MICROPOROUS AND MESOPOROUS MATERIALS
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2025
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IF 4.7
Zongpeng Liu,Shaojian Hu,Qingquan Hao,Rui Ma,Yuning Zhang,Bencheng Wu,Jianhua Zhu
Nowadays, heterogeneous catalytic esterification for synthetic esters production is believed more compatible with the postulates of green chemistry and sustainability goals. In this work, we developed hydrophobic stannous oxide supported on mesoporous silica KIT-6 materials (SnO/KIT-6) via a feasible synthesis and post-grafting modification approach, which served as solid heterogeneous catalysts and then tested in the synthesis of complex polyolester (CPE). The catalytic behaviour of as-prepared catalysts was also systematically investigated and the highest carboxyl conversion ( ca. 95.6%) could be achieved under the optimal preparation conditions within the studied range. The obtained results revealed that Lewis acidity of the tin-based catalysts played a crucial role in esterification conversion efficiency, which varied depending upon the dispersion of different SnO loading. Furthermore, the reusability of the catalyst was evaluated and demonstrated relatively stable catalytic activity for up to five consecutive cycles. Additionally, the possible esterification reaction mechanism of CPE over the modified S-SnO/KIT-6 was also elucidated. The resultant catalysts leveraged full advantage of the unique textural properties and adequate surface hydrophobicity, intensively facilitating the diffusion of large polar molecules and resisting to deactivation from generated water. Collectively, the findings of present study may provide some valuable insights for adopting productive and environmentally benign catalytic processes to synthesize ester-based lubricants in the future.
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Nanomaterials
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2025
·Vol. 15
·期 17
·1313
·
IF 4.3
Tingting Liu,Yang Zhao,Jie Feng
Oxidative stress is the key contributor to the onset of numerous diseases. Herein, we develop tea polyphenol–zinc (Tp-Zn) using a metal–polyphenol coordination strategy through a simple hybrid approach. The product is characterized by methods such as dynamic light scattering (DLS), ultraviolet–visible spectroscopy (UV–vis) and transmission electron microscopy (TEM) to evaluate the particle size and potential of Tp-Zn. Oxidative stress was induced in mice by administering diquat (25 mg/kg body weight) followed by pre-treatment with 210 mg/kg body weight tea polyphenols (TPs), 280 mg/kg body weight Tp-Zn, and 70 mg/kg body weight ZnSO4for 7 days. Results showed that Tp-Zn treatment significantly improved intestinal barrier function by preventing the diquat-induced down-regulation of tight junction proteins Zonula Occludens protein 1 (ZO-1) and occludin. It also mitigated liver inflammation and damage, as evidenced by reduced serum levels of Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), and Alkaline phosphatase (AKP). Furthermore, Tp-Zn enhanced the antioxidant response in both the intestine and liver by up-regulating the mRNA expression of antioxidant enzymes and reducing the levels of Malondialdehyde (MDA) and reactive oxygen species (ROS) compared to the diquat group (DIQ group). Also, the detection of ROS in the small intestine confirmed Tp-Zn markedly increased intestinal Nuclear factor erythroid 2-related factor 2 (Nrf2) expression compared to the control group. This study aims to clarify that metal–polyphenol coordination with multifaceted regulation of the inflammatory microenvironment could be a novel approach for preventing or treating oxidative stress-related diseases.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2025
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IF 3.8
Chen Lifang,Chen Jiaqi,Lei Ying,Lin Pengcheng,Cao Donglin,Xiao Wei,Hu Liangshan
Interleukin-6 (IL-6) is an acute phase response protein. Its level rapidly increases in infection, trauma, and acute inflammatory states. It usually appears earlier than other inflammatory markers such as C-reactive protein and procalcitonin. Therefore, detecting abnormal IL-6 levels (The clinical reference range is greater than 7 pg mL −1 ) faster can help humans receive timely treatment and recover their health. This article successfully synthesized a medium-entropy oxide nanoenzyme. It does not require the involvement of hydrogen peroxide and has a low Michaelis constant of 0.101 mM. Based on the interaction between La-based medium-entropy oxide (MEO-La) nanoenzyme and secondary antibody, specific detection of IL-6 in enzyme-linked immunosorbent assay is achieved. The concentration of IL-6 in human serum can be qualitatively detected. The detection limit and linear range are 0.03 pg mL −1 and 5–1000 pg mL −1 , respectively. This work not only is of great significance for better understanding the unique properties of medium-entropy nanoenzymes but also has enormous potential for biochemical sensing of human health. Graphical This work develops a medium entropy oxide nanoenzyme for ultrasensitive IL-6 detection, achieving a detection limit of 0.03 pg mL −1 . The hydrogen peroxide free system has shown great potential in early disease diagnosis and biochemical sensing applications.
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JOURNAL OF MEDICINAL CHEMISTRY
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2025
·
IF 6.8
Wenchen Pu,Xianyan Shen,Xin Fan,Yuanyuan Zheng,Xuesha Liu,Jiao Li,Jian-Kang Zhou,Juan He,Rong Wei,Yanqiu Gong,Qingquan Zheng,Yao Luo,Yingli Guo,Min Ai,Yue Ming,Zixia Ye,Yun Zhao,Chun Wang,Yong Peng
Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths globally, and the need for effective systemic therapies for HCC is urgent. Our previous work reveals that Pin1 is a potential anti-HCC target, which regulates miRNA biogenesis and identifies API-1 as a novel Pin1 inhibitor to suppresses HCC. However, a great demand in HCC therapy as well as the limited chemical stability and pharmacokinetic feature of API-1 motivated us to find improved Pin1 inhibitors. Herein, we designed and synthesized diverse 6-O-benzylguanine derivatives and discovered API-32 as a novel Pin1 inhibitor with better stability and pharmacokinetic property over API-1. API-32 directly interacted with the Pin1 PPIase domain to inhibit Pin1 activity. API-32 significantly suppressed the cell proliferation and migration of HCC cells by blocking Pin1’s downstream signal. Moreover, API-32 exhibited an enhanced inhibitory function against the HCC tumor in mice models without obvious toxicity, making it a promising drug candidate for HCC treatment.
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ChemCatChem
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2025
·
IF 3.9
Xiaoqi Tian,Dongxu Chen,Houde She,Jingwei Huang,Lei Wang,Qizhao Wang
Volatile organic compounds (VOCs) pose significant environmental and health risks, necessitating effective remediation strategies. This study addresses these challenges by synthesizing ZnSn(OH) 6 /TiO 2 heterojunction composites using a coprecipitation-hydrothermal coupling technique. Experiments showed that the synergistic effect of ZnSn(OH) 6 and TiO 2 significantly reduced the band gap (3.10 eV) of the composites and enhanced the visible light absorption ability, whereas the photogenerated electron–hole pair complexation was effectively suppressed through the interfacial charge transfer mechanism. Under simulated sunlight, 15% ZnSn(OH) 6 /TiO 2 degraded toluene at an initial concentration of 2,500 ppm by up to 90.51% in 90 min, with a mineralization rate of more than 84.51%, which is about three times higher than the performance of pure ZnSn(OH) 6 . Cycling experiments showed that the degradation rate remained at 90.32% after five times of reuse, demonstrating excellent stability. A combination of density functional theory (DFT) calculations and radical trapping experiments revealed that ·OH and ·O 2 − were the main active species in the composites, and the hydroxyl structure of ZnSn(OH) 6 promoted the adsorption and activation of toluene. This work presents a novel interfacial engineering and crystallographic regulation strategy for deep mineralization of VOCs, providing insights for designing cost-effective, durable environmental photocatalysts. Graphical This study describes the synthesis, structural, and surface characterization of TiO 2 nanoparticle-decorated layered ZnSn(OH) 6 composite catalysts, systematically evaluates their photocatalytic activity, degradation kinetics, and long-term stability for gaseous toluene under simulated solar light, and investigates photogenerated electron-hole migration pathways, separation efficiency, and reactive oxygen species formation mechanisms.
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CHEMISTRY-A EUROPEAN JOURNAL
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2024
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IF 3.9
Meiyan Liu,Chenglong Li,Guanming Liao,Fenggui Zhao,Chunxia Yao,Nan Wang,Xiaodong Yin
Graphical Two 1,4-azaborinine [6]helicenes, H[6]BN1 and H[6]BN2 , exhibit blue fluorescence with narrow FWHMs below 31 nm and high PLQY up to 92 %. Desirable circularly polarized luminescence with g lum reaching 4~5×10 −4 and good configurational stability are relized for H[6]BN1 and H[6]BN2 . Mechanochromism occurs between H[6]BN1 ′s crystalline and amorphous states by modulationg π-π intermolecular interanctions. An turquoise OLED based H[6]BN1 is manufactured with the external quantum efficiency (EQE) of 3.18 %. Boron-doped helicenes, known for their unique electronic and photophysical properties, are of great interest for numerous applications. This research introduces two new azabora[6]helicenes, H[6]BN1 and H[6]BN2 , synthesized through an efficient method. These molecules have boron and nitrogen atoms in opposing positions, enhancing their distinctive attributes. Both helicenes show excellent emission properties, with H[6]BN1 and H[6]BN2 exhibiting narrowband blue fluorescence and circularly polarized luminescence (CPL), achieving g lum values of 4~5×10 −4 which is beneficial for chiroptical applications. The addition of a donor group, 3, 6-di-tert-butyl-9H-carbazole, in H[6]BN2 improves luminescence, likely due to enhanced molecular orbital overlap and electron delocalization. H[6]BN1 ′s needle-like single crystals exhibit mechanochromism, changing luminescent color from yellow to green under mechanical stress, which is promising for stimulus-responsive materials. In conclusion, this study presents a novel class of BN[6]helicenes with superior chiroptical properties. Their combination of electronic features and mechanochromism makes them ideal for advanced chiroptical materials, expanding the potential of helicene-based compounds and offering new directions for the synthesis of molecules with specific chiroptical characteristics.
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RSC Advances
·
2025
·Vol. 15
·期 19
·14594-14603
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IF 4.6
Bingxue Guo,Jinfen Lou,Tingting Kuang,Yanping Wang,Kai Zhang,Jun Qin,Min He,Yufei Liu,Yong-Ji Gong
PA6 is widely used but vulnerable to thermo-oxidative aging, impacting its durability. Hindered phenols are key antioxidants that extend the service life of PA6 by slowing this aging process. However, the effect of molecular structural differences on their antioxidant activity is still elusive, impeding their development and application. Here, two antioxidants, 2-((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionyl)oxy)ethyl acrylate (PEA) and 2-((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionyl)oxy)propyl acrylate (PPA), were utilized to enhance the thermo-oxidative aging resistance of PA6. Their primary difference is that PPA possesses an electron-donating group in its molecular structure. The methyl functional group in the PPA molecule can increase the electron cloud density around the benzene ring, resulting in PPA having a higher free radical scavenging rate compared to PEA. In addition, in contrast to PEA, the low volatility and mobility of PPA ensure that its antioxidant activity can be fully utilized during aging. These factors collectively support the excellent antioxidant activity of PPA (PPA > PEA). As a result, the PA6/PPA composite maintains 88% of its original tensile strength after 12 days of continuous aging, whereas PA6/PEA and PA6/1010 (commercial antioxidant) composites retained 70% and methyl 30%, respectively. These encouraging findings provide a theoretical basis for the synthesis of antioxidants.
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POLYMER
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2025
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IF 4.5
Xuelian Liu,Qian Li,Yuying Zheng,Weijie Zheng
Antistatic nylon-6 (PA6) composites have attracted considerable attention due to their tailored properties for electronics, textiles, and automotive applications. In this paper, the antistatic PA6 composites comprising with polypropylene (PP), aminated multi-walled carbon nanotubes (MWCNTs-NH 2 ) and aminated carbon black (CB–NH 2 ) were prepared by melt blending and compression molding. In the composite system, PP was used as the co-matrix to assist the phase separation of PA6. MWCNTs-NH 2 and CB-NH 2 were introduced as conductive fillers. All composites showed good thermal stability with the T 5 % higher than 376 °C and the composites containing fillers showed higher residues after thermal degradation due to the good thermal stability of MWCNTs-NH 2 and CB-NH 2 . The DSC and XRD results indicated that the crystallization properties of the composite materials were determined by PA6 and PP rather the conductive fillers. In general, the introduction of conductive fillers decreased the mechanical properties but effectively improved the conductivity of the composites and then the antistatic properties. Besides, the antistatic analysis and mechanical test denoted that MWCNTs-NH 2 and CB-NH 2 showed synergistic effect on improving the antistatic and mechanical properties of the composites, which was more evident at high MWCNTs-NH 2 quantity. The micromorphologies obtained by SEM first confirmed the ductile fracture of these composites, and then disclosed a two-phase structure of PA6 and PP polymer matrix, where the conductive fillers were found in the PA6 phase. Considering both mechanical and antistatic properties, the composite (PCNB-3) containing both 3 phr MWCNTs-NH 2 and CB-NH 2 was proposed for the antistatic PA6 composite.
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JOURNAL OF ORGANIC CHEMISTRY
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2025
·
IF 3.6
Haoyang Liu,Hailiang Xing,Peilan Yu,Yanjie Wang,Jia-Lei Yan,Junyang Liu,Min Wang
A facile copper-catalyzed, base-controlled cyclization reaction has been developed for the synthesis of 9-membered cycloalkyne and 6-membered heterocycle sultams under mild conditions. This protocol utilizes a copper-catalyzed intramolecular A3 (alkyne–aldehyde–amine) coupling reaction to efficiently synthesize 9-membered cycloalkyne sultams in yields up to 90%. Alternatively, by substituting NaHCO3 with DBU, the protocol achieves selective deprotection of the N-propargyl group, thereby facilitating the formation of 6-membered heterocyclic sultams, also in high yields.
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JOURNAL OF HAZARDOUS MATERIALS
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2025
·
IF 11.3
Cheng Tan,Chunyang Kang,Pan Liu,Yajuan Sun,Hui Jin
The neurotoxicological consequences of chronic exposure to polystyrene nanoplastics (PSNPs) at environmentally relevant concentrations remain poorly understood, particularly their impact on hippocampal neurons dysfunction. In this study, a mouse model co-exposed to PSNPs and/or luteolin (LUT) was replicated by intraperitoneal injection to investigate the mechanism and effective treatment of PSNPs induced striatal neurodegeneration. Here, we elucidated that PSNPs exposure induced striatal injury characterized by neuronal disorganization and mitochondrial dysfunction in vivo and in vitro. Notably, PSNPs triggered oxidative dysregulation and iron accumulation by enhancing antioxidant enzyme activity and suppressing lipid peroxidation, leading to ferroptosis and neuroinflammation. Additionally, PSNPs exposure induced a decrease in glycolysis and tricarboxylic acid (TCA) cycle imbalance by disrupting G6PD/glutathione-dependent pathway, leading to an imbalance in cellular energy metabolism. Our findings highlighted the role of the Piezo1/CaN/NFAT1 axis in PSNPs-induced ER Ca 2 + homeostasis imbalance, which was effectively inhibited by LUT. Notably, LUT alleviated the susceptibility to striatal ferroptosis induced by PSNPs via the G6PD/glutathione axis. Collectively, our study provides critical insights into the neurotoxic mechanisms of PSNPs and establishes LUT as a agent against PSNPs-induced neurodegeneration. These findings underscore the urgent need for environmental regulation of nanoplastics and offer potential strategies for combating their health effects.
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BIOORGANIC CHEMISTRY
·
2025
·
IF 4.7
Lixin Niu,Yun He,Xing Zhang,Yanfei Peng,Ding Wang,Tao Wang,Zunting Zhang
A concise and efficient photo-induced rearrangement and oxidation of 2-(3-methylbenzofuran-2-yl)-3-phenyl-1 H -indoles 1 for the synthesis of 5-(2-hydroxyphenyl)-5-methyl-5,7-dihydro-6 H -benzocarbazol-6-ones 2 is described. Irradiation of compounds 1 in anhydrous dichloromethane solution, using 313 nm UV light in an air atmosphere, resulted in the formation of compounds 2 with yields ranging from 55% to 98%. Using the 6π-electrocyclization strategy of compounds 1 containing a methyl, a quaternary carbon stereocenter was introduced in the compounds 2 . The carbonyl group of compounds 2 was formed by the photo-induced oxidation of C-H bond to C-OH and hemiketal-keto tautomerization. Additionally, the antitumor activities of compounds 2 were evaluated and found to demonstrate equivalent or superior activity compared to Cisplatin against various tumor cell lines, including leukemia HL-60, lung cancer A549, liver cancer HepG2, breast cancer MDA-MB-231 and colon cancer SW480. The anticancer activity of compound 2f was particularly significant, with IC 50 values of 2.99, 9.06, 6.81, 9.29, and 14.93 μM respectively, and its IC 50 value of normal cells 11.18 μM. Compound 2k had a relatively high IC 50 values against cancer cells, whereas its IC 50 value greater than 40μM for normal cells.
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ChemSusChem
·
2020
·Vol. 13
·期 9
·2239-2244
·
IF 7.962
Yuwen Luo,Feipeng Zheng,Luojia Liu,Kaixiang Lei,Xuesen Hou,Gang Xu,Hui Meng,Jifu Shi,Fujun Li
Graphical Tunable operating voltage : The anion effect induces a varied redox ability of p-type organic radicals, leading to tunable operating voltage of Zn–organic radical batteries. DFT calculations reveal that the stronger interaction of the anion with the organic radical host, the higher the operating voltage of the Zn–organic radical battery. In contrast to traditional rechargeable rock-chair metal-ion batteries, dual-ion batteries (DIBs) involve redox reactions with anions rather than cations in p-type cathodes. In principle, regulating the electrochemical performance of the DIB by different anion species is highly feasible. Herein, the anion effect on the electrochemical performance of a DIB, the aqueous Zn– organic radical battery (Zn-ORB), consisting of a poly(2,2,6,6tetramethylpiperidinyloxy-4-yl vinyl ether) cathode and a Zn anode, was investigated by DFT calculations. SO 4 2− , CF 3 SO 3 − , and ClO 4 − with different molecular electrostatic potential values were selected as anion models. DFT calculations revealed that a stronger electrostatic interaction of the anion with the organic radical resulted in a higher operating voltage of the Zn-ORB, which was consistent with experimental results. These results bring new insight into the redox chemistry of p-type organic radicals with anions and will promote the development of high-power aqueous Zn-ORBs as well as inspire more investigations into the anion effect towards novel battery designs.
研究领域:
电化学
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电池技术
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材料科学
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计算化学
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