JOURNAL OF MEMBRANE SCIENCE
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2022
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IF 10.53
Jiang Fan,Wufeng Wu,Zong Lu,Yanying Wei
The Metal-Organic Framework (MOF) materials are ideal molecular sieving membrane materials due to the regular pores with high-density and good designability, which have been widely studied in gas separation, desalination, and nanofiltration , etc. However, most preparation methods of MOF polycrystalline membranes are always time-consuming and the as-synthesized MOF membranes are thick. Here in this work, the ultrathin 210 nm-UiO-66 polycrystalline membranes are rapidly synthesized in 1 h, where sonication is utilized to generate massive tiny nucleation followed with rapid microwave-assisted membrane growth. The Na + rejection of the UiO-66 membrane maintains at 99.6% for 700 h long-term experiment with 0.16 L/(m 2 h bar) of water flux in forward osmosis, indicating the good quality and excellent stability of the as-synthesized membrane. This strategy is also expected to synthesize many other continuous defect-free MOF membranes with ultrathin thickness rapidly.
研究领域:
材料科学
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化学工程
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膜技术
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DOI
高影响因子
CHEMICO-BIOLOGICAL INTERACTIONS
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2022
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IF 5.168
Liangping Li,Wenqing Du,Hui Wang,Yufei Zhao,Zetian Huang,Yan Peng,Shulan Zeng,Guohai Zhang
p53 inactivation is a common feature in non-small cell lung cancer (NSCLC) resulting in NSCLC malignant transformation . Targeting serine 392 phosphorylation to restore p53 anticancer activity has proven to be an effective therapeutic strategy against NSCLC. A synthetic p53 activator, NA-17, has been developed that shows promise in preclinical models of NSCLC. However, NA-17 exhibits limited therapeutic efficacy in oncogene-driven tumors as well as relatively high toxicity to normal cells. It is possible that high efficiency and low toxicity p53 activators can be obtained by optimizing the leading molecule. Here, we performed high-throughput screening of compounds optimized based on NA-17 to identify new p53 activators. Two promising candidates named MX-C2 and MX-C3 were identified, both exhibited considerable therapeutic efficacy in oncogene-driven tumor models. Similar to NA-17, MX-C2/3 induced p53 activation via phosphorylating serine-392 without DNA damage. Both compounds showed broad antitumor activity in NSCLC cells and limited toxicity in normal cell lines. Moreover, MX-C2/3 suppressed tumor progression by arresting the cell cycle at G2/M phase, exhibiting a different mechanism of cell cycle arrest than NA-17. In addition, MX-C2/3 promoted the enrichment of p-p53 (s392) in mitochondria, leading to the conformational activation of Bak for cell apoptosis, which is consistent with NA-17. Finally, we demonstrated that MX-C2 significantly inhibited tumor growth without obvious systemic toxicity in oncogene-driven HCC-827 xenograft models. Collectively, we report two p53 activators with high-efficiency and low-toxicity that target p53 serine 392 phosphorylation for anticancer translational investigation.
研究领域:
肿瘤学
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分子生物学
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药理学
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癌症研究
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DOI
PubMed
高影响因子
Journal of Materials Chemistry A
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2018
·Vol. 6
·期 21
·9922-9929
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IF 9.931
Yang Chen,Bohan Shan,Chengyin Yang,Jiangfeng Yang,Jinping Li,Bin Mu
Two environmentally friendly and efficient synthesis methods, NH3-assisted synthesis and solvent-evaporated conversion, have been developed for the synthesis of a series of M(NA)2 (M = Zn, Co, Cu, Cd; NA = nicotinate) flexible MOFs. The two-dimensional M(NA)2 (M = Zn, Co) and three-dimensional M(NA)2 (M = Cu, Cd) materials exhibit peculiar structural transformation. These frameworks can be obtained from dehydration of M(NA)2(H2O)4 (M = Zn, Co, Cu, Cd) which are zero-dimensional supramolecular structures. Interestingly, the structural transformation of M(NA)2 (M = Zn, Co, Cd) is reversible after liquid water adsorption. Due to the flexible structure of these MOFs, they exhibit abnormal NH3 adsorption properties. The two-dimensional Zn(NA)2 shows a gate-opening behavior for NH3 adsorption. Its layers opened at a pressure of 0.22 bar in the first cycle, resulting in a two-step NH3 uptake with a capacity of 10.2 mmol g−1 at 1 bar. The gate-opening pressure shifted to a lower value with cycles. Co(NA)2 has a huge NH3 uptake of 17.5 mmol g−1, which is top-ranking among the reported values. For the NH3 adsorption over Cu(NA)2 and Cd(NA)2, the adsorption rates increase and adsorption equilibrium is achieved faster after three cycles. Their maximum capacity at 1 bar is 13.4 and 6 mmol g−1, respectively. More importantly, all MOFs can be regenerated under vacuum and heating conditions of 150 °C for 70 min, and they all retained the capacity. The advantages of environmentally friendly synthesis, large adsorption capacity, and regenerable properties indicate that M(NA)2 (M = Zn, Co, Cu) are promising candidates for NH3 adsorption.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
MATERIALS RESEARCH BULLETIN
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2023
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IF 5.4
Zhiwei Li,Zhengxiang Bian,Yurong Ren,Zhihui Chen,Jiujun Xu
(1-x)(0.9Ba 1.003 Ti 0.97 Ca 0.03 O 3 –0.1(Bi 0.51 Na 0.47 ) 0.94 Ba 0.06 TiO 3 )-xNa(Nb 0.85 Ta 0.15 )O 3 ( x = 0.03–0.15) ceramics were designed and fabricated through a bidirectional optimization strategy using traditional solid reaction method. The results revealed that the introduction of Na(Nb 0.85 Ta 0.15 )O 3 increased the vacancy concentration at the A site , conducing to improved polarization and reduced grain size. The substitution at the B site disrupted the long-range ordered ferroelectric domains and generated polar nanodomains, leading to enhanced relaxation behavior. The optimum energy storage density of 3.57 J/cm 3 and efficiency of 87.5% were simultaneously achieved under the electric field of 220 kV/cm in the sample with x = 0.09. Moreover, it also exhibits extremely high-power density (∼57 MW/cm 3 ), ultrafast discharge time (∼103 ns), high discharge density (1.35 J/cm 3 ), along with excellent temperature (30‒120 °C) and frequency stability (1‒100 Hz) under the equivalent electric field of 120 kV/cm. This novel design strategy provides theoretical guidance for the development of advanced electrical energy storage devices.
研究领域:
材料科学
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能源存储
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DOI
高影响因子
FUEL
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2022
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IF 8.035
Quanwang Zhong,Junwei Liao,Qian Zhang,Songbai Qiu,Qingwei Meng,Xiaoping Wu,Tiejun Wang
Developing biomass-derived fuels is a highly competent approach towards the current serious carbon emission issue caused by fossil fuel. The direct upgrading of the aqueous bio-ethanol to higher alcohols as diesel blending and bio-jet fuel precursors showed great potential in techno-economic. In this work, a water-tolerant Na-doped porous carbon encapsulated Ni nanocomposite was fabricated by direct pyrolyzing of Na-containing organic precursors for direct upgrading of aqueous ethanol. The higher alcohols yield of 35.0 C-mol% with C4-C7 selectivity of 51.9% and C8-C16 selectivity of 33.8% were achieved. The C4-C7 alcohols showed the excellent inter-miscibility with diesel at the 0–90% blending proportion. The C8-C16 higher alcohols with iso/n-OH (isomerized/normal alcohol) ratio of 1.86 can be directly used to produce desired jet fuel by hydrodeoxygenation treatment. Experiment and characterization results indicated that the Ni@C catalyst could spontaneously transfer from aqueous phase to the produced oil (higher alcohols) phase. The coupling of phase-transfer and basic sites of Ni@C-NaGlu effectively promoted the secondary C C coupling of higher alcohols to form C8-C16 alcohols. In general, this work provides a novel feasible approach to produce higher alcohol diesel blending and bio-jet fuel precursors from widely available bio-ethanol.
研究领域:
能源化学
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催化化学
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DOI
高影响因子
ACS Applied Energy Materials
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2022
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IF 6.959
Chi Wei,Gaoxu Huang,Jiayi Mao,Jia Cai,Xiaopan Jin,Mengjia Guan,Feng Yu,Bin Dai,Yongsheng Li
Sodium metal batteries (SMBs) are attracting intensive attention as an appealing candidate for high-energy-density batteries, owing to the high specific capacity, rich abundance, and low cost of metallic sodium (Na). However, the practical application of SMBs has been greatly hindered by the uncontrollable dendrite growth and unstable solid electrolyte interfaces, which are responsible for the poor Na stripping/plating reversibility and short lifespan. Herein, we report an atomically dispersed Fe-doped mesoporous carbon nanosphere (Fe-MCN) as a sodiophilic host for facilitating homogeneous Na nucleation and deposition behaviors. Benefitting from the advantages of uniform mesoporous structures with large surface areas and atomically dispersed Fe doped in the carbon nanospheres, low nucleation barriers and subsequent homogeneous deposition behavior of Na metal are achieved, which give rise to highly reversible stripping/plating performance and outstanding cycling stability. As a result, the Na||Cu cell based on Fe-MCN-modified Cu substrates exhibits outstanding electrochemical performance with a high Coulombic efficiency of 99.97% over 850 cycles, and an ultralong cycling lifespan of 2600 h at 1 mA cm–2 and 1 mA h cm–2 is demonstrated by the symmetric cell with Na@Fe-MCN@Cu anodes. Moreover, the Na3V2(PO4)3 full cell based on the Na@Fe-MCN@Cu anode guarantees outstanding cycling stability for 2000 cycles with a capacity retention as high as 84%, showing high potential in the practical application of SMBs.
研究领域:
材料科学
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电化学
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DOI
高影响因子
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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2026
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IF 17.6
Shiqi Wang,Tianwei Cui,Min Zhang,Yijun Song,Yue Zhou,Biao Li
In oxygen-redox cathodes, voltage hysteresis largely arises as oxygen redox generally proceeds with electrochemical reactions followed by chemical reactions that normally drive asymmetrical charge and discharge pathways. Although different superstructures, such as ribbon and mesh units, were intentionally introduced to mitigate voltage hysteresis, those structures remain as model compounds that can hardly be implemented in real-world applications. Here, inspired by the classical Li-rich layered Li[Li 0.2 Ni 0.2 Mn 0.6 ]O 2 , we design a new O3-type sodium layered oxide, NaLi 0.2 Ni 0.2 Mn 0.6 O 2 , that delivers 205.2 mA h g − 1 with reversible oxygen redox but shows mitigated voltage hysteresis and suppressed voltage decay. Atomic-resolution scanning transmission electron microscopy reveals that deep desodiation reconstruts an addtional inverse-honeycomb superstructure in the alkali layer, which is retained after discharge and extended cycling. Li analogues prepared via (electro)chemical ion-exchange reactions from pristine and charged-state Na precursors further reveal the critical role of this inverse-honeycomb ordering in suppressing voltage hysteresis. Thermal relaxation experiments combined with spectroscopic studies show that inverse-honeycomb ordering suppresses Ni-centered ligand-to-metal charge transfer associated with chemical relaxation, allowing the reduction process to proceed from a nonequilibrium state, thereby mitigating voltage hysteresis. Our study provides practical significance in this newly designed Na compound NaLi 0.2 Ni 0.2 Mn 0.6 O 2 by taking advantage of in situ formation of inverse-honeycomb ordering. Graphical An O3-type NaLi 0.2 Ni 0.2 Mn 0.6 O 2 cathode undergoes electrochemically induced reconstruction of inverse-honeycomb ordering in the alkali layer during deep desodiation. The reconstructed superstructure suppresses Ni-centered ligand-to-metal charge transfer, preserves more high-voltage cationic-redox contribution, and reduces delayed low-voltage oxygen reduction, thereby mitigating voltage hysteresis and voltage decay while maintaining high reversible capacity.
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DOI
高影响因子
Materials Today Energy
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2026
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IF 8.1
Peijun Zhu,Xin Zhou,Jiahao Lu,Zhixiong Zou,Liang Zhao,Ruizhi Yang
O3-type layered oxides are considered as potential materials for sodium-ion batteries (SIBs) because of their cost competitiveness and high reversible capacity. Whereas, their commercialization is limited by sluggish Na + kinetics, irreversible phase transition, and poor air stability. Herein, to address these challenges, we propose zirconium (Zr) doping to regulate the structure of O3-NaCu 0.2 Fe 0.3 Mn 0.5 O 2 (CFM). With the incorporation of Zr into CFM, the diffusion channel is expanded, and the detrimental phase transition is suppressed, thereby the Na + diffusion kinetics is facilitated and the layered structure is stabilized. The optimized NaCu 0.15 Fe 0.3 Mn 0.5 Zr 0.05 O 2 (CFM-Zr0.05) cathode delivers a high capacity of 121.5 mAh g −1 and a favorable capacity retention of 70% after 400 cycles at 1C. When paired with hard carbon anode, the full cell maintains 84.8% of its initial capacity after 100 cycles at 0.5C, demonstrating promising practical application potential. Furthermore, Zr-doped CFM cathode demonstrates enhanced air stability by mitigating Na + /H + exchange. This work presents a rational design strategy to achieve high-performance O3-type layered oxide cathodes, benefitting the development of SIBs for large-scale energy storage.
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DOI
高影响因子
Biomaterials Advances
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2026
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IF 6.7
Linfeng Fan,Zhiyuan Dai,Xinna Bai,Xudan Liu,Zhangui Tang,Hao Pan,Yan Zhang,Dou Zhang
KNN nanoparticles act as nucleating agents in PVDF films, promoting β-phase formation and enhancing piezoelectric properties. • The piezoelectric field generated by KNN/PVDF film promotes fibroblast migration. • Elevated TGF-β and VEGF expression accelerates angiogenesis and wound healing. Electrical stimulation that mimics endogenous electric fields represents a promising therapeutic strategy for wound healing. In this study, a lead-free piezoelectric composite film was fabricated by incorporating (K,Na)NbO 3 (KNN) ceramics into a polyvinylidene fluoride (PVDF) matrix via tape casting. The introduction of KNN fillers significantly enhanced the β-phase content and piezoelectric output of PVDF. Under ultrasound irradiation, the resulting KNN/PVDF film effectively promoted fibroblast proliferation and migration in vitro, achieving a 54.84% migration rate within 24 h and upregulating key wound-repair genes, including TGF-β and VEGF. In vivo, the composite film markedly accelerated the healing of full-thickness skin defects in rats, promoted neovascularization, and achieved approximately 95% wound closure by day 9. These results demonstrate that the KNN/PVDF composite film provides an effective wireless platform for biomimetic electrical stimulation in tissue regeneration.
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DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2026
·
IF 19.7
Juan Long,Gui Yang,Yang Wu,Lin Wang,Yawen Xiao,Shiping Zhang,Huachao Che,Juhong Zhan,Xiaoyong Wu,Bin Huang,Fengzhi Jiang,Shaowen Cao,Xuejun Pan
Ultrathin g-C 3 N 5 with Na-K sites, N-vacancies, and –C N was synthesized. • CN-Na-K yields 4739.89 μmol‧g −1 ‧h −1 H 2 O 2 under aeration-free conditions. • –C N and N-vacancies synergistically boost π-electron delocalization. • Na-K dual sites drive both ORR and WOR pathways for H 2 O 2 production. Photocatalytic solar-driven H 2 O 2 synthesis offers a sustainable energy route but is often limited by the need for supplemental oxygen. To overcome barriers, a distinctive ultra-thin g-C 3 N 5 nanosheet with cyano groups (–C N), N-vacancies, and Na-K dual active sites (CN-Na-K) was structured for H 2 O 2 production in natural-oxygen-conditions (aeration-free). The introduction of the –C N function as an electron pump to construct an internal electric field (IEF) promoted charge separation. Simultaneously, N-vacancies broke the structural localization to enhance π-electron delocalization, creating high-speed channels for carrier transport. Crucially, the Na-K dual sites acted as catalytic centers that enabled the water oxidation reaction (WOR) by driving the formation of key intermediates (*O 2 , *OOH, and *OH), where Na + acted as a powerful electron sink, and K + promoted excited-state electrons and stabilized holes. Therefore, the –C N, N-vacancies, and Na-K dual active sites synergistically promoted an enhanced H 2 O 2 production rate of CN-Na-K (1260.03 μmol‧g −1 ‧h −1 in LED lamp and 4739.89 μmol‧g −1 ‧h −1 in Xe lamp) under aeration-free conditions. Besides, characterizations and density functional theory (DFT) calculations confirmed the CN-Na-K system produced H 2 O 2 via a dual-channel pathway for the oxygen reduction (ORR) and WOR. This work provides a systemic design for electronic delocalization and dual active site engineering to achieve efficient aeration-free H 2 O 2 production. Download: Download high-res image (262KB) Download: Download full-size image
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DOI
高影响因子
DESALINATION
·
2025
·
IF 9.8
Jianning Liu,Jialu Chen,Zirui Wang,Shanxia Luo,Fengfeng Gao,Xiao Du,Wenbiao Ma,Xiaogang Hao
Efficient recovery of residual lithium from lithium precipitation brine has always been a major challenge. A stable and efficient lithium extraction system and a driven mode need to be constructed. This study presents an innovative coupled electrochemical system combining a chlorine-doped polypyrrole (PPy−Cl) electrode with the LiMn 2 O 4 electrode. In this system, the LiMn 2 O 4 film electrode and chlorine-doped polypyrrole were synchronized to remove lithium and chlorine ions, and complete de-intercalation of LiMn 2 O 4 could be achieved at the cell voltage of 1.1 V, which greatly reduces energy consumption. No manganese ions were detected in the solution compared to the 1.43 % manganese dissolution loss after 10 tests on the graphite plate (GP) used as an auxiliary electrode. In addition, self-electrical-energy recuperation can be achieved by utilizing the low potential difference between Li 1-x Mn 2 O 4 and polypyrrole. The performances of the self-driven(SD) mode and the constant-current(CC) mode were compared to achieve externally controlled energy release. The intercalation capacity reached 33.82 mg g −1 at 0.4 mA cm −2 , and the intercalation efficiency was maintained at 88.12 % after 10 tests. During the first discharge, the discharge efficiency of the SD mode was only 54.08 % of the CC mode. Furthermore, the system exhibited high selectivity (51.3) in the lithium-precipitated brine with a high concentration of Na + and Li + (Na + /Li + = 8.47). These results indicate that the proposed strategy has significant potential in Li + resource recovery and can be used in a variety of Li + resource recovery applications.
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Yanni Li,Zhigui Zhang,Baobao Wang,Runguo Zheng,Dan Wang,Zhishuang Song,Yanguo Liu,Zhiyuan Wang
High-entropy oxides (HEOs) represent promising anode materials for lithium-ion batteries, yet understanding the intricate relationship between their multi-element composition, crystal structure, and lithium storage mechanism remains a fundamental challenge. This study systematically investigates this relationship in (XCoNiCuZn)O (X = Li, Na, Mg) HEOs by modulating the fifth element. While all compositions form a single rock-salt structure, the cationic radius and valence state of X dictate both the lattice parameters and the electrochemical reaction pathway. It is revealed that (LiCoNiCuZn)O and (MgCoNiCuZn)O undergo a conversion-dominated phase transition mechanism, whereas (NaCoNiCuZn)O follows a solid-solution reaction. This mechanistic divergence, elucidated through in-situ EIS, ex-situ XRD/XPS, and kinetic analysis, directly governs the electrochemical performance. The Li-based HEOs (LiCoNiCuZn)O demonstrates exceptional performance, delivering a high capacity of 549.7 mAh g −1 with 83.4% retention after 300 cycles at 0.5 A g −1 , attributable to its effective charge compensation and superior ion conductivity. This work establishes a clear correlation from cationic modulation to storage performance, offering critical guidance for the rational design of HEOs for energy storage.
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高影响因子
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