INTERNATIONAL IMMUNOPHARMACOLOGY
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2020
·
IF 3.943
Ji Li,Ziquan Sun,Yu Lin,Yan Yan,Haichao Yan,Bao Jing,Zhiyang Han
Periodontitis is a common chronic disease. Osteoclast differentiation contributes to alveolar bone resorption which is a distinct phenomenon during periodontitis. Syndecan 4 (SDC4), a member of the syndecan family, was found to be highly expressed during periodontitis. However, little is known about its role in periodontitis. Herein, we explored the role of SDC4 in osteoclast differentiation. An experimental periodontitis rat model was established by ligating the right first molar. The SDC4 expression in periodontium was detected by western blot and immunofluorescence. Our study demonstrated that SDC4 was highly expressed in the periodontium of periodontitis rats. It was positively transcriptionally regulated by NF-κB. SDC4 silencing abrogated osteoclast differentiation induced by RANKL, while SDC4 overexpression enhanced osteoclast differentiation. Moreover, SDC4 enhanced autophagy induced by RANKL. 3-MA, an autophagy inhibitor, was employed to explore whether SDC4 impacts osteoclast differentiation through activating autophagy. Treatment with 3-MA abolished osteoclast differentiation which was enhanced by SDC4, indicating that SDC4 promotes osteoclast differentiation through activating autophagy. This study reveals that SDC4 may contribute to osteoclast differentiation during periodontitis through activating autophagy. It sheds light on the important role of SDC4 in periodontitis.
研究领域:
牙医学
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细胞生物学
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分子生物学
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PubMed
高影响因子
BIOORGANIC CHEMISTRY
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2020
·
IF 4.831
Chong Zhang,Yan Qu,Xin Ma,Manping Li,Sen Li,Yue Li,Liqiang Wu
Tumor-specific prodrug treatment renders the exclusive delivery of antitumor agents with the lowest untoward effects. In this work, we reported the synthesis and biological assessment of four NQO1-activatable combretastatin A-4 prodrugs constituted by active drug CA-4, different self-immolating linkers, and NQO1-responsive trigger groups. The in vitro antiproliferative activities showed that prodrug 4 displayed greater selective toxicity toward the tumor cells that overexpressed NQO1, taxol-resistant A549 cells, hypoxia-exposed A549 and HepG2 cells, and incurred lower damage to normal cells in comparison with combretastatin A-4, prodrugs 1 , 2 , and 3 . Moreover, based on a mechanistic study, NQO1 triggered prodrug 4 to effectively liberate the parent drug combretastatin A-4 and kill tumor cells. Furthermore, we also demonstrated that prodrug 4 exerted a stronger anticancer effect and greater safety than combretastatin A-4 under in vivo conditions. Hence, from the above results, NQO1 can be used as a specific delivery system for releasing anticancer agents; besides, prodrug 4 can serve as a candidate lead for developing specific anticancer agents.
研究领域:
药理学
·
肿瘤学
·
药物化学
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DOI
PubMed
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Theranostics
·
2019
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IF 8.063
Shuai Zhang,Peilin Hu,Tao Liu,Zhen Li,Yongcan Huang,Jinqi Liao,Md Rana Hamid,Liru Wen,Ting Wang,Cuiping Mo,Mauro Alini,Sibylle Grad,Tianfu Wang,Di Chen,Guangqian Zhou
Rationale The small molecule Kartogenin (KGN) promotes cartilage regeneration in osteoarthritis (OA) by activating stem cells differentiation, but its pharmacological mode-of-action remains unclear. KGN can be cleaved into 4-aminobiphenyl (4-ABP) and phthalic acid (PA) following enzymolysis of an amide bond. Therefore, this study investigated whether 4-ABP or PA exerted the same action as KGN. Methods KGN, 4-ABP and PA were analyzed in cartilage of mice after oral, intravenous or intra-articular administration of KGN by liquid chromatography-mass spectrometry method. Their effect on proliferation and chondrogenic differentiation of mesenchymal stem cells (MSC) was evaluated in vitro . Furthermore, their effect on cartilage preservation was tested in mice OA model induced by destabilization of medial meniscus. OA severity was quantified using OARSI histological scoring. Transcriptional analysis was used to find the possible targets of the chemicals, which were further validated. Results We demonstrated that while oral or intra-articular KGN delivery effectively ameliorated OA phenotypes in mice, only 4-ABP was detectable in cartilage. 4-ABP could induce chondrogenic differentiation and proliferation of MSC in vitro and promote cartilage repair in OA mouse models mainly by increasing the number of CD44 + /CD105 + stem-cell and prevention of matrix loss. These effect of 4-ABP was stronger than that of KGN. Transcriptional profiling of 4-ABP-stimulated MSC suggested that RPS6KA2 and the PI3K-Akt pathway were 4-ABP targets; 4-ABP could activate the PI3K-Akt pathway to promote MSC proliferation and repair OA injury, which was blocked in RPS6KA2- knockdown MSC or RPS6KA2- deficient mice . Conclusion 4-ABP bio-distribution in cartilage promotes proliferation and chondrogenic differentiation of MSC, and repairs osteoarthritic lesions via PI3K-Akt pathway activation.
研究领域:
药理学
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骨科
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干细胞生物学
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分子生物学
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DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2024
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IF 7.4
Pengshan Guo,Dongmei Yu,Chuntao Zhao,Jianping Wang,Ji Cheng,Wenxuan Fan,Tongtong Ma,Tian Gao,Jinghua Li
The increasing demand for potash has led to the increased use of 4-dodecyl morpholine (DMP), an important froth flotation agent for the extraction for potash extraction by “reverse flotation-cold crystallization”. As it is not easy to be stable and decompose in its natural state, it has seriously endangered the environment of salt lakes and the development of salt lake resources. The development of a safe and harmless catalytic system to accomplish the degradation and removal of DMP is urgent. Herein, A Cu 2 O/SnO 2 /PDA (CSP) nanoparticle with a synergistic effect of photocatalysis and Fenton-like catalysis was developed, and the CSP had a good photothermal conversion efficiency. Under 808 nm NIR irradiation, not only the catalyst activity was enhanced, but also the complexation rate of electron-hole pairs was reduced, which effectively increased the degradation efficiency of DMP (an increase of about 31.56 %). In addition, by analyzing the degradation products of DMP, the possible pathways of the DMP degradation process were proposed and, at the same time, the degradation catalytic system we used was proved to be safe and harmless. A new pathway is provided for the degradation and removal of DMP in the salt lake environment.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2026
·
IF 19.7
Mengyao Gu,Yifan Gao,Haojie Ding,Yuanyu Shan,Yujiao Gao,Shuai Liang,Xia Huang
Electrochemical advanced oxidation processes have shown great potential in water treatment, but controlling toxic intermediates during degradation remains challenging. In this study, an electrocatalytic dual-membrane filtration (EDMF) system with tunable electrode configuration was constructed to regulate the redox sequence in 4-chlorophenol (4-CP) degradation. By alternating the electrode order—anode–cathode (A–C) vs. cathode–anode (C–A)—we systematically investigated the influence of configuration on degradation efficiency, reaction pathway selection, and environmental safety. The dual-membrane systems significantly outperformed single-electrode configurations, achieving over 80% 4-CP removal at 3 V. While the A–C configuration exhibited high ·OH and 1 O 2 -mediated oxidation, the C–A configuration followed a sequential reduction–oxidation mechanism, where cathodic reduction preferentially cleaved the C–Cl bond before anodic oxidation. Quenching experiments, electron paramagnetic resonance, and density functional theory calculations confirmed that the highest occupied molecular orbital / lowest unoccupied molecular orbital distribution of 4-CP rationalizes the pathway selectivity. Although both configurations achieved high dechlorination, the C–A system markedly reduced the accumulation of toxic chlorinated intermediates, leading to lower acute toxicity, mutagenicity, and bioaccumulation potential of transformation products. These findings highlight electrode sequence as a key design parameter to balance efficiency and safety, providing a new strategy for electrocatalytic treatment of halogenated organic pollutants.
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ChemistrySelect
·
2026
·Vol. 11
·期 36
·e74577
·
IF 2.3
Haixia Hu,Yiying Shi,Zhongyu Duan,Wenjun Zhang
Zirconium-based metal–organic framework (MOF) UiO-66 is a commonly used host framework material in the research field of fluorescent probes. However, the pure UiO-66 material lacks functional sites for targeted recognition and thus cannot achieve specific fluorescence detection. In view of this, terephthalic acid (TPA) and 2,6-pyridinedicarboxylic acid (DPA) were used as mixed ligands to coordinate with Zr 4+ for constructing a MOF in this paper. Subsequently, 4-methyl-7-hydroxycoumarin (4-Mu) and Eu 3+ were introduced for functional modification, and UiO-66(DPA)@4-Mu/Eu 3+ fluorescent material with dual emission centers was finally synthesized. It was investigated that UiO-66(DPA)@4-Mu/Eu 3+ can serve as a dual-emission ratiometric fluorescent probe for the efficient detection of doxycycline (DOX) content in aqueous solution. Under the excitation wavelength of 365 nm, the fluorescence color of the probe system gradually changed from blue to red with the increase of DOX concentration. Further analysis revealed that the fluorescence intensity ratio I 618 /I 430 of the system was positively correlated with DOX concentration, enabling highly sensitive detection of DOX with a limit of detection as low as 2.64 µM. Graphical Zr 4+ coordinates with terephthalic acid and 2,6-pyridinedicarboxylic acid as mixed ligands. 4-Methyl-7-hydroxycoumarin is introduced together with Eu 3+ to realize functionalization. The obtained UiO-66(DPA)@4-Mu/Eu 3+ material exhibits dual-emission property and can efficiently detect doxycycline in aqueous solution, which provides a new strategy for the functional design of metal–organic frameworks (MOFs).
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高影响因子
ACS Applied Electronic Materials
·
2026
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IF 4.7
Yinghui Wang,Weimin Xia,Biao Guan,Jing Li,Chengmin Hou,Xiaofang Zhang
Nonlinear dielectric polymers for high-power density capacitors generally possess a high dielectric constant (εr), a large breakdown electric field (Eb), but a large dielectric loss (tan δ) due to the relaxation of high polar dipoles. To address the inherent trade-off between dielectric response and loss, we propose a low polarity polystyrene-4-vinylpyridine (P(S-r-4VP)) multipolymer by incorporating a 4-vinylpyridine (4VP) into polystyrene (PS) using conventional emulsion polymerization. Interestingly, compared to pure PS, the π-electron density of P(S-r-4VP) is significantly improved for the addition of functional 4VP unit, thereby promoting the strong electronic polarization response under an electrical field. As such, εr and Eb of the P(S-r-4VP) films increase with molar content of 4VP, and reach to 3.7 at 100 Hz and ∼550 MV/m, respectively. Notably, the P(S-r-4VP) copolymer exhibits a considerable discharged energy density (Ue) of 3.43 J/cm3 under an electrical field of 500 MV/m. Thus, this work offers valuable insights for the application of polystyrene-based polymers in dielectric energy storage areas.
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高影响因子
WATER RESEARCH
·
2026
·
IF 12.8
Xinwei Xu,Jueyao Li,Baowei Shen,Lingyu Zhang,Yongming Tang
To clarify the role of Ni-based compounds in the catalytic chlorination process, NiOOH, Ni(OH) 2 and NiO catalysts were prepared and their catalytic performances were investigated by employing 4-chlorophenol (4-CP) as a model pollutant in this study. Compared with the nearly pure phases of Ni(OH) 2 and NiO, the NiOOH catalyst is dominated by β-NiOOH phase, and exhibits a mixed state of Ni II and Ni III with an actual formula of NiO 0.91 (OH) 1.09 . The average valence state of Ni in the NiOOH is +2.90. A cycle of Ni species for catalytic oxidation process of free chlorine (FC) is proposed for NiOOH. β-NiOOH phase is oxidized by FC to γ-NiOOH phase containing Ni IV species, and then the γ-NiOOH phase are reduced by surface water to β-NiOOH phase or Ni(OH) 2 phase, accompanied by the generation of 1 O 2 species. Also, the reduction of the high-valence NiOOH phases such as β-NiOOH and γ-NiOOH can be reduced by organics since their Fermi levels are lower than the level of highest occupied molecular orbital of 4-CP. The NiOOH catalyst exhibits the TOC removal of around 50% in 100 mg/L 4-CP + 100 mg/L FC at pH 7, higher than the Ni II catalysts (less than 10%). 1 O 2 species dominate the mineralization of 4-CP via the successive oxidation and open-ring reactions, and reactive chlorine species mainly contributes to the conversion of 4-CP to the polychlorinated products. In addition, the high-valence Ni species (Ni III /Ni IV ) significantly contribute to the removal of 4-CP (∼26% contribution ratio) via the direct surface oxidation.
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Journal of Macromolecular Science Part A-Pure and Applied Chemistry
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2013
·
IF 0.807
Feng Chen,Daoxing Dai,Jingtao Yang,Zhengdong Fei,Mingqiang Zhong
We reported controlled synthesis of methacrylic acid, 2-(diethylamino) ethyl methacrylate and 2-acrylamido-2-methyl-1-propa- nesulfonic acid (three electrolyte-type monomers) via reversible addition-fragmentation chain transfer (RAFT) polymerization with the chain transfer agent (CTA) (4-cyanopentanoic acid)-4-dithiobenzoate and initiator (I) 4,4′-azobis(4-cyanovaleric acid) in homogeneous aqueous media. Three distinct [monomer]0: [I]0: [CTA]0 ratios (50:0.2:1, 100:0.2:1, 500:0.2:1) were conducted. The polymerizations exhibited the characteristics of a controlled/“living” polymerization which demonstrated well-controlled molecular weight and low molecular weight distribution. Finally, the results of this investigation were used as a guide for the preparation of a series of well-defined polyelectrolytes (DPn = 50–500, PDI = 1.08–1.17) in high yield.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2014
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IF 2.045
Jun-su Jin,Yi-wei Wang,Hai-fei Zhang,Xing Fan,Hao Wu
The operating conditions of measuring the equilibrium solubility of 4-hydroxybenzaldehyde in supercritical carbon dioxide (SCCO2) were chosen at temperatures of (308, 318, and 328) K and five pressure points from (11.0 to 21.0) MPa, while the solubility data in SCCO2 with three different cosolvents (ethanol, ethyl acetate, and acetone) at 0.04 (mol·mol–1) were obtained at 318 K and the aforementioned pressure. The solubility of 4-hydroxybenzaldehyde revealed that the presence of cosolvents could greatly improve the dissolving ability of solvent. The solubilities of solutes with five kinds of functional groups substituted for the formyl group (−CHO) of 4-hydroxybenzaldehyde have been investigated on the aspects of melting point and intermolecular force. The data of 4-hydroxybenzaldehyde in pure SCCO2 were successfully correlated with three semiempirical models (Chrastil, Méndez-Santiago, and Teja (M-S-T) and Bartle models) for a deviation of (6.82 to 8.50) %, while the data with cosolvents were calculated by three different models (modified Chrastil, modified M-S-T, and Sovova models) for a deviation of (2.98 to 8.87) %. The thermodynamic properties of 4-hydroxybenzaldehyde were investigated.
研究领域:
化学工程
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超临界流体技术
·
热力学
·
分离过程
·
物理化学
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DOI
高影响因子
MOLECULES
·
2026
·Vol. 31
·期 17
·2987
·
IF 5.1
Huan Deng,Qingsong Xie,Shengnan Li,Hai Lu,Hongyan Wei,Tiehong Song
In this work, a BiFeO3/MoS2(BM) material was utilized to establish a piezophotocatalytic system under combined visible-light (Vis) illumination and mechanical stirring (MS), which synergistically activated peroxymonosulfate (PMS) toward the oxidation of 4-chlorophenol (4-CP), a representative refractory organic pollutant in water. Under mechanical stirring, the piezoelectric effect in BM generates a polarized electric field that promotes the separation of photogenerated electron–hole pairs, thereby providing more charge carriers for PMS activation and subsequent radical generation. The degradation performance, underlying mechanism, toxicity of degradation products, reusability, and applicability in different water matrices in the BM(1:3)/PMS process were comprehensively evaluated. The results indicated that BM(1:3) exhibited superior performance over other BM ratios (BM(2:1), BM(1:1), and BM(1:2)), achieving 91.6% removal of 4-CP within 30 min at a rotation speed = 1000 rpm, PMS = 2.0 mM, BM(1:3) = 0.5 mg/L, and initial 4-CP = 10 mg/L. Furthermore, water quality parameters exerted notable impacts on 4-CP decomposition. A pH of 4.7 was favorable, and the presence of Cl−enhanced the 4-CP degradation, while HCO3−and H2PO4−suppressed the removal efficiency; SO42−and HA showed negligible influence. DFT calculations identified the reactive sites on 4-CP that are prone to attack by various reactive oxygen species (e.g., •O2−,1O2, •OH, and SO4•−), resulting in the transformation of 4-CP through three degradation pathways into smaller organic intermediates, most of which were less toxic than 4-CP. The BM(1:3) catalyst exhibited satisfactory reusability; however, a significant decrease in 4-CP degradation efficiency was observed in the lake water matrix. Overall, the synergy between photocatalysis and the piezoelectric effect in the BM(1:3)/PMS system offers a useful research foundation for the piezophotocatalytic degradation of persistent organic pollutants such as 4-CP.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·Vol. 74
·期 32
·25119-25128
·
IF 6.7
Li Biao,Ying Rui-Ning,Wang Xian-Quan,Zhao Jing,Lin Hong-Yan,Wang Da-Wei,Yang Guang-Fu
4-Hydroxyphenylpyruvate
dioxygenase (HPPD) has become an attractive
target for herbicide development owing to the slow development and
low risk of resistance to its inhibitors. However, most available
HPPD inhibitors exhibit limited crop selectivity and poor efficacy
against grasses. Therefore, the exploration of novel molecular scaffolds
is of great research value. In this study, we adopted a ring-fusion
strategy to enhance π–π stacking interactions and
developed a structurally novel pyrazole-4-chloro-benzimidazolin-2-one
scaffold. Through systematic structural optimization, compound II-19 showed the strongest enzyme inhibitory activity, with
an IC 50 of 52 nM, about 6-fold higher potency than the
positive control, mesotrione. The crystal structure of At HPPD- II-19 revealed that the inhibitor engages in characteristic
chelation and π–π stacking interactions within
the active site, and the 3-NO 2 -benzyl group contributes
additional hydrophobic interactions and a possible weak water-mediated
interaction involving Gln293. Additionally, I-5 showed
excellent broad-spectrum weed control and good safety toward peanut
at 30 g a.i./ha. These results indicate that compound I-5 is a promising candidate for the development of new HPPD inhibitors
for weed control in peanut fields.
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