CELLULOSE
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2021
·Vol. 28
·期 9
·5867-5879
·
IF 5.044
Wang Lujie,Wen Xiaodong,Zhang Xujun,Yuan Shuntao,Xu Qingbo,Fu Feiya,Diao Hongyan,Liu Xiangdong
In this article, carboxymethyl chitosan (CMC) and (3-carboxypropyl) trimethylammonium chloride (CPTC) were used as raw materials to prepare an antibacterial cotton fabric with excellent laundering durability. CMC was first anchored to the surface of cotton fiber via esterification between the carboxyl groups of CMC and the hydroxyl groups of the cellulose molecules on the cotton fiber surface, and then the CPTC was linked to the CMC chains via amidation to the amino groups of the grafted CMC chains. The antibacterial tests showed that the bacteriostatic reduction rate (BR) of the finished cotton fabric against S. aureus and E. coli was above 99.9%, and the BR value of modified cotton fabric remained above 99.9% even after 120 laundering cycles. The results of cytotoxicity, vapor transmissibility, and tensile strength of the fabric samples, as well as the evaluation of water absorption and flexibility show that the modified cotton fabrics are safe and comfortable.
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POLYMERS FOR ADVANCED TECHNOLOGIES
·
2021
·Vol. 32
·期 8
·3113-3122
·
IF 3.665
Zhiming Chen,Weiqiu Wen,Jianwei Guo
Natural chitosan (CS) is composed of a larger hydrophilic skeleton with great biocompatibility. A hypoxia sensitive amphiphilic conjugate (CS-NBCF) was synthesized by conjugating CS with nitrobenzyl chloroformate (NBCF). Subsequently, nano micelles with high stability (CMC = 0.0030 mg/ml) were formed by self-assembly of the polymers in deionized water. The hypoxia-responsive function was demonstrated by examining the size variations of polymeric micelles under the hypoxia conditions. Doxorubicin (DOX) was encapsulated into the micellar core, the drug loading and encapsulation efficiency of DOX were 15.0% and 52.6%, respectively. The in vitro release experiments showed that DOX could be released rapidly in hypoxic environment, and the release amount was up to 68% in 24 h. It was found from the cytotoxicity experiment that that the toxicity of the blank micelles was low, while DOX-loaded micelles exhibited a good anti-cancer effect under hypoxic conditions, and the cell inhibition rate of MCF-7 was high up to 63%. As a result, the demonstrated properties endowed as-developed polymeric micelles with promising application as drug delivery system in tumor treatment.
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MOLECULES
·
2021
·Vol. 26
·期 8
·2152
·
IF 4.412
Qingtong Xie,Xudong Zheng,Liuting Li,Liqun Ma,Qihui Zhao,Shiyuan Chang,Lijun You
A pectin/chitosan matrix-loaded curcumin film (PCCF) with a deep eutectic solvent (DES) as the solvent and plasticizer was prepared in this study. Different quantities of curcumin (identified as PCCF-0, PCCF-1, PCCF-2. PCCF-3) were loaded on the pectin/chitosan film in order to evaluate their effects on the film properties. Results showed that curcumin could interact with the pectin/chitosan matrix and form a complex three-dimensional network structure. PCCF could promote the thickness, tensile strength, thermal properties, antioxidant and antiseptic capacities, but deteriorate the light transmission and elongation at the same time. The addition of curcumin would change the color of the film, without significantly affecting the moisture content. The tensile strength of PCCF-3 reached the maximum value of 3.75 MPa, while the elongation decreased to 10%. Meanwhile, the water-resistance properties of PCCF-3 were significantly promoted by 8.6% compared with that of PCCF-0. Furthermore, PCCF showed remarkable sustained antioxidant activities in a dose-dependent manner. PCCF-3 could inhibit DPPH and ABTS free radicals by 58.66% and 29.07%, respectively. It also showed antiseptic capacity on fresh pork during storage. Therefore, curcumin addition could improve the barrier, mechanical, antioxidant and antiseptic properties of the polysaccharide-based film and PCCF has the potential to be used as a new kind of food packaging material in the food industry.Keywords:chitosan;pectin;curcumin;film;DES
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2021
·
IF 3.517
Lingying Wu,Yuling Wu,Xun Che,Dandan Luo,Jiaju Lu,Ruibo Zhao,Muhammed Zubair Iqbal,Quan Zhang,Xiumei Wang,Xiangdong Kong
In this study, we recruited chitosan (CS) both for selenium nanoparticles (SeNPs) synthesis and for the development of a thermoresponsive nanocomposite hydrogel with the addition of glycerol phosphate (GP). Considering that SeNPs are toxic at high concentrations, five different ingredients of the nanocomposite hydrogel system with low concentrations of SeNPs (1.25–20 μg/mL) were prepared. The gelation conditions, structural characteristics, and mechanical properties of SeNPs-loaded thermosensitive CS/GP hydrogels were investigated. We also evaluated their antioxidizing activities and biocompatibility of the CS/GP/SeNPs hydrogels. Our study demonstrated that the incorporation of SeNPs in the hydrogel improved its mechanical properties, antioxidant activity, and degree of swelling. According to the properties of SeNPs and CS/GP thermosensitive hydrogels, the combination of these two technologies in an appropriate manner would be a promising antioxidant system for drug delivery and tissue engineering.
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CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Shuifang Mao,Bin Wang,Lin Yue,Wenshui Xia
In order to improve the anti-inflammatory activity of chitosan oligosaccharide (COS), chitosan oligosaccharide graft citronellol derivatives (COS-g-Cit1-3) were successfully synthesized via grafting citronellol (Cit) onto COS backbone. The degrees of substitution (DS) of COS-g-Cit1-3 were 0.165, 0.199 and 0.182, respectively. The structure of COS-g-Cit1-3 was confirmed by UV–vis, FT-IR, 1 H NMR and elemental analysis. The in vivo anti-inflammatory activity evaluation results displayed that COS-g-Cit1-3 drastically reduced the paw swelling, and the oedema inhibitions were 22.58 %, 29.03 % and 25.81 %, respectively. The results indicated that the anti-inflammatory effects of COS-g-Cit1-3 were significantly higher than COS and COS-g-Cit2 exhibited the highest anti-inflammatory ability. The results also presented that COS-g-Cit1-3 reduced the expression levels of TNF-α by promoting the secretion of IL-4 and IL-10. Moreover, western blot analysis data proved that COS-g-Cit1-3 inactivated the NF-κB signaling pathway via inhibiting the phosphorylation of p65, IKBα and IKKβ.
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Regenerative Biomaterials
·
2021
·Vol. 8
·期 2
·
IF 6.353
Li Yue,Leng QingQing,Pang XianLun,Shi Huan,Liu YanLin,Xiao SuSu,Zhao Ling,Zhou Ping,Fu ShaoZhi
Dermal injury, including trauma, surgical incisions, and burns, remain the most prevalent socio-economical health care issue in the clinic. Nanomedicine represents a reliable administration strategy that can promote the healing of skin lesions, but the lack of effective drug delivery methods can limit its effectiveness. In this study, we developed a novel nano-drug delivery system to treat skin defects through spraying. We prepared curcumin-loaded chitosan nanoparticles modified with epidermal growth factor (EGF) to develop an aqueous EGF-modified spray (EGF@CCN) for the treatment of dermal wounds. In vitro assays showed that the EGF@CCN displayed low cytotoxicity, and that curcumin was continuously and slowly released from the EGF@CCN. In vivo efficacy on wound healing was then evaluated using full-thickness dermal defect models in Wistar rats, showing that the EGF@CCN had significant advantages in promoting wound healing. On day 12 post-operation, skin defects in the rats of the EGF@CCN group were almost completely restored. These effects were related to the activity of curcumin and EGF on skin healing, and the high compatibility of the nano formulation. We therefore conclude that the prepared nano-scaled EGF@CCN spray represents a promising strategy for the treatment of dermal wounds.
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Journal of Environmental Chemical Engineering
·
2021
·
IF 5.909
Fengyan Liang,Tingting Hou,Sidong Li,Lusheng Liao,Puwang Li,Chengpeng Li
Due to easy availability and biodegradability , chitosan (CS)-based porous adsorbents have attracted significant interest in oil-spill and organic solvent removal. Herein, a multi-network CS-based sponge was fabricated via ion and hydrogen bond cross-linking using lemon, followed by covalent cross-linking via heptanal, in-situ loading of Fe 3 O 4 -polydopamine (PDA) particles and polylactic acid (PLA) coating. The as-fabricated sponge was systematically characterized by Fourier transform-infrared spectrometry (FT-IR), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), X-ray photoelectron spectroscopy (XPS), scanning electron microscope (SEM), transmission electron microscope (TEM), static water contact angles (WCA) and so on. The as-fabricated CS-based sponge exhibits excellent elasticity, which could be compressed to large strains (80%) at a relatively high stress (0.685 MPa). The WCA of the targeted sponge can reach to 152.2 ± 1.2º after multiple surface functionalization. In addition, the degradation rate of the as-fabricated sponge can still reach 45.01 ± 1.11% within 15 days. Particularly, the sponge could selectively adsorb oil/organic solvent with up to 50 times of its own weight, and effectively separate the surfactant-stabilized oil-in-water emulsion with a flux of 8753 ± 423.56 L m −2 h −1 . Last but not least, the sponge can be driven and recycled magnetically. In conclusion, this promising multifunctional sponge can be applied as a new absorbent for oil-water separation.
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ChemCatChem
·
2021
·Vol. 13
·期 19
·4142-4150
·
IF 5.686
Jiaxin Liu,Peiyun Li,Renfeng Jiang,Xiucheng Zheng,Pu Liu
Graphical Catalytic Hydrolysis : Ruthenium nanoparticles with different dosages are immobilized on a naturally cationic polysaccharide polymer (chitosan, CS) via an adsorption-in situ reduction method for boosting AB hydrolysis. Catalyzed by the optimal Ru/CS catalysts, the turnover frequency is 338.1 min −1 in alkaline solution at 303 K and the apparent activation energy is 41.3 kJ mol −1 , which are superior to many results reported previously. Developing an advanced heterogeneous catalyst is essential for realizing high-performance ammonia borane (AB) hydrolysis, which is a safe and efficient way to generate hydrogen. In this work, a series of ruthenium (Ru) nanoparticles (NPs) immobilized on chitosan (CS) natural polymers are synthesized via an adsorption-in situ reduction method. Various analytical techniques, including XRD, XPS, FT-IR, SEM and TEM, are adopted to explore the structure-catalytic performance relationships of the obtained catalysts for hydrolysis of AB. Benefitting from the possible interaction between Ru NPs and the amino and hydroxyl groups in CS, the as-prepared catalysts exhibit excellent catalytic behavior for hydrogen generation from AB hydrolysis. Catalyzed by the optimal Ru/CS, the turnover frequency reaches up to 331.8 min −1 in NaOH solution at 303 K, and the corresponding apparent activation energy is 41.3 kJ mol −1 , which are superior to many results previously reported. This work demonstrates that the obtained Ru/CS is a promising and efficient catalyst for the hydrolysis of solid hydrogen storage materials.
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ACS Sustainable Chemistry & Engineering
·
2020
·
IF 7.632
Jiaqi Shan,Dagang Liu,Fan Su,Minyu Li,Huafeng Tian,Mengna Guo,Wenhao Qiao,Jie He,Qin Li,Jun Qian
Highly surface-charged rigid bionanofibrils are difficult to be processed into integrated foams or aerogels owing to lack of good interfibrillar adhesion. An alternative solution is to involve flexible hydrophilic polymers for gluing fibril bundles, allowing a perfect alignment under ice induction in the lyophilized foams. In this work, we incorporated the defibrillated chitin/chitosan nanofibrils (CTF/CSF) into gelatinized starch foams and investigated the effects of surface charge, solid content, nanofibril loading, and directional orientation on the dimensional stability, morphology, crystallinity, compressive stress, and flame-retardant properties of lyophilized composite foams. Results show that CTF with low positive surface charges presents stable electroattractions to negatively charged starch and also exhibits sustainable reinforcement effects on the composite foam. What is more, compact, small porous, and lamellar CTF-supported foams exhibit relatively high resistance to flammable combustion. In the case of high loading of polycationic CSF, directional freeze-drying successfully induced the channel orientation along the vertical, horizontal, spiral, or bi/triphase junctional direction in the anisotropic foams, which revealed variable compression properties according to the fibril alignment.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Shuifang Mao,Xiaoli Liu,Wenshui Xia
In this study, chitosan oligosaccharide (COS) was modified by grafting Linalool (Lin) on its backbone to improve its anti-inflammatory activity. By changing the molar ratios of COS to Lin, three different degrees of substitution COS-g-Lin1-3 were prepared. The degrees of substitution of derivatives were 0.65, 0.80 and 1.14 respectively. The structure of COS-g-Lin1-3 were characterized by UV–vis, FT-IR, 1 H NMR and elemental analysis in order to show the COS-g-Lin1-3 successfully synthesized. Besides, the thermal stability , solubility, pH stability as well as crystallinity were also investigated. The results revealed that the derivatives exhibited higher thermal stability and more remarkable anti-inflammatory property against hyaluronidase and collagenase than that of COS. The good biocompatibility made this novel material a promising and effective compound for anti-inflammatory applications.
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Journal of the Taiwan Institute of Chemical Engineers
·
2020
·
IF 4.794
Yefeng Liu,Peng Zuo,Fei Wang,Ying Lv,Ruixin Wang,Weizhou Jiao
In this study, Keggin- and Dawson-type polyoxometalates (POMs) were immobilized on chitosan (CS)-modified Fe 3 O 4 @CS by electrostatic interaction for the preparation of heterogeneous catalysts Fe 3 O 4 @CS@POM (POM=PMo 12 , PW 12 , SiW 12 , P 2 W 17 , or P 2 W 18 ). The oxidative desulfurization (ODS) of dibenzothiophene (DBT) by Fe 3 O 4 @CS@POMs was evaluated. It is found that Fe 3 O 4 @CS@POM shows the good ODS performance due to the good dispersion of POM on Fe 3 O 4 surface and the good accessibility of substrate to it leaded by the full swelling of the cross-linked CS in acetonitrile . The catalytic activity follows the order of Fe 3 O 4 @CS@PMo 12 > Fe 3 O 4 @CS@PW 12 > Fe 3 O 4 @CS@P 2 W 17 > Fe 3 O 4 @CS@P 2 W 18 > Fe 3 O 4 @CS@SiW 12 . At 333 K, the desulfurization rate of DBT (500 ppm) reaches 99.7% at 60 min and 100% at 90 min in the presence of 0.1 g of Fe 3 O 4 @CS@PMo 12 and 100 µL of H 2 O 2 . The ODS process can be well described by the pseudo-first-order kinetic model (R 2 > 0.99) with a high kinetic constant (0.0761 min −1 ) and a low apparent activation energy (60.57 kJ / mol). In addition, the as-prepared catalyst can be easily separated and recycled in the external magnetic field, and it still has the good reusability for several times, stemming from the stable encapsulation of POM clusters by cross-linked chitosan on Fe 3 O 4 surface.
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Materials Science & Engineering C-Materials for Biological Applications
·
2021
·
IF 7.328
Hairui Suo,Jiaying Zhang,Mingen Xu,Ling Wang
Three-dimensional (3D) printing is a promising method to prepare scaffolds for tissue regeneration. Collagen and chitosan composites are superior materials for tissue engineering scaffold but rarely printed due to their poor printability. Here, we prepared a series of tunable hybrid collagen/chitosan bioinks with significantly improved printability through hydrogen bond interaction and printed them into scaffolds by carefully controlling the temperature. Rheological tests proved the printable bioinks had sound shear thinning behavior, dramatical viscosity variation with temperature, and the gelation temperature from 7 to 10 °C. Chitosan could decrease the swelling ratio of the printed scaffolds, while their degradation rate increased with collagen proportion and the values of Young's modulus and tensile strength increased with chitosan proportion. Moreover, the scaffolds containing 2% (m/v) collagen and 2% (m/v) chitosan had a homogeneous and compact honeycomb-like structure, demonstrating the strengthening effect of chitosan. Cell viability assay presented vigorous cell growth on the surface of scaffolds, meanwhile, live cells were also found inside and at the bottom of the scaffolds, indicating the migration of cells. Therefore, chitosan can improve the printability of collagen and the hybrid collagen/chitosan bioinks can be printed into scaffolds with regulated properties, thus can fit different applications in tissue engineering.
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