OPTICAL MATERIALS
·
2025
·
IF 4.2
Daiwen Xiao,Ka-Leung Wong,Peter A. Tanner
The behavior of nanoparticles in media of different refractive index has received considerable theoretical and experimental investigation. However, the behavior of larger particles, of micron size, has not been established. We have chosen Eu 3+ as a marker of environmental changes. Dilution of this ion into LaPO 4 gives a simple, fingerprint emission spectrum which has been studied via its luminescent lifetime, the R 2 (( 5 D 0 → 7 F 2 )/( 5 D 0 → 7 F 1 ) intensity ratio) and the electric dipole:magnetic dipole intensity ratio, (ED:MD), of spectral features. Measurements of micron-sized particles of LaPO 4 :Eu 3+ synthesized by several methods have been made for dispersions in alcohols, in compressed glass discs, in melted glass discs, in phosphor in glass (PiG) and in melted PiG. The experimental results are discussed and rationalized. The Eu 3+ 5 D 0 emission lifetime is reasonably constant in the bulk powders, powders dispersed in alcohols or compressed discs but is smaller in PiGs and melted glass discs. In the PiGs the structural integrity of LaPO 4 :Eu 3+ is maintained until they are melted at higher temperature. The change in lifetime, when varying the composition of the PiG, follows the Virtual Cavity Model. For dispersal of the particles in solvents there is a cut-off particle size below 1 μm where the electronic spectra of the moiety become insensitive to the environment and the properties are determined by refractive index. The remarkable change in R 2 ratio in the different systems considered – by a factor of nearly 600 % - and the corresponding decrease in 5 D 0 lifetime – by a factor of nearly 60 % - illustrates the versatility of the lanthanide ion.
研究领域:
材料科学
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发光材料
·
无机化学
·
光子学
·
固态物理
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Kexin Wei,Fan Yang,Yang Sun,Chunhui Yu,Junpu An,Kaiyi Chen,Shijia Li,Jiabao Guo,Yongfeng Li
The development of efficient and low-cost non-precious metal bifunctional oxygen electrocatalysts remains a critical challenge for advancing zinc-air batteries. In this study, we designed and synthesized three-dimensional carbon nanofiber catalysts integrated with sulfur- and nitrogen-doped carbon anchoring FeS/MnS heterostructures, leveraging an interfacial engineering approach. Originating from this strategy, the optimized FeS/MnS@CNFs shows a higher half-wave potential (E 1/2 ) of 0.88 V for ORR and a lower overpotential (E j=10 ) of 230 mV at 10 mA cm −2 for OER. The theoretical studies elucidate that the significant work function difference (0.43 eV) between FeS and MnS induces a built-in electric field at their heterointerface. This field drives electron transfer from MnS to FeS, which consequently strengthens the covalency of Fe S bonds and significantly enhances the adsorption capability for the *OOH intermediate species. When employed as the air-cathode catalyst, the FeS/MnS@CNFs-based zinc-air battery achieved a remarkable peak power density of 223 mW cm −2 and maintained stable operation for over 280 h at 10 mA cm −2 . Further theoretical modeling of the heterostructure elucidated that the built-in electric field modulates Fe S bond energies through electronic rearrangement, providing a fundamental explanation for the enhanced oxygen electrocatalytic performance and improved structural stability.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2018
·
IF 3.862
Jianmei Sun,He Bao,Yajie Peng,Haimin Zhang,Ya Sun,Jiajun Qi,Hailong Zhang,Yang Gao
This study aims to evaluate the effects of Gelucire44/14 on the in vitro transport, in situ intestinal absorption, as well as in vivo antidiabetic efficacy of berberine (BBR). In the in vitro study, Gelucire44/14 (0.1%, v/v) increased the absorptive transport of BBR across the intestinal membrane of a rat and reduced the relative transport in the secretory direction, thus demonstrating its potential inhibitory effect on intestinal P-glycoprotein (P-gp). In the in situ absorption study, Gelucire44/14 (0.1%, v/v) increased BBR absorption, and this enhancing effect was more significant in the ileum than in the colon of a rat. Oral delivery of BBR with Gelucire44/14 (0.1%, v/v) to diabetic mice, compared with the BBR group, induced a significant hypoglycemic effect on day 7 and day 12 after administration. This result was well correlated with the results of the in vitro study, indicating the important contribution of the P-gp inhibitory effect of Gelucire44/14 to the improvement of the antidiabetic efficacy in vivo . In addition, Gelucire44/14 (0.1%, v/v) neither increased the levels of protein and lactate dehydrogenase in intestinal perfusion nor changed the morphology of the rat intestinal epithelium relative to those of the negative control. This finding suggested that 0.1% (v/v) Gelucire44/14 caused no apparent membrane damage to rat intestine. In conclusion, Gelucire44/14 exhibited potential for enhancing the oral absorption of BBR, thereby improving the antidiabetic efficacy of BBR.
研究领域:
药理学
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糖尿病研究
·
药物递送系统
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高影响因子
International Journal of Biological Sciences
·
2026
·Vol. 22
·期 14
·7628
·
IF 11.7
Xudong Ding,Jia Du,Zhaoyu Wang,Lu Lu,Saijun Fan
Radiation-induced intestinal injury (RIII) limits abdominal and pelvic radiotherapy. Safe and effective radioprotectors that do not protect tumors remain an unmet need. Here, we examined the radioprotective effect of taurine (Tau) in mice subjected to whole-abdominal irradiation (WAI) and whether this effect depends on sex. Tau treatment improved post-irradiation survival, preserved intestinal stem cells, prevented mucosal barrier breakdown, and reduced systemic inflammation. These effects, however, were sex-dependent. In male mice, Tau altered the gut microbiota, increasing Ligilactobacillus abundance and shifting arginine and proline metabolism. In female mice, Tau maintained circulating estrogen levels, which in turn upregulated AICDA expression and enhanced IgA-mediated intestinal immunity. Under the specific dosing regimens and radiation parameters utilized in this study, Tau neither altered baseline tumor progression nor compromised the tumor response to irradiation. We conclude that Tau protects against RIII through sex-specific mechanisms, microbiota reprogramming in males and estrogen-AICDA-IgA signaling in females, without compromising the antitumor efficacy of radiotherapy.
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PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
·
2025
·
IF 3.3
Xiaorui Wang,Mingming Huang,Wenhui Li,Yingying Shi,Yinuo Tang,Han Zhang,Bin Wu,Zheng Zhang,Zunyang Song,Jingying Shi
Peach fruit is highly susceptible to Monilinia fructicola ( M. fructicola ), a pathogen that causes significant postharvest losses. Enhancing the efficacy and reducing the dosage of chemical fungicides are critical for controlling brown rot caused by M. fructicola . Natural volatile organic compounds (VOCs) have been proposed as a selective method for managing postharvest pathogen infection. Among these, 2-decanone, a natural volatile produced by fungi and insects, has demonstrated potential in inhibiting pathogen growth. In this study, 60 μL/L 2-decanone effectively inhibited the growth of M. fructicola mycelia. It also reduced spore germination and appressorium formation by downregulating the expression of MfBmp1 and MfPls1 , respectively. In addition, 2-decanone induced spore apoptosis by increasing reactive oxygen species (ROS) accumulation and exacerbating mitochondrial damage. When applied to peach fruit, 2-decanone fumigation significantly reduced disease incidence and lesion diameter compared to the control group, without adversely affecting fruit quality during storage. Furthermore, we observed that 2-decanone exhibited synergistic effects when combined with boscalid, effectively inhibiting the growth of M. fructicola . Applying boscalid 15 days before harvest and fumigating with 2-decanone postharvest provided similar brown rot suppression as boscalid alone but used only one-tenth the amount of fungicide. Overall, 2-decanone fumigation presents an effective strategy for controlling postharvest brown rot disease in peaches, and its combined use with boscalid introduces a promising approach for enhancing postharvest peach fruit preservation.
研究领域:
植物病理学
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采后生物学
·
农药科学
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分子微生物学
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食品保鲜
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Metabolites
·
2022
·Vol. 12
·期 5
·415
·
IF 5.581
Jida Zhang,Lu Lu,Xiaoyu Tian,Kaili Wang,Guanqun Xie,Haichang Li,Chengping Wen,Changfeng Hu
Cardiac involvement, displayed as premature cardiovascular disease (CVD), is one of common clinical symptoms of patients with systemic lupus erythematosus (SLE), contributing to mortality of the disease. The precise underlying pathological mechanism(s) for the cardiac involvement in lupus remains poorly understood. Lipids and their metabolites are directly involved in atherosclerosis development, oxidative stress, and inflammation, which are closely related to the development of CVD. In the study, shotgun lipidomics was exploited to quantitatively analyze cellular lipidomes in the cardiac tissue of MRL/lpr mice at two different time points (i.e., pre-lupus and lupus state) with/without treatment with glucocorticoids (GCs). Urine protein, spleen index, and renal histopathological evaluation of the mice were also performed for assessment of SLE onset and/or outcome. Lipidomics analysis revealed that the deposition of cholesterol and the aberrant metabolism of lipids caused by the increased energy metabolism and the enhanced activation of phospholipases, both of which were originally induced by inflammation, were already present in cardiac tissues from lupus-prone mice even at pre-lupus state. These lipid alterations could further induce inflammation and autoimmune responses, accelerating the process of CVD. In addition, the present study also demonstrated that GCs therapy could not only delay the progression of SLE, but also partially corrected these alterations of lipid species in cardiac tissue due to their anti-inflammatory effect. Thus, the medications with better anti-inflammatory effect might be a useful therapeutic method for premature CVD of SLE.Keywords:systemic lupus erythematosus;lipidomics;inflammation;premature cardiovascular disease;glucocorticoids
研究领域:
免疫学
·
心脏病学
·
药理学
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EXPERIMENTAL BRAIN RESEARCH
·
2015
·Vol. 233
·期 11
·3133-3143
·
IF 2.036
Meng Fei,Ge Hong-You,Wang Yong-Hui,Yue Shou-Wei
A afferent fibers have been reported to participate in the development of the central sensitization induced by inflammation and injuries. Current evidence suggests that myofascial trigger points (MTrPs) induce central sensitization in the related spinal dorsal horn, and clinical studies indicate that A fibers are associated with pain behavior. Because most of these clinical studies applied behavioral indexes, objective evidence is needed. Additionally, MTrP-related neurons in dorsal root ganglia and the spinal ventral horn have been reported to be smaller than normal, and these neurons were considered to be related to A fibers. To confirm the role of A fibers in MTrP-related central changes in the spinal dorsal horn, we studied central sensitization as well as the size of neurons associated with myofascial trigger spots (MTrSs, equivalent to MTrPs in humans) in the biceps femoris muscle of rats and provided some objective morphological evidence. Cholera toxin B subunit-conjugated horseradish peroxidase was applied to label the MTrS-related neurons, and tetrodotoxin was used to block A fibers specifically. The results showed that in the spinal dorsal horn associated with MTrS, the expression of glutamate receptor (mGluR1α/mGluR5/NMDAR1) increased, while the mean size of MTrS-related neurons was smaller than normal. After blocking A fibers, these changes reversed to some extent. Therefore, we concluded that A fibers participated in the development and maintenance of the central sensitization induced by MTrPs and were related to the mean size of neurons associated with MTrPs in the spinal dorsal horn.
研究领域:
神经科学
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疼痛研究
·
生理学
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Micromachines
·
2017
·Vol. 8
·期 9
·
IF 1.833
Pengfei Lu,Liangyu Wu,Xiangdong Liu
A simple and robust co-flowing microfluidic device for double emulsion preparation is designed and assembled to visually study the double emulsion formation by the use of a microscope and high-speed camera. Using a visualization system, the transient processes of double emulsion formation in co-flowing stream are observed and recorded for a variety of flow rates. The effects of flow rates of each fluid on flow modes, drop sizes, and polydispersities are examined and analyzed. The results indicate that the detaching of the inner drops accelerates the detaching of the outer drops and speeds up the drop formation process of double emulsions. The manipulation of flow rates is capable to actively control the sizes of the inner and outer drops as well as the number of inner drops encapsulated. Without surface modification, the microfluidic device produces a variety of emulsions, including the single-core and multi-core O/W/O double emulsions as well as binary emulsions of single and double emulsions. The proposed co-flowing microfluidic device is highly desirable in producing double emulsions in an easy and cheap way.
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JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Yunyun Li,Chang Lu,Nali Zhu,Jiang Chao,Wenjun Hu,Zhiyuan Zhang,Yongjie Wang,Lichun Liang,Jinkan Chen,Diandou Xu,Yuxi Gao,Jiating Zhao
Sulfur-fertilizer is commonly applied in croplands and in immobilizing Hg in contaminated soil. However, there is still great uncertainty and controversy concerning Hg transportability and transformation when supplying sulfur in paddies with complex conditions. Herein, we explored the effect of adding sulfate in paddy soil at different rice growth stages on soil Hg release and MeHg accumulation in rice and uncovered the correlation between sulfur induced MeHg production and the dynamically changed soil E h , dissolved Fe, and dissolved organic carbon (DOC). In specific, sulfate addition at early stages (flooding period) triggered the decrease of E h and increase of DOC and dissolved Fe, which in turn promoted Hg release and favored MeHg generation (increased by 235.19–555.07% vs control). Interestingly, adding sulfate at late stages (drainage condition), as compared with that at early stages, alleviated Hg release and MeHg production accompanied by the increase of E h and decrease of dissolved Fe and DOC. The microcosmic experiment further confirmed the reduction of sulfate to sulfide promoted the change of E h , thereby stimulating HgS dissolution in soil extract. The results give clues on the rational application of sulfur-fertilizer and through the water-sulfur fertilizer management considering the correspondingly changed soil conditions to diminish Hg bioavailability and MeHg production in paddies and paddy-like environments.
研究领域:
环境科学
·
土壤化学
·
农业管理
·
污染控制
·
生物地球化学
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Nutrients
·
2023
·Vol. 15
·期 4
·973
·
IF 5.9
Haiyan Zhou,Wenjing Liu,Yiqian Lv,Ke Liu,Yin Wang,Shuangli Meng,Tong Kang,Yuechao Bao,Huicui Meng
We aimed to examine the effect of natto and red yeast rice (NR) supplementation on lipid and lipoprotein profiles, gene expressions of cholesterol metabolism, and the composition of gut microbiota in ApoE-/-mice. Forty-one male ApoE-/-mice aged 7–8 wks old were randomly fed a control diet (CD), CD + NR (oral gavage at 0.3 g/kg BW/day), high-fat and high-cholesterol diet (HFD), or HFD + NR for 12 wks. Fasting blood samples, liver and intestine tissues and fecal samples were collected at week 12. Biochemical parameters, gene expressions in cholesterol metabolism and gut microbiota composition and diversity were measured using standard methods. NR supplementation had no significant effect on lipid and lipoprotein profiles. Compared with the HFD group, HFD + NR resulted in higher mRNA expressions of HMGCR and CYP7A1 (bothP-NR< 0.05) and ABCA1 (P-diet*NR= 0.0134,P-NR= 0.0407), lower mRNA expression of PCSK9 (P-diet*NR= 0.0002), lower fasting glucose concentrations (P-diet*NR= 0.0011), and lower relative abundance of generaBacteroidesandLactococcus(bothP-NR< 0.01) andCoriobacteriaceae_UCG-002(P-diet*NR= 0.0007). The relative abundance ofLactococcuswas inversely correlated with HMGCR and CYP7A1, and the relative abundance ofCoriobacteriaceae_UCG-002was positively correlated with PCSK9 and inversely correlated with ABCA1 (allP< 0.05). These findings suggest that NR supplementation may regulate gene expressions in cholesterol metabolism via changes in the gut microbiota in HFD-fed ApoE-/-mice.Keywords:natto;red yeast rice;gene expression;cholesterol metabolism;gut microbiota
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Pathogens
·
2022
·Vol. 11
·期 9
·1020
·
IF 4.531
Julio Abel Alfredo dos Santos Simone Come,Yibin Zhuang,Tianzhen Li,Simone Brogi,Sandra Gemma,Tao Liu,Edson Roberto da Silva
Arginase is a metalloenzyme that plays a central role inLeishmaniainfections. Previously, rosmarinic and caffeic acids were described as antileishmanial agents and asLeishmania amazonensisarginase inhibitors. Here, we describe the inhibition of arginase inL. amazonensisby rosmarinic acid analogs (1–7) and new caffeic acid-derived amides (8–10). Caffeic acid esters and amides were produced by means of an engineered synthesis inE. coliand tested againstL. amazonensisarginase. New amides (8–10) were biosynthesized inE. colicultured with 2 mM of different combinations of feeding substrates. The most potent arginase inhibitors showed Ki(s) ranging from 2 to 5.7 μM. Compounds2–4and7inhibitedL. amazonensisarginase (L-ARG) through a noncompetitive mechanism whilst compound9showed a competitive inhibition. By applying an in silico protocol, we determined the binding mode of compound9. The competitive inhibitor of L-ARG targeted the key residues within the binding site of the enzyme, establishing a metal coordination bond with the metal ions and a series of hydrophobic and polar contacts supporting its micromolar inhibition of L-ARG. These results highlight that dihydroxycinnamic-derived compounds can be used as the basis for developing new drugs using a powerful tool based on the biosynthesis of arginase inhibitors.Keywords:arginase;Leishmania amazonensis;biosynthesis;natural products;molecular modeling
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JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Xuemei Bao,Qianqian Liu,Jiahui Yang,Furong Wang,Fengjiao Yu,Jian Yu,Yang Yang
Fouling control is of great significance for polymeric membrane-based wastewater purification and reclamation. Herein, we designed a reactive polysulfone (PSF) ultrafiltration (UF) membrane integrating resorcinol–formaldehyde (RF) resin nanospheres and β -FeOOH nanoparticles ( [email protected] /PSF) with unique self-cleaning performance. The [email protected] /PSF membrane with an optimal RF resin and β -FeOOH loading showed a reasonable water flux (376.3 L m −2 h −1 bar −1 ) and high rejection (97.5%) to bovine serum albumin. Besides, the membrane could capture trace amount of cationic dyes in the feed solution via electrostatic attraction. After organic fouling, the permeation flux of the membrane was effectively recovered under visible-light irradiation at neutral pH. We confirmed that the low-bandgap RF resin nanospheres blended in the PSF matrix produced H 2 O 2 in-situ upon absorption of visible light. Then the adjacent β -FeOOH nanoparticles catalyzed the conversion of the self-supplied H 2 O 2 to •OH radicals. The [email protected] /PSF membrane provided a unique platform to perform cascade reaction for production of •OH radicals concentrated in restricted space, which effectively degraded the adsorbed organic foulants. The proposed self-cleaning mechanism that can work under sunlight and ambient condition is expected to simplify and economize the cleaning operations of polymeric UF composite membranes in complex wastewater purification.
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