TOXICOLOGY AND INDUSTRIAL HEALTH
·
2021
·
IF 2.273
Chong Wang,Yao Shu,Li Xu,Qiling Liu,Bei Zhang,Hong Zhang
Bisphenol A (BPA), a component of polycarbonate and epoxy resins, has been reported to induce learning and memory deficits. However, the mechanisms have not been fully elucidated. Growing evidence has suggested that N-methyl-d-aspartate receptors (NMDARs) are involved in cognitive impairments. In this study, BPA was administered to female Sprague–Dawley rats (six per dose group) at concentrations of 0 (control), 4, 40, and 400 μg/kg·body weight/day from gestation day 1 through lactation day 21. Spatial learning was evaluated using the Morris water maze on postnatal day 22. Expression levels of NMDARs were determined using real-time polymerase chain reaction and Western blot. The results showed that male offspring exposed to BPA exhibited increased latency in reaching the platform and reduced time in the target quadrant, and the number of crossing the platform was less, as compared with the control group. The mRNA and protein expression levels of NMDARs in the hippocampus were significantly downregulated when compared with the control group of male offspring. The data showed that maternal exposure to BPA at low dosage can cause cognitive deficits in male rat offspring, probably due to a decrease in NMDARs in the hippocampus.
研究领域:
神经科学
·
毒理学
·
发育生物学
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Zhiqiang Sun,Panpan Wang,Dongwei Lu,Caihong Liu,Jun Ma
Three dimensional (3D) poly(N-vinylpyrrolidone)-grafted-mesoporous silica (MS-g-PVP) was first synthesized, and explored as a filler for enhancing filtration performance of poly(vinylidene fluoride) (PVDF) composite membrane in this study. Membrane structure, interfacial property and filtration performance of the composite membranes were studied in detail. The relationships of mesoporous silica properties with membrane performance was systemically revealed. The 3D morphology of MS-g-PVP, that stably anchored in PVDF, endowed the membrane with defects-free, uniform and straight finger-like pores structure, and thus greatly enhanced water flux (maximized to 80.7 L m -2 h −1 , over 5.7 times than that of pristine PVDF membrane), without BSA rejection efficiency changing (98.6%). Three reasons can be accounted for the membrane performance improvement: i. The hydrophilic MS-g-PVP well dispersed in PVDF membrane matrix, and facilitated the formation of the evenly porous structure for the composite membrane; ii. Surface segregation of MS-g-PVP with the amount and diversity of oxygen-/nitrogen-containing groups on membrane surface, thus improving membrane surface hydrophilicity with contact angle decreasing from 89.0 ° to 70.6 ° ; iii. Numerous mesopores inside of MS-g-PVP provided additional water pathways. In addition, these synergistic effects also enhanced the fouling-resistance of PVDF/MS-g-PVP membrane, whose flux recovery ratio maintained at 85.8% even after three “fouling-cleaning” dynamic BSA solution (0.2 g L -1 ) filtration cycles.
研究领域:
材料科学
·
环境工程
✓ 已验证
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 35
·29638-29645
·
IF 3.289
Xin Ge,Xinzhi Chen,Chao Qian,Shaodong Zhou
Ullmann type C–N coupling reaction catalyzed by copper(I) with D-glucosamine derivatives as promoters was studied by means of combined experimental/theoretical investigation. The catalytic role of D-glucosamine was addressed. In contrast with previous speculations, the amino group may not count in the catalytic cycle in which the oxidative addition/reductive elimination mechanism works. Experimental results are in good agreement with theoretical findings. Extensive work indicates the wide applicability of the C–N coupling strategy exploited in this work.
研究领域:
有机化学
·
催化化学
·
药物化学
·
计算化学
·
合成方法学
·
生物正交化学
·
金属有机化学
✓ 已验证
DOI
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2024
·
IF 2.3
Dandan Niu,Danyang Zhou,Mengke Zhan,Lijing Lei,Jinhua Zhu,Xiuhua Liu
γ-Cyclodextrin-based metal-organic frameworks (γ-CD-MOF) were successfully synthesized using the solvent diffusion method and applied as carriers for trans-N-p-coumaroyltyramine (N-p-t-CT, NCT) to study the solubability, stability, sustained release and inhibitory activity against α-glucosidase. The solubilization effect of γ-CD-MOF on N-p-t-CT was performed using impregnation (NCT@CD-MOF-1) and co-crystallization (NCT@CD-MOF-2) methods. X-ray diffraction, scanning electron microscope (SEM), fourier transform infrared spectrometer (FTIR), and N2 adsorption/desorption were used to characterize the MOFs before and after loading NCT. The results showed that NCT@CD-MOF-2 had a better solubability for N-p-t-CT, 145.03 μg/mg of drug loading capacity could be achieved, and the solubility of NCT@CD-MOF-2 in water was 366 times higher than free N-p-t-CT. In addition, the stabilities of N-p-t-CT under temperature, UV light and pH conditions were greatly improved after encapsulation in γ-CD-MOF. Furthermore, NCT@CD-MOFs had a sustained release of N-p-t-CT over an extended period in vitro due to the primary encapsulation in pore structures. Notably, γ-CD-MOF loaded with N-p-t-CT showed superior inhibitory activity against α-glucosidase compared to free N-p-t-CT. Cytotoxicity studies demonstrated that NCT@CD-MOF-2 had low toxicity in vitro and perfect biocompatibility with HL-7702 cells, and γ-CD-MOF could reduce the toxicity of free N-p-t-CT at higher concentrations.
研究领域:
药剂学
·
生物化学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Yangke Long,Shun Li,Yiping Su,Shuyang Wang,Shiyin Zhao,Shubin Wang,Zhen Zhang,Wei Huang,Yong Liu,Zuotai Zhang
The poor performance and severe metal leaching of iron-based Fenton-like catalysts during reaction are the main bottlenecks that suppress their practical applications. Herein, a well-defined structure was achieved by confining catalytically active but unstable sulfur-containing iron species within S/N co-doped porous carbon (Fe-S@SNC) through a simple pyrolysis route. The hierarchically porous and highly conductive carbon host not only provided abundant exposed active sites and fast mass/electron-transfer, but also prohibited the aggregation of iron composites during catalysis. The synergistic effects of confined iron nano-composites and heteroatoms (S/N) significantly elevated the activation of peroxymonosulfate (PMS). As a result, the Fe-S@SNC/PMS system exhibited excellent catalytic degradation performance for various contaminants including dyes, phenolic compounds, and antibiotics. Importantly, a low iron leaching was detected during usage due to the nano-confinement effect of carbon layers, and therefore solves the long-term issue of secondary pollution caused by metal leaching. Furthermore, the underlying degradation mechanism of Fe-S@SNC/PMS system was systematically investigated by radical quenching tests, EPR analysis, and chronoamperometry experiments. It was found that the superoxide anion radical (O 2 − ) was the predominant free radicals that contributed to the radical oxidation of organic pollutants, while the electron transfer mediation on Fe-S@SNC resulted in the non-radical oxidation. Additionally, the LC-MS results coupled with time-dependent HPLC spectra validated that the degradation efficiency and intermediate products were significantly dependent on solution pH and background species. This work provides new insight into the design and activation mechanism of iron-based PMS activators.
研究领域:
环境科学
·
催化材料
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DOI
高影响因子
TRANSACTIONS OF NONFERROUS METALS SOCIETY OF CHINA
·
2018
·
IF 1.795
Cai-xia WANG,Hui-ping HU,Xue-jing QIU,Ze-ying CHENG,Lu-jia MENG,Li ZHU
A novel silica-supported tert-butyl 2-picolyamino-N-acetate chelating resin (Si-AMPY-1) was successfully synthesized and characterized by elemental analysis, FT-IR, SEM and 13 C CP/MAS NMR. The adsorption behaviors of the Si-AMPY-1 resin for Cu(II) and Ni(II) were studied with batch and column methods. The batch experiments indicated that the Si-AMPY-1 resin adsorbed Ni(II) mainly via physisorption, while adsorbed Cu(II) via chemisorption. The column dynamic breakthrough curves revealed that the Si-AMPY-1 resin can efficiently separate Cu(II) from the simulated nickel electrolyte before the breakthrough point. Moreover, the concentration of Cu(II) in the column effluent was decreased to be less than 3 mg/L within the first 43 BV (bed volumes), and the mass ratio of Cu/Ni was 21:1 in the saturated resin, which completely satisfied the industrial requirements of the nickel electrorefining process. Therefore, it was concluded that the Si-AMPY-1 resin can be a promising candidate for the deep removal of Cu(II) from the nickel electrolyte.
研究领域:
材料科学
·
环境工程
✓ 已验证
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2018
·
IF 5.123
Jean de Dieu Habimana,Jian Ji,Fuwei Pi,Eric Karangwa,Jiadi Sun,Wei Guo,Fangchao Cui,Jingdong Shao,Claudine Ntakirutimana,Xiulan Sun
Herein, a novel class-specific artificial receptor-based on molecularly imprinted polymer (MIP)-coated quantum dots (QDs@MIP) was synthesized, characterized, and used for the detection and quantification of the bacterial quorum signaling molecules N-acyl-homoserine lactones (AHLs), a class of autoinducers from Gram-negative bacteria. The QDs@MIP was prepared by surface imprinting technique under controlled conditions using CdSe/ZnS QDs as the signal transducing material. The synthesis of the QDs@MIP was characterized by transmission electron microscopy , scanning electron microscopy, Fourier transform infrared spectroscopy , X-ray diffraction analysis, and fluorescence spectroscopy . After template elution, the obtained cavities sensitively and selectively recognized the target AHLs of interest. The fluorescence intensity of the QDs@MIP was significantly quenched compared to the control non-imprinted polymer (QDs@NIP) upon exposure to different AHL concentrations. It also had a good linearity in the range from 2 to 18 nM along with a detection limit of 0.66, 0.54, 0.88, 0.72 and 0.68 nM for DMHF, C4-HSL, C6-HSL, C8-HSL and N-3oxo-C6-HSL, respectively. Most interestingly, the proposed sensor exhibited high sensitivity, good stability and fast response (30 s) towards the target molecules due to successful formation of surface imprints. The practicability of the developed sensor in real samples was further confirmed through the analysis of bacterial supernatant samples with satisfactory recoveries ranging from 89 to 103%. According to these results, the as-prepared QDs@MIP can be used as a new potential supporting technique for the rapid and real-time detection of bacterial pathogens in food safety and healthcare facilities.
研究领域:
生物化学
·
微生物学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Yuezhen Mao,Rongna Chen,Huanhuan You,Yang Liu,Sunrui Luan,Li Hou,Faming Gao
Antimony-based anodes possessing advantages of stable operating voltage and high theoretical capacity can replace graphene as alloy-based electrodes material in LIBs applications. However, the problems of capacity decaying and poor stability of Sb-based materials due to volume expansion and structural crushing during the long-term cycling remain to be solved. Therefore, we propose a strategy of using S and N co-doped carbon nanofibers encapsulated with Sb nanoparticles to overcome the above problems. The proposed material exhibits an excellent lithium storage performance with a high reversible specific capacity of 734 mAh g −1 at 0.1 A g −1 after 50 cycles (474.8 mAh g −1 at 1 A g −1 after 800 cycles, 394.5 mAh g −1 at 2 A g −1 after 2000 cycles). Importantly, a specific capacity of 288.5 mAh g −1 remains after more than 5000 cycles. The superior electrochemical performance of the S and N co-doped electrode is attributed to the proven structure and stability of the carbon matrix alleviating the volume changes of Sb during the process of lithium intercalation and extraction. The alloying/de-alloying reactions of the S@Sb@N-CNFs composite in the first charging/discharging process were systematically investigated by ex-situ XRD . This strategy of S and N co-doped carbon matrix could establish Sb-based materials as potential high-performance anodes for LIBs.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Shaohua Peng,Wenshuang Xu,Hui Liu
Stimuli-responsive hydrogels could effectively solve the problem that traditional drug carriers were difficult to deliver drug on-demand. However, some shortcomings such as complex preparation, single responsiveness, and narrow application still needed to be urgently overcome. In view of this situation, two kinds of hydrogels were elaborately designed in this work. In the unique ethanol/water mixed solvent , a homogeneous reaction system consisting of methacrylic acid (MAA) and N-isopropylacrylamide (NIPAM) was constructed, and a dual-responsive P(MAA-co-NIPAM) hydrogel was successfully synthesized. A near-infrared (NIR) responsive multi-functional PPy/P(MAA-co-NIPAM) hydrogel was subsequently prepared by the introduction of polypyrrole (PPy) via in-situ polymerization. NIR-responsive swelling, photodeformable, and photothermal ability of the hydrogel under NIR light irradiation were explored. It was found that rapid shape and temperature change could be achieved within 60 s for PPy/P(MAA-co-NIPAM) hydrogel. With doxorubicin as a model drug, the drug loading and in vitro controlled releasing behaviors under different conditions were comprehensively investigated. It was confirmed that the multi-responsive hydrogels had controllable drug releasing ability under different stimulations, which would realize potential targeted drug delivery in physiological environment. This work might provide a new synthetic method of hydrogel for drug releasing, which was expected to expand the potential application domain of hydrogel materials in NIR penetration targeted therapy.
研究领域:
药学
·
材料科学
·
生物医学工程
·
高分子化学
·
控制药物递送
✓ 已验证
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2023
·
IF 6
Zihao Dong,Yajuan Qu,Yuyang Jiao,Ke Xue,Wenguang Zhu,Hai Liu,Jianguang Qi,Yinglong Wang
A series of poly(1-vinyl-3-methylimidazole dimethyl phosphate- co -N-isopropylacrylamide) oligomers was synthesized by reversible addition-fragmentation chain transfer polymerization. The co-oligomers exhibited a pH-tunable lower critical solution temperature (LCST) phase transition in aqueous solutions. By changing the pH of the aqueous solution (HCI), the hydrogen bonding between the internal molecules of the co-oligomers and water molecules was weakened, which effectively reduced the cloud-point temperature. Poly(1-vinyl-3-methylimidazole dimethyl phosphate- co - N -isopropylacrylamide) oligomers exhibit an upper critical solution temperature (UCST) type of phase transition in an ester solution, which is associated with the formation and breaking of hydrogen bonds within the co-oligomers molecules. FT-IR analysis revealed the effect of temperature on hydrogen bonding between the functional groups. Energy decomposition, Electrostatic Potential (ESP), Atoms-in-Molecules (AIM), and Interaction region indicator (IRI) analyses demonstrated the presence of hydrogen bond donors N–H and imidazole ring C–H, and hydrogen bond acceptors C = O and P = O in the co-oligomers. The sites of hydrogen bonding between the co-oligomers and the solvent molecules as well as intermolecular forces were found to be the main factors contributing to the LCST/UCST-type phase transition.
研究领域:
高分子化学
·
物理化学
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2022
·
IF 10.319
Yang Lin,Song He,Zhiyong Ouyang,Jianchao Li,Jie Zhao,Yanhe Xiao,Shuijin Lei,Baochang Cheng
Hierarchical porous carbon co-doped with heterogeneous atoms has attracted much attention thanks to sizable internal void space accommodating electrolyte, high-density microporous structure physically confining polysulfides (LPS), and heterogeneous atoms serving as active sites to capture LPS. However, solely relying on carbon material defects to capture LPS proves ineffective. Hence, metal compounds must be introduced to chemisorb LPS. Herein, cobalt ions are in-situ grown on the polydopamine layer coated on the surface of biomass-derived S, N, P co-doped hierarchical porous carbon (SNP-PC). Then a layer of nitrogen-doped porous carbon (MPC) dotted with CoSe nanoparticles is acquired by selenizing. Thus, a strong-polar/weak-polar composite material of SNP-PC studded with CoSe nanoparticles is obtained (SNP-PC@MPC@CoSe). Button cells assembled with SNP-PC@MPC@CoSe-modified separator enable superb long-cycle stability and satisfactory rate performance. An excellent rate capacity of 796 mAh g −1 at a high current rate of 4 C with an ultra-low capacity fading of 0.06% over 700 cycles can be acquired. More impressively, even in a harsh test condition of 5.65 mg cm −2 sulfur loading and 4 μL mg −1 ratio of electrolyte to active materials, the battery can still display a specific capacity of 980 mAh g −1 (area capacity of ∼5.54 mAh cm −2 ) at 0.1 C. This work provides a promising route toward high-performance Li-S batteries.
研究领域:
材料科学
·
能源存储
·
纳米技术
✓ 已验证
DOI
高影响因子
PEST MANAGEMENT SCIENCE
·
2023
·
IF 4.1
Tianze Li,Min Lv,Houpeng Wen,Jiawei Du,Zhen Wang,Shaoyong Zhang,Hui Xu
Background Phytopathogenic fungi can cause a direct loss in economic value of agriculture. Especially Valsa mali Miyabe et Yamada, a devastating phytopathogenic disease especially threatening global apple production, is very difficult to control and manage. To discover new potential antifungal agents, a series of thiosemicarbazone derivatives of 3-acetyl- N -benzylindoles were prepared. Their antifungal activities were first tested against six typically phytopathogenic fungi including Curvularia lunata , Valsa mali , Alternaria alternate , Fusarium graminearum , Botrytis cinerea and Fusarium solani . Then their mechanism of action against V. mali was investigated. Results Derivatives displayed potent antifungal activity against V. mali . Notably, 3-acetyl- N -benzylindole thiosemicarbazone (IV-1: EC 50 : 0.59 μ g mL −1 ), whose activity was comparable to that of a commercial fungicide carbendazim (EC 50 : 0.33 μ g mL −1 ), showed greater than 98-fold antifungal activity of the precursor indole. Moreover, compound IV-1 displayed good protective and therapeutic effects on apple Valsa canker disease. By scanning electron microscope (SEM) and RNA-Seq analysis, it was demonstrated that compound IV-1 can destroy the hyphal structure and regulate the homeostasis of metabolism of V. mali via the ergosterol biosynthesis and autophagy pathways. Conclusion 3-Acetyl- N -(un)substituted benzylindoles thiosemicarbazones (IV-1–IV-5) can be studied as leads for further structural modification as antifungal agents against V. mali . Particularly, these ergosterol biosynthesis and autophagy pathways can be used as target receptors for design of novel green pesticides for management of congeneric phytopathogenic fungi. © 2023 Society of Chemical Industry.
研究领域:
农业科学
·
植物病理学
·
化学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）