BIOORGANIC CHEMISTRY
·
2024
·
IF 4.5
Ting Wang,Xiufeng Liao,Xiaodi Zhao,Kai Chen,Yangzhonghui Chen,Hui Wen,Dali Yin,Yuchen Wang,Bin Lin,Sen Zhang,Huaqing Cui
Mimicking the transition state of tryptophan (Trp) and O 2 in the enzymatic reaction is an effective approach to design indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors. In this study, we firstly assembled a small library of 2-substituted benzo-fused five membered heterocycles and found 2-sulfinyl-benzoxazoles with interesting IDO1 inhibitory activities. Next the inhibitory activity toward IDO1 was gradually improved. Several benzoxazoles showed potent IDO1 inhibitory activity with IC 50 of 82–91 nM, and exhibited selectivity between IDO1 and tryptophan 2, 3-dioxygenase (TDO2). Enzyme binding studies showed that benzoxazoles are reversible type II IDO1 inhibitors, and modeling studies suggested that the oxygen atom of the sulfoxide in benzoxazoles interacts with the iron atom of the heme group, which mimics the transition state of Fe-O-O-Trp complex. Especially, 10b can effectively inhibit the NO production in lipopolysaccharides (LPS) stimulated RAW264.7 cells, and it also shows good anti-inflammation effect on mice acute inflammation model of croton oil induced ear edema.
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高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2021
·
IF 4.464
Zhipeng Li,Shuo Wu,Guizheng Zou
Discriminating the electrochemiluminescence (ECL) of differed luminophores is crucial for ECL multiplexing. However, because of the limited potential window for ECL assay and the overlapped triggering-potential-range between different luminophores, the potential-resolved ECL multiplexing with good resolutions ( R s ) is still a great challenge. Herein, a single anodic ECL from two luminophores in the aqueous solution was discriminated completely (baseline separation, R s ≥ 1.5) in a potential-resolved way with the water-soluble CuInS 2 @ZnS ( [email protected] ) nanocrystals (NCs) and [Ru(bpy) 2 (dcbpy)] 2+ as luminophores and N 2 H 4 as the co-reactant. N 2 H 4 could be electrochemically oxidized to reducing radicals and then reacted with the electrochemically oxidized [email protected] NCs and [Ru(bpy) 2 (dcbpy)] 2+ in sequence to produce co-reactant ECL. The potential-resolved ECL of [email protected] NCs/N 2 H 4 and [Ru(bpy) 2 (dcbpy)] 2+ /N 2 H 4 could be well defined and distinguished from each other upon potential scanning ( R s = 2.60) and utilized for simultaneously determining human prostate specific antigen and carcinoma antigen 125 at the pathological cut-off concentration ( R s = 1.56).
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POLYMER TESTING
·
2020
·
IF 3.275
Zhipeng He,Huichao Liu,Guang Yang,Chi Jiang,Muwei Ji,Jiali Yu,Mingliang Wang,Caizhen Zhu,Jian Xu
Cyclization reaction of poly(acrylonitrile-co-2-acrylamido-2-methylpropane sulfonic acid) [P(AN-co-AMPS)] copolymer during thermal oxidative stabilization (TOS) process was investigated by FTIR and two dimensional (2D) correlation analysis technique. The results showed the mechanism of cyclization reaction at different temperatures were varying. At 200 °C, the cyclization reactions generated by autocatalytic cyclization mechanism. While at higher temperatures, the cyclization reactions took place through ionic cyclization mechanism and free radical cyclization mechanism. The AMPS comonomer could reduce the heat release of cyclization reactions and improve the stability at 200 and 230 °C. At higher temperatures, the cyclization reactions were facilitated rapidly. However, the oxidation and degradation reactions were also intense, which will cause the molecular chain to break and defects in the final carbon fibers (CFs). This research has theoretical guiding significance for the optimization of heat treatment conditions for PAN copolymers used as CFs.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Liyan Wei,Biao Zhou,Ke Xiao,Bo Yang,Gang Yu,Juying Li,Caizhen Zhu,Junmin Zhang,Huabo Duan
2,2′,4,4′-tetrabromodiphenyl ether (BDE47) was difficult to be rapidly degraded by common reductive debromination or oxidative decomposition. In this study, the debromination via surfactant-assisted zero valent zinc (Zn 0 ) reduction and subsequent Fenton oxidation was combined to completely degrade BDE47. Firstly, Zn 0 integrated with surfactants including cetyltrimethylammonium chloride (CTAC), polyethylene glycol dodecyl ether (Brij35), or 1-dodecanesulfonic acid sodium salt (SDS) were evaluated for their reactivity to debrominate BDE47. CTAC-assisted Zn 0 system presented the highest removal efficiency of 98.6% for BDE47 ( C 0 = 5 mg/L) under the optimized conditions including 0.3 g/L of Zn 0 particles and 0.05 g/L of CTAC at 25 °C and pH 4.0 during 1-h reaction. Subsequently, the debromination products as low-brominated BDEs were attacked by hydroxyl radicals (•OH) from Fenton reagent, which were decomposed into short-chain carboxylic acids and even mineralized within 2-h oxidation. In addition, HPLC, GC–MS, LC–MS/MS, and IC were employed to detect intermediates during this reaction/oxidation process and the pathways of debromination and oxidation were proposed according to carbon and bromine balance. The above combination achieved the complete degradation of BDE47 via a relative low-cost method to rapidly remove PBDEs, which provide a new approach for the effective treatment of halogenated organic pollutants.
研究领域:
环境科学
·
化学工程
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高影响因子
Membranes
·
2025
·Vol. 15
·期 2
·54
·
IF 3.6
Yin Yang,Juan Liu,Qi Zhou,Siqi Shao,Lingling Zou,Wenjun Yuan,Meihua Zhu,Xiangshu Chen,Hidetoshi Kita
Silicalite-2 membranes were successfully prepared on tubular α-Al2O3supports by secondary hydrothermal synthesis, and the pervaporation performance of the membrane was evaluated by separation of a 5 wt% ethanol/H2O mixture at 60 °C. The effects of templating agent content, water–silicon ratio and crystallization time on the separation performance of Silicalite-2 membranes were investigated. When the TBAOH/SiO2and H2O/SiO2molar ratios of the precursor synthesis solution were 0.2 and 120, a dense Silicalite-2 membrane could be prepared on the surface of the tubular α-Al2O3support after 72 h. The silane coupling agent was utilized to treat the Silicalite-2 membranes, and the effects of silane coupling agent dosage on their properties were also explored. The pervaporation performance of the Silicalite-2 membrane was greatly improved with a 5.7 wt% trimethylchlorosilane (TMCS) solution and the flux and separation factor of the membrane reached 1.75 kg·m−2·h−1and 22 for separation of 5 wt% EtOH/H2O at 60 °C, respectively.
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Frontiers in Chemistry
·
2020
·
IF 3.693
Xue Qi,Bi Fu-qiang,Zhang Jun-lin,Wang Zi-jun,Zhai Lian-jie,Huo Huan,Wang Bo-zhou,Zhang Sheng-yong
Design and synthesis of new compounds with both high detonation performances and good safety properties have always been a formidable task in the field of energetic materials. By introducing -ONO2 and -NHNO2 moieties into 1,2,4-oxadiazole- and 1,2,5-oxadiazole-based backbones, a new family of energetic materials, including ammonium 3-nitramino-4-(5-hydroxymethyl-1,2,4-oxadiazol-3-yl)-furazan (4), 3,3′-bis[5-nitroxymethyl-1,2,4-oxadiazol-3-yl]-4,4′-azofuroxan (6), [3-(4-nitroamino-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazol-5-yl]-methylene nitrate (8), and its energetic ionic salts (10–12), were synthesized and fully characterized. The energetic and physical properties of the materials were investigated through theoretical calculations and experimental determination. The results show that the oxadiazole-based compounds exhibit high enthalpy of formations, good detonation performances, and extraordinary insensitivities. In particular, the hydrazinium salt (11) shows the best energetic properties (11: d = 1.821 g cm−3; P = 35.1 GPa, vD = 8,822 m s−1, IS = 40 J, FS > 360N). The ESP and Hirshfeld surface analysis indicated that a large number of hydrogen bonds as well as π-π stacking interactions within molecules might be the key reason for their low sensitivities and high energy-density levels.
研究领域:
化学
·
材料科学
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高影响因子
MOLECULAR CARCINOGENESIS
·
2024
·
IF 3
Beibei Wang,Xin Fan,Lingang Wang,Xiaosong Wei
Sorbin and SH3 domain-containing 2 (SORBS2) is an RNA-binding protein and has been implicated in the development of some cancers. However, its role in bladder cancer (BC) is yet to be established. The expression of SORBS2 in BC tissues was determined from the Gene Expression Omnibus and Gene Expression Profiling Interactive Analysis databases and collected paired tumor/normal samples. The effects of SORBS2 on BC cells were detected by CCK-8, colony formation, Transwell, dual-luciferase, RNA immunoprecipitation, chromatin immunoprecipitation, and DNA pull-down assays. In vivo, BC cell growth and metastasis were studied by a xenograft subcutaneous model and a tail-vein metastasis model. The results showed that SORBS2 expression was significantly decreased in BC tissues and cells. SORBS2 overexpression inhibited cell proliferation, migration, invasion, and epithelial–mesenchymal transition in vitro and tumor growth and metastasis in vivo, while silencing SORBS2 produced the opposite effect. Mechanistically, we found that SORBS2 enhanced the stability of tissue factor pathway inhibitor (TFPI) mRNA via direct binding to its 3′ UTR. Restoration of TFPI expression reversed SORBS2 knockdown-induced malignant phenotypes of BC cells. In addition, SORBS2 expression was negatively regulated by the transcription factor specificity protein 1 (SP1). Conversely, SORBS2 can be transcriptionally regulated by SP1 and inhibit BC cell growth and metastasis via stabilization of TFPI mRNA, indicating SORBS2 may be a promising therapeutic target for BC.
研究领域:
肿瘤学
·
分子生物学
·
癌症研究
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高影响因子
RARE METALS
·
2020
·Vol. 39
·期 12
·1473-1482
·
IF 2.161
Feng Shao-Ping,Huang Kun
Abstract Separation of palladium (Pd) and platinum (Pt) by solvent extraction is difficult because of their extremely similar physicochemical properties. Development of new extractants with a high extraction efficiency and excellent separation selectivity is the primary focus for enhancing the separation of Pd and Pt by solvent extraction. In this study, a new extractant, 2-((2-methoxyethyl)thio)-1H-benzimidazole (MOBI), which contains N, S, and O atoms, was synthesized and used to separate Pd(II) and Pt(IV) from a hydrochloric acid aqueous solution. The experimental results revealed that Pd(II) and Pt(IV) were effectively separated under the optimal conditions: MOBI concentration of 0.005 mol·L −1 , HCl concentration of 0.2 mol·L −1 , organic/aqueous (O/A) phase ratio of 1.0, and contact time of 15 min. The separation coefficient between Pd(II) and Pt(IV) was 1246.40, which indicates that MOBI has a higher selectivity for Pd(II) than Pt(IV). In addition, the mechanism of coordination between Pd(II) and MOBI was demonstrated through the slope method, Fourier transform infrared spectroscopy (FTIR), hydrogen-1 nuclear magnetic resonance spectroscopy ( 1 H NMR), and carbon-13 nuclear magnetic resonance spectroscopy ( 13 C NMR). The results revealed that MOBI could coordinate with Pd(II) via the N atom in the benzimidazole ring of MOBI molecules to form [Pd(MOBI) 2 Cl 2 ] (O) . Graphic abstract
研究领域:
化学
·
材料科学
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JOURNAL OF FLUORESCENCE
·
2016
·Vol. 27
·期 2
·701-714
·
IF 1.601
Gan Qian,Qi Yongyu,Xiong Yahong,Fu Yinlian,Le Xueyi
Two new mononuclear mixed ligand copper(II) complexes [Cu(PBO)(Gly-gly)(H 2 O)]·ClO 4 ·1.5H 2 O ( 1 ) and [Cu(PBO)(Gly- L -leu)(H 2 O)]·ClO 4 ( 2 ) (PBO is 2-(2′-pyridyl)benzoxazole, Gly-gly and Gly- L -leu are Glycyl-glycine anion and Glycyl- L -leucine anion, respectively), have been prepared and characterized by various analytical and spectral techniques. The interactions of the complexes with DNA were investigated using multi-spectroscopic methods (absorption, emission, circular dichroism), viscometry and electrochemical titration as well as molecular docking technique. The results indicated that 1 and 2 are bound to calf thymus DNA (CT-DNA) through an intercalative mode. The thermodynamic analyses revealed that the reactions between the Cu(II) complexes with DNA are spontaneous with negative Gibbs free energy (Δ G ). The positive changes of enthalpy (Δ H ) and entropy (Δ S ) suggested that the binding processes are dominated by hydrophobic interaction accompanying with endothermic. Also, the complexes exhibited efficient oxidative cleavage of pBR322 plasmid DNA in the presence of ascorbic acid, probably induced by •OH as reactive oxygen species. In addition, 1 and 2 displayed excellent antioxidant activities with the IC 50 values of 0.112 and 0.191 μM, respectively, using the mean of nitroblue tetrazolium (NBT) photochemical reduction under a nonenzymatic condition. Moreover, the complexes were screened for their in vitro cytotoxicity against three human carcinoma cell lines (HeLa, PC-3 and A549), in which 2 owns higher cytotoxicity, which was consistent with DNA binding and cleavage ability order of the complexes. This results showed the in vitro biochemical potentials of the Cu(II)-dipeptide complexes with aromatic heterocyclic, viz. effective metallopeptide-nucleases, SOD mimics and non-platinum chemotherapeutic metallopharmaceuticals and their structure-activity relationship, which may contribute to the rational molecular design of new metallopeptide based chemotherapeutic agents.
研究领域:
生物化学
·
药理学
·
分子生物学
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高影响因子
JOURNAL OF FLUORESCENCE
·
2008
·Vol. 19
·期 3
·487-493
·
IF 2.101
Ma Shuhui,Mu Wei,Gao Jigang,Zhou Jie
A novel spectrofluorometric method, using 2-(2-pyridyliminomethyl)phenol as a fluorescent probe, was developed for the determination of superoxide anion radical (O 2
•− ) and superoxide dismutase activity (SOD). The new fluorescent probe was synthesized and characterized with elemental analysis and IR spectra. It was oxidized by O 2
•− to form a less fluorescence product. Based on this reaction, a spectrofluorometric method was proposed and successfully used to determine superoxide anion radicals and SOD activity. The effects of interferences were studied. The reaction was simple, precise and sensitive. It was applied to determine SOD activity in garlic, papaya and spinach successfully.
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高影响因子
INORGANIC CHEMISTRY
·
2026
·
IF 4.6
Qunhua Zhong,Yimeng Zhou,Tianle Ren,Jianjun Zhu,Di Li,Deli Jiang
Abstract Photocatalytic CO2 reduction to carbonaceous fuels is a promising strategy to mitigate massive carbon emissions, yet the highly selective CO2 conversion remains challenging due to the unsatisfactory charge separation and limited active sites of pristine semiconductor photocatalysts. Herein, we report the in situ fabrication of oxygen vacancy rich W/H co-doped rutile TiO2 (W/H-TiO2) via a two-step wet chemical approach for high-efficiency photocatalytic CO2 reduction to CO. The optimized W/H-TiO2 exhibited high activity and selectivity for the photocatalytic reduction of CO2 to CO (57.96 μmol g–1 h–1 and 96.3%), which were significantly higher than those of other TiO2 counterparts. Experimental characterizations and density functional theory (DFT) calculations reveal that the synergistic effect of H/W co-doping accelerates the migration and separation of photogenerated charge carriers and reduces the formation energy barrier for the key *COOH intermediate, thereby markedly boosting the CO2 photoreduction activity and product selectivity of W/H-TiO2. This work establishes a dual-doping-induced oxygen vacancy strategy for electronic structure engineering, providing a new paradigm for the rational design of high-performance TiO2 based photocatalysts toward efficient CO2 photoreduction.
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CHEMISTRY & BIODIVERSITY
·
2026
·Vol. 23
·期 10
·e71800
·
IF 2.9
Qian Luo,Yu Yang,Rui Xu,Xue Zhao,Hui‐Fang Tan,Yu‐Ying Wei,Er‐Wei Li,Li‐Xia Chen,You‐Zhi Zhang,Chang‐Wei Li
Two new 3,4‐ seco ‐ergostane‐type steroidal saponins ( 1 and 2 ) were isolated from the fermentation products of the fungus Xylaria necrophora SZSS1‐2‐2, together with four known compounds: 2‐hexylidene‐3‐methylsuccinic acid ( 3 ), xylcarpin C ( 4 ), (24 R )‐22,23‐dihydroxy‐ergosta‐4,6,8(14)‐trien‐3‐one 23‐ β ‐D‐glucopyranoside ( 5 ), and 5‐carboxymellein ( 6 ). The structures and absolute configurations of the new compounds were elucidated by comprehensive spectroscopic analyses, electronic circular dichroism (ECD), and GIAO 1 3 C NMR computational methods, and chemical hydrolysis followed by derivatization to determine the D‑mannose configuration of the sugar moiety. All isolated compounds ( 1–6 ) were evaluated for their biological activities. Only compound 5 showed selective inhibitory activity, inhibiting BV2 microglial cells with an IC 50 value of 17.10 ± 4.18 µM. Additionally, none of the compounds exhibited antimicrobial activity against the tested microorganisms. Two new 3,4‐seco‐ergostane saponins ( 1 – 2 ) and four known compounds were isolated from Xylaria necrophora . Structures were elucidated via spectroscopy, ECD, and computational NMR. Compound 5 selectively inhibited BV2 microglial cells (IC 5 0 = 17.10 µM), while all compounds showed no antimicrobial activity against tested microorganisms.
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