Catalysts
·
2025
·Vol. 15
·期 9
·826
·
IF 4
Anran Zhu,Zhufan Zou,Yu Cong,Yinghua Yin,Ning Li
A novel two-step strategy was developed for the efficient synthesis of decalin and octahydroindene from lignocellulose-derived platform compounds. In the first step, bicyclic intermediates were directly generated via a cascade dehydration/Robinson annulation of 4-hydroxy-2-butanone with cyclohexanone (or cyclopentanone). Among the evaluated catalysts, CaO demonstrated the highest activity and selectivity. Based on CO2-TPD results, the excellent performance of CaO can be rationalized by its proper basicity. In the second step, these intermediates were selectively hydrodeoxygenated to decalin (or octahydroindene) over Ni/H-ZSM-5 catalyst. Under the investigated reaction conditions, ~90% overall yields of decalin and octahydroindene were achieved. This work provides a viable strategy for the selective conversion of lignocellulose-derived platform compounds to the additives for improving the thermal stability of aviation fuel.
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Pharmaceuticals
·
2025
·Vol. 18
·期 9
·1383
·
IF 4.8
Hongtao Han,Dan Hu,Yaoming Deng,Jiayi Song,Yuyang Sheng,Jingxin Liu,Chengyu Wu,Bin Zeng
Background:Skin whitening agents often face challenges such as poor stability and low permeability. To overcome these issues, a novel 4-butylresorcinol (4-BR)/D-a- Tocopherol Polyethylene Glycol Succinate (TPGS) deep eutectic solvent (DES) system was developed, which can self-assemble into carrier-free nanoparticles (NPs).Methods: The 4-BR/TPGS DES was synthesized and characterized by theoretical calculations, DSC, FTIR, 1H-NMR, and 2D NMR to confirm its successful formation.Results: The self-assembled 4-BR/TPGS DES NPs showed a 3.46-fold increase in skin permeability, a 1.53-fold improvement in 4-BR stability, a 1.55-fold increase in melanin inhibition in B16 cells, and a 2.16-fold higher melanin suppression in zebrafish compared with traditional 4-BR oil-based formulations. These results indicated the excellent whitening efficacy and transdermal delivery potential of this formulation.Conclusions: The combination of TPGS-based DES and self-assembly technology represents a revolutionary approach for advanced transdermal delivery and the development of skin care products.
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PubMed
高影响因子
APPLIED CLAY SCIENCE
·
2018
·
IF 3.641
Junhua Zhang,Zhaoli Yan,Liangjie Fu,Yi Zhang,Huaming Yang,Jing Ouyang,Deliang Chen
Acid-activated sepiolite nanofibers (ASep) were organically modified with (3-aminopropyl) triethoxysilane (APTES) to produce the amino-functionalized nanofibers (NH 2 -ASep). Due to the amino groups, highly dispersed silver nanoparticles (AgNPs) were assembled on the surface of NH 2 -ASep by a simple chemical reduction approach, and the AgNPs were smaller than those directly deposited onto ASep surface. The as-synthesized Ag/NH 2 -ASep nanofiber catalysts exhibited an excellent catalytic activity in the reduction process of 4-nitrophenol to 4-aminophenol with full conversion within 150 s in the presence of NaBH 4 as the reductant . The results indicated that Ag/NH 2 -ASep nanofiber catalysts exhibited excellent catalytic activities because the highly dispersed of small-sized AgNPs were exposed on the surface of highly dispersed nanofibers with amino functional groups, allowing effective contact with the reactants and catalysis of the reaction. Moreover, the Ag/NH 2 -ASep nanofiber catalysts are stable and easy to use for the catalytic reaction due to their one-dimensional nanofiber structure with functional amino groups.
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高影响因子
Journal of Materials Chemistry C
·
2023
·Vol. 11
·期 31
·10660-10672
·
IF 6.4
Yonggang Zhao,Congyan Xu,Zhineng Zhou,Yufei Chen,Ying Zhang,Lang Wu,Xu Su,Xinghuan Hu,Shurong Wang
High-temperature sulfoselenization is essential in producing Cu2ZnSn (S,Se)4 (CZTSSe) thin-film solar cells. At high temperature, the Cu2ZnSn(S,Se)4 phase-transition speed is fast, which causes grain transition to mature quickly, followed by grain decomposition. Although grain surfaces are relatively flat at low temperatures, the small grain and more grain boundaries lead to low efficiency. In this study, a dynamic-temperature sulfoselenization process was adopted to utilize both the advantages of high and low temperatures comprehensively. Different constant- and variable-temperature sulfoselenization processes were developed for annealing Cu–Zn–Sn–S precursor films prepared in the air using dimethyl sulfoxide (DMSO) and 2-methoxyethanol (MOE) dual solvent systems. As a result, CZTSSe films with a flat, holeless, and dense surface, and a single-layer large grain penetrating the whole cross-section were fabricated by a proper variable-temperature sulfoselenization process. Finally, 11.11% total-area power conversion efficiency (12.22% active area efficiency) of CZTSSe solar cells (without antireflection coating) based on the variable-temperature sulfoselenization process was achieved successfully. Compared with the highest efficiency of 9.10% of CZTSSe film solar cells fabricated from the stable-temperature sulfoselenization annealing process, the efficiency was improved by 22%. The variable-temperature annealing processes in this study can also be applied to the preparation of other multi-element thin-film semiconductor materials.
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高影响因子
TURKISH JOURNAL OF CHEMISTRY
·
2026
·Vol. 50
·期 5
·542-553
·
IF 2
LIU JUN,LIAO HONGGUANG,LIU XUANYAN
Herein, AgCu nanodendrites were fabricated via a facile one-step displacement reaction at ambient temperature with Zn powder as the reducing agent. The morphology, structure, and composition of the products were systematically characterized by transmission electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The results demonstrate that the structure and morphology of the catalysts are strongly dependent on the Ag/Cu molar ratio. The catalytic performance was evaluated by the reduction of 4-nitrophenol (4-NP) at room temperature, in comparison with monometallic Ag and Cu catalysts. The catalytic activity follows the order Ag1Cu1 > Ag1Cu3 > Ag3Cu1 > Ag > Cu. The optimized Ag1Cu1 catalyst achieves 98.6% 4-NP conversion within 341 s, which is significantly faster than monometallic Ag (98.5% in 566 s) and Cu (98.8% in 1608 s). Moreover, the Ag1Cu1 catalyst retains 87% conversion after five consecutive cycles, showing good stability and reusability. The unique aggregated dendritic structure not only leads to composition-dependent catalytic activity but also facilitates catalyst separation from the reaction system. This work provides a simple and efficient strategy for constructing bimetallic nanodendrites and offers promising prospects for environmental remediation of wastewater containing 4-NP.
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高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2021
·
IF 7.446
Jinxin Che,Xiaoyang Dai,Jian Gao,Haichao Sheng,Wenhu Zhan,Yang Lu,Dan Li,Zizheng Gao,Zegao Jin,Binhui Chen,Peihua Luo,Bo Yang,Yongzhou Hu,Qiaojun He,Qinjie Weng,Xiaowu Dong
Rash is one of the primary dose-limiting toxicities of Akt (protein kinase B) inhibitors in clinical trials. Here, we demonstrate the inhibition of Akt2 isozyme may be a driver for keratinocyte apoptosis, which promotes us to search for new selective Akt inhibitors with an improved cutaneous safety property. According to our previous research, compound 2 is selected for further optimization for overcoming the disadvantages of compound 1, including high Akt2 inhibition and high toxicity against HaCaT keratinocytes. The dihedral angle-based design and molecular dynamics simulation lead to the identification of Hu7691 (B5) that achieves a 24-fold selectivity between Akt1 and Akt2. Hu7691 exhibits low activity in inducing HaCaT apoptosis, promising kinase selectivity, and excellent anticancer cell proliferation potencies. Based on the superior results of safety property, pharmacokinetic profile, and in vivo efficacy, the National Medical Products Administration (NMPA) approved the investigational new drug (IND) application of Hu7691.
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PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2018
·
IF 3.04
Jie-Fei Miao,Yan-Fu Peng,Shi Chen,Wei-Jie Gao,Qiu-Xing Yang,Peng Zhu,Jing Guo,Jinhua Tao,Lin Luo,Yanan Zhang,Yong Ling
This study aims to design and synthesize a novel harmine derivative N -(4-(hydroxycarbamoyl) benzyl)-1-(4-methoxyphenyl)-9H-pyrido [3,4-b]indole-3-carboxamide (HBC) as histone deacetylase (HDAC) inhibitor, and evaluate its antitumor activities and anti-metastasis mechanism. HBC not only exerted significant ant-proliferation activity against five human cancer cell lines, especially for HepG2 cell with an IC 50 value of 2.21 μM, which is nearly three-fold lower than SAHA (IC 50 = 6.26 µM), but also showed selective HDAC1/6 inhibitory effects in vitro. However, HBC had little effect on normal hepatic cells LO2. Furthermore, HBC simultaneously increased the acetylation of histone H3 , H4, and α-tubulin, induced hypochromism by electrostatical interaction with CT-DNA, triggered more significant cancer cell apoptosis and cell cycle arrest at G2/M than SAHA by inhibition of both CDK1 and cyclin B in a concentration dependent manner. In addition, scratch and invasion assay showed that HBC also dose-dependently suppressed migration and invasion capacities of highly metastatic HCC HepG2 cells through down-regulated the expression of tumor metastasis related proteins MMP-2 and MMP-9, significantly better than SAHA. Finally, HBC showed low acute toxicity to mice and significant growth inhibition of the hepatoma tumor in vivo. These results demonstrate that novel harmine-based HDAC inhibitor HBC not only exhibited selective HDAC1/6 inhibitory activity and significant in vitro and in vivo antitumor activity, but also possessed DNA binding effect, apoptosis induction, cell cycle arrest effects, and potent anti-metastasis mechanisms, which may hold great promise as therapeutic agent targeting HDAC1/6 for the intervention of human cancers.
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PubMed
高影响因子
ChemistrySelect
·
2025
·Vol. 10
·期 21
·e01335
·
IF 2
Yu-cheng Jiang,Bao-guang Zhu,Xiang-li Long
Graphical The production of 1-(4-chlorophenyl)-1H-pyrazol-3-ol from the oxidation of 1-(4-chlorophenyl)-pyrazolidin-3-one by air under the catalysis of Co(II)@AC has been enhanced by modifying the activated carbon with H₂C₂O₄ solution to increase the acidic groups and micropores on the carbon surface. The production of 1-(4-chlorophenyl)-1 H -pyrazol-3-ol by oxidizing 1-(4-chlorophenyl)- pyrazolidin-3-one with H 2 O 2 suffers from some shortcomings. The oxidation of 1-(4-chlorophenyl)-pyrazolidin-3-one to 1-(4-chlorophenyl)-1 H -pyrazol-3-ol can be realized by air catalyzed with Co(II)@AC (prepared by supporting cobalt(II) on activated carbon). Air is a good substitute for H 2 O 2 because it can minimize the cost, hazards, and pollution, which is beneficial to the improvement of the production process for pyraclostrobin. In this study, activated carbon has been modified by H 2 C 2 O 4 solution to improve the catalytic performance of Co(II)@AC. The experiments indicate that the best carbon is made by heating the carbon at 300 °C for 3 h with a heating rate of 5 °C/min in N 2 after being soaked in 0.4 mol/L H 2 C 2 O 4 solution at 50 °C for 12 h with an L/S ratio of 40/1 mL/g. The 1-(4-chlorophenyl)-1 H -pyrazol-3-ol concentration obtained by Co(II)@AC immobilized on the optimized carbon is 39.39% over that catalyzed by Co(II)@AC loaded on the original carbon. Characterization results reveal that modification with H 2 C 2 O 4 increases the specific surface area and enhances the acidity on the carbon surface. The oxidation rate of 1-(4-chlorophenyl)-pyrazolidin-3-one is primarily determined by the physical structure. The selectivity toward 1-(4-chlorophenyl)-1 H -pyrazol-3-ol is mainly influenced by the chemical characteristics.
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高影响因子
Inorganic and Nano-Metal Chemistry
·
2017
·
IF 0
Huimin Li,Shasha Li,Yuanrui Wang,Yafeng Li,Qian Qiao
In this article, two novel metal-organic frameworks (MOFs) have been constructed by tuning the metal ions using identical ligand—FDA. Although both of them contain linear trinuclear secondary building unit (SBU) and infinite chain along with SBU, the different metal ions as node can result in the different connection of FDA. As a result, compound I shows 4,4-networks, and compound II contains 3-ring and 4-ring.
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JOURNAL OF MOLECULAR STRUCTURE
·
2023
·
IF 3.8
Nanhao Jin,Yuqi Liu,Xiaoming Liu,Yue Zhao,Han Chen,Xinying Wang,Yuebin Feng,Huilong Luo,Wei Li
Four MOFs with two identical structures were constructed by using 1,4-bis(4-pyridyl)-2,3-diaza-1,3-butadiene (4-bpd) and 1,3-dicarboxyadamantane (H 2 adc) as linkers, and Co 2+ , Ni 2+ as metal nodes by solvothermal method. Single-crystal X-ray diffraction revealed that complexes [Co 2 (adc) 2 (4-bpd)] n ( 1 ) and [Ni 2 (adc) 2 (4-bpd)] n ( 2 ) have the same two-dimensional molecular structure, while complexes [Ni(Hadc) 2 (H 2 O) 2 ] n ( 3 ) and [Co(Hadc) 2 (H 2 O) 2 ] n ( 4 ) exhibit identical one-dimensional chain-like molecular structures. The photo/electrocatalytic performances and thermal stability of four complexes were investigated. Introducing 4-bpd to form mixed-ligand complexes 1 and 2 enables the degradation of crystal violet (CV) dye in a Fenton-like system. Furthermore, there is an improvement in the oxygen evolution reaction (OER) catalytic performance among the MOFs of the same metal nodes. It is worth mentioning that in this study, Co-based MOFs showed better catalytic performance than Ni-based MOFs, which is mainly attributed to the distinctive electronic structure of Co 2+ and Ni 2+ d orbitals.
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高影响因子
POULTRY SCIENCE
·
2026
·Vol. 105
·期 11
·107437
·
IF 4.5
Zhanbang Ma,Fangfang Wang,Bing Wang,Zhihui Zuo,Zongxi Han,Huixin Li,Deying Ma
Vitamin D is increasingly recognized as an important regulator of innate and adaptive immunity, yet its antiviral role in chickens during fowl adenovirus serotype 4 (FAdV-4) infection remains unclear. In this study, we investigated the effects of oral vitamin D 3 supplementation on humoral immunity, tissue viral load, and immune-related gene expression in FAdV-4-infected chickens. Ninety 8-day-old specific pathogen-free chickens were randomly divided into two groups (n = 45/group) and fed a basal diet. The experimental group received oral vitamin D 3 dissolved in 0.1 mL soybean oil at a dose equivalent to 3000 IU/kg diet daily for 3 weeks, whereas the control group received soybean oil alone. After supplementation, all birds were challenged with FAdV-4. Vitamin D 3 supplementation significantly reduced tissue viral loads and increased serum antibody levels compared with the control group. At the transcriptional level, vitamin D 3 modulated key innate and adaptive immune markers, including Toll-like receptors (TLRs), avian β-defensins, and cytokines. It downregulated several TLRs and reduced the pro-inflammatory cytokines interleukin (IL)-6 and IL-8, while increasing the antiviral cytokines interferon-γ and IL-1β. Vitamin D 3 also increased vitamin D receptor expression, decreased inducible nitric oxide synthase, and reduced the apoptosis regulators B-cell lymphoma-2 (BCL-2) and Bcl2-associated X protein in selected tissues. In conclusion, vitamin D 3 supplementation enhanced antiviral defense against FAdV-4 infection, possibly by promoting humoral immunity and modulating innate immune and apoptosis-related responses. These findings provide new insight into the role of vitamin D 3 in limiting FAdV-4 infection and support its potential as a nutritional strategy for controlling viral diseases in poultry.
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Zhongzhou Si,Haodong Chen,Shakoor Kashif,Ting Li,Fanghui Ma,Minghui Yang
Copper nanoclusters were synthesized based on 4-mercaptobenzoic acid (P-MBA) as template. • The addition of small molecule terephthalic acid (PTA) can enhance the fluorescence intensity. • The reaction between PTA and ascorbic acid can produce a blue fluorescent substance PTA-OH. • Acid phosphatase can catalyze the hydrolysis of l -ascorbic acid-2-phosphate to AA. • A ratiometric fluorescence assay for acid phosphatase was developed. Copper nanoclusters were synthesized based on 4-mercaptobenzoic acid (P-MBA) as template (P-MBA-CuNCs). Small molecule terephthalic acid (PTA) was then utilized to modify P-MBA-CuNCs and enhance the fluorescence intensity. Individual P-MBA-CuNCs were self-assembled into nanosheet aggregates in aqueous solution due to π-π stacking and hydrogen bonding interactions. These inter-cluster interactions accelerated the nonradiative process, resulting in quenching of the fluorescence. However, there is strong interaction between PTA and P-MBA, which blocks the inter-cluster interaction of CuNCs and enhances the fluorescence emission. In addition, the reaction between PTA and ascorbic acid (AA) can produce a blue fluorescent substance PTA-OH. Acid phosphatase (ACP) can catalyze the hydrolysis of l -ascorbic acid-2-phosphate (AAP) to AA. Therefore, a ratiometric fluorescence assay for ACP was constructed based on the CuNCs/PTA system with fluorescence intensity of CuNCs unchanged and fluorescence intensity of PTA-OH increased. The assay has linear response to ACP in the concentration range of 0.01–15 U/L, with detection limit as low as 0.003 U/L. The method was successfully applied to determination of the ACP in the human serum samples. Ratio fluorescence assay for acid phosphatase based on 4-mercaptobenzoic acid templated copper nanoclusters. Download: Download high-res image (111KB) Download: Download full-size image
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