INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2024
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IF 5.3
Haofei Ji,Zhilin He,Ying Huang,Xiuen Cao,Qubo Zhu
5-Fluorouracil (5-FU) is a conventional nucleotide analogue used for cancer treatment. However, its clinical application faces challenges such as low stability and non-specific toxicity. With the remarkable advancements in DNA nanotechnology, DNA-based self-assembled nanocarriers have emerged as powerful tools for delivering nucleotide drugs. In this study, we have designed a non-linear hybrid chain reaction involving a fuel strand with AS1411 aptamer sequence to construct a dendritic structure capable of carrying 5-FU. This structure specifically targets cancer cells with overexpressed nucleolin on their surface, allowing the 5-FU to exert its anticancer effects and achieve therapeutic outcomes. Furthermore, we have also investigated the mechanistic action of this drug delivery system, aiming to establish a novel therapeutic platform for 5-FU treatment.
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ChemNanoMat
·
2024
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IF 2.6
Delong Yang,Ziting Du,Jinhang Dai,Qingya Cao,Zhaobao Xiang,Gang Chen,Fukun Li
Here, a series of nitrogen-doped carbon (NC) supported transition metal oxide catalysts were prepared by pyrolysis of chitosan-metal salt mixtures for the efficient synthesis 2,5-diformylfuran (DFF) from 5-hydroxymethylfurfural (HMF) and fructose. Among them, supported molybdenum-based species on nitrogen-doped carbon (Mo/NC) exhibited excellent activity and selectivity for selective oxidation of HMF to DFF. The presence of nitrogen species reduces the electron cloud density around the Mo species, thereby improving the catalytic activity. Moreover, the interaction between active MoO2 species on the catalyst surface and NC ensured the stability of the catalyst, resulting in no significant loss of activity after four catalytic cycles. 99.5% and 55.1% yields of DFF with full conversion were obtained from HMF and fructose respectively over Mo/NC-chitosan-600 in DMSO under ambient air. In order to enhance DFF yield from fructose, sulfonate groups were introduced into Mo/NC-chitosan-600 catalyst, leading to the highest DFF yield of 70.2%. In addition, this catalyst also allowed 10.0%, 22.9% and 33.3% DFF yields from glucose, sucrose and inulin, respectively.
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JOURNAL OF PHARMACY AND PHARMACOLOGY
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2017
·Vol. 69
·期 6
·743-752
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IF 2.405
Wang Meng,Huang Can,Su Yong,Yang Cui,Xia Quan,Xu Du-juan
ObjectivesInhibition of autophagy has been increasingly recognized as a potential therapeutic approach against cancer. Our previous reports showed that Astragaloside II improves hepatic cancer cells resistance by downregulating MDR1 and P-gp .The purpose of this study was to further investigated the effect of autophagy on AS-II reversing multidrug resistance and its molecular mechanism in hepatocellular carcinoma cells in vitro.MethodsBel-7402 and Bel-7402/FU cell lines were used in this study. Western blot was used to detect the expression of autophagy-related protein, p-mTOR and p-p79s6k, MTT was used to analyse cell viability, GFP-LC3 punctate dots distribution was observed by GFP-LC3 transient transfection under fluorescence microscopy and silencing of autophagy-related genes was detected by small interfering RNA transfection.Key findingsAstragaloside II was able to significantly decrease the expression of LC3-II and Beclin-1 in a dose-dependent manner, Astragaloside II (80 μm) further decreased LC3-II formation, Beclin-1 and GFP-LC3 puncta dots stimulated with 5-fluorouracil (0.2 mm) in Bel-7402/FU cells (P < 0.05). In addition, Astragaloside II is capable of sensitizing cells to 5-fluorouracil-induced cell death via inhibition of pro-survival autophagy involvement of MAPK-mTOR pathway.ConclusionsThese findings suggested that Astragaloside II could suppress autophagy by interfering with Beclin-1 and LC3 via MAPK-mTOR pathway, through which sensitized human cancer resistant cells to 5-FU-induced cell death.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Yongzhi Xiong,Shengchun Hu,Jianchun Jiang,Yajun Liu,Wei Zhao,Xialin Ji,Changzhou Chen,Mengmeng Fan,Kui Wang
Herein, a novel ball milling-pyrolysis strategy was proposed for preparing a highly dispersed Ni 3 Fe nanoalloy catalyst (Ni 3 Fe@NC) used for 5-hydroxymethylfurfural (HMF) electro-oxidation reaction. The Ni 3 Fe@NC delivered a high current density of 100 mA cm −2 at a low potential of 1.467 V vs RHE, with a HMF conversion rate of over 99.6 %, 2,5-furan dicarboxylic acid (FDCA) selectivity of 97.1 % and a Faraday efficiency of 96.7 %. Theoretical calculations, in-situ EIS, quasi-in-situ XRD and XPS demonstrated that Fe-doping optimizes the electronic structure of Ni 3 Fe@NC and regulates its d -band center, which not only promoted the reconstruction of Ni 3 Fe@NC to form high-oxidation-activity Ni 2+δ and Ni 3+δ species but also reduced the reaction barrier of the key rate-determining step (*5-Hydroxymethyl-2-furancarboxylic acid (HMFCA)→*5-formyl-2-furancarboxylic acid (FFCA)) during HMFOR. Based on this interesting work, we provided a facile macroscopic preparation strategy on highly dispersed nanoalloy catalyst for efficient electro-oxidation of HMF.
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Inorganic Chemistry Frontiers
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2024
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IF 6.1
Yifei Li,Senyao Meng,Ping Wang,Miao He,Jiasai Yao,Cheng Yang,Fangzhou Mo,Jiang Li,Zhenxing Li
The crystal facet of CeO2 is crucial in governing the catalytic performance of CeO2. However, studies on the relationship between the photocatalytic oxidation performance of CeO2 and its crystal facets are scarce. Herein, we synthesized a series of CeO2. Through loading Cu single atoms (Cu/CeO2), the facet effects of crystal facets on photocatalytic selective oxidation were systematically studied by employing the selective oxidation of 5-hydroxymethylfurfural to 2,5-diformylfuran as a model. Because the (110) facet's superior electron transfer efficiency is feasible for absorbing 5-hydroxymethylfurfural, eliminating α-H, and desorbing 2,5-diformylfuran, the selectivity of Cu/CeO2-nanorods (Cu/CeO2-R) with the (110) facet (93.34%) is much higher than that of Cu/CeO2-nanocubes (Cu/CeO2-C) with the (100) facet (32.22%) and Cu/CeO2-nanooctahedra (Cu/CeO2-O) with the (111) facet (15.20%). DFT calculation shows that Cu 3d exhibits orbital hybridization with Ce 5d and 4f, which provides a favorable pathway for electron transfer. This work delves into the facet-performance relationship during the photocatalytic process.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Jiantao Su,Xiaohui Yang,Hui Shi,Shuangquan Yao,Minghao Zhou
Catalytic conversion of biomass-derived value-added chemicals was of great significance for the utilization of renewable biomass resources to instead of fossil chemicals. Biomass-derived lignin was regarded as an important support and 5-hydroxymethylfurfural (HMF) was a vital platform chemical derived from cellulose. Herein, a series of lignin-MOF hybrid catalysts were prepared and modified with different heteropolyacids (HPAs), which were then successfully introduced into the selective conversion of HMF to 5-hydroxymethylfurfuryl alcohol (MFA). The effect of different HPA, calcination temperature, etc. were all studied, and all catalysts were well characterized. It was confirmed that silicotungstic acid modified catalyst (Ni 3 Co-MOF-LS@HSiW) exhibited the best catalytic performance, while the highest conversion of HMF was up to 100%, with the best MFA yield of 86.5%. The finding in this study could provide novel insights for the utilization of lignin and preparation of value-added biomass-derived chemicals.
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AICHE JOURNAL
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2024
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IF 3.5
Xin Zhao,Linghan Xiao,Fengliang Wang,Zirong Shen,Ruiqi Fang,Yingwei Li
Herein, we report a controllable and versatile strategy for the synthesis of highly dispersed Co nanoparticles embedded in open-channel hierarchically porous N/O-doped carbon skeleton. Moreover, the pore sizes of the hierarchical structures can be easily tuned by adjusting the size of precursors. The as-obtained Co@NC-2ST exhibits unprecedented activity and selectivity in the oxidative esterification of 5-hydroxymethylfurfural (HMF) to dimethyl furan-2,5-dicarboxylate under base-free and atmospheric conditions. In particular, the achieved turnover frequency value is an order of magnitude higher than that of the state-of-art heterogeneous catalysts reported to date. A combination of experimental and density function theory studies reveals that the unique features of Co@NC-2ST enable a novel reaction route, that is, the CHO group of HMF is preferentially esterified instead of the OH group. This can be attributed to the nucleophilic addition reaction caused by the attack of methoxy anion on the CHO group of HMF.
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JOURNAL OF SOLID STATE CHEMISTRY
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2024
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IF 3.2
Feng Ye,Shuanshi Fan,Xuemei Lang,Yanhong Wang,Yihui Lv,Gang Li
Developing hierarchical zeolites is highly important for catalytic applications. In this study, micro- and submicron-sized hierarchical ZSM-5 zeolites, composed of aggregated nanosized ZSM-5 crystals, were facilely synthesized without any mesoporogen. The effects of the gel composition in a mesoporogen-free system on the formation of ZSM-5 aggregates were studied. The results revealed that the Na 2 O/SiO 2 molar ratio and the aluminum source exerted significant impacts. Furthermore, we demonstrated that the morphology and size of the ZSM-5 aggregate could be easily adjusted by varying the gel composition. Mechanistic insights indicated that the formation of hierarchical ZSM-5 aggregates in the mesoporogen-free system likely followed a space-confined growth mechanism.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2024
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IF 3.8
Cong Wang,Gang Li,Zheng Huang,Anfeng Peng
The cumbersome air isolation process is one of the main constraints in the development of linear α-olefins prepared by ethylene oligomerization. An effective way to solve this problem is to eliminate the use of an alkyl-aluminum cocatalyst. Herein, two forms of Versailles/Santa Barbara-5 (VSB-5) (VSB-5-H3PO4 and VSB-5-NaH2PO2) are prepared and used as heterogeneous catalysts in ethylene oligomerization in the presence of LiAlH4 as a cocatalyst. Compared to other Ni-MOFs and Ni silica–aluminate catalysts, VSB-5s maintain a wider distribution of Linear α-olefin (LAO) products at relatively high activity. In the reuse test of the catalyst, the Al species from LiAlH4 cover the surface of the catalyst and decrease its activity, which could be removed by acid treatment. In situ IR studies show that active centers for ethylene oligomerization may form in VSB-5 assisted by LiAlH4. In addition, a Cossee–Arlman-type mechanism is proposed.
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FOOD CHEMISTRY
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2024
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IF 8.5
Teng Liu,Yumin Niu,Kexin Cheng,Qichao Fei,Dengyong Liu
The present study aimed to elucidate the pathway of pigment formation and identify the source of antioxidant activity during sugar smoking. Building upon previous research, this investigation replicated the sucrose cleavage process involved in sugar-smoking through model reactions to obtain distinct model reaction products. The products were analyzed using various techniques such as ultraviolet–visible spectrometry, Fourier-transform infrared spectroscopy, high-performance liquid chromatography, and high-performance liquid chromatography-tandem mass spectrometry. The findings revealed that the pyrolysis of sucrose at 330 °C yielded glucose and fructose, with fructose pyrolysis producing significantly more 5-HMF than glucose. Moreover, the antioxidant capacity of 5-HMF was found to make a substantial contribution. The primary source of 5-HMF was identified as fructose resulting from the cleavage of sucrose at 330 °C, while the primary pathway for the formation of the sugar-smoking pigment 5-GGMF was attributed to the intermolecular dehydration of 5-HMF and glucose at 150 °C.
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ACS Applied Materials & Interfaces
·
2025
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IF 8.2
Yan Chen,Ming-Kun Yang,Shan-Xin Li,Suo-Luan Zhou,Cheng-Nuo Hu,Yun-Han Yang,Li-Juan Yang
Developing efficient and recyclable iodine adsorbents is crucial for addressing radioactive iodine pollution. An imidazole cation-bridged pillar[5]arene polymer (P5–P5I) was synthesized via a salt formation reaction. P5–P5I exhibited a high iodine vapor capture capacity of 2130.0 mg/g and a maximum adsorption capacity of 1935.3 and 942.4 mg/g for I2 and I3– in solution, respectively. The adsorption kinetics of I2 and I3– on P5–P5I in aqueous solution followed a pseudo-second-order kinetic model, reaching adsorption equilibrium within a few minutes. P5–P5I demonstrated the ability to selectively capture I2 and I3– in the presence of competing anions (10–1000-fold), removing over 97.1% of iodine from various environments. Meanwhile, under extreme conditions (strong acids, strong bases, and high temperature), P5–P5I still has a superior adsorption performance and cycling ability for I2 and I3–. Molecular modeling revealed that P5–P5I could synergistically enhance iodine capture through multiple weak interactions, including host–guest, C–H···I hydrogen bond, and electrostatic interactions. This study indicates that P5–P5I has promising applications for rapid and efficient iodine uptake from vapor and various aqueous media.
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Journal of Environmental Chemical Engineering
·
2024
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IF 7.4
Kanglu chang,Xiaowen kong,Yining Zhang,Xumei Tao,Liang Huang
Photo-assisted thermo-catalytic conversion of glucose to 5-hydroxymethylfurfural (HMF) is one of the most promising ways for channeling solar energy. Photo-assisted thermo-catalytic conversion of glucose and HMF yield were improved with SnO 2 /Cr-MOFs/Cr(OH) 3 catalysts under visible light irradiation at 135 ℃-165 ℃ nitrogen atmosphere. SnO 2 /Cr-MOFs/Cr(OH) 3 afforded relatively high Lewis acidity and Brønsted acidity, which was beneficial for thermo-catalytic conversion of glucose. The light and the interface between SnO 2 and Cr-MOFs/Cr(OH) 3 assistantly promoted the HMF formation. The photo-generated holes (h + ) under light irradiation was the driving force for the formation of “free” protons from water and carboxylic acid in Cr-MOFs, which acted as Brønsted acid sites to promote HMF formation. With 576 mg glucose as the substrate and DMSO as the solvent, 92 % glucose conversion with 43.2 % HMF yield was achieved at 150 ℃ for 2 h under nitrogen atmosphere and 500 W Xe lamp irradiation. The results demonstrate the promise of photo-assisted thermo-catalytic conversion of glucose in the future.
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