might providing a reasonable and reliable way for ascorbic acid detection.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 6
·1-7
·
IF 5.479
Qiao Juan,Liu Qianrong,Wu Han,Cai Huiwu,Qi Li
A fluorescent probe is described for the determination of serum glucose after hepatotoxin-induced liver injury. The probe is based on the use of a water-soluble polymer and has been prepared from a multi-functional azlactone polymer as the linker, amino boronic acid, and Alizarin Red as the signalling moiety. The excitation/emission peaks of the polymeric fluorescent probe are at 468/567 nm. Fluorescence is reduced on addition of glucose. Intensity drops linearly in the 0.1 mM to 14 mM glucose concentration range. The probe was applied to non-enzymatic detection of glucose in rat serum after CCl 4 -induced liver damage.
A polymer based fluorescent probe has been constructed and applied for non-enzymatic monitoring of serum glucose following hepatotoxin induced liver injury.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 4
·1-8
·
IF 5.479
Mei He,Wang Xuedong,Zeng Tai,Huang Ling,Wang Qun,Ru Daoping,Huang Tongliang,Tian Falin,Wu Huimin,Gao Jimin
Gold nanobipyramids were synthesized by a seed-mediated growth method and then supported by multi-walled carbon nanotubes (denoted as AuNBP/MWCNTs). The electrocatalytic activity of the AuNBP/MWCNTs on a glassy carbon electrode (GCE) towards direct glucose oxidation and hydrogen peroxide reduction was superior to that of AuNBPs and MWCNTs. The modified GCE, operated at a typical working voltage of +0.15 V (vs. SCE) and in 0.1 M NaOH solution, exhibits a linear response in the 10 μM to 36.7 mM glucose concentration range with a 3.0 μM detection limit (at S/ N = 3) and a sensitivity of 101.2 μA mM −1 cm −2 . It also demonstrates good sensitivity towards hydrogen peroxide in at pH 7 solution at a working potential of −0.50 V (vs. SCE), with a linear response range from 5.0 μM to 47.3 mM, a sensitivity of 170.6 μA mM −1 cm −2 and a detection limit of 1.5 μM.
A electrochemical sensing platform based on the use of gold nanobipyramids and multi-walled carbon nanotubes nanocomposites (AuNBP/MWCNTs) is described for the determination of glucose and hydrogen peroxide.
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SENSORS
·
2019
·Vol. 19
·期 5
·1203
·
IF 3.031
Nannan Shen,Haijun Xu,Weichen Zhao,Yongmei Zhao,Xin Zhang
Glucose concentration is an important physiological index, therefore methods for sensitive detection of glucose are important. In this study, Au foam was prepared by electrodeposition with a dynamic gas template on an Au nanoparticle/Si substrate. The Au foam showed ultrasensitivity, high selectivity, and long-term stability in the quantitative detection of glucose. The foam was used as an electrode, and the amperometric response indicated excellent catalytic activity in glucose oxidation, with a linear response across the concentration range 0.5 μM to 12 mM, and a limit of detection of 0.14 μM. High selectivity for interfering molecules at six times the normal level and long-term stability for 30 days were obtained. The results for electrochemical detection with Au foam of glucose in human serum were consistent with those obtained with a sensor based on surface-enhanced Raman spectroscopy and a commercial sensor. This proves that this method can be used with real samples. These results show that Au foam has great potential for use as a non-enzymatic glucose sensor.Keywords:Au foam;bubble-templated electrodeposition;non-enzymatic glucose sensor;amperometric response
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MICROCHEMICAL JOURNAL
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2019
·
IF 3.206
Zhao Wang,Hong Yan Yue,Ze Min Yu,Shuo Huang,Xin Gao,Bao Wang,Shan Shan Song,En Hao Guan,Wan Qiu Wang,Hong Jie Zhang
Spherical nickel nanoparticles were prepared by an N 2 H 4 -based solution reduction route. Then, graphene was deposited on the template of nickel nanoparticles by chemical vapor deposition (CVD) at a high temperature. After etching nickel, small-sized, porous and free-standing 3D graphene foam (3D GF) was obtained. It was transferred on the indium tin oxide (ITO) glass (3D GF/ITO) for electrochemical determination of levodopa in the presence/absence of uric acid . The results show that the pore size of the 3D GF is ~1 μm. The electrode shows a high sensitivity of 0.24 μA·μM −1 for the detection of levodopa. The electrode also shows a low measured limit of detection, superior selectivity, reproducibility and stability. Meanwhile, it shows a great potential in the clinical application.
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ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Wenfang Deng,Yi Peng,Hui Yang,Yueming Tan,Ming Ma,Qingji Xie,Shaowei Chen
Detection of hydrogen peroxide is of great significance for clinical diagnosis and biomedical research. Ratiometric detection represents an effective method that is generally based on horseradish peroxidase. In the present study, ruthenium ion-complexed carbon nitride (Ru–C3N4) nanosheets are found to serve as a peroxidase mimic and can catalyze the conversion of o-phenylenediamine to fluorescent 2,3-diaminophenazine in the presence of H2O2. The produced 2,3-diaminophenazine also results in the apparent quenching of the Ru–C3N4 photoluminescence due to the inner filter effect. These unique characteristics can be exploited for the construction of an effective, peroxidase-free ratiometric fluorescence framework for the detection of H2O2 and glucose, which has also been used in the successful detection of glucose in human serum. Results from this study not only demonstrate a new peroxidase mimic but also provide a novel ratiometric fluorescence platform for the detection of H2O2 and metabolites involving reactions of H2O2 generation in the absence of horseradish peroxidase.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 8
·1-9
·
IF 5.479
Wang Guiqian,Feng Lisha,Li Wei,Zhang Jinli,Fu Yan
Four natural nucleotides including 5′-cytidine monophosphate (CMP), 5′-thymidine monophosphate (TMP), guanosine monophosphate (GMP) and 5′-adenosine monophosphate (AMP) were employed to modulate the coordination environment and the valence state of PtCl 4 2− . This is the first report that natural nucleotides have the ability to produce highly active Pt nanoclusters. The latter are shown to act as peroxidase mimetics. Both the size distribution and the charge state of Pt-nucleotide nanozymes vary with the chemical structures of nucleotides, thereby contributing to distinct enzyme-like activities. By adopting Pt-CMP as a signal amplifier, a photometric assay was well-established for quantitative determination of glucose. The assay is based on the oxidation of glucose by glucose oxidase. The oxidation product (H 2 O 2 ) is detected at 652 nm via the Pt-CMP-catalyzed oxidation of 3,3′,5,5′-tetramethylbenzidine with H 2 O 2 . Response is linear in the 5 to 100 μM glucose concentration range, and the limit of detection is 0.12 μM (at S/N= 3). The method excels by a low signal background, high sensitivity, and low consumption of energy and materials.
Peroxidase mimicking Pt nanoclusters were synthesized by employing natural nucleotides as both the reducing agent and the stabilization template.
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AAPS PHARMSCITECH
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2019
·Vol. 20
·期 5
·1-11
·
IF 2.608
Zhang Kangyi,Wang Qilong,Yang Qiuxuan,Wei Qiuyu,Man Na,Adu-Frimpong Michael,Toreniyazov Elmurat,Ji Hao,Yu Jiangnan,Xu Ximing
The aim of this study was to develop a self-microemulsifying drug delivery system (SMEDDS) for enhancement of the oral bioavailability of isoliquiritigenin (ISL) as well as evaluate its in vivo anti-hyperuricemic effect in rats. The ISL-loaded self-microemulsifying drug delivery system (ISL-SMEDDS) was comprised of ethyl oleate (EO, oil phase), Tween 80 (surfactant), and PEG 400 (co-surfactant). The ISL-SMEDDS exhibited an acceptable narrow size distribution (44.78 ± 0.35 nm), negative zeta potential (− 10.67 ± 0.86 mV), and high encapsulation efficiency (98.17 ± 0.24%). The in vitro release study indicated that the release rates of the formulation were obviously higher in different release media (HCl, pH 1.2; PBS, pH 6.8; double-distilled water, pH 7.0) compared with the ISL solution. The oral bioavailability of the ISL-SMEDDS was enhanced by 4.71 times in comparison with the free ISL solution. More importantly, ISL-SMEDDS significantly reduced uric acid level by inhibiting xanthine oxidase (XOD) activity in the model rats. Collectively, the prepared ISL-SMEDDS proved to be potential carriers for enhancing the solubility and oral bioavailability of ISL, as well as ameliorating its anti-hyperuricemic effect.
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Analytical Methods
·
2019
·Vol. 11
·期 28
·3570-3577
·
IF 2.378
Baoya Zhu,Mingyu Tang,Liying Yu,Yaoyao Qu,Fang Chai,Lihua Chen,Hongbo Wu
In this paper, silicon nanoparticles (Si NPs) were synthesized by a simple one-step procedure by applying uric acid as reducing agent. The as-prepared Si NPs exhibited emission at 425 nm under excitation at 345 nm, allowing them to be developed as a fluorescent and colorimetric probe for detection of Cu2+ and Mn2+. As a probe, the fluorescence and color change of the Si NPs induced by Cu2+ and Mn2+ exhibited contrast. As a fluorescence probe, the Si NPs exhibited intense enhancement caused by Cu2+ and Mn2+ with detection limits of 0.562 μM (Cu2+) and 1.02 μM (Mn2+). More significantly, the Si NPs could be applied to effectively detect Cu2+ and Mn2+ in real samples. Interestingly, a Si NPs-based gel membrane was fabricated and established to be selective for visual recognition of Cu2+ and Mn2+. A cell imaging experiment revealed that the Si NPs possessed excellent biocompatibility and low cytotoxicity in living cells. Additionally, the powder form of the Si NPs can be easily prepared and used to visualize latent fingerprints (LFPs) with good performance.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Pengcheng Ma,Xiaoyan Ma,Qi Suo,Fang Chen
Copper nanoparticles (Cu NPs) were uniformly deposited on a nickel foam substrate (Cu NPs@NiF electrode) rapidly by one-step electrochemical deposition in the aqueous solution of copper sulfate, which can be successfully applied to catalyze glucose oxidation, and act as a non-enzymatic glucose sensor. The specific structure and morphology of Cu NPs were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The electro-oxidation of glucose on Cu NPs@NiF catalytic oxidation of process was proved by cyclic voltammetry (CV). It is found that Cu NPs show remarkable catalytic activity to glucose, involving in multistep catalytic of Cu NPs, in which the transform from Cu (II) into Cu (III) is the key to success. The performances of electrode sensitivity were investigated by CV and chronoamperometry methods in alkaline conditions. It is found that the developed sensor had excellent glucose sensing performances, including two-section broad linear detection ranges (0.002–0.650 mM and 0.65–6.00 mM), high corresponding sensitivity (2679 μA cm −2 mM −1 and 1122 μA cm −2 mM −1 ), fast response time (<3 s) and a low detection limit (0.5 μM, S/N = 3). In short, the Cu NPs@NiF electrode developed by low-cost, efficient and simple preparation method is expected to be used for the development of non-enzymatic glucose sensors.
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Materials Science & Engineering C-Materials for Biological Applications
·
2019
·
IF 4.959
Zhiwei Lu,Lan Wu,Junjun Zhang,Wanlin Dai,Guangquan Mo,Jianshan Ye
In this work, a simple strategy for fabricating a 3D nitrogen doped holey graphene hydrogel decorated with NiCo 2 O 4 nanoflowers (NHGH/NiCo 2 O 4 ) via a one-pot hydrothermal method with subsequent calcination is reported for the first time. The novel NHGH/NiCo 2 O 4 nanocomposites featured high electrical conductivity, large and accessible surface areas, abundant active sites, and excellent electrocatalytic performance. Considering the excellent catalytic activity of NiCo 2 O 4 , a sensitive and bifunctional electrochemical non-enzymatic biosensor was established for the determination of glucose and hydrogen peroxide (H 2 O 2 ). The obtained biosensor exhibited wide linear ranges (glucose: 0.005–10.95 mM; H 2 O 2 : 1–510 μM) and a low detection limits (glucose: 0.39 μM; H 2 O 2 : 0.136 μM) in alkaline solution (S/N = 3). Excellent electrocatalytic activity of this sensor was ascribed to the synergistic effects of the hybrid structure between the NiCo 2 O 4 nanoflowers and NHGH. Furthermore, the sensitive biosensor also exhibited high selectivity and could be applied to determine glucose in real blood samples. Taken together, the results reveal that the proposed hybrid nanocomposite could be a promising electrochemical biosensor.
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