RSC Advances
·
2014
·Vol. 4
·期 32
·16612-16617
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IF 3.708
Keli Zhong,Xue Zhou,Ruibin Hou,Pei Zhou,Shuhua Hou,Yanjiang Bian,Gang Zhang,Lijun Tang,Xiaohong Shang
A water-soluble fluorescent sensor (L) based on 2-(2-(8-hydroxyquinolin)-yl)benzimidazole has been synthesized and characterized. Sensor L displays highly selective and sensitive recognition of Hg2+ with a fluorescence “ON–OFF” response in buffered aqueous solution (1% dimethyl sulfoxide (DMSO), Tris–HCl 10 mM, pH = 7.4). X-ray crystal structure of the L–Hg2+ complex reveals that the oxygen and nitrogen atoms of 8-hydroxyquinoline and the imine N atom of the benzimidazole unit (N1) bind Hg2+ through a 1 : 1 binding stoichiometry. The fluorescence quenching mechanism is qualitatively evaluated by quantum chemical calculations which show that the fluorescence quenching phenomenon is caused by ligand-to-metal charge transfer (LMCT) in the excited state.
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Food Analytical Methods
·
2017
·Vol. 10
·期 10
·3434-3442
·
IF 2.038
Hu Kai,Deng Zhifen,Li Sui,Wu Mingxia,Liu Wei,Zhang Shusheng
In this study, bis(tetraoxacalix[2]arene[2]triazine) modified silica gel was successfully prepared and used as an efficient sorbent for solid-phase extraction. Coupled with ultra-high pressure liquid chromatography (UHPLC), the extraction performance of the sorbent was evaluated by using three flavonoids as model analytes. Main parameters, which affecting extraction efficiency were carefully optimized. The results showed that multiple intermolecular interactions were involved in the sample pretreatment procedure, including π–π, hydrophobic and hydrogen bonding interactions. Under the optimal conditions, the proposed method was applied for the analysis of three flavonoids in grape juice. Satisfactory linear ranges for flavonoids were obtained in the range of 5–200 ng mL −1 for quercetin, 1–200 ng mL −1 for luteolin, and 2–200 ng mL −1 for kaempferol, with good correlation coefficients (>0.9996). Limits of detection (LODs) were in the range of 0.5–2 ng mL −1 , and the LOQs were between 1 and 5 ng mL −1 . The recovery values of spiked grape juice ranged from 97 to 106% with relative standard deviations (RSDs) less than 4.7% ( n = 3). This method exhibited the advantages of simplicity, rapidity, and low solvent consumption, and was promising for the separation and determination of flavonoids in grape juice and other matrixes.
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JOURNAL OF APPLIED MICROBIOLOGY
·
2025
·Vol. 136
·期 11
·
IF 3.2
Ling Lijun,Zhang Wenyue,Mo Rongxiu,Kong Fanjin,Jiang Yijuan,Feng Lijun,Li Yao,Yue Rui,Zhou Yongpeng
AimsLanzhou lily (Lilium davidli var. unicolor) possesses both nutritional and medicinal value, however, its bulbs are highly susceptible to postharvest physical damage. Pathogenic bacteria readily infiltrate through these wounds, resulting in extensive decay and consequent economic losses. This study demonstrates that optimized volatile organic compound (VOC) combinations can significantly reduce effective antimicrobial concentrations and broaden the antimicrobial spectrum through synergistic effects, while exhibiting excellent preservation potential.Methods and ResultsFrom decayed lily bulbs, this study isolated and identified two bacterial strains, Bacillus cabrialesii SH-3 and Bacillus amyloliquefaciens SH-5, both exhibiting opportunistic pathogenicity. Fifteen binary VOC combinations were evaluated using fractional inhibitory concentration index (FICI), identifying QM (1/8 MIC 2-methylbutyric acid + 1/8 MIC 3- methylpentanoic acid, FICI = 0.25) and QH (1/2 3-methylpentanoic acid + 1/8 3-hepten-2-one, FICI = 0.625) as optimal formulations. Mechanistic studies revealed these combinations disrupt bacterial membrane integrity, induce protein/nucleic acid leakage, and trigger oxidative stress and metabolic dysfunction.ConclusionsAgainst SH-3, only QM showed synergistic effects, reducing required concentrations by 87.5% compared to individual minimum inhibitory concentration (MIC). For SH-5, all combinations demonstrated additive effects, with QH achieving potent inhibition at 50% and 87.5% reduced concentrations for respective components. Applied at MIC levels, both formulations significantly suppressed postharvest decay while maintaining bulb quality.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2022
·
IF 3.119
Guang Yang,Shaoming Fang,Jianqiang Zhang,Ruijuan Wang,Ruixue Liu,Renjie Xu,Chunjuan Huang
The solubility of 2-amino-3-chloropyrazine (ACPY) in some binary cosolvent mixtures of (methanol, isopropyl alcohol, ethylene glycol (EG), N,N-dimethylformamide (DMF)) plus water and the experimental solubility of 2-amino-3,5-dibromopyrazine (ADPY) in (ethanol + water), (isopropyl alcohol + water), (EG + water), and (PG + water) were all determined by the isothermal saturation method from 278.15 K to 323.15 K at 101.2 kPa. The trend of the system temperature and the change of the solvent partner are both factors that affect the dissolution. As the temperature goes higher, the amount of dissolution follows, but the higher is the water content of the solvent, the less solute will be dissolved. The combination of DMF and water is best for the dissolution of ACPY, and the addition of ethanol to water shows an advantage of dissolving ADPY over other combinations. The experimentally obtained dissolution data were then calculated by using three models for the two miscible solvent systems. For ADPY, RAD and RMSD maximums were 2.63 × 10–2 and 2.10 × 10–5. For ACPY, RAD and RMSD were no greater than 6.55 × 10–2 and 6.83 × 10–4.
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Gels
·
2022
·Vol. 8
·期 5
·322
·
IF 4.432
Zhichuan Tang,Zhengsong Qiu,Hanyi Zhong,Hui Mao,Kai Shan,Yujie Kang
Filtration loss control under high-temperature conditions is a worldwide issue among water-based drilling fluids (WBDFs). A core–shell high-temperature filter reducer (PAASM-CaCO3) that combines organic macromolecules with inorganic nanomaterials was developed by combining acrylamide (AM), 2-acrylamide-2-methylpropane sulfonic acid (AMPS), styrene (St), and maleic anhydride (MA) as monomers and nano-calcium carbonate (NCC). The molecular structure of PAASM-CaCO3was characterized. The average molecular weight of the organic part was 6.98 × 105and the thermal decomposition temperature was about 300 °C. PAASM-CaCO3had a better high-temperature resistance. The rheological properties and filtration performance of drilling fluids treated with PAASM-CaCO3were stable before and after aging at 200 °C/16 h, and the effect of filtration control was better than that of commonly used filter reducers. PAASM-CaCO3improved colloidal stability and mud cake quality at high temperatures.Keywords:filtration reducer;high temperature;water-based drilling fluid;nanomaterials;calcium carbonate
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Shuyang Dong,Liang Li,Yajun Wu,Xueli Huang,Xuefeng Wang
Polymer gels can be effectively applied to plug fractured reservoirs and carbonate cave strata. Herein, polyvinyl alcohol (PVA), acrylamide, and 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) were used as raw materials to prepare interpenetrating three-dimensional network polymer gels using formation saltwater in the Tahe oilfield (Tarim Basin, NW China) as a solvent. The effect of AMPS concentration on the gelation properties of PVA in high-temperature formation saltwater was analyzed. Further, the effect of PVA concentration on the strength and viscoelastic properties of polymer gel was studied. The polymer gel could retain stable continuous entanglement at 130 °C and exhibited satisfactory thermal stability. Continuous step oscillation frequency tests showed that it exhibited an excellent self-healing performance. Scanning electron microscopy images of the simulated core by gel plugging showed that the polymer gel could firmly fill the porous media, indicating that the polymer gel exhibits excellent application prospects in oil and gas reservoirs under high-temperature and high-salinity conditions.
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JOURNAL OF MEDICINAL CHEMISTRY
·
2021
·
IF 7.446
Zhipeng Chen,Lina Zhang,Junjie Yang,Lu Zheng,Fanjie Hu,Siqin Duan,Kutty Selva Nandakumar,Shuwen Liu,Hang Yin,Kui Cheng
The previous virtual screening of ten million compounds yielded two novel nonlipopeptide-like chemotypes as TLR2 agonists. Herein, we present the chemical optimization of our initial hit, 1-phenyl-3-(thiophen-2-yl)urea, which resulted in the identification of SMU-C80 (EC50 = 31.02 ± 1.01 nM) as a TLR2-specific agonist with a 370-fold improvement in bioactivity. Mechanistic studies revealed that SMU-C80, through TLR1/2, recruits the adaptor protein MyD88 and triggers the NF-κB pathway to release cytokines such as TNF-α and IL-1β from human, but not murine, cells. To the best of our knowledge, it is the first species-specific TLR1/2 agonist reported until now. Moreover, SMU-C80 increased the percentage of T, B, and NK cells ex vivo and activated the immune cells, which suppressed cancer cell growth in vitro. In summary, we obtained a highly efficient and specific human TLR1/2 agonist that acts through the MyD88 and NF-κB pathway, facilitating cytokine release and the simultaneous activation of immune cells that in turn affects the apoptosis of cancer cells.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2021
·
IF 2.694
Huan Ye,Ying Yu,Sile Shi,Chi Cai,Haoran Liu,Weiping Luo
In this study, the solid–liquid equilibrium (SLE) data of 3-methyl-2-nitrobenzoic acid (3-M-2-NBA), 3-methyl-4-nitrobenzoic acid (3-M-4-NBA), and 5-methyl-2-nitrobenzoic acid (5-M-2-NBA) in n-butanol, iso-butanol, tert-butanol, and sec-butanol were determined using the method of dynamic laser at atmospheric pressure. The experimental SLE data indicate that within the temperature range studied (290.15–348.95 K), the solubilities of 3-M-2-NBA, 3-M-4-NBA, and 5-M-2-NBA in the above four solvents are proportional to the temperature. The molar fraction of solubility of the same solute in different solvents from low to high is as follows: iso-butanol < n-butanol< sec-butanol < tert-butanol. The molar fraction of solubility of the three solutes in the same solvent from low to high is as follows: 3-M-4-NBA < 3-M-2-NBA<5-M-2-NBA. The experimental data were correlated using the Apelblat model, λh model, and NRTL activity coefficient model, and the calculated solubilities agree satisfactorily with the measured results. The best model for every system was selected using the result of Akaike information criterion analysis.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2018
·
IF 4.816
Yong-Yu Qi,Qian Gan,Ya-Xian Liu,Ya-Hong Xiong,Zong-Wan Mao,Xue-Yi Le
In the search for more effective anticancer drugs with less toxic side effects, dipeptides were introduced into the Cu(II) complex of 5-methyl-2-(2′-pyridyl)benzimidazole (HPBM). Analytical and spectroscopic techniques were employed to thoroughly characterize complexes [Cu(Gly-gly)(HPBM)(H 2 O)]ClO 4 ·0.5H 2 O ( 1 ) and [Cu(Gly- L -leu)(HPBM)(H 2 O)]ClO 4 ( 2 ) (where Gly-gly = Glycyl-glycine anion, Gly- L -leu = Glycyl- l -leucine anion). The solution stability studies performed by ultraviolet–visible (UV–Vis) spectroscopy confirmed the stability of the complexes in the buffer solutions. The DNA binding affinity was evaluated using multi-spectroscopy, viscosity measurement and molecular docking methods and further quantified by K b and K app values, revealing an intercalative mode. Moreover, gel electrophoresis analysis revealed that the complexes could damage CT DNA through a hydroxyl radical pathway in the presence of ascorbic acid . All the complexes displayed favorable antimicrobial and cytotoxic activities toward the tested microorganisms ( Bacillus subtilis , Staphylococcus aureus , Escherichia coli and Pseudomonas aeruginosa ) and cancer cells (A549, HeLa and PC-3). Most importantly, the possible anticancer mechanism of the complexes was explored by determining the cells morphological changes, intracellular reactive oxygen species (ROS) levels, location in mitochondria, mitochondrial membrane potentials and the expression of Bcl-2 family proteins. The results showed that the complexes could induce apoptosis in HeLa cells through an ROS-mediated mitochondrial dysfunction pathway, which was accompanied by the regulation of Bcl-2 family proteins.
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Chinese Journal of Natural Medicines
·
2017
·
IF 1.667
Qiong YU,Li-Long JIANG,Na LUO,Ya-Xi FAN,Jiang MA,Ping LI,Hui-Jun LI
Polygoni Multiflori Radix (PMR) has been commonly used as a tonic in China for centuries. However, PMR-associated hepatotoxicity is becoming a safety issue. In our previous in vivo study, an interaction between stilbenes and anthraquinones has been discovered and a hypothesis is proposed that the interaction between stilbene glucoside-enriching fraction and emodin may contribute to the side effects of PMR. To further support our previous in vivo results in rats, the present in vitro study was designed to evaluate the effects of 2, 3, 5, 4′-tetrahydroxystilbene-2- O-β -D-glucopyranoside (TSG) on the cellular absorption and human liver microsome metabolism of emodin. The obtained results indicated that the absorption of emodin in Caco-2 cells was enhanced and the metabolism of emodin in human liver microsomes was inhibited after TSG treatment. The effects of the transport inhibitors on the cellular emodin accumulation were also examined. Western blot assay suggested that the depressed metabolism of emodin could be attributed to the down-regulation of UDP-glucuronosyltransferases (UGTs) 1A8, 1A10, and 2B7. These findings definitively demonstrated the existence of interaction between TSG and emodin, which provide a basis for a better understanding of the underlying mechanism for PMR-induced liver injury.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Liye Shuai,Qun Li,Jia Liu,Jiabin Wu,Xinning Huang,Jianglong Yu,Jinxiao Dou,Huaiguang Li,Xingxing Chen
The rational design of efficient photoanodes is essential for advancing solar-driven water oxidation. This study addresses the intrinsic challenges of bismuth vanadate (BiVO 4 ), such as sluggish charge kinetics and severe surface recombination, through the construction of a ternary composite photoanode via synergistic interfacial modification and cocatalyst integration. A hierarchical architecture was fabricated through sequential low-temperature chemical bath deposition and electrodeposition, integrating a CoFe-layered double hydroxide (CoFe-LDH) interlayer and nickel-hydroxynitrate (Ni 2 (NO 3 ) 2 (OH) 2 ) onto BiVO 4 substrates. The optimized BiVO 4 /CoFe-LDH@Ni 2 (NO 3 ) 2 (OH) 2 photoanode achieves a photocurrent density of 5.57 mA/cm 2 at 1.23 V vs. reversible hydrogen electrode (V RHE ) under Air Mass 1.5 Global (AM 1.5G) illumination, accompanied by a 251 mV cathodic shift in onset potential. Comprehensive characterizations-including X-ray photoelectron spectroscopy (XPS), open-circuit photovoltage (OCP) decay, time-resolved photoluminescence (TRPL) decay, electron paramagnetic resonance (EPR) and Kelvin probe force microscopy (KPFM)-reveal that the oxygen vacancy (O v )-rich CoFe-LDH@Ni 2 (NO 3 ) 2 (OH) 2 layer facilitates efficient charge transfer within BiVO 4 and generates a pronounced built-in electric field, thereby significantly enhancing interfacial charge separation. Concurrently, density functional theory (DFT) calculations demonstrate that the interfacial effect of CoFe-LDH@Ni 2 (NO 3 ) 2 (OH) 2 substantially lowers the thermodynamic barrier for the oxygen evolution reaction (OER). This study offers fundamental insights for fabricating high-efficiency BiVO 4 -based photoanodes.
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JOURNAL OF CHEMICAL THERMODYNAMICS
·
2022
·
IF 3.269
Pan Zhang,Yanxi Ji,Wenya Li,Lihua Xu,Lemeng Wang,Dong Fu
The viscosities of N -(2-aminoethyl)ethanolamine (AEEA), 1,4-butanediamine (BDA) and N-methyl- 1,3-propane- diamine (MAPA) activated 2- diethylaminoethanol (DEAE) aqueous solutions were measured at temperatures ( T ) from 303.2 K to 323.2 K, respectively. The DEAE mass fractions ( w DEAE ) and the other three amines ( w AEEA / w BDA / w MAPA ) are 0.300 to 0.500 and 0.050 to 0.150 respectively. The Weiland equation was used to calculate the viscosity of these three solutions, and the calculation results were satisfied with data of the experimental results. With the aid of experimentally determined viscosity data, the activation energy ( E a) of these three solutions was predicted through the Arrhenius formula. With the help of the viscosity data and the diffusion coefficient model of CO 2 in water, the CO 2 diffusion coefficient ( D CO2 ) in these three solutions was calculated. The quantitative relationship between the calculated values (viscosity, activation energy and diffusion coefficient) and the operation conditions (solution mass fraction and temperature) was analyzed. Our results show that the DEAE-BDA absorbent has better application potential due to its lower viscosity, higher CO 2 diffusion coefficient and lower activation energy.
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