CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Tao Zhou,Jingjing Chen,Zenghui Mai,Haobo Zhang,Xiaoli Wu,Wenpeng Li,Jingtao Wang
Unraveling molecular transport behaviors in extremely confined two-dimensional (2D) nanochannels, especially the impact of sub-nanometer interlayer spacing, is essential for designing high-precision separation membranes. However, it remains a challenging issue due to the complex physical and chemical structures of conventional 2D lamellar membranes. Herein, vertically aligned graphene oxide (GO) membranes featuring stable and long-range nanochannels are constructed. Significantly, the interlayer spacing is precisely tuned from 0.76 to 0.98 nm by controlling relative humidity with saturated salt solutions. It is demonstrated that, for these GO membranes, organic solvent permeance generally increases monotonically with increasing interlayer spacing. In stark contrast, water transport exhibits an anomalous non-monotonic dependence, with a minimum permeance of 0.52 LMH bar −1 at a critical interlayer spacing of 0.87 nm, significantly lower than 4.35 and 3.46 LMH bar −1 at 0.81 and 0.92 nm, respectively. This phenomenon originates from the confinement-induced reconstruction of hydrogen-bond networks into an ice-like ordered structure at the critical spacing, which markedly elevates the diffusion energy barrier, thus leading to the lowest permeance. This work reveals the molecular transport behaviors under extreme confinement, providing novel theoretical insights into confined molecular transport.
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Yue-Yang Zhang,Zi-Xin Chen,Gang Nie,Huiling Wang,Qiaolin Li,Shi-Yu Liu
Bio-activated esters containing a functional alcohol and an acid moiety as recognition unit have emerged in bioimaging and drug discovery. When the alcohol moiety is designated as an imaging dye or a drug, disease-related enzyme activity can be visualized, or the drug can be delivered to disease lesions with aberrant enzyme expression. However, although the carboxylic acid moiety is co-delivered to enzyme-overexpressing sites along with the alcohol part, the leaving acid groups are typically non-functional. Therefore, we sought to develop a dual-functional ester design platform by incorporating a biologically active acid with functional alcohol moieties. In this study, we selected carboxylesterase 2 (CES2) as the target enzyme and first proposed aspirin-based esters as a potential CES2-targeting scaffold. A prototype compound ( HFC-AS ) was initially constructed and characterized as a dual-functional ester, which exhibited high sensitivity and specificity for CES2 sensing and significantly improved antitumor efficacy compared to the combined addition of HFC-OH and aspirin. Subsequently, an aspirin-based fluorescent probe ( DDX-AS ) was developed, displaying an ultrafast reaction rate toward CES2 while maintaining high sensitivity and selectivity. Consequently, CES2 activity in living systems could be rapidly detected with high specificity, enabling imaging of both subcutaneous transplanted and pulmonary metastatic melanoma. Furthermore, an aspirin-based prodrug ( SN-38-AS ) was developed and demonstrated a higher tumor growth inhibition rate (98%) than the clinically used prodrug irinotecan (89%), while also exhibiting an improved safety profile. Collectively, a new strategy for CES2-targeted bioimaging and drug delivery was proposed and evaluated, showing great potential for disease diagnosis and drug development.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Lan Li,Lihao Lei,Jingmei Li,Shuangli Zhang,Shuai Wu,Linfeng Yang,Yujie Jiang,Luyin Chen,Rongyu Li,Xianhui Yin,Zhuo Chen,Youhua Long,Fengpei Du,Yue Ma
A porous, high-strength PAA-g-DSMS hydrogel mulch was engineered from spent mushroom substrate via DES-ball milling and microwave grafting. • The hydrogel demonstrated high water absorption, strong water retention, and excellent film-forming performance. • As liquid mulch, it achieved 92.0% Chinese cabbage seed germination and superior soil moisture–temperature regulation over commercial products.. • Soil burial and composting confirmed biodegradability, low ecotoxicity, and increased abundance of beneficial soil fungi. Renewable polysaccharides from agricultural residues represent attractive alternatives for functional materials that address drought stress and plastic mulch pollution. In this study, the cellulose and hemicellulose polysaccharides present in spent mushroom substrate (SMS) were enriched with choline chloride/lactic acid deep eutectic solvents (DES) combined with ball milling. This synergistic pretreatment effectively increases the relative contents of cellulose and hemicellulose by promoting lignin depolymerization via acid catalysis and disrupting the lignin-carbohydrate complex structure, thereby improving the accessibility of reactive hydroxyl groups on polysaccharides. The resulting lignocellulosic material (DSMS) was grafted and copolymerised with acrylic acid under microwave irradiation to form a porous and high mechanical strength hydrogel (PAA-g-DSMS). PAA-g-DSMS exhibited high water absorption capacity, strong water retention and good film-forming performance. When used as liquid mulch, PAA-g-DSMS significantly improved soil moisture retention and temperature buffering capacity and made the seed germination rate of Chinese cabbage reach 92.0%, which was superior to commercial superabsorbent polymers and commercial liquid film. Soil burial and composting experiments further prove that it has biodegradability and low ecological toxicity and can also increase the abundance of beneficial soil fungi. This study highlights the critical role of renewable polysaccharides from agricultural waste in biodegradable mulching film, offering a sustainable solution for water saving agriculture and soil health management. Through DES-assisted ball milling and subsequent microwave-assisted graft copolymerization with acrylic acid, cellulose/hemicellulose (polysaccharides) extracted from mushroom residue is converted into a hydrogel that enhances soil moisture and temperature retention for improved crop growth. Download: Download high-res image (105KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Fei Zhan,Chuanwei Zhou,Fengjian Yang,Changsheng Liu,Lili Sun,Yuan Yuan
UPG-PAN integrates self-lubrication, wet adhesion, and fatigue resistance. • UPG-2 achieved 3.22 MPa strength and 92.5% fatigue resistance. • Glycerol migration lowered contact angle to 28° and friction to 0.035. • PAN-2 provided 27.53 kPa wet adhesion to subchondral bone. • UPG-PAN showed good cytocompatibility and milder early tissue response. Articular cartilage remains a significant clinical challenge. The ideal implant would support joint loads, resist fatigue, reduce friction, adhere to wet subchondral bone and demonstrate good biocompatibility. Although hydrogels have a hydration profile similar to that of cartilage, many lack long-term durability under load. Elastomers have higher mechanical strength, but they often show poor surface lubrication and weak wet-tissue adhesion. In this study, we developed a biomimetic bilayer elastomeric cartilage substitute, named UPG-PAN. It contains a self-lubricating upper elastomer layer, UPG, and a wet-adhesive lower hydrogel layer, PAN. In the UPG layer, thermoplastic polyurethane (TPU) forms the elastic load-bearing framework. Poly(ethylene glycol)-modified poly(glycerol sebacate) (PEGS) and glycerol (Gly) regulate chain entanglement, reversible hydrogen bonding, surface hydration, and energy dissipation. The UPG-2 elastomers maintained MPa-level compressive strength (∼3.22 MPa), tunable modulus (∼1.58 MPa), stable cyclic compression behavior, and good fatigue resistance (∼92.5%). Gly migrated toward the material surface during formation and drying. This migration formed an OH-rich hydrated lubricating layer. The layer improved surface wettability and helped maintain low friction during reciprocating sliding (∼0.035 COF). The PAN layer was prepared by photocuring PEGS-Ac, PEGS-NH 2 , and acrylic acid (AAc). This layer formed a continuous UPG-PAN interface and strong wet adhesion to bone (∼27.53 kPa). The adhesion was related to interfacial chain interpenetration, hydrogen bonding, crosslinking, and electrostatic interactions. L929 cell culture and rat subcutaneous implantation showed good biological safety. Compared with TPU-PAN, UPG-PAN showed improved cytocompatibility and a milder early inflammatory response. Overall, UPG-PAN combines fatigue-resistant mechanical support, self-lubrication, wet fixation, and biocompatibility. This bilayer design may help slow local cartilage degeneration and delay invasive joint replacement in patients with focal cartilage defects.
✓ 已验证
产品关联
DOI
高影响因子
Advanced Science
·
2026
·
IF 14.1
Zesheng Chen,Yanchao Yu,Xingyuan Xiao,Wenwen Cheng,Ye Yang,Zhengyao Zhang,Wang Wang,Zhijun Zhou,Weikang Hu,Xiaolong Wang,Bing Li,Kwang Leong Choy,Yun Chen,Zijian Wang
Impaired wound healing in diabetes is closely associated with cellular ferroptosis. Microneedle-assisted gas therapy exerts molecular regulation of ferroptosis, representing a promising approach for accelerating diabetic wound healing. To date, O 2 and H 2 gas therapies have consistently been conducted independently and have never been integrated into a single system. Whether and how their synergy might be realized remains a defining challenge. Herein, we propose a concept of integrated O 2 and H 2 gas therapy, demonstrated by fabricating a gas-producing microneedle material. Platinum@MIL-101(Fe)-NH 2 @phosphotungstic acid (PMP) nanoparticles are synthesized as a visible light-driven photocatalyst for H 2 and O 2 co-evolution. The rational design of a spatially separated structure boosts their photocatalytic efficiency under physiological conditions. PMP nanoparticles are further incorporated with bilayer gelatin methacryloyl (GelMA)/PMP composite microneedles (denoted as GPM microneedles). The obtained GPM microneedles enable transdermal delivery of PMP nanoparticles for integrated O 2 and H 2 gas therapy, and demonstrate desirable biocompatibility and pro-regenerative effects. The mechanism of integrated O 2 and H 2 gas therapy has been identified as a TNFAIP3/hnRNPA1 ubiquitination/ferroptosis signaling axis, establishing for the first time a direct link to ferroptosis. In conclusion, this study yields a transformative concept and a ferroptosis-targeting microneedle material with well-defined molecular mechanism for diabetic wound management.
✓ 已验证
产品关联
DOI
高影响因子
ChemCatChem
·
2026
·Vol. 18
·期 16
·e71016
·
IF 4.1
Zhuoxi Li,Chengen Ho,Jun Shi,Rui Chen,Yicun Cai,Bin Li,Tianhao Li,Qiang Chen,Jinyuan Liu,Tongwen Yu
The catalytic selectivity of heterogeneous reaction can be effectively regulated by the design of the thickness of zeolite in zeolite-supported noble metal catalysts. Herein, taking the industrially important hydrogenolysis of the biomass-derived compound vanillin as an example, ZSM-5 zeolite with a thinner b -axis (75 nm) loaded with platinum particles (denoted as Pt/ut-ZSM-5) exhibited 99% conversion and 97% selectivity toward the target product 2-methoxy-4-methylphenol. In contrast, the ZSM-5-supported platinum catalyst with a longer b -axis (175 nm) showed only 63.4% conversion and 50% selectivity, respectively. Molecular dynamics simulations reveal that the translocation times for intermediate vanillyl alcohol through thinner ZSM-5 is longer than vanillin, and the diffusion of 2-methoxy-4-methylphenol in thinner ZSM-5 is faster than that of vanillin. The dynamics of vanillin, vanillyl alcohol and 2-methoxy-4-methylphenol exhibit discontinuous behavior, accompanied by intermittent kinetic restrictions arising from free energy barriers within the straight tunnel of ZSM-5. The translocation times of vanillin and vanillyl alcohol through the thicker ZSM-5 zeolite are typically longer than those through the thinner one; the movement of vanillyl alcohol is still slower than vanillin in thicker zeolite. The slower release of intermediate vanillyl alcohol in both thinner and thicker ZSM-5 demonstrates the possible rate-limiting step in the reaction-diffusion process. Graphical Ultrathin b -axis ZSM-5 accelerates the diffusion of reactants and intermediate by-products to the external surface, where they react with the supported Pt particles, resulting in excellent catalytic hydrogenation performance. Under mild conditions, the catalyst achieved complete vanillin (VAN) conversion and over 97% selectivity toward 2-methoxy-4-methylphenol (MMP).
✓ 已验证
产品关联
DOI
高影响因子
Small Science
·
2026
·Vol. 6
·期 8
·e70382
·
IF 7
Min Chen,Yaping Lu,Xinmin Zhang,Yixin Song,Fengtao Shao,Xuetao Gao,Zhichao Liu,Chunmei Xu,Yiting Peng,Yaping Feng,Kai Xi,Yatao Liu
Lithium–sulfur (Li–S) batteries represent promising energy storage devices by virtue of their ultrahigh theoretical energy density, yet their practical deployment is severely impeded by the polysulfide shuttle, sluggish sulfur redox kinetics, and progressive degradation of lithium anodes. Herein, we design a thiol-functionalized UiO-66 (UiO-66-SH)-coated polypropylene separator that addresses these challenges simultaneously. The UiO-66-SH combines abundant coordinatively unsaturated Zr sites and SH groups, enabling both strong chemical anchoring of lithium polysulfides and catalytic acceleration of their conversion to Li 2 S. The modified separator exhibits superior electrolyte wettability, a high Li + transference number (0.76), and enhanced ionic conductivity. Furthermore, it regulates lithium deposition to achieve a dendrite-free anode and mitigates polysulfide-induced corrosion. Consequently, Li–S cells incorporating UiO-66-SH/PP separator deliver an initial discharge capacity of 821.3 mAh g −1 at 1 C, retain 521 mAh g −1 after 500 cycles, and achieve a high-rate capacity of 590.9 mAh g −1 at 5 C. Even under a high sulfur loading of 5.05 mg cm −2 , a reversible capacity of 620.1 mAh g −1 is maintained after 200 cycles. This work offers a rational design of a multifunctional MOF-based separator that integrates polysulfide entrapment, catalytic conversion, and anode protection, paving the way toward high-performance, long-life Li–S batteries.
✓ 已验证
产品关联
DOI
高影响因子
Pharmaceuticals
·
2026
·Vol. 19
·期 9
·1336
·
IF 5.7
Shini Zhang,Xiao-Li Luo,Hangxing Yang,Ganghua Huang,Jing Leng,Tao Yang
Background:Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder for which effective treatments remain limited. Liubao tea, a distinctive post-fermented dark tea, develops unique aged and areca nut aromas through prolonged storage. However, comprehensive studies on its anti-Alzheimer’s disease effects are lacking. This study aimed to identify the bioactive constituents of Liubao tea with varying storage durations and aroma profiles, and to further evaluate its neuroprotective potential against Alzheimer’s disease.Methods:Chromatography and spectrophotometry were employed to quantitatively determine the primary bioactive components in various Liubao tea samples. A D-galactose-induced Alzheimer’s disease zebrafish (Danio rerio) model was established to evaluate the neuroprotective effects of the aqueous extract of Liubao tea.Results:The contents of theabrownins, theaflavins, tea pigments, and catechins showed potential associations with the anti-AD capacity of Liubao tea. Variations in these bioactive components appeared to correlate with the neuroprotective activity.Conclusions:This study elucidates the anti-AD potential of aged Liubao tea and associates its characteristic constituents with neuroprotective effects. The findings provide essential theoretical support for developing Liubao tea as a promising natural product candidate worthy of further anti-AD research.
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Jiahui Li,Xuan Li,Youlin Xue,Jinfeng Bi
The effect of electron beam irradiation (EBI) on raisin pectin properties remains unclear regarding structural differences across pectin fractions. This study investigated the effects of EBI on the structural changes of three pectin fractions including WSP fraction, CSP fraction and NSP fraction in raisins as well as their correlations with polyphenol release and variations in antioxidant activity. EBI induced differential structural modifications of pectin fractions by disrupting hydrogen and glycosidic bonds, and altering molecular weight, crystallinity, monosaccharide composition and molecular conformation. EBI raised the molecular weight and HG content of WSP, reduced its RG-I ratio, Rg and Rc, leading to molecular aggregation and conformational contraction. Increasing irradiation doses induced de-esterification and molecular weight reduction in CSP, which exhibited maximum linearity and minimal branching at 4 kGy. NSP had the highest structural stability with intact HG and branched RG-I regions. The 4 kGy treatment maximized the release of (+)-catechin, (−)-Epigallocatechin, proanthocyanidins, protocatechuic acid, caffeic acid, quercetin, achieving the optimal antioxidant capacity. EBI degraded the RG-I and HG domains of WSP and the HG region of NSP, facilitating polyphenol release and enhancing the overall antioxidant activity of raisins. This work provides theoretical support for the processing of dried fruits via EBI technology.
✓ 已验证
产品关联
DOI
高影响因子
Acta Biomaterialia
·
2026
·
IF 10.4
Hao Zhang,Yining Wang,Tian Deng,Jiahui Peng,Xiaxin Ye,Xing Zeng,Jingjing Zhu,Linzhe Huang,Xiaoming Zheng,Yun Li,Yang Kang
Sepsis is a serious syndrome characterized by acute dysfunction of multiple organs, and there is a notable lack of effective preventive strategies and interventions. As a natural anti-inflammatory and antioxidant feedback regulator in the body, itaconic acid can precisely and synergistically modulate anti-inflammatory and antioxidant effects through various mechanisms, providing a metabolic regulation strategy for inflammatory diseases and diseases related to oxidative damage. Previous studies primarily utilized small molecule derivatives of itaconate, such as dimethyl itaconate (DMI) and itaconate 4-octyl ester. However, their in vivo stability and tissue targeting capabilities are often suboptimal, significantly reducing their anti-inflammatory and antioxidant efficacy in disease treatment. Poly itaconic acid (pIA) was synthesized through a one-step polymerization method, and pIA NPs were prepared using nanoprecipitation, effectively addressing the current challenges associated with itaconic acid delivery. Through comprehensive in vitro and in vivo evaluations, the nanoparticles have demonstrated good biocompatibility in the inflammatory microenvironment and can specifically release, thereby enhancing its targeting at the sites of inflammation. In contrast to dimethyl itaconate, pIA NPs exhibited enhanced anti-inflammatory and antioxidant properties, which more effectively safeguard against multi-organ dysfunction caused by sepsis and increase the survival rate in mice. Mechanistic investigations demonstrated that these therapeutic benefits mainly occurred through the facilitation of nuclear factor erythroid 2-related factor 2 nuclear translocation and the reprogramming of macrophages by pIA NPs. Furthermore, the preparation process of the nanoparticles are simple and cost-effective, providing a foundation for the clinical translational application of itaconic acid. Statement of significance This work innovatively developed a simple, safe esterase-responsive polymer delivery system for itaconic acid, solving defects of complex preparation, poor stability and targeting of conventional systems. It advanced sepsis therapy and macrophage metabolic regulation research. For journal readers, it links nanomedicine, immunometabolism and sepsis treatment, providing valuable insights for researchers in inflammatory diseases and drug delivery. Download: Download high-res image (236KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2026
·
IF 4.6
Ni Xiao-Qi,Xu Xiang-Yang,Zhu Yao-Feng,Wang Hui-Ya
The rapid advancement of communication technologies and wearable applications has increased the demand for high-performance flexible electromagnetic wave absorption materials. Conventional conductive fibers are often constrained by their poor wearability, weak interfacial stability, and limited absorption efficiency, which restrict their reliability and practical applicability in dynamic environments. Herein, a flexible and robust electromagnetic-absorbing fiber was successfully fabricated via wet spinning techniques, which integrates multi-walled carbon nanotubes (MWCNTs), polyaniline (PANI), and aramid nanofibers (ANFs). Polymerization of PANI on the MWCNTs surface is employed to optimize impedance matching and enhance interfacial compatibility, while ANFs serve as a continuous structural skeleton, improving the mechanical strength and spinnability. The resulting composite fibers exhibited a tensile strength of (202.0±8.0) MPa and an elongation at break of 13.6%±0.9%, stable electrical conductivity under mechanical deformation, and ultrasonic cleaning. Notably, the fiber architecture enables superior electromagnetic wave absorption, achieving a minimum reflection loss of −62.07 dB and an effective bandwidth of 3.24 GHz compared to the powder counterparts, owing to the extended propagation path and multiple scattering within the aligned fiber network. In addition, the composite fibers demonstrated self-extinguishing behavior during combustion, reflecting their inherent flame-retardant characteristics. This study provides a feasible strategy for developing flexible, high-performance electromagnetic wave (EMW)-absorbing fibers for next-generation protective textile materials.
✓ 已验证
产品关联
DOI
高影响因子
BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA
·
2026
·Vol. 40
·期 11
·2347-2359
·
IF 2.6
Haitao Yu,Aiguo Yuan,Jieqiong Zhou,Laxiang Yang
Antibiotic residues in water present significant ecological and public health challenges, necessitating the development of efficient advanced oxidation processes. The present study investigated a novel vacuum ultraviolet/ultraviolet/persulfate (VUV/UV/PS) process for degrading sulfamethazine (SMN), a representative sulfonamide antibiotic, in water. SMN degradation was assessed under UV, UV/PS, VUV/UV, and VUV/UV/PS conditions. All processes exhibited pseudo-first-order kinetics, with apparent rate constants of 0.12, 0.28, 0.25, and 0.52 min‒1, respectively. The VUV/UV/PS process achieved near-complete SMN removal (99.4%) within 10 min, surpassing the performance of UV/PS (94.4%) and VUV/UV (91.7%). Quenching by tert-butanol and methanol decreased the apparent rate constant to 0.31 and 0.16 min‒1, respectively, indicating the contributions of both hydroxyl radicals and sulfate radicals. The degradation rate increased with persulfate concentration but approached saturation above 5 mM. Higher initial SMN concentrations inhibited the reaction kinetics, while mildly acidic conditions enhanced degradation. Chloride and sulfate had minimal effects, whereas nitrate, bicarbonate, and particularly natural organic matter significantly inhibited degradation. Analysis of transformation products indicated three concurrent pathways: N–S bond cleavage, hydroxylation, and oxidation, followed by further oxidation of intermediates. These findings demonstrate the VUV/UV/PS process as a rapid and mechanistically robust approach for SMN removal in water treatment.
KEY WORDS: Sulfamethazine, Degradation, Vacuum ultraviolet, Persulfate, Radicals
Bull. Chem. Soc. Ethiop. 2026, 40(11), 2347-2359
DOI: https://dx.doi.org/10.4314/bcse.v40i11.5
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）