INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yaoxun Zhang,Zhuo Chen,Jian Zou,Peiyong Feng,Xin Jing
Soft and wet hydrogels often struggle to achieve both toughness and high sensitivity simultaneously, limiting their usefulness in flexible devices. To tackle this challenge, we devised a strategy that combines supramolecular sodium alginate nanofibers, utilizing Zr 4+ as physical crosslinkers, with surface crack engineering via the micro-phase separation of polyaniline, to create a physically and chemically dual crosslinked polyacrylamide (PAM)/sodium alginate (SA)/polyaniline (PANI) hydrogel with exceptional toughness and high sensitivity. Owing to the supramolecular sodium alginate nanofibers, the dual crosslinked hydrogel exhibited a tensile strength of 0.391 MPa, an elongation at break of 568.9 %, and a toughness of 1.020 MJ/m 3 . The in-situ polymerized polyaniline layer, confined within the dense network, introduced micro-cracks onto the hydrogel surface, resulting in a high gauge factor of 11.4 for the fabricated hydrogel. Furthermore, integrating this hydrogel into a triboelectric nanogenerator transformed it into self-powered sensors capable of detecting external forces and generating various signals without power supply. These findings suggest that the developed hydrogel held great potential in diverse fields, including human motion detection, human-machine interaction, and wearable electronic devices.
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MOLECULAR BIOTECHNOLOGY
·
2025
·
IF 2.5
Chang Rui,Fang Wenjuan,Yang Xing,Jin Jiahui,Han Xijun,Ma Linlin,Li Yanfei,Chen Xiaoyan
Myocardial DNA damage plays a critical role in the pathogenesis of cardiovascular diseases, frequently leading to adverse outcomes such as myocardial infarction and heart failure. This study elucidated the protective effects of sodium alginate (SA) against myocardial DNA damage and explored the underlying molecular mechanisms involved. Hydrogen peroxide (H₂O₂) -stimulated AC16 cells were employed as an in vitro model to induce myocardial DNA damage, and CCK-8 assays established that SA exhibited no cytotoxicity at concentrations up to 800 µM. The protective effects of SA on myocardial DNA damage were shown to be mediated by VSNL1 using immunofluorescence, western blotting and qPCR analyses. To further substantiate this mechanism, lentiviral transduction was utilized to achieve VSNL1 overexpression, whereas targeted siRNA silencing was employed for VSNL1 knockdown. Following VSNL1 overexpression, a reduction in γ-H2AX protein expression was observed, accompanied by increased levels of CNP and NPR-B proteins on the cell membrane, as well as a decrease in intracellular calcium ion concentrations. Conversely, knockdown of VSNL1 reduced the protective effects of SA, highlighting its critical role in the mediation of cardioprotective mechanisms. Taken together, these findings suggest that SA exerts a potential protective effect against myocardial DNA damage through upregulating VSNL1, activating the CNP/NPR-B signaling pathway, and decreasing intracellular calcium ion accumulation. These results underscore that SA is a promising therapeutic candidate for the attenuation of myocardial injury.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Jing Chen,Yannan Zhang,He Liu,Haiqin Lu,Xu Xu,Minggui Shen
The evolution of production and lifestyle patterns has led to an increasing demand for multifunctional packaging materials that exceed the capabilities of traditional single-function options, thus driving continuous innovation in the field. In this study, a novel approach is presented, where camellia seed cake protein, derived from camellia seed oil production by-products, is incorporated into sodium alginate to create biobased active packaging films. The antioxidant and UV-shielding properties of the sodium alginate-camellia seed cake protein films are enhanced by the incorporation of camellia seed cake protein. A closely intertwined structure is created between sodium alginate and camellia seed cake protein through electrostatic interactions, resulting in effective water vapor barrier capabilities. Furthermore, the active packaging films exhibit antimicrobial activity against E. coli and S. aureus , providing significant advantages for fruit preservation. This research is essential in delaying fruit spoilage, extending shelf life, and providing new insights into the development of biobased multifunctional food packaging materials.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Yuyu Zhang,Wanling Cai,Zuliang Chen
With the demand for rare earth elements (REEs) increasing in the high-tech sector, the recovery of REEs from secondary sources is becoming very critical. In this study, sodium alginate/polyvinyl alcohol (SA/PVA) beads obtained by cross-linking alginate with polyvinyl alcohol were used to recover REEs from real rare-earth wastewaters. The results showed that SA/PVA beads are less affected by temperature and exhibited adsorption selectivity for REEs. The efficiency of adsorbing REEs ranged from 27.6% to 52.6%, but was significantly higher than that of 9.2% Mn. Meanwhile, among the observed REEs, SA/PVA beads revealed a preference for light REEs (44.3% − 52.6%). The adsorption process was investigated utilizing advanced characterization methods, namely Scanning Electron Microscope, Fourier Transform Infrared Spectrometer, and X-ray Diffraction Spectra. Combined with the results of Pearson correlation analysis, we proposed that the adsorption process involves the combined effects of ion exchange, complexation, electrostatic interaction and pore filling. As well, a desorption efficiency of more than 76.9% can be achieved with sodium citrate, which makes possible the effective recovery of REEs. In summary, this study provides a promising green, environmentally friendly and sustainable material for the enrichment and recovery of REEs from mining wastewater.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Ziwei Zhang,Wenjing Zhang,Lang Ding,Ming Liu,Bowen Zheng,Chenxin Yi,Jing Chen,Shuai Zhou
Human skin achieves high sensitivity and a wide range of tactile perception through its gradient structure and the synergistic function of various receptors. However, significant challenges remain in achieving multifunctional synergy enhancement for artificial skin. This study develops a soft-tough bilayer gradient hydrogel based on a salting-out and ion coordination toughening strategy, achieving high sensitivity (7.35 kPa −1 , 0–3 kPa) and a broad stress sensing range (0–75.44 kPa). The soft layer is designed with a low-density polyacrylamide (PAM) network, where weak chemical crosslinking improves both elasticity and sensitivity. Meanwhile, the tough layer is formed by a high-density dual crosslinked network of polyacrylamide /polyvinyl alcohol/sodium alginate, followed by post-treatment in ZnSO 4 solution. The combined effects of salting-out and ion coordination greatly enhance toughness, extend the stress detection range, and strengthen interlayer adhesion. Furthermore, this study integrates the hydrogel into a robotic arm and develops a gel-controller-computer tactile feedback system that simulates the conditioned reflex mechanism, enabling non-destructive recognition and precise grasping of objects with varying hardness. Moreover, the bilayer gradient hydrogel-based sensor facilitates comprehensive recognition of an object's weight and shape. This research offers a novel approach to advancing artificial skin, bioinspired robotics, and intelligent sensing technologies.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
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IF 7.7
Guodong Chai,Ning Wang,Meiling Xu,Lina Ma,Xinglong Liu,Qiteng Ding,Shuai Zhang,Anning Li,Guofeng Xia,Yingchun Zhao,Wencong Liu,Dadong Liang,Chuanbo Ding
Bacterial infection, hyperinflammation and hypoxia, which can lead to amputation in severe cases, are frequently observed in diabetic wounds, and this has been a critical issue facing the repair of chronic skin injuries. In this study, a copper-based MOF (TAX@HKUST-1) highly loaded with taxifolin (TAX) with a drug loading of 41.94 ± 2.60 % was prepared. In addition, it has excellent catalase activity, and by constructing an oxygen-releasing hydrogel (PTH) system with calcium peroxide (CaO 2 ), it can be used as a nano-enzyme to promote the generation of oxygen from hydrogen peroxide (H 2 O 2 ) to provide sufficient oxygen to the wound, and at the same time, solve the problem of the oxidative stress damage caused by excess H 2 O 2 to the cells during the oxygen-releasing process. On the other hand, TAX and HKUST-1 in PTH synergistically promoted antimicrobial and anti-oxidative stress properties, and the bacterial inhibition rate against Staphylococcus aureus and Escherichia coli reached 90 %. In vivo experiments have shown that PTH hydrogel is able to treat diabetic skin repair by inhibiting the expression of inflammation-related proteins and promoting epidermal neogenesis, angiogenesis and collagen deposition.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Mingxue Xia,Xiao Meng,Limin Lin,Ang Gao,Yunhe Diao,Xuying Liu,Huige Yang
Hydrogel-based flexible electronic devices have garnered significant attention due to their excellent mechanical properties, high electrical conductivity, and signal sensitivity. Nevertheless, internal water molecules crystallize inevitably at low temperatures, impairing the performance of hydrogels. Designing anti-freezing and tough hydrogels to meet long-term stability requirements is extremely challenging. A double physically crosslinked PVA/SA-g-DA/Fe 3+ hydrogel was fabricated using a two-step method. The coordination mode between catechol groups and ferric ions was modified by adjusting pH of soaking solution, subsequently regulating antifreeze performance and mechanical properties of the hydrogels. The obtained PVA/SA-g-DA/Fe 3+ hydrogel is stretchable, tough, and has a remarkable freeze tolerance (−42.21 °C). The hydrogels can be assembled into a strain sensor to monitor various human activities accurately at normal and low temperatures. This study proposes a strategy for designing hydrogels for supporting signal detection in cold environments.
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FOOD CHEMISTRY
·
2024
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IF 8.5
Meirong Xu,Siqun Liu,Jiaxin Wen,Bingyang Wang,Huifang Wang,Xiaojie Lian,Xianghua Gao,Baolong Niu,Wenfeng Li
Silver-metal organic framework (Ag@MOF) has exhibited outstanding antimicrobial activity in antimicrobial applications, and reducing the biotoxicity associated with silver has become a research priority. In this study, Ag@MOF was initially modified with sodium alginate (SA) to form SA-Ag@MOF. The results showed that SA could control the release of Ag + , reducing the release by about 8% at 24 h, and the biotoxicity was significantly reduced. Finally, SA-Ag@MOF was applied as an antimicrobial agent in citric acid-modified PVA film to develop a novel composite antimicrobial film. When added at 2 MIC , the CA3-M2 film can effectively inhibit the growth of E. coli and S. aureus , and the inhibition rate has reached 98%. For white radish packaging applications, CA3-M2 film inhibited the growth of surface microorganisms, while ensuring moisture and tissue hardness to extend shelf-life up to 7 days. Overall, the strategy conceived here can be a theoretical basis for novel antimicrobial packaging .
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JOURNAL OF POLYMER RESEARCH
·
2025
·Vol. 32
·期 10
·1-15
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IF 2.8
Li Hui,Li Yangyang,Yan Haotan,Liao Xunhua,Wang Ning,Xue Zijian,Wang Shiyu,Li Wen,Chen Zhenbin,Liu Hong
This work prepared a lignin-based double-layer slow-release fertilizer (SRF). We prepared sodium alginate-zinc ammonium phosphate microbeads as the inner core of fertilizer by ion exchange method, cellulose acetate butyrate (CAB) co-blended with degradable material polylactic acid (PLA) as the inner coating, and two chemically modified lignin (sulfonated lignin and epoxy-aminated lignin) as the second coating. The synthesized Materials were characterized morphologically and structurally by FTIR, TG, XRD and SEM. The viscosity, mechanical property, water contact angle, water-holding property, water-retention and slow-release property of the samples were evaluated. PC-SRF, PSC-SRF and PEC-SRF all had superior water-retention and nutrient release property compared to sodium alginate-zinc ammonium phosphate. The release of urea and phosphorus in the single-layer PC-SRF reached equilibrium after 34 and 36 days, and their cumulative release rates reached 87.09% and 86.19%, respectively. The release of urea and phosphorus from the bilayer PSC-SRF reached equilibrium after 38 and 40 days, and the cumulative release rates reached 83.57% and 82.07%, respectively; the release of urea and phosphorus from the bilayer PEC-SRF prepared under the same conditions reached equilibrium after 38 and 42 days, and the cumulative release rates reached 81.47% and 81.66%, respectively. Graphical abstract
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BIOMACROMOLECULES
·
2025
·
IF 5.4
Xiaomin Zhang,Zhuoya Zhang,Weilei Tang,Yuanfeng Ye,Xiaoli Yang,Guangshui Li,Mei Chen,Xinyan Zhang,Guozhao Ning
Wearable devices characterized by their flexibility are garnering significant interest, particularly in light of the emergence of notable conductive hydrogels. Although many of these hydrogels are highly conductive, they often lack adhesion. The ideal hydrogel should possess superior adhesive properties and a wide range of responsiveness. This study introduces a distinctive interpenetrating network conductive hydrogel, synthesized via a single-pot method employing lignosulfonate sodium and sodium alginate. The hydrogel’s high mechanical strength (∼196 kPa modulus, ∼435 kPa tensile) and conductivity stem from its dynamic hydrogen bonds, electrostatic interactions, and 3D network. Furthermore, the hydrogel exhibits adhesive properties due to sulfonic, phenolic hydroxyl, carboxyl, and hydroxyl groups from lignosulfonate sodium and sodium alginate, enabling it to adhere to various material surfaces. It also detects human physiological signals with wireless monitoring capability, demonstrating a rapid response (∼100 ms) and high sensitivity, with a maximum gauge factor of 4 at strains of 0–10%.
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Journal of Water Process Engineering
·
2024
·
IF 6.3
Can Cai,Longfei Gao,Yuzhu Xiong
In this work, Fe 3 O 4 magnetic particles were in-situ grown on the surface of Montmorillonite (MTT) via co-precipitation method, and a green, recyclable chitosan (CS)/carboxymethyl cellulose (CMC)/sodium alginate (SA)/MMT-Fe 3 O 4 double network (DN) hydrogel (C-M-SD/MMT-Fe 3 O 4 ) was successfully synthesized. The magnetization of MMT-Fe 3 O 4 addition improved the maximum compressive strength of CS/CMC/SA double network hydrogel (C-M-SD), reaching 17.13 kPa. The adsorption capacities of the magnetized DN hydrogel for methylene blue (MB) and Cu 2+ were 224.49 mg/g and 121.15 mg/g, respectively. Moreover, cytotoxicity tests using CCK8 solution showed that the cell activity was >80 % after 24 h culture in the prepared hydrogel extracts, which demonstrated that the prepared hydrogel adsorbent did not release any toxic substances into the water source throughout the adsorption process . It can be concluded from the Vibrating Sample Magnetometer (VSM) that the saturation magnetization of the prepared magnetic double-network hydrogel reaches 15 emu/g and the coercivity is 0, showing the superparamagnetism . The synthesized C-M-SD/MMT-Fe 3 O 4 hydrogel possesses excellent mechanical properties, natural degradability, recyclability and biocompatibility, making it an ideal candidate for wastewater treatment applications.
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Food Chemistry-X
·
2024
·
IF 6.5
Jinman He,Wanli Zhang,Gulden Goksen,Mohammad Rizwan Khan,Naushad Ahmad,Xinli Cong
In this study, zein-pectin nanoparticles loaded with Wampee [ Clausena lansium (Lour.) Skeels] (WEO) were developed. The particle size of the nanoparticles is 515.9 nm, polydispersity index is 0.4 and zeta potential is −39.3 mV. Subsequently, the ZWP was incorporated into sodium alginate (SA)-based film (ZWP-S). The films were then analyzed to determine their physical properties and thermal stability, and also to examine their microstructure and intermolecular forces using SEM, FTIR, and XRD techniques. Additionally, the films were evaluated for their antimicrobial and antioxidant activity, as well as their ability to sustain the release of WEO. Overall, the ZWP-S film conferred excellent functional properties, including UV barrier performance, mechanical properties (21 % increase in tensile strength), water sensitivity, stability, more compact structure, high antioxidant activity and long-lasting antimicrobial activity, surpassing those of the control film. Consequently, it was applied as a novel coating for preserving strawberries, rotting rate of strawberries was reduced by 43 % at 6d, yielding promising results in prolonging the freshness of the fruit.
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