JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
·
IF 9.4
Shan Xu,Dongxu Jiao,Xiaowen Ruan,Zhaoyong Jin,Yu Qiu,Jinchang Fan,Lei Zhang,Weitao Zheng,Xiaoqiang Cui
Efficient production of green hydrogen energy is crucial in addressing the energy crisis and environmental concerns. The oxygen evolution reaction (OER) poses a challenge in conventional overall water electrolysis due to its slow thermodynamically process. Urea oxidation reaction (UOR) offers an alternative anodic oxidation method that is highly efficient and cost-effective, with favorable thermodynamics and sustainability. Recently, there has been limited research on bifunctional catalysts that exhibit excellent activity for both OER and UOR reactions. In this study, we developed a selenium and iron co-doped nickel sulfide (SeFe-Ni 3 S 2 ) catalyst that demonstrated excellent Tafel slopes of 53.9 mV dec −1 and 16.4 mV dec −1 for OER and UOR, respectively. Density Functional Theory (DFT) calculations revealed that the introduction of metal (iron) and nonmetallic elements (selenium) was found to coordinate the d-band center, resulting in improved adsorption/desorption energies of the catalysts and reduced the overpotentials and limiting potentials for OER and UOR, respectively. This activity enhancement can be attributed to the altered electronic coordination structure after the introduction of selenium (Se) and iron (Fe), leading to an increase in the intrinsic activity of the catalyst. This work offers a new strategy for bifunctional catalysts for OER and UOR, presenting new possibilities for the future development of hydrogen production and novel energy conversion technologies. It contributes towards the urgent search for technologies that efficiently produce green hydrogen energy, providing potential solutions to mitigate the energy crisis and protect the environment.
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PHYTOMEDICINE
·
2025
·
IF 8.3
Yufeng Deng,Qi hu,Zhiying Song,Mengyuan Nie,Zhiguo Wu,Yongrong Lei,Meng Liu,Dujuan Zhan,Baogang Xie
Objective Hepatocellular carcinoma (HCC) remains a leading cause of cancer mortality. Targeted therapies like lenvatinib face limitations due to resistance and immunosuppression. d -Glucaro-1,4-lactone (1,4-GL), a bioactive natural compound with anti-HCC activity, holds unexplored synergistic potential with lenvatinib. This study investigates the combinatorial efficacy of 1,4-GL and lenvatinib against HCC and elucidates the underlying mechanisms. Methods Efficacy was evaluated in H22 tumor-bearing mice treated with lenvatinib (20 mg/kg/day) ± 1,4-GL (25, 50, 100 mg/kg/day). Tumor inhibition, serum cytokines (TNF-α, IFN-γ, AFP), oxidative stress markers (MDA, SOD), liver enzymes (ALT, AST), and splenic T-cell subsets (flow cytometry) were assessed. Histopathology was analyzed via H&E staining. Lenvatinib pharmacokinetics (serum, liver, tumor) with/without 1,4-GL was determined in mice and SD rats using UPLC-MS/MS. In vitro, combinatorial effects on proliferation (CCK-8), migration (scratch assay), and clonogenicity (colony formation) were tested in Huh7 and HepG2 cells. STAT3 phosphorylation and PD-L1 expression (protein: Western blot; mRNA: RT-qPCR) were analyzed. PD-L1 induction was achieved using IFN-γ (20 ng/ml). Results The medium-dose combination (LMGL) achieved 89.97% tumor inhibition in H22 mice, significantly reducing tumor mass by 75% vs. lenvatinib alone (0.21±0.18 g vs. 0.84±0.79 g, p < 0.01). H&E staining revealed extensive necrosis in combination groups. Serum TNF-α and IFN-γ levels significantly increased ( p < 0.001), while AFP approached baseline. Flow cytometry showed an elevated CD4⁺/CD8⁺ T-cell ratio. Oxidative stress was modulated (reduced MDA and elevated SOD, p < 0.01). Pharmacokinetic studies revealed no significant differences in lenvatinib exposure or steady-state concentrations ( p > 0.05) with 1,4-GL co-administration. In vitro, 1,4-GL significantly reduced lenvatinib's IC 50 (Huh7: 18.54 μmol/l; HepG2: 30.34 μmol/l). Combinatorial treatment markedly downregulated PD-L1 protein/mRNA and inhibited STAT3 phosphorylation ( p < 0.05). Scratch and colony formation assays indicated synergy stemmed from immunomodulation and signaling inhibition, not enhanced anti-migration/proliferation. Conclusion 1,4-GL potently synergizes with lenvatinib against HCC by enhancing oxidative stress, reconstituting antitumor immunity, and suppressing the STAT3/PD-L1 signaling axis, without perturbing lenvatinib pharmacokinetics. This defines a novel phytochemical-based combinatorial strategy with significant clinical translation potential for HCC therapy.
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Journal of Materials Chemistry C
·
2019
·Vol. 7
·期 33
·10379-10388
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IF 6.641
Tao Hua,Keyi Zhang,Zu-Sheng Huang,Lingyun Wang,Hao Tang,Herbert Meier,Derong Cao
In this paper, the encapsulated insulated molecular wire (EIMW) and 2′,7′-bis(hexyloxy)spiro[cyclopenta[2,1-b:3,4-b′]dithiophene-4,9′-fluorene] (SPDF) were specifically designed as efficient anti-aggregation π-bridges for two novel D–A–π–A metal-free sensitizers (IBT1 and IBT2). Compared with the reference dye IBT3 with 3,3′-dihexyl-2,2′-bithiophene (DHBT) as an anti-aggregation π-bridge, both the dyes IBT1 with EIMW and IBT2 with SPDF as π-bridges can suppress intermolecular aggregation more efficiently. The π-bridge of SPDF shows the strongest anti-aggregation ability due to the rigid ‘T’ configuration among these dyes. Meanwhile, the π-bridge of EIMW shows better anti-aggregation ability than DHBT because of the larger steric hindrance of the former. Finally, when the dyes IBT1 and IBT2 are co-sensitized with IBT3, respectively, the new devices exhibit high efficiencies of 7.85% and 7.64%, respectively, which are comparable to that of N719 (7.85%). The results demonstrate that the dyes with EIMW and SPDF as anti-aggregation π-bridges are promising candidates for efficient DSSCs and dye aggregation can be effectively inhibited by structural engineering of the π-spacer.
研究领域:
材料科学
·
化学工程
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DYES AND PIGMENTS
·
2023
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IF 4.5
Peiyu Wu,Shengxiong Zhang,Wenjun Zhang,Weijie Song
Dual functional electrochromic (EC)/electrofluorochromic (EFC) materials play a pivotal role in wearable and smart electronic equipments. Developing new materials with high performance of EC/EFC properties is still a big challenge. Here a new D-A structure polymer PPDOTTPD based on thieno(3,4-c)pyrrole-(4,6)dione ( TPD ) was synthesized by Stille coupling, and the EC/EFC properties were investigated for the first time. PPDOTTPD film exhibits reversible color changes from purple neutral state to transparent colored state in the process of reversible redox. Photophysical and electrochemical studies revealed that the polymer has outstanding EC properties, including high optical contrast (52%), fast response time (0.5 s/0.7 s), high coloring efficiency (427.1 cm 2 C −1 ) and good stability. What's more, PPDOTTPD exhibited EFC phenomenon. PPDOTTPD film showed an intense red near-infrared fluorescence with a peak of 672 nm, which gradually doped with the increase of applied potential with a maximum contrast ratio of 12.9. The EC/EFC dual-functional device based on PPDOTTPD was also successfully fabricated, which exhibited high optical and fluorescence contrast. The fine dual-functional performance indicates TPD can be further explored as potential acceptors for synthesizing high performance D-A molecules for intelligent optical devices.
研究领域:
材料科学
·
电子工程
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2026
·
IF 19.7
Daoyue Xie,Junjie Ni,Huinan Che,Bin Liu,Yanhui Ao
The efficiency of photocatalytic O 2 activation for reactive oxygen species (ROS) generation is limited by kinetically sluggish electron transfer. Overcoming this limitation, we engineered a heterointerface (forming BaTiO 3 /Bi 12 O 17 Cl 2 , BTO/BOC) to facilitate d-p orbital hybridization by strain engineering, thereby creating a surface electron-rich region. Results demonstrate that strain engineering amplifies the d-p orbital hybridization effect, significantly enhancing O 2 adsorption strength. Furthermore, strain application enriches the electronic states near the Fermi level, enabling more electrons to migrate to the material surface to participate in O 2 activation. Consequently, the optimized BTO/BOC-3 exhibits exceptional ROS productivity, with 1.584 and 432.96 µmol g⁻¹ h⁻¹ yields for hydroxyl radical (·OH) and superoxide radical (·O 2 ⁻), respectively. This enables superior sulfamethoxazole (SMX) degradation performance, representing 2.88-fold and 11.08-fold enhancements over photocatalysis and piezo-catalysis, while toxicity simulations confirm reduced ecotoxicity of the degradation intermediates. This work pioneers a novel pathway for efficient piezo-photocatalytic ROS generation, enabling high-performance environment remediation.
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Biomaterials Advances
·
2026
·
IF 6.7
Jie Shi,Hongyan Liu,Jiafan Bai,Wenzhen Peng,Jie Weng,Wei Zhi,Jianxin Wang,Min Jia
Engineered HA/D-Mannose nanoparticles with temporal dual-targeting for colitis stages. • Achieved colon-specific drug release via a pH-responsive shell overcoming oral barriers. • Simultaneously targets inflammatory macrophages and damaged intestinal epithelium. • A single nanoparticle enables triple therapy: antioxidant, anti-inflammatory, and barrier repair. • Achieved >80% mucosal healing in ulcerative colitis within 7 days. Ulcerative colitis (UC) is characterized by complex spatiotemporal heterogeneity, which poses significant challenges for effective treatment. Herein, we constructed DS-HDLTQs, a core-shell nanodelivery platform with dynamic dual-targeting capabilities. This platform utilizes hyaluronic acid (HA) and D-mannose (D-Man) to target acute inflammation and promote repair. It also features a dopamine-alginate (DA-SA, or DS) shell to achieve pH-responsive release specifically at colonic lesions. In animal experiments, DS-HDLTQs achieved 83.3% mucosal healing in just 7 days, significantly outperforming single-targeting systems. The DA-SA protective layer ensures pH-responsive release in the colon with an efficiency of up to 92.7%. Such therapeutic enhancement is driven by three synergistic mechanisms: molecular functional synergy (restoring antioxidants), spatiotemporal targeting-pathological process synergy (accelerating barrier reconstruction), and immune-epithelial repair synergy (promoting macrophage polarization and epithelial regeneration). DS-HDLTQs demonstrated a 12.7-fold increase in drug concentration at the lesion site. This design resolves the core contradiction between dynamic pathology and oral delivery efficiency, providing a new paradigm for UC treatment and potential applications in other inflammatory diseases. Download: Download high-res image (527KB) Download: Download full-size image
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CNS & Neurological Disorders-Drug Targets
·
2017
·Vol. 16
·期 2
·187-198
·
IF 2.506
Ming-Xia Song,Bao-Qi Rao,Bin-Bin Cheng,Yi,Wu,Hong Zeng,You-gen Luo,Xian-Qing Deng
Background: Epilepsy and depression are two of the common diseases seriously threatening life and health of human. A shared neurobiological substrate led to the bidirectional relationship and high comorbid occurrence of the two disorders. Recently, an increasing number of patients with epilepsy (PWE) require some form of antidepressant medication. However, most of the available antidepressants are inadequate for PWE for some reasons. So, the search for novel and increasingly effective drugs with anticonvulsant and antidepressant activities is necessary. Methods: A series of 2-substituted-6-(4H-1,2,4-triazol-4-yl)benzo[d]oxazoles (5a-p) were designed and synthesized. Their anticonvulsant activities were evaluated using maximal electroshock shock (MES) and subcutaneous pentylenetetrazole (scPTZ) seizure models in mice. Their antidepressant activities were screened with the forced swimming test (FST). Results: All the compounds showed anti-MES activities in different degree, among which 5g and 5j were the most promising one with ED50 value of 31.7 and 12.7 mg/kg, respectively. What’s more, 5g and 5j also exhibited nice anti-scPTZ activities and low neurotoxicity. Interestingly, these compounds also showed good antidepressant activities in FST. And the efficacy of 5g were also confirmed by a tail suspension test and a open field test. The pretreatment of thiosemicarbazide (an inhibitor of γ- aminobutyric acid synthesis enzyme) significantly increased the ED50 of 5g in MES and reversed the reductions in the immobility time of 5g in FST. Conclusion: Triazole-containing benzo[d]oxazole is a good skeleton to develop compounds with both anticonvulsant and antidepressant activities. We have got the compound 5g, which display remarkable antidepressant and anticonvulsant activities, and the GABAergic system was involved in the action mechanism of 5g.
研究领域:
药物化学
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神经药理学
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中枢神经系统疾病
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药物设计与开发
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Nano Today
·
2025
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IF 10.9
Wei Hu,Jiaxi Xu,Mingchen Lv,Min Sun,Zhen Fan,Jianzhong Du
Immunotherapy offers enduring cancer treatment by activating the immune system to eliminate cancer cells, but faces challenges like tumor immune evasion and low immunogenicity. Chirality, crucial in biological interactions, remains underexplored for immune modulation. Inspired by the metal-binding domain of manganese superoxide dismutase, we develop a cyclic D/L peptide for chirality-driven immune activation. The cyclic L -Tyr- D -His- L -Asp- D -His (YhDh) peptide coordinates with Mn 2+ to self-assemble into nanoparticles, cloak with tumor cell membranes for homologous targeting. Compared to all-L or all-D peptides, YhDh nanoparticles promote costimulatory molecule expression on dendritic cells (DCs). Upon intravenous administration, they are oxidized at melanoma sites with tyrosinase overexpression, enabling photothermal-induced immunogenic cell death (ICD). Chiral peptides synergize with Mn 2+ -mediated cGAS-STING activation and ICD, enhancing DC maturation and T cell infiltration (4.36- and 2.88-fold), suppressing tumor metastasis while establishing immune memory. Such chiral cyclic peptides offer a novel strategy for immune activation by regulating peptide chirality.
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ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
·
2022
·Vol. 112
·期 2
·e21970
·
IF 2.454
Pan Zhang,Zi-Yan Liu,Dan Yu,Cui-Xian Xu,Yan Hu,Ya-Ping Liang,Jie Jin,Ming Li
Microplitis bicoloratus parasitism can induce apoptosis of hemocytes in the M. bicolortus host, Spodoptera litura . However, it is unclear how M. bicolortus parasitism regulates host signaling pathways to induce apoptosis. Expression of cyclophilin D (CypD) and p53 was significantly upregulated in S. litura hemocytes at 6 days postparasitization. In the parasitized hemocytes, there was mitochondrial membrane potential (△Ψ m ) loss, cytochrome c (Cyt C) release from mitochondria, and caspase-3 activation. These occurred while hemocytes were undergoing upregulation of CypD and p53. Parasitism also promoted the interaction between CypD and p53. CypD silencing could rescue the apoptotic phenotypes induced by parasitism, but had no effect on apoptosis in unparasitized S. litura . These findings suggest that the CypD-p53 pathway may be an important component of the parasitism-induced immunosuppressive response and establish a basis for further studies of parasitoid/host interactions. Research highlights Microplitis bicoloratus parasitism upregulates the expression of CypD and p53 and induces host hemocyte apoptosis. M. bicoloratus parasitism promotes the CypD-p53 interaction, resulting in Cyt C release from mitochondria and caspase-3 activation.
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APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Xianwei Li,Shuangxiu Ma,Fang Luo,Zehui Yang
Electrochemical hydrogenerations of nitrogen and oxygen molecules are of significance for nitrogen reduction and oxygen reduction reactions. Strengthening the binding between active sites and gaseous molecules is beneficial for enhancing the catalytic performance, especially in NRR catalysis. In this work, we have engineered the oxygen vacancies in Co 3 O 4 nanoparticles to boost the catalytic activity towards NRR and ORR. Ascribing to the p-d hybridization between Co and N atoms, N 2 electrochemical adsorption is promoted and the related energy barrier of N 2 protonation is significantly decreased by 50%; as a consequence, Faradaic efficiency is 11.2% at −0.4 V vs. RHE, 3-fold higher than Co 3 O 4 /CNT; moreover, due to the oxygen vacancies in Co 3 O 4-x /CNT leading to a higher oxophilicity, Co 3 O 4-x /CNT showed a better selectivity in ORR catalysis and kinetic current density at 0.85 V vs. RHE is boosted by 2.4 times. Consequently, Co 3 O 4-x /CNT exhibits a better rechargeable zinc air battery performance than Pt/C-IrO 2 by a factor of 2.2.
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ELECTROANALYSIS
·
2022
·Vol. 34
·期 10
·1564-1571
·
IF 3.077
Bo Kong,Xiang Yang,Huiqian Dai,Yu Wu,Hong-Bing Lu,Wei Liu,Xiaoying Liu
In this work, an electrochemical sensor was developed based on the delaminated titanium carbide nanosheet (d-Ti 3 C 2 T x ) and fullerene (C 60 ) composite modified glassy carbon electrode (GCE). The composite materials d-Ti 3 C 2 T x /C 60 were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The prepared modified electrode (d-Ti 3 C 2 T x /C 60 /GCE) exhibited commendable electrocatalytic activity for the oxidation of baicalein. Under the optimum detection conditions, the detection of baicalin showed a wide linear range of 0.015–4.0 μM with a detection limit of 0.005 μM. In addition, the d-Ti 3 C 2 T x /C 60 /GCE showed good reproducibility, stability and anti-interference. It was also successfully used for the determination of baicalin in the commercially available Shuanghuanglian oral liquid with satisfactory results.
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MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Yueting Liao,Yaohai Zhang,Qiyang Zhao,Wei Xiang,Bining Jiao,Xuesu Su
Metal organic framework MIL-101(Cr) was successfully synthesized as a selective adsorbent by a facile self-assembly technique and combined with UPLC-MS/MS for enrichment and determination of neonicotinoids in fruit juices and tea beverages. Therein, MIL-101(Cr) was characterized by Fourier transform infrared spectrometry, scanning electron microscopy, X-ray diffraction, and N 2 adsorption–desorption isotherms. Box-Behnken design was applied to optimize the significant variables including the sorbent amount, pH of the matrix, eluant volume, extraction time and desorption time. The optimized conditions were sorbent amount of 20 mg, eluent volume of 1 mL, extraction time of 5 min and desorption time of 4 min. Under the optimized conditions, excellent sensitivity was achieved with the limit of detection of 0.0019–0.02 μg/L and limit of quantification of 0.0063–0.067 μg/L. Good linearity (R 2 ≥ 0.9988) was obtained within the range of 1–1000 μg/L, and the recovery was 71.04%-101.64% with relative standard deviations (RSDs) of 1.25%-8.82% in spiked samples. The inter- and intra-day RSDs were both<8.54%. The adsorption isotherms investigated for acetamiprid, thiacloprid, and imidacloprid pesticides better fitted with the Freundich adsorption isotherm with bimolecular adsorption capacity of 71.43, 68.49, and 50.38 mg/g, respectively. These results indicate that the nanocomposite is feasible for adsorption of the target analytes at trace amounts from fruit juices and tea beverages.
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