Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 22
·3576-3581
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IF 5.047
Xianqi Feng,Jun Xu,Yanxia Liu,Wenpeng Zhao
In this study, a novel and facile glucose detection system based on inverse opal hydrogels (IOHGs) was developed. Based on the intuitive structural colour, the gel sensors could be used for the detection of carbohydrates containing 1,2-cis-diol groups and diagnosis of diabetes without the assistance of sophisticated analysis instruments. Compared to the case of traditional opal sensors, the stable network structure of the IOHG samples endowed them with reusability for multiple times, which could suffer 10 cyclic detections without any reduction in sensitivity; possessing the combined advantages of high sensitivity, a stable network, and easy processing, IOHGs might open up a new avenue and propose a promising prospect in the detection and identification of diverse organic compounds.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 4
·1-8
·
IF 5.479
Mei He,Wang Xuedong,Zeng Tai,Huang Ling,Wang Qun,Ru Daoping,Huang Tongliang,Tian Falin,Wu Huimin,Gao Jimin
Gold nanobipyramids were synthesized by a seed-mediated growth method and then supported by multi-walled carbon nanotubes (denoted as AuNBP/MWCNTs). The electrocatalytic activity of the AuNBP/MWCNTs on a glassy carbon electrode (GCE) towards direct glucose oxidation and hydrogen peroxide reduction was superior to that of AuNBPs and MWCNTs. The modified GCE, operated at a typical working voltage of +0.15 V (vs. SCE) and in 0.1 M NaOH solution, exhibits a linear response in the 10 μM to 36.7 mM glucose concentration range with a 3.0 μM detection limit (at S/ N = 3) and a sensitivity of 101.2 μA mM −1 cm −2 . It also demonstrates good sensitivity towards hydrogen peroxide in at pH 7 solution at a working potential of −0.50 V (vs. SCE), with a linear response range from 5.0 μM to 47.3 mM, a sensitivity of 170.6 μA mM −1 cm −2 and a detection limit of 1.5 μM.
A electrochemical sensing platform based on the use of gold nanobipyramids and multi-walled carbon nanotubes nanocomposites (AuNBP/MWCNTs) is described for the determination of glucose and hydrogen peroxide.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Chuanjie Fang,Jian Sun,Bin Zhang,Yuchen Sun,Liping Zhu,Hideto Matsuyama
Developing nanofiltration (NF) membranes with highly efficient and precise separation ability is of great significance for the molecular and ionic separations. In this work, positively charged composite NF membranes were engineered via soaking of polysulfone (PSF) ultrafiltration membranes in poly( N -vinyl imidazole) (PVI) solutions followed by a quaternization crosslinking step. The PVI was firmly attached to the PSF membrane by this method and acted as an active separation layer of the composite NF membrane. The obtained composite NF membrane featured a high rejection (83%) to vitamin B 12 (molecular radius: 0.74 nm) but a low rejection (24.6%) to vitamin B 2 (molecular radius: 0.47 nm), exhibiting a great potential in precisely molecular separation. Furthermore, the ionic separation ability of the composite NF membrane was confirmed with a rejection order of Na 2 SO 4 < MgSO 4 < NaCl < MgCl 2 and the MgCl 2 rejection reached up to 90.1%. Compared to conventional polyamide NF membranes, the developed PVI/PSF composite NF membranes were characterized with high separation precision to organic molecules, higher rejection over cationic ions than over anionic ones, better chlorine resistance and stability in long-term operation. In addition, the membrane fabrication process is convenient and easily scaled up in industry. This work offers a novel alternative of NF membranes for high precision in molecular and ionic separations.
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ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Wenfang Deng,Yi Peng,Hui Yang,Yueming Tan,Ming Ma,Qingji Xie,Shaowei Chen
Detection of hydrogen peroxide is of great significance for clinical diagnosis and biomedical research. Ratiometric detection represents an effective method that is generally based on horseradish peroxidase. In the present study, ruthenium ion-complexed carbon nitride (Ru–C3N4) nanosheets are found to serve as a peroxidase mimic and can catalyze the conversion of o-phenylenediamine to fluorescent 2,3-diaminophenazine in the presence of H2O2. The produced 2,3-diaminophenazine also results in the apparent quenching of the Ru–C3N4 photoluminescence due to the inner filter effect. These unique characteristics can be exploited for the construction of an effective, peroxidase-free ratiometric fluorescence framework for the detection of H2O2 and glucose, which has also been used in the successful detection of glucose in human serum. Results from this study not only demonstrate a new peroxidase mimic but also provide a novel ratiometric fluorescence platform for the detection of H2O2 and metabolites involving reactions of H2O2 generation in the absence of horseradish peroxidase.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 8
·1-10
·
IF 5.479
Zhu Yanyan,Zhang Xuan,Sun Jiameng,Li Meng,Lin Yulong,Kang Kai,Meng Yang,Feng Zhongliang,Wang Jing
Ultrafine platinum nanoparticles are grown on a 3D graphene framework (GF–Pt) via a hydrothermal method. The material, when placed on a glassy carbon electrode (GCE), displays enhanced electrocatalytic activity towards glucose oxidation. This is assumed to be the result of the numerous easily accessible active sites, an enlarged electrochemically active area, and the presence of multiple electron/ion transport channels. The modified GCE can be operated at a low potential (− 0.15 V vs. Ag/AgCl) has linear responses in the 0.1 μM − 0.01 mM and 0.01 mM – 20 mM glucose concentration range, and a 30 nM detection limit. It was applied to the rapid determination of glucose in human serum samples.
Schematic presentation of a glassy carbon electrode modified with ultrafine Pt nanoparticles grown on a graphene framework (GFs–Pt). GFs–Pt presents enhanced electrocatalytic activity towards glucose oxidation. GFs–Pt is used in a sensitive non-enzymatic amperometric glucose sensor.
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MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING
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2019
·
IF 4.081
Xinghai Liu,Enzuo Liu,Jiajun Li,Chunnian He,Naiqin Zhao
The interface plays a vital role in determining the microstructure and mechanical properties of metal matrix composites . The interfacial reactant, aluminum carbide (Al 4 C 3 ), has a great influence on the mechanical properties of carbon nanomaterials reinforced aluminum matrix composites (C/Al). However, due to the relatively weak controllability of Al–C interfacial reaction by traditional ex-situ methods, there is a lack of comprehensive study on the evolution and strengthening effects of Al 4 C 3 so far. In this study, Al 4 C 3 nanophase was produced by an appropriate annealing treatment from 500 °C to 630 °C in in-situ synthesized carbon nanosheets/aluminum composites (CNS/Al). The evolution and strengthening effects of Al 4 C 3 was investigated comprehensively. It was found that the formation of Al 4 C 3 plays a vital role in reducing the interfacial thermal expansion and improving the Al–C interfacial wettability . Thereby, a robust interfacial bonding among CNS, Al 4 C 3 and Al forms, resulting in the improvement of tensile strength of the composites. The tensile strength of the 1.0 wt%-CNS/Al composite after 30 min annealing at 600 °C reaches 245 MPa, which is ~113% higher than pure Al. The 22.3% of elongation exhibits a favorable strength-ductility balance. The main strengthening mechanisms are the Orowan dislocation strengthening, load transfer and grain refinement. The evolution of CNS and Al 4 C 3 combined with their strengthening contributions were quantitatively investigated in detail.
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TALANTA
·
2019
·
IF 4.916
Yaxue Jia,Shucheng Sun,Xiujun Cui,Xiaohong Wang,Li Yang
We show that vanadomolybdophosphoric heteropoly acid (H 5 PMo 10 V 2 O 40 , PMoV 2 ), one of the polyoxometalates (POMs), presents peroxidase-like activity that can catalyze the luminol/H 2 O 2 reaction to generate chemiluminescence (CL) emission. Based on this foundation, we report an enzyme-free luminol/H 2 O 2 /PMoV 2 CL system that can be utilized for the ultrasensitive detection of H 2 O 2 . The CL intensity exhibits good linear dependence on H 2 O 2 concentration in a wide range up to 5000 nM with a limit-of-detection of 5 nM. The method was successfully used for the determination of glucose in human serum. Our study paves the way for the application of functional POM materials in a variety of biosensing assays, such as the determination of cholesterol, uric acid , lactate, etc., in which H 2 O 2 is a product of oxidoreductase enzymes.
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AGRONOMY JOURNAL
·
2019
·Vol. 111
·期 5
·2341-2349
·
IF 1.805
Jing Li,Yin Min Htwe,Yong Wang,Yaodong Yang,Yi Wu,Dongxia Li,Abdul Kareem,Rencai Wang
Haustorium absorbs energy from the endosperms (liquid and solid) and plays a key role in nutrient mobilization during coconut germination and seedling growth. This study was conducted to shed light on possible interactions between haustorium and endosperms during this process. Germination rates and morphological changes of coconut cultivars Hainan Tall (HT) and Red Dwarf (RD), as well as the profiles of sugars and fatty acids in endosperms and haustorium were also analyzed. Results showed that liquid and solid endosperm inside the coconut exhausts successively, while haustorium occupies the nut gradually. Haustorium had significant positive correlation with seedling, while it had significant negative correlation with liquid and solid endosperms. Sugars in liquid endosperm continuously decreased, whereas in solid endosperm and haustorium accumulated at early stages and decreased later along with the aggressive seedling growth. Fatty acids in solid endosperm shared a very similar trend with sugars. In conclusion, haustorium development and seedling growth mainly depend on the nutrients stored in the liquid endosperm at early stages and then depend on the solid endosperm, in which fatty acids degrade rapidly to sugar so as to provide enough energy. These findings could be applicable in coconut germination and seedling propagation. Core Ideas Relative cool season (25–29°C) is more suitable for coconut germination and local variety (HT) is more adaptable. Development mainly depends on stored nutrients in liquid endosperm at early stages and then on solid endosperm. Fatty acids in solid endosperm degrade rapidly to sugars since liquid endosperm almost exhausted. Conversion of fatty acids to sugars helps provide enough energy for rapidly growing haustorium and seedling.
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TALANTA
·
2019
·
IF 4.916
Fei Qu,Qianqian Yang,Bingjie Wang,Jinmao You
Recently, the aggregation-induced emission (AIE) of nanoclusters triggered by metal ions has been received great attentions. However, the good AIE efficiency usually requires excessive metal ions, which may result in an undesired competition between metal ions and targets. In this work, by the synergistic effect of Pb 2+ and Zr 4+ , a fewer amounts of metal ions can induce more aggregates of glutathione-capped Cu nanoclusters (CSH-CuNCs), resulting in a higher AIE efficiency. Next, by virtue of the oxidative property of H 2 O 2 , the AIE of GSH-CuNCs-Pb 2+ -Zr 4+ system quenches linearly with the concentration of H 2 O 2 from 1 to 60 μmol/L. Moreover, many biological substrates, such as glucose and cholesterol, can generate H 2 O 2 in the presence of their specific oxidases and O 2 . Therefore, the detection of glucose or cholesterol can also be achieved by the proposed method, and the limits of detection of glucose and cholesterol are 0.37 and 2.7 μmol/L, respectively. Finally, this method has been validated to be sensitive and selective for glucose or cholesterol detection in human serum samples.
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APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Li Zhang,Xiaodan Li,Yunyu Jin,Youlin Zhang,Xiaomin Liu,Yulei Chang,Lijun Xu,Huiying Zhao,Langping Tu,Dan Wang,Xianggui Kong,Bin Xue
The advances in surface-enhanced Raman scattering (SERS) have resulted in significant improvements for sensing glucose, achieving a highly detecting sensitivity of the order of μM. Highly sensitive glucose detection, however, is still a challenge due to extremely small Raman scattering cross section of glucose molecules and weak interaction between the molecules and the metal nanoparticles . Here, we designed a novel homogeneous SERS-based nanoplatform composing of the SERS tags and glucose oxidase in aqueous solution for a highly sensitive glucose detection. Adding glucose caused enzymatic oxidation reaction to etch the tip electric field ( E ) of silver nanotriangle. Thus, the decreased intensity of E was greatly amplified by the change of SERS signal ( E 4 dependent), which resulted in an excellent glucose detection limit of 0.4 nM was firstly achieved. Furthermore, the nonlinear relationship between the decreased SERS intensity and the glucose concentrations was reasonably revealed based on theoretical calculations and deeply understanding of the enhancement mechanism, which is very useful in improving the sensitivity and accuracy of trace glucose detection. The as-prepared nanoplatform showed good sensitivity and high selectivity only through observing the SERS intensity change, which is potential for highly sensitive and practical glucose detection for clinical trace analyses.
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AAPS PHARMSCITECH
·
2017
·Vol. 19
·期 2
·541-550
·
IF 2.451
Liu Daichun,Galvanin Federico,Yu Ying
The purpose of this study was to prepare ginkgolide B (GB) lyophilized powder for injection with excellent appearance and stable quality through a formulation screening and by optimizing the freeze-drying process. Cremophor EL as a solubilizer, PEG 400 as a latent solvent, and mannitol as an excipient were mixed to increase the solubility of GB in water to more than 18 times (about from 2.5 × 10 −4 mol/L (0.106 mg/mL) to 1.914 mg/mL). Formulation screening was conducted by orthogonal design where the content of GB in the solution before lyophilization (using external standard method of HPLC) and reconstitution time after lyophilization were the two evaluation indexes. The optimized formulations were GB in an amount of 2 mg/mL, Cremophor EL in an amount of 16% ( v / v ), PEG 400 in an amount of 9% ( v / v ), mannitol in an amount of 8% ( w / v ), and the solution pH of 6.5. Through four single-factor experiments (GB adding order, preparation temperature of GB solution, adding amount, and adsorption time of activated carbon), the preparation process of GB solution was confirmed. The glass transition temperature of maximally GB freeze-concentrated solution was − 17.6°C through the electric resistance method. GB lyophilized powder began to collapse at − 14.0°C, and the fully collapsed temperature was − 13.0°C, which were determined by freeze-drying microscope. When the collapse temperature was determined, the primary drying temperature was obtained. Thereby, the freeze-drying curve of GB lyophilized powder was initially identified. The freeze-drying process was optimized by orthogonal design, the qualified product appearance and residual moisture content were the two evaluation indexes. The optimized process parameters and process were (1) shelf temperature, decreased from room temperature to − 45.0°C, at 0.5°C/min in 2 h; (2) shelf temperature increased from − 45.0 to − 25.0°C, at 0.1°C/min, maintained for 3 h, and the chamber pressure was held at 10 Pa; (3) shelf temperature was increased from − 25.0 to − 15.0°C at 0.1 °C/min, maintained for 4 h, and the chamber pressure was held at 10 Pa; and (4) shelf temperature was increased from − 15.0 to 20.0°C at 1.0 °C/min, maintained for 4 h, and the chamber pressure was raised up to 80 Pa. In these lyophilization process conditions, the products complied with relevant provisions of the lyophilized powders for injection. Meanwhile, the reproducibility was satisfactory. Post-freezing annealing had no significantly beneficial effects on shortening the freeze-drying cycle and improving the quality of GB lyophilized powder.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2017
·
IF 9.446
Lingyun Jiang,Lipeng Zhou,Jinyu Chao,Huiting Zhao,Tianliang Lu,Yunlai Su,Xiaomei Yang,Jie Xu
Conversion of biomass derived carbohydrates to alkyl levulinates is an important process due to the wide application of alkyl levulinates as chemicals and biofuel additives. Efficient conversion of cheap and abundant glucose to alkyl levulinates over easily separated and regenerated solid catalyst is highly desirable. Here, the transformation of glucose to methyl levulinate (MLE) was studied over dual solid acid catalysts. The synergistic effect of solid Brønsted (B) acid and solid Lewis (L) acid was observed. A combined catalyst system consisting of both B acid and L acid was found to be more efficient for the production of MLE from glucose. 62% yield of MLE was given over the combined catalyst of SO 4 2− /ZrO 2 and Sn-Beta prepared by postsynthesis method at 170 °C for 24 h. The roles of L acid sites of SO 4 2− /ZrO 2 and Sn-Beta, and B acid sites of SO 4 2− /ZrO 2 were discussed in detail. Alternative biomass-derived carbohydrates also gave moderate to good yields of MLE. Recyclability studies indicated that the combined catalyst system can be reused without significant change in the yield of MLE, proving its easy recovery and thermal stability during regeneration.
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