CARBOHYDRATE POLYMERS
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2018
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IF 5.158
Jing-Bo Hu,Shu-Juan Li,Xu-Qi Kang,Jing Qi,Jia-Hui Wu,Xiao-Juan Wang,Xiao-Ling Xu,Xiao-Ying Ying,Sai-Ping Jiang,Jian You,Yong-Zhong Du
Based on the abnormally increased expression of CD44 receptors on renal tubule epithelial cells during ischemia/reperfusion-induced acute kidney injury (AKI), we developed a hyaluronic acid-curcumin (HA-CUR) polymeric prodrug targeting to epithelial cells and then relieving oxidative stress damages. The water solubility of HA-CUR was significantly enhanced and approximately 27-fold higher than that of CUR. Cellular uptake test showed HA-CUR was preferably internalized by H 2 O 2 -pretreated tubular epithelial (HK-2) cells compared with free CUR benefiting from the specific binding between HA and CD44 receptors. Biodistribution results further demonstrated the increased accumulation of HA-CUR in kidneys with 13.9-fold higher than that of free CUR. Pharmacodynamic studies indicated HA-CUR effectively ameliorated AKI, and the exact mechanism was that HA-CUR protected renal tubule epithelial cells from oxidative stress damage via inhibiting PtdIns3K-AKT-mTOR signaling pathway. Taken together, this study provides a new therapeutic strategy for the treatment of AKI based on the pathogenesis of the disease.
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高影响因子
Journal of Food Measurement and Characterization
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2025
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IF 3.3
Xu Wei,Li Lala,Xin Yingying,Kang Mengyao,Li Penglin,Luo Denglin,Zhang Lihua
This study develops novel antimicrobial camellia oil composite films based on konjac glucomannan (KGM) and κ-carrageenan (KC) incorporated with a curcumin (CUR)-loaded camellia oil nanoemulsion to address food packaging safety and sustainability. The composite solutions and films were systematically characterized. The results demonstrate that the integration of KGM significantly enhanced the rheological characteristics of the composite solution, while also improving the hydrophilicity of the resulting composite film. Thermogravimetric analysis (TGA) revealed that 0.4% KGM elevated the maximum thermal degradation temperature to 250.23 °C, significantly enhancing thermal stability. Fourier transform infrared (FTIR) and X-ray diffraction (XRD) analyses further demonstrated that KGM and KC established a stabilizing network structure through hydrogen bonding interactions. Confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM) indicated that KGM concentrations between 0.1% and 0.3% promoted uniform emulsion droplet dispersion and a smooth film surface. It is noteworthy that when the concentration of KGM was 0.1%, the composite film showed a zone of inhibition of 4.64 mm against Escherichia coli and 4.67 mm for Staphylococcus aureus , which were significantly larger than those of other formulations. In summary, this research presents a theoretical framework designed to enhance the development of high-performance, multifunctional antimicrobial packaging materials, with the objective of fostering sustainable food practices.
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Innovative Food Science & Emerging Technologies
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2026
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IF 6.9
Haoran Li,Yongsheng Ni,Yumeng Li,Baocai Xu
Photodynamic inactivation (PDI) is a promising non-thermal antimicrobial technology. However, its practical application is constrained by the low-light utilization efficiency and poor adhesion of photosensitizers. To address these limitations, we developed a curcumin/octyl gallate/chitosan (COS) coating. COS was prepared via a two-stage self-assembly process by incorporating a curcumin/octyl gallate (CUR/OG) assembly into a chitosan (CS) matrix. The CUR/OG, characterized by a band gap of 2.3 eV, imparted visible-light activity to the COS. Furthermore, the COS exhibited good adhesion, storage stability, and photostability. Compared to pristine CS, the COS exhibited a 1.3-fold enhancement in adhesion strength. Upon visible-light irradiation, it achieved up to a 6.5-log CFU reduction in the population of four representative foodborne bacteria ( Pseudomonas fragi , Brochothrix thermosphacta , Escherichia coli O157:H7, and Staphylococcus aureus ). Biochemical analyses indicated that COS-mediated PDI was associated with the disruption of bacterial cell membrane integrity, impairment of energy metabolism, and induction of oxidative stress. Under visible light, the COS extended the refrigerated shelf-life of prepared mutton to 1.5 times that of the untreated control. Moreover, the COS-mediated PDI maintained approximately 99.99% reduction in bacterial counts after three consecutive reuse cycles on food contact surfaces. This study provided an effective approach for enhancing the bactericidal activity and adhesion of photodynamic coatings, offering a promising solution for preservation of prepared mutton.
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FOOD CHEMISTRY
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2026
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IF 10.4
Chaoping Fang,Jingtao Mei,Xiaohua Wu,Licong Yang
Water-soluble antioxidants exhibit strong activity but limited effectiveness in edible oils due to poor lipid solubility and short residence time. In this study, a food-grade sodium alginate–chitosan hydrogel bead system encapsulating curcumin-loaded selenium nanoparticles (Cur@Se) was developed to enhance antioxidant delivery and stability in lipid matrices. The Cur@Se-loaded bead(chitosan concentration 5 mg/mL) formed a dense crosslinked network with improved mechanical strength (65% increase in hardness), high encapsulation efficiency (98%), and enhanced anti-swelling capacity (20%), enabling sustained release in the oil phase. This bead exhibited strong antibacterial activity against Staphylococcus aureus and Escherichia coli . Schaal oven tests demonstrated this hydrogel bead significant oxidative protection in soybean oil, reducing peroxide, acid value, p-anisidine, and total oxidation values by 31%, 39%, 33%, and 53%. Comparable protection was observed in rapeseed oil. This work highlights a food-grade, dual-functional delivery strategy integrating sustained release, interfacial antioxidant activity, and antimicrobial effects, providing a promising alternative to synthetic antioxidants for edible oil preservation.
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高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2026
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IF 7.1
Mengna Zhang,Qinchao Zhu,Tingmei Chu,Wei Xia,Hualing Xie,Jianchang Jin,Gongshuai Song,Xichuang Guo,Jinyan Gong
Peimine (P) and curcumin (CM) possess significant bioactivities but suffer from poor water solubility, low bioavailability, and limited stability. To address these challenges, P-CM self-assembled microparticles (SMPs) were prepared via non-covalent interactions and systematically characterized. The results demonstrated that optimal self-assembly reaction conditions occurred at pH 9, 25 °C, and a P:CM molar ratio of 1:1, yielding uniform nanoparticles (284 nm, PDI = 0.202) with a zeta potential of −19.77 mV. P-CM SMPs exhibited superior antioxidant activities, with ABTS, DPPH radical scavenging activity and FRAP values of 62.69%, 34.18%, and 81.02%, respectively, as well as enhanced anti-inflammatory activity compared to their individual components. To further improve stability and control release, the P-CM SMPs were encapsulated in a hollow zein-chitosan (HZ-CH) composite, achieving high encapsulation efficiency (96.0%). HZ-CH-SMPs exhibited storage stability over time and sustained-release behavior under simulated gastrointestinal conditions. This study provides a theoretical basis for designing delivery strategies integrating molecular self-assembly and protein-polysaccharide encapsulation to overcome solubility and bioavailability limitations of bioactive compounds in functional foods.
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8
Pengrui Wu,Xindi Wei,Zhihong Song,Chunling Nie,Zhonghui Shen,Yijun Liu,YanBo Wang,JianGuo Wang,Hong Zeng
Developing environmentally friendly delivery systems capable of encapsulating, protecting, and promoting the absorption of bioactive components in the human body is crucial for those with low oral bioavailability and poor stability. This study developed W/O/W emulsion-filled sodium alginate (SA) hydrogel for the co-delivery of hydrophilic riboflavin and hydrophobic curcumin. Firstly, W/O/W emulsion was prepared using peanut protein isolate (PPI)-bacterial cellulose nanofibers (BCNFs) as the hydrophilic emulsifier and lecithin as the lipophilic emulsifier, and the effect of stabilizer concentrations on emulsion stability was investigated. Results showed that PPI and BCNFs self-assembled into stable complexes through electrostatic interaction and hydrogen bonding, thereby improving the emulsification properties of PPI. Subsequently, SA was added to the outer aqueous phase of emulsions, and its influence on emulsion properties and stabilization mechanism was investigated. SA significantly improved the stability and rheological properties of PPI-BCNFs-stabilized W/O/W emulsions. Finally, the loading capacity of this system for riboflavin and curcumin and its gastrointestinal fate were evaluated. We found this delivery system efficiently co-delivered both hydrophilic and hydrophobic bioactive components and improved their photostability and thermal stability. Moreover, the bioaccessibilities of riboflavin and curcumin were significantly increased to 61.97% and 45.66%, respectively. This was attributed to SA forming a composite interfacial layer on droplets and a dense gel network in the continuous phase, thereby acting as a physical barrier to better protect the encapsulated components. This delivery system holds promise for the development of functional foods incorporating multiple nutraceuticals.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.1
Zongmei Huang,Cong-Ting Wu,Jing Li,Lu-Shuang Li
Illegal addition of curcumin (Cur) in food poses a significant public health threat, creating an urgent need for sensitive, reliable detection methods. In this work, dual-emission carbon dots (DCDs) were synthesized via a one-step hydrothermal method with Rose Bengal and melamine as raw materials. Based on the distinct fluorescence responses of DCDs to Cur at two characteristic wavelengths, a novel ratiometric fluorescence sensor for Cur detection was constructed. The emission at 432 nm is primarily governed by inner filter effect, while quenching at 532 nm is associated with the fluorescence resonance energy transfer. The sensor shows a robust linear range of 0.1–20 μM with a limit of detection of 0.089 μM. The sensor was successfully employed for the detection of Cur in various food samples, including chili, ginger, and mustard powder, achieving recovery rates between 92.75% and 110.00%. This work enriches CDs synthesis strategies and provides a sensitive, cost-effective, rapid method for Cur detection, supporting food industry monitoring needs.
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8.8
Fazhu Li,Tingting Yang,Guanghua Xia,Zhongyuan Liu,Dawei Yu,Zhidong Liu,Liming Zhang,Jiamei Wang
ACP treatment enhanced encapsulation and controlled release of curcumin / resveratrol. • ACP promoted hydrogen bonding and electrostatic interactions in nanoemulsions • ZCR/SA-NE-3 min showed excellent emulsifying and antioxidant activity. • Nanoemulsions prepared with ACP-pretreated ZCR/SA nanoparticles effectively reduced TVC and MDA levels in refrigerated tilapia • Nanoemulsions prepared with ACP-pretreated ZCR/SA nanoparticles extended the shelf life of refrigerated tilapia from 4 to 8 days. Oxidative degradation and microbial contamination cause quality deterioration of aquatic products under refrigeration, posing a major challenge to their preservation. In this study, zein-curcumin-resveratrol‐sodium alginate nanoparticles (ZCR/SA NPs) were pretreated with atmospheric cold plasma (ACP) for 1–4 min. The ACP-modified NPs were further fabricated into antioxidant nanoemulsions (NEs), and the influences of ACP pretreatment on the physicochemical properties, encapsulation efficiency, and sustained-release performance of the resultant NEs were systematically explored. The ACP treatment significantly improved the loading efficiency and controlled release of curcumin and resveratrol ( P < 0.05). FT-IR and XRD analyses indicated the formation of stronger hydrogen bonding and electrostatic interactions within the NEs system, which improved structural stability. Among all samples, ZCR/SA-NEs-3 min exhibited the best emulsifying properties (ESI = 358.57 ± 14.60 min, EAI = 30.51 ± 1.52 m 2 /g) and strong antioxidant activity (DPPH: 74.7 ± 1.67%, ABTS: 76.4 ± 2.17%). Importantly, ZCR/SA-NEs-3 min could significantly delay the spoilage process of tilapia fillets during 8 days of storage. Compared with the control group, the total viable count decreased from 8.07 ± 0.04 to 5.20 ± 0.04 lg₁₀ CFU/g, the malondialdehyde content dropped from 1.57 ± 0.03 to 0.49 ± 0.01 mg MDA/kg, and the shelf life was extended from 4 days to 8 days. This study not only revealed the mechanism underlying property improvement of NEs by ACP-modified NPs, but also provided an eco-friendly and innovative strategy for efficient preservation of aquatic products. Download: Download high-res image (265KB) Download: Download full-size image
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LIVER INTERNATIONAL
·
2026
·Vol. 46
·期 6
·e70696
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IF 6.2
Ling Liu,Jintao Zheng,Ye Wang,Chenao Yang,Yuqiang Shan,Changku Jia
Background & Aims Hepatic fibrosis (HF) is a key pathological process in the development of chronic liver disease, and the activation of hepatic stellate cells (HSCs) is its core driving factor. Although curcumin, as a natural polyphenolic compound, has therapeutic potential, its specific mechanism in HF is still unclear. Methods This study used the CCl4-induced mouse HF model and explored its mechanism through single-cell RNA sequencing (scRNA-seq) combined with in vitro and in vivo experimental systems. Results The results showed that curcumin attenuated liver injury and fibrosis levels in mice with HF in a dose-dependent way, alleviated liver pathological damage, improved liver function indicators, and inhibited the release of inflammatory factors. ScRNA-seq analysis revealed a significant reduction in the number of activated HSCs after curcumin treatment, and the key gene Crispld2 was identified through perturbation model prediction and pseudo-temporal analysis. Curcumin significantly downregulated the expression of Crispld2 and inhibited the activation of the PI3K/AKT signalling pathway. In the TGF—β—induced LX-2 cell activation model, curcumin inhibited HSC proliferation, promoted apoptosis, reduced fibrosis-related protein expression, and decreased inflammatory cytokine secretion by regulating Crispld2. Overexpression of Crispld2 reversed the anti-fibrotic effect of curcumin, while the PI3K/AKT pathway inhibitor LY294002 restored its therapeutic effect. Animal experiments further confirmed that curcumin improved HF by regulating the Crispld2/PI3K/AKT axis. Conclusions This study elucidates the molecular mechanism by which curcumin exerts anti-HF effects by inhibiting the activation of the PI3K/AKT pathway mediated by Crispld2, providing a new strategy for targeted therapy of Crispld2. Lay Summary This study investigated the ameliorative effects of curcumin, a natural compound, on hepatic injury and fibrosis in mouse models of liver fibrosis. The underlying mechanism involves the suppression of the key gene Crispld2, which subsequently blocks the aberrant activation of the PI3K/AKT signalling pathway, thereby inhibiting the activation of hepatic stellate cells and exerting hepatoprotective functions. These findings furnish novel scientific evidence supporting the therapeutic application of curcumin in patients with liver fibrosis and shed new light on the development of Crispld2-targeted pharmaceutical agents. Curcumin can alleviate liver injury and fibrosis in mice with hepatic fibrosis. The underlying mechanism is that curcumin blocks the PI3K/AKT signalling pathway by targeting and inhibiting Crispld2, thereby suppressing the activation of HSCs and ameliorating hepatic fibrosis.
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ACS Applied Materials & Interfaces
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2026
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IF 7.8
Congshu Feng,Jiaxin Wu,Zilong Chen,Jinghang Li,Xinyang Deng,Wei Wang,Lesan Yan
Tumor cell survival and progression are critically dependent on intracellular redox homeostasis, with mitochondria playing a central role in maintaining this balance via antioxidant defenses. Consequently, therapeutic strategies that target mitochondrial function to disrupt this delicate balance are attracting increasing attention. Natural pro-oxidant drugs exhibit unique biological activities and relatively low systemic toxicity, demonstrating considerable promise compared to conventional chemotherapeutic agents. However, their clinical translation is impeded by poor solubility, rapid clearance, and limited tumor penetration. To overcome these limitations, this study designed a reactive oxygen species (ROS)-responsive amphiphilic block prodrug copolymer (PCC), which was synthesized via polycondensation of a cinnamaldehyde (CA)-functionalized ROS-cleavable thioketal monomer (TCA) with curcumin (Cur) and mPEG. This design enables the codelivery of CA and Cur. The self-assembled PCC nanoparticles demonstrated favorable biocompatibility and high drug delivery efficiency. In vitro, PCC NPs were effectively internalized by 4T1 tumor cells, where they rapidly and continuously released CA and Cur upon intracellular ROS stimulation. The two agents acted synergistically to promote ROS generation, induce calcium ion overload, and reduce mitochondrial membrane potential. This process established a positive feedback loop that amplified oxidative stress, disrupted the redox homeostasis of tumor cells, and ultimately induced apoptosis. Compared with free CA and Cur, PCC exhibited significantly cytotoxicity against 4T1 cells with the half-inhibitory concentration (IC50) of 13.93 μM, which is markedly lower than the 21.66 μM for free Cur and 193.06 μM for free CA. In vivo experiments confirmed that PCC nanoparticles could accumulate at tumor sites via the enhanced permeability and retention (EPR) effect, achieving a tumor inhibition rate of up to 86% and significantly suppressing tumor growth compared to other experimental groups. This work constructs an intelligent delivery platform based on a ROS-responsive drug delivery system, offering a promising strategy for the efficient delivery of natural antitumor drugs.
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ACS Applied Polymer Materials
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2026
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IF 5.2
Jie Zhang,Xinru Wang,Jinyu Shan,Dong Yang,Guangming Tian,Yunzhi Dang,Jianhua Ma
Excessive exudate accumulation and bacterial infection form a vicious cycle that causes wound maceration and persistent inflammation, representing a critical clinical challenge in chronic wound care. Although conventional hydrophilic dressings absorb exudate, they fail to enable directional fluid removal and lack active regulation of the wound microenvironment, including antioxidation and long-term antibacterial activity. Herein, we report a multifunctional integrated strategy combining green chemistry and electrospinning to fabricate an asymmetrically wettable Janus nanofibrous dressing (CP/PCA) for efficient biofluid management and synergistic antibacterial/antioxidative therapy. Curcumin (Cur) was used as both a reducing and capping agent for the in situ green synthesis of curcumin-functionalized silver nanoparticles (CAgNPs), which suppressed AgNP aggregation and introduced antioxidative activity. A bilayer structure was then fabricated via sequential electrospinning: a hydrophilic polyethylene glycol/cellulose acetate (PEG/CA) layer as the “pumping layer” and a curcumin-functionalized silver nanoparticle-loaded hydrophobic poly(ε-caprolactone) (PCL) layer as the “barrier layer”. Owing to the strong wettability gradient between the two layers, the Janus dressing displayed outstanding unidirectional liquid transport (self-pumping), spontaneously draining excess exudate from the hydrophobic wound-contacting side to the hydrophilic layer, maintaining a suitable moist interface and preventing maceration. Released Ag+ and curcumin exhibited synergistic antibacterial activity against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, with inhibition zones of 2.2, 1.5, and 1.3 mm, respectively. The dressing also showed excellent reactive oxygen species (ROS) scavenging ability and favorable hemocompatibility (hemolysis rate <5%). Overall, this green-synthesized CAgNP-based Janus nanofibrous dressing integrates unidirectional exudate removal, long-term broad-spectrum antibacterial activity, and antioxidative protection, offering a promising synergistic strategy for infected wound healing.
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International Journal of Nanomedicine
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2026
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IF 8.7
Tao Chen,Xingyu Liu,Dandan Li,Zhichan Cheng,Xi Zheng,Zhijie Yu
Purpose Current antidepressants are limited by insufficient efficacy of conventional monoaminergic drugs and poor brain penetration across the blood-brain barrier. This study designed pure curcumin loaded lipid nanoparticle (CNP) with optimized brain-targeting delivery for depression therapy.Methods Cur molecules first self-assembled into carrier-free drug nanoparticles. Subsequently, CNP were then prepared via thin-film dispersion and fully characterized in terms of particle size, PDI, DSC, XRD, TEM. The antidepressant effect of CNP was systematically investigated via in vitro and in vivo assays, including cellular uptake, LPS-induced stress model in BV2 cells, and in vivo CUMS depression model.Results CNP displayed uniform spherical morphology with an average size of 115.8 ± 18.3 nm, PDI of 0.216 ± 0.015 and zeta potential of −27.1 mV, along with high encapsulation efficiency (86.11 ± 4.28%), drug loading (6.62 ± 0.45%) and sustained release behavior. The cellular uptake efficiency of the CNP group reached 41.47 ± 1.45%, which was more than double that of the Cur group (17.21 ± 0.54%). In vitro studies showed that CNP not only rescued the viability of cells damaged by corticosterone and hydrogen peroxide but also exerted significantly enhanced anti-inflammatory and antioxidant effects in lipopolysaccharide induced cellular stress models. In vivo studies indicated that CNP alleviated depressive-like behaviors more effectively.Conclusion CNP exhibits significantly enhanced antidepressant efficacy, thus providing a promising approach for developing brain-targeted therapeutics for MDD.
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