MOLECULES
·
2022
·Vol. 27
·期 17
·5427
·
IF 4.927
Song Li,Jing Yan,Qiangqiang Zhu,Xinxiang Liu,Senlin Li,Shenhou Wang,Xuanjun Wang,Jun Sheng
Tea contains high levels of the compound epigallocatechin gallate (EGCG). It is considered an important functional component in tea and has anti-cancer, antioxidant, and anti-inflammatory effects. The eight phenolic hydroxyl groups in EGCG’s chemical structure are the basis for EGCG’s multiple biological effects. At the same time, it also leads to poor chemical stability, rendering EGCG prone to oxidation and isomerization reactions that change its original structure and biological activity. Learning how to maintain the activity of EGCG has become an important goal in understanding the biological activity of EGCG and the research and development of tea-related products. Metal–organic frameworks (MOFs) are porous materials with a three-dimensional network structure that are composed of inorganic metals or metal clusters together with organic complexes. MOFs exploit the porous nature of the material itself. When a drug is an appropriate size, it can be wrapped into the pores by physical or chemical methods; this allows the drug to be released slowly, and MOFs can also reduce drug toxicity. In this study, we used MOF Zn(BTC)4materials to load EGCG and investigated the sustained release effect of EGCG@MOF Zn(BTC)4and the biological effects on wound healing in a diabetic mouse model.Keywords:EGCG;MOF;wound healing;diabetes
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高影响因子
Journal of Energy Storage
·
2025
·
IF 9.8
Jiaxin Ou,Wenqing Xu,Ye Sun,Honghai Zhang,Yuchao He,Zongyi Wen,Yachun Lu,Jianwen Yang,Quanqi Chen
Potassium vanadium phosphate (K 3 V 3 (PO 4 ) 4 ) has emerged as one of the most promising cathode candidates for potassium-ion batteries because of exceptionally stable structural framework, yet suffers from intrinsic poor electronic conductivity characteristic of polyanionic compounds. Herein, a strategic Mg 2+ doping approach was adopted to prepare Mg-doped K 3 V 3 (PO 4 ) 4 /C (K 3+x V 3-x Mg x (PO 4 ) 4 /C, x = 0.1, 0.2 and 0.3) composites, where larger Mg 2+ (0.72 Å) substitution for V 3+ (0.64 Å) effectively widens K + diffusion pathways. Optimal doping of Mg 2+ significantly elevates K + diffusion, rate capability, and cyclability beyond undoped K 3 V 3 (PO 4 ) 4 /C. The optimal K 3.2 V 2.8 Mg 0.2 (PO 4 ) 4 /C (Mg0.2-KVP/C) demonstrates comprehensive performance enhancements over pristine K 3 V 3 (PO 4 ) 4 /C, exhibiting 16.5 % higher initial discharge capacity (67.0 vs. 57.5 mAh g −1 ) at 1C with significantly improved cycling stability (85.8 % vs. 65.5 % capacity retention after 150 cycles). Notably, Mg0.2-KVP/C maintains 63.8 % larger capacity at 5C rate (53.4 vs. 32.6 mAh g −1 ) while achieving capacity retention of 75.2 % after 1000 cycles-representing a 50 % improvement in long-term cycle stability compared to the undoped K 3 V 3 (PO 4 ) 4 /C. The significant improvement in electrochemical performance of K 3 V 3 (PO 4 ) 4 /C upon Mg doping suggests that strategic ionic doping is an effective strategy for improving potassium storage performance of K 3 V 3 (PO 4 ) 4 /C and other polyanionic compounds for potassium-ion batteries.
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PLANT SCIENCE
·
2015
·
IF 3.607
Chao Huang,Qing-Bo Yu,Xin-Bo Yuan,Zi-Ran Li,Jing Wang,Lin-Shan Ye,Ling Xu,Zhong-Nan Yang
The fructokinase-like protein2 (FLN2) is a component of the PEP complex. FLN2 knockout mutants displayed a delayed greening phenotype on sucrose-containing medium. Our previous work indicated that partial PEP activity is essential for its greening phenotype. In this study, we further report that sufficient Rubisco accumulation is critical for fln2-4 greening. Sugar serves many important functions, such as an energy source and signaling molecule. Through pharmacological experiments using a sugar analog and sugar signaling inhibitor, we demonstrate that sugar serves as energy to support the fln2-4 greening. Seed-reserve and photosynthetic CO 2 -fixation are the primary energy sources for early seedling growth . No obvious differences were observed in the seed-reserve of the wild-type and fln2-4 by comparing their seed size and dark-germination, indicating that the defective carbon fixation may account for the energy deficit in fln2-4 during its early seedling growth. The Rubisco content was low in fln2-4 , but it rapidly accumulated during the greening of fln2-4 . Expression of a nuclear-encoded rbcL gene facilitates Rubisco accumulation and partially complements the mutant defects. These results suggest that the Rubisco accumulation is critical for fln2-4 greening. In summary, the rapid Rubisco accumulation that depends on sufficient PEP activity is important for normal seedling growth.
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ACS Catalysis
·
2024
·
IF 11.3
Li Jiang,Yiqian Yang,Lin Huang,Yan Zhou,Junwei An,Yuchun Zheng,Yiwei Chen,Yanhong Liu,Jianhui Huang,Ee Lui Ang,Suwen Zhao,Huimin Zhao,Rongzhen Liao,Yifeng Wei,Yan Zhang
The various isomers of hydroxyproline (HP) are widely distributed in nature, serving as key components of structural proteins, while their quaternized betaine derivatives function as osmoprotectants in many organisms. Aerobic bacteria degrade HPs through a variety of well-studied mechanisms. Recent studies show that certain anaerobic bacteria degrade HPs through distinct mechanisms, involving the O2-sensitive glycyl radical enzymes (GREs) t4L-HP dehydratase (HypD) and t4D-HP C–N lyase (HplG). Here, we report the discovery of two more GREs, N-methyl c4L-HP dehydratase (HpyG) and N-methyl c4D-HP dehydratase (HpzG), which catalyze radical-mediated dehydration of the two N-methyl-c4HP enantiomers, while also displaying significant activities toward their unmethylated substrates. Both GREs are associated with homologues of pyrroline-5-carboxylate reductase, which catalyze reduction of their products N-methyl-pyrroline-5-carboxylate to form N-methyl-proline. Crystal structures of HpyG and HpzG in complex with their substrates revealed active site architectures distinct from that of HypD and provided insights into the mechanism of enantioselective radical-mediated dehydration. Our research further expands the repertoire of diverse chemical mechanisms involved in the bacterial metabolism of highly prevalent HP isomers and derivatives in the anaerobic biosphere.
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Cell Reports
·
2023
·Vol. 42
·期 9
·113090-113090
·
IF 8.8
Wang D,Zhu Z,Fu Y,Zhang Q,Zhang Y,Wang T,Weng Y,Wen Y,Cao W,Tao G,Wang Y
Polycystic ovary syndrome (PCOS) is an endocrine disorder and the main cause of anovulatory infertility, in which persistent activation of androgen receptor (AR) due to aberrant acetylation modifications of transcription is a potential trigger; however, the precise mechanisms of AR activation are poorly understood. In this study, AR activation in dehydroepiandrosterone- and letrozole-induced rat PCOS ovaries coincided with a marked increase of a chromatin acetylation "reader" BRD4. Further bioinformatic analysis showed that the AR promoter contained highly conserved binding motifs of BRD4 and HIF-1α. BRD4 and HIF-1α inducibly bound to the histone 3/4 acetylation-modified AR promoter, while administration of a BRD4-selective inhibitor JQ1 reduced the binding and AR transcription and improved the adverse expression of the core fibrotic mediators in PCOS ovaries and DHT-treated granulosa cells. Our data indicate that BRD4 upregulation and the resultant AR transcriptional activation constitute an important regulatory pathway that promotes ovarian fibrosis in PCOS.
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PubMed
高影响因子
Journal of Materials Chemistry C
·
2020
·Vol. 9
·期 6
·1958-1965
·
IF 7.059
Zhixue Liu,Xiaohan Sun,Xianyin Dai,Jingjing Li,Peiyu Li,Yu Liu
Herein, we reported highly efficient light-harvesting amphiphilic supramolecular assemblies based on a tetraphenylethylene derivative (TPE-4Py), an amphiphilic sulfonatocalix[4]arene (SC4A-C6), and a sulfite fluorescent probe (SP). The obtained assemblies not only showed obvious signal amplification compared to SP alone, with an antenna effect of up to 28.1 based on highly efficient energy transfer of 75.2% from TPE-4Py/SC4A-C6 to SP, but also displayed an excellent ratiometric fluorescence signal output toward sulfites. Meanwhile, the assemblies showed no obvious cytotoxicity to A549 cells and could be used to sense sulfites in the cells. This strategy for constructing supramolecular assemblies not only resulted in a high-efficiency light-harvesting platform but also amplified the signal of the probe because of the high antenna effect and thus constitutes an effective method for fabricating fluorescent cell sensors.
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高影响因子
ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Yanchun Yang,Xiaojiao Kang,Lijian Huang,Daocheng Pan
Alkali metal doping plays a crucial role in fabricating high-performance Cu(In,Ga)(S,Se)2 and Cu2ZnSn(S,Se)4 (CZTSSe) thin film solar cells. In this study, we report the first experimental observation and characterizations of the alloyed LixCu2–xZnSn(S,Se)4 thin films. It is found that Cu+ ions in Cu2ZnSn(S,Se)4 thin films can be substituted with Li+ ions, forming homogeneous LixCu2–xZnSn(S,Se)4 (0 ≤ x ≤ 0.29) alloyed thin films. Consequently, the band gap, conduction band minimum, and valence band maximum of LixCu2–xZnSn(S,Se)4 thin films are profoundly affected by Li/Cu ratios. The band alignment at the LixCu2–xZnSn(S,Se)4/CdS interface can be tuned by changing the Li/Cu ratio. We found that the photovoltaic parameters of the LixCu2–xZnSn(S,Se)4 solar cell devices are strongly influenced by the Li/Cu ratios. Besides, the lattice constant, carrier concentration, and crystal growth of LixCu2–xZnSn(S,Se)4 thin films were studied in detail.
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高影响因子
CHINESE SCIENCE BULLETIN
·
2014
·Vol. 59
·期 11
·1097-1103
·
IF 1.365
Liu Juan,Liu Zhengping,Wang Liyuan,Sun Haiyan
Calix[4]resorcinarene, prepared by the acid-catalyzed condensation of resorcinol and paraldehyde, was used as the core of the molecular glass compound. The hydroxyl groups of calix[4]resorcinarene were partly protected by tert-butoxycarbonyl ( t -BOC) and then esterified with 2-diazo-1-naphthoquinone-4-sulfonyl chloride (2,1,4-DNQ-Cl). Upon irradiation to 365 nm light, the 2,1,4-DNQ groups undergo photolysis to generate a small quantity of sulfonic acid other than indene carboxylic acid. The generated sulfonic acid can further catalyze the deprotection of the t -BOC group. So, a new type of single-component chemically amplified i-line positive photoresist can be formed by the molecular glass compounds. The lithographic performance of the resist was evaluated with high resolution and photosensitivity with an i-line stepper.
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高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2021
·
IF 3.196
Ronghui Wu,Zhuoran Chen,Xingjun Gao,Xinlei Chen,Shouwen Jin,Li He,Bin Chen,Daqi Wang
Cocrystallization of the ordinarily accessible 4-dimethylaminopyridine (DMAP), with a series of aromatic acids gave a gross of eight anhydrous and hydrous multicomponent molecular salts. The eight salts have been characterised by XRD, IR and EA, their melting points were also reported. Their structural and supramolecular manners are fully evaluated. The result unveils that among all the crystals only the ring N at the DMAP moieties are protonated with the organic acids deprotonated, giving the ion pair. Apart from salt 8 , all the crystal packing is interpreted by the strong charge-assisted N-H⋯O H-bonds from the NH + and the deprotonated acidic groups. The O-H•••O H-bonds were also found at 3 – 8 . All compounds are organic salt, the cation and anion were at 1:1 for 1 – 5 and 7 - 8 , salt 6 has the ratio of 2:1. Further analysis on the crystal packing showed that a different sets of additional CH-N, CH-O/CH 3 -O, CH-S, CH 3 -CH, CH 3 -CH 3 , CH 3 -C π , CH-π/CH 3 -π, I-π, O-S, I-I and π-π contacts contribute to the stabilization and expansion of the total 2D/3D structures. For the synergism of the various weak forces these salts took homo/hetero supramolecular synthons or both.
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BIODEGRADATION
·
2018
·Vol. 29
·期 2
·129-140
·
IF 2.41
Mao Fei,Liu Xiaohong,Wu Kang,Zhou Chen,Si Youbin
Because of extensive sulfonamides application in aquaculture and animal husbandry and the consequent increase in sulfonamides discharged into the environment, strategies to remediate sulfonamide-contaminated environments are essential. In this study, the resistance of Shewanella oneidensis MR-1 and Shewanella sp. strain MR-4 to the sulfonamides sulfapyridine (SPY) and sulfamethoxazole (SMX) were determined, and sulfonamides degradation by these strains was assessed. Shewanella oneidensis MR-1 and Shewanella sp. strain MR-4 were resistant to SPY and SMX concentrations as high as 60 mg/L. After incubation for 5 days, 23.91 ± 1.80 and 23.43 ± 2.98% of SPY and 59.88 ± 1.23 and 63.89 ± 3.09% of SMX contained in the medium were degraded by S. oneidensis MR-1 and Shewanella sp. strain MR-4, respectively. The effects of the initial concentration of the sulfonamides and initial pH of the medium on biodegradation, and the degradation of different sulfonamides were assessed. The products were measured by LC–MS; with SPY as a substrate, 2-AP (2-aminopyridine) was the main stable metabolite, and with SMX as a substrate, 3A5MI (3-amino-5-methyl-isoxazole) was the main stable metabolite. The co-occurrence of 2-AP or 3A5MI and 4-aminobenzenesulfonic acid suggests that the initial step in the biodegradation of the two sulfonamides is S–N bond cleavage. These results suggest that S. oneidensis MR-1 and Shewanella sp. strain MR-4 are potential bacterial resources for biodegrading sulfonamides and therefore bioremediation of sulfonamide-polluted environments.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Qing Zheng,Nannan Wu,Ruijuan Qu,Gadah Albasher,Wanming Cao,Beibei Li,Nouf Alsultan,Zunyao Wang
4- tert -butylphenol (4-tBP) is a phenolic endocrine disrupting chemical that has attracted great attention due to its wide occurrence, environmental persistence, and possible toxic effects. In this study, we systematically investigated the transformation of 4-tBP in ferrate (VI) oxidation process. The second-order reaction rate constant ( k app ) of Fe(VI) with 4-tBP decreases with solution pH, and the k app value was determined as 295 M −1 ·s −1 at pH 8.0. The removal efficiency of 4-tBP was slightly decreased by Mg 2+ and HCO 3 – , while accelerated at varying degrees by the presence of Cu 2+ and humic acid. Product analysis revealed that 4-tBP was mainly transformed into hydroxylation products, benzene-ring cleavage products, dimers and higher polymerization products via oxygen atom transfer, ring-opening of the benzene ring and radical coupling reaction. Furthermore, initial reactions of 4-tBP were rationalized by theoretical analysis of atom partial charges, frontier electron densities, and spin densities. Nearly complete removal of 4-tBP (20 μM) was achieved after 5 min of reaction in both ultrapure water and natural waters, demonstrating the feasibility of this Fe(VI) oxidation method in treating phenols-contaminated waters.
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高影响因子
Journal of Flow Chemistry
·
2021
·Vol. 12
·期 2
·153-160
·
IF 2.786
Liu Lanshan,Hong Xinlin,Hu Xiaohong
4-pyridinemethanol is well known as an important pharmaceutical intermediate and chemical raw material. Its preparation by electrochemical method has seen a recent explosion of interest. In this paper, we report the synthesis of 4-pyridinemethanol by electrochemical reduction of ethyl isonicotinate using an undivided flow electrolysis cell. The experiments were conducted under different conditions, including applied charge, initial concentration of ethyl isonicotinate and H 2 SO 4 , current density, and electrode materials. The yield of 4-pyridinemethanol reached up to 71 % under the optimal conditions. The oxidation of target product was avoided by using Ti/IrO 2 anode in the absence of membrane separation. Furthermore, the repeat cycle experiments and cyclic voltammetric experiments showed that this approach possessed good reproducibility and stability.
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危险品化学品经营许可证（带存储）